针刺结合高压氧及药物治疗突发性聋临床研究

目的对针刺结合高压氧及药物治疗突发性聋进行临床研究, 观察其疗效;方法选取陕西省人民医院康复医学科2019年1月至2021年1月突发性聋患者228例, 随机分为治疗组121例, 对照组107例;治疗组采用高压氧+针刺+药物治疗, 对照组采用针刺+药物治疗, 每组治疗7次, 观察疗效。结果治疗组显效率68.6%、总有效率85.1%, 对照组显效率57.9%、总有效率71.0%, 2组疗效比较差异有统计学意义(P<0.05);结论高压氧结合针刺及药物治疗突发性聋的疗效优于单纯针刺加药物治疗。     

药物联合高压氧治疗突发性聋132例

 目的 探讨药物联合高压氧治疗(hyperbaric oxygen treatment,HBOT)突发性聋的效果.方法 连续就诊的261例突发性聋患者随机分为药物治疗组(对照组)和HBOT结合药物治疗组(CHBOT),对照组采用常规药物治疗,HBOT组除上述药物治疗外,在舱内压力达0.20 MPa下,吸纯氧30 min 2次(中间吸空气10 min),1/d.在治疗后第30天或其间结束治疗的时间点按预定疗效指标评价.结果 与对照组相比,CHBOT 组听力显著改善(P＜0.01);耳鸣显著减轻,有效率为 76.8%, 对照组为56.63%(P＜0.01).在有眩晕的患者中,CHBOT组98.11% 的患者消失,而对照组仅 83.3%消失(P＜0.05).CHBOT组疗程明显短于对照组(P＜0.01).分析显示,无论采用何种治疗方法,入院前病程长、听力丧失(PTA＞55 dB)明显以及伴随眩晕的患者预后差.结论 CHBOT治疗突发性聋的疗效明显优于单纯药物治疗.尽早启动HBOT结合药物治疗是提高突发性聋治愈率的重要途径.     

激光和药物治疗突发性聋的疗效分析

目的 探讨激光对突发性聋的疗效。方法 对266例突发性聋患者用低强度He-Ne激光血管内照射与常规药物治疗,并进行疗效分析。结果 各治疗组间疗效差异有显著意义（P＜0．05）,且激光治疗组总有效率为82％。结论 提示激光的应用可作为治疗突发性耳聋的手段之一。     

高压氧治疗突发性耳聋的疗效及疗程选择

目的:探讨高压氧联合药物治疗对突发性耳聋的疗效判定及疗程的选择。方法:选取中国科学技术大学第一附属医院耳鼻咽喉科2017年1月至2018年12月收治的突发性耳聋患者95例。依据患者意愿分为对照组(单纯药物治疗,33例)、高压氧5次组(药物联合高压氧5次治疗,32例)和高压氧10次组(药物联合高压氧10次治疗,30例)。治疗前后比较纯音听力变化,观察3组患者不同治疗方案疗效的差异。结果:对照组总有效率54%,高压氧5次组总有效率56%,高压氧10次组总有效率83%。高压氧10次组疗效明显优于对照组和高压氧5次组,差异有统计学意义( P<0.05),对照组和高压氧5次组之间总有效率差异无统计学意义( P>0.05)。 结论:高压氧联合药物治疗有利于突聋患者听力恢复,但治疗疗程需满足1个疗程即10次治疗。     

高压氧联合糖皮质激素治疗难治性突发性聋疗效观察

目的 观察高压氧(hyperbaric oxygen,HBO)联合糖皮质激素(glucocorticoid,GC)对难治性突发性聋临床疗效.方法 经患者知情同意,并经医院伦理委员会批准,根据患者是否使用GC治疗,将有完整临床资料的79例突发性聋患者分为HBO联合GC治疗组44例,单纯HBO组35例.另外,在我院同期耳鼻喉科收治的复诊就医的突发聋患者中,选取使用GC治疗但未进行HBO治疗患者32例,作为单纯GC组.通过分析治疗有效率、治愈率和听力改善率,对比联合治疗与单纯HBO治疗及单纯GC药物治疗的疗效差异.结果 HBO联合GC组患者的治疗有效率(59.52％)和听力改善率[(61.3±14.7)％]明显高于单纯HBO组[28.13％,(43.6±5.5)％]和单纯GC组[31.25％,(56.4±4.1)％].结论 对难治性突发性聋HBO联合GC较单纯HBO治疗或GC治疗效果更好.     

