Role of <Emphasis Type="Italic">Helicobacter pylori</Emphasis> infection in the pathogenesis of minimal hepatic encephalopathy and effect of its eradication

Background and Aim  

Helicobacter pylori (H. pylori) bacteria convert urea to ammonia, which has been implicated in causation of hepatic encephalopathy in patients with liver cirrhosis. The role of H. pylori infection in causation of minimal hepatic encephalopathy (MHE) has not been well studied. We looked at the relationship of H. pylori infection with MHE and hyperammonemia in patients with liver cirrhosis and the effects of anti-H. pylori treatment in patients with MHE and H. pylori infection.     

Characterization of clarithromycin resistance in isolates of <Emphasis Type="Italic">Helicobacter pylori</Emphasis> from the UAE

Background  

Clarithromycin therapy is effective in eradicating Helicobacter pylori. However, the resistance of H. pylori to clarithromycin is increasingly reported. The present study aimed to characterize the types of mutations present in the 23S rRNA genes of isolates of clarithromycin-resistant H. pylori from the UAE.     

Prevalence of <Emphasis Type="Italic">Helicobacter pylori</Emphasis>infection among new outpatients with dyspepsia in Kuwait

Background  

Testing and treatment for Helicobacter pylori has become widely accepted as the approach of choice for patients with chronic dyspepsia but no alarming features. We evaluated H. pylori status among outpatients with uninvestigated dyspepsia in Kuwait.     

The effect of <Emphasis Type="Italic">H. pylori</Emphasis> eradication on meal-associated changes in plasma ghrelin and leptin

Background  

Appetite and energy expenditure are regulated in part by ghrelin and leptin produced in the gastric mucosa, which may be modified by H. pylori colonization. We prospectively evaluated the effect of H. pylori eradication on meal-associated changes in serum ghrelin and leptin levels, and body weight.     

Introduction of an examination and treatment for <Emphasis Type="Italic">Helicobacter pylori</Emphasis> infection in high school health screening

Background  

Recently, a significant relationship between gastric cancer and Helicobacter pylori infection has been proven. The purpose of this study was to elucidate the actual conditions of H. pylori infection in Japanese teenagers.     

Effect of <Emphasis Type="Italic">Helicobacter pylori</Emphasis> Infection on Symptoms of Gastroenteritis Due to Enteropathogenic <Emphasis Type="Italic">Escherichia coli</Emphasis> in Adults

Background  

Helicobacter pylori can cause hypochlorhydria in some hosts and predispose to diarrheal infections.     

The diagnostic value of endoscopy and <Emphasis Type="Italic">Helicobacter pylori</Emphasis> tests for peptic ulcer patients in late post-treatment setting

Background  

Guidelines for management of peptic ulcer patients after the treatment are largely directed to detection of H. pylori infection using only non-invasive tests. We compared the diagnostic value of non-invasive and endoscopy based H. pylori tests in a late post-treatment setting.     

Elevated Serum Matrix Metalloproteinase-3 and -7 in <Emphasis Type="Italic">H. pylori</Emphasis>-Related Gastric Cancer Can Be Biomarkers Correlating with a Poor Survival

Background  

Helicobacter pylori (H. pylori) infection up-regulates the expression of matrix metalloproteinases (MMPs), which may be involved in chronic inflammation, ulceration, and even cancer