高压氧联合常规药物治疗突性耳聋的疗效观察

目的：探讨提高突发性耳聋疗效的方法。方法：将突发性耳聋病例分为两组,高压氧联合常规药物治疗组３０例,常规药物对照组２８例,结果：临床总有效率分别为９０％、４６．４％,两组差异显（Ｐ〈０．００５）,治疗中未发生并发症,结论：高压氧联合常规药物治疗突发性聋可明显提高疗效,且具有较高的安全性。     

突发性耳聋患者不同类型听力曲线与临床疗效关系分析

目的 分析突发性耳聋患者不同类型听力曲线与临床疗效的关系.方法 回顾性分析本院收治的113例（118耳）突发性耳聋患者临床资料,按不同的初始听力曲线分为低频型23耳,中频型9耳,高频型28耳,平坦型41耳和全聋型17耳5组.均在接受高压氧治疗的同时给予1-3周的静脉用药治疗.结果 经治疗后患者各型听力曲线有效率分别为：低频型95.7%,中频型77.8%,高频型60.7%,平坦型78%和全聋型52.9%.结论 不同类型听力曲线突聋患者中,低频型疗效最好,其次为平坦型、中频型,全聋型疗效最差.     

鼓室内注射地塞米松治疗中重度-重度突发性感音神经性聋

目的:观察鼓室内注射地塞米松对单侧中重度-重度突发性感音神经性聋的疗效.方法:选择经过常规治疗无效的单侧中重度-重度突发性感音神经性聋患者17耳,地塞米松经鼓膜穿刺鼓室内注射,2.5 mg/次,1次/3 d,10 d为1个疗程,共3次,比较治疗前后纯音听阈的变化情况.结果:治疗后纯音测听结果显示,1例显效,4例有效,12例无效,有效率为29.4%.结论:鼓室内注射地塞米松治疗可以改善部分常规治疗效果欠佳的中重度-重度突聋患者的听力.     

高压氧综合治疗突发性耳聋效果分析

目的 :对比观察 3种方法治疗突发性耳聋的疗效 ,探讨较为理想的治疗方案。方法 :随机将 15 6例突发性耳聋患者分为高压氧治疗组 (HBO组 )、单纯药物治疗组 (药物组 )、高压氧加药物治疗组 (综合组 ) 3组进行疗效比较和分析。结果 :总有效率综合组 93 9% ,HBO组 80 7% ,药物组 75 9% ;痊愈率综合组疗效优于HBO组 (X2 =5 92 9,P <0 0 5 )和药物组 (X2 =11 10 8,P <0 0 1) ;HBO组与药物组比较无显著性差异 (X2 =0 819,P >0 0 5 )。 3种治疗方法均显示 ,病程越短 ,疗效越好。结论 :综合组疗效确切 ,是治疗突发性耳聋的较好手段     

高原地区药物联合高压氧治疗突发性耳聋疗效观察

目的：观察高原地区药物联合高压氧治疗突发性耳聋的疗效。方法：选择突发性耳聋132例,随机分为对照组和观察组各66例。对照组采用常规药物治疗,观察组在对照组治疗基础上加用高压氧辅助治疗,比较两组的临床疗效。结果：观察组总有效率为89.4%,显著高于对照组的71.2%（P〈0.05）。两组≤7天、8~14天的总有效率显著高于15~30天、≥31天的总有效率（P〈0.05）;而观察组15~30天、≥31天的总有效率又显著高于对照组同一时间点的总有效率（P〈0.05）。有伴随症状者总有效率为72.5%,显著低于无伴随症状者的90.4%（P〈0.05）。结论：高原地区药物联合高压氧治疗突发性耳聋临床疗效优于常规药物治疗。     

Knee injury and Osteoarthritis Outcome Score (KOOS) - validation of a Swedish version

The Knee injury and Osteoarthritis Outcome Score (KOOS) is a self-administered instrument measuring outcome after knee injury at impairment, disability, and handicap level in five subscales. Reliability, validity, and responsiveness of a Swedish version was assessed in 142 patients who underwent arthroscopy because of injury to the menisci, anterior cruciate ligament, or cartilage of the knee. The clinimetric properties were found to be good and comparable to the American version of the KOOS. Comparison to the Short Form-36 and the Lysholm knee scoring scale revealed expected correlations and construct validity. Item by item, symptoms and functional limitations were compared between diagnostic groups. High responsiveness was found three months after arthroscopic partial meniscectomy for all subscales but Activities of Daily Living.     

The acutely limping child

Acute limping may be the result of multiple pathologies in children. The differential diagnosis varies based on the age of the child. Irrespective of age, the initial imaging work-up includes AP and frog leg radiographs of the pelvis and ultrasound; MRI may sometimes be helpful. In children less than 3 years, infections and trauma are most frequent. MRI is the imaging modality of choice when osteomyelitis is clinically suspected. Between the ages of 3 and 10 years, transient synovitis of the hip and Legg-Calvé-Perthes disease are main considerations but infection, inflammation and focal bony lesions are also considered. In children over 10 years, slipped capital femoral epiphysis also is considered.     

Do Balance Board Training Programs Reduce the Risk of Ankle Sprains in Athletes?

Introduction Ankle sprains are the most common musculo-skeletal injury that occurs in athletes,particularly in sports that require jumping and landing on one foot such as soccer,and basketball(1-4).These injuries often result in significant time loss from participation,long-term disability,and have a major impact on health care costs and resources(5-8).     

High Intensity Interval Training:New Insights

KEY POINTS ·High-intensity interval training(HIT)is characterized by repeated sessions of relatively brief，intermittent exercise.often performed with an“a11 out”effort or at an intensity close to that which elicits peak oxygen uptake(i.e.，≥90%of VO2 peak).     

Endovascular management of carotid-cavernous fistulas

Objective To investigate endovascular treatment of traumatic direct carotid-cavernous fistulas （CCF） and their complications such as pseudoaneurysms. Methods： Over a five-year period, 22 patients with traumatic direct CCFs were treated endovascularly in our institution. Thirteen patients were treated once with the result of CCF occluded, 8 twice and 1 three times. Treatment modalities included balloon occlusion of the CCF, sacrifice of the ipsilateral internal carotid artery with detachable balloon, coll embolization of the cavernous sinus and secondary pseudoaneurysms, and covered-stem management of the pseudoaneurysms. Results All the direct CCFs were successfully managed endovascularly. Four patients developed a pseudoaneurysm after the occlusion of the CCF with an incidence of pseudoaneurysm formation of 18.2% （4/22）. A total number of 8 patients experienced permanent occlusion of the ICA with a rate of ICA occlusion reaching 36.4% （8/22）. Followed up through telephone consultation from 6 months to 5 years, all did well with no recurrence of CCF symptoms and signs. Conclusion Traumatic direct CCFs can be successfully managed with endovascular means. The pseudoaneurysms secondary to the occlusion of the CCFs can be occluded with stent-assisted coiling and implantation of covered stents.     

Developmental validation of the PowerPlex(®) ESI 16 and PowerPlex(®) ESI 17 Systems: STR multiplexes for the new European standard

In response to the ENFSI and EDNAP groups’ call for new STR multiplexes for Europe, Promega^® developed a suite of four new DNA profiling kits. This paper describes the developmental validation study performed on the PowerPlex^® ESI 16 (European Standard Investigator 16) and the PowerPlex^® ESI 17 Systems. The PowerPlex^® ESI 16 System combines the 11 loci compatible with the UK National DNA Database^®, contained within the AmpFlSTR^® SGM Plus^® PCR Amplification Kit, with five additional loci: D2S441, D10S1248, D22S1045, D1S1656 and D12S391. The multiplex was designed to reduce the amplicon size of the loci found in the AmpFlSTR^® SGM Plus^® kit. This design facilitates increased robustness and amplification success for the loci used in the national DNA databases created in many countries, when analyzing degraded DNA samples. The PowerPlex^® ESI 17 System amplifies the same loci as the PowerPlex^® ESI 16 System, but with the addition of a primer pair for the SE33 locus. Tests were designed to address the developmental validation guidelines issued by the Scientific Working Group on DNA Analysis Methods (SWGDAM), and those of the DNA Advisory Board (DAB). Samples processed include DNA mixtures, PCR reactions spiked with inhibitors, a sensitivity series, and 306 United Kingdom donor samples to determine concordance with data generated with the AmpFlSTR^® SGM Plus^® kit. Allele frequencies from 242 white Caucasian samples collected in the United Kingdom are also presented. The PowerPlex^® ESI 16 and ESI 17 Systems are robust and sensitive tools, suitable for the analysis of forensic DNA samples. Full profiles were routinely observed with 62.5 pg of a fully heterozygous single source DNA template. This high level of sensitivity was found to impact on mixture analyses, where 54–86% of unique minor contributor alleles were routinely observed in a 1:19 mixture ratio. Improved sensitivity combined with the robustness afforded by smaller amplicons has substantially improved the quantity of data obtained from degraded samples, and the improved chemistry confers exceptional tolerance to high levels of laboratory prepared inhibitors.     

Bronchial stump fistula :treatment with covered retrievable hinged metallic stents-preliminary clinical experience

Objective To evaluate the preliminaily clinical efficacy and retrievability of a retrievable hinged covered metallic stent in the treatment of the bronchial stump fistula （BSF）. Methods Between April 2003 and March 2005, 8 patients with bronchial stump fistula after pneumonectomy or lobectomy were treated with two types （A and B） of retrievable hinged covered metallic stents. Type A stent was placed in 6 patients and type B in 2 under fluoroscopic guidance. The stent was removed with a retrieval set when BSF was healed or complications occurred. Results Stent placement in the bronchial tree was technically successful in all patients, without procedure-related complications. Immediate closure of the BSF was achieved in all patients after the procedure. Stents were removed from all patients but one. Removal of the stents was difficult in two patients due to tissue hyperplasia. Patients were followed up for 6 - 21 months. Placement of the stents remained stable in all patients except one due to severe cough. Permanent closure of BSF was achieved in 7 （87.5%） of 8 patients. Conclusion Use of a retrievable hinged covered expandable metallic stent is a simple, safe, and effective procedure for closure of the BSF. Retrieval of the stent seems to be feasible. （J Intervent Radiol, 2007, 16： 253-257）     

Prevalence and severity of hip and groin pain in sub‐elite male football: a cross‐sectional cohort study of 695 players

The purpose of this study was twofold: (a) to investigate the prevalence of hip and groin pain in sub‐elite male adult football in Denmark and (b) to explore the association between prevalence and duration of hip and groin pain in the previous season with the Copenhagen Hip and Groin Outcome Score (HAGOS) in the beginning of the new season. In total 695 respondents from 40 teams (Division 1–4) were included. Players completed in the beginning of the new season (July–Sept 2011) a self‐reported paper questionnaire on hip and/or groin pain during the previous season and HAGOS. In total 49% (95% CI: 45–52%) reported hip and/or groin pain during the previous season. Of these, 31% (95% CI: 26–36%) reported pain for >6 weeks. Players with the longest duration of pain during the previous season had the lowest HAGOS scores, when assessed at the beginning of the new season, P < 0.001. This study documents that half of sub‐elite male adult football players report pain in the hip and/or groin during a football season. The football players with the longest duration of pain in previous season displayed the lowest HAGOS scores in the beginning of the new season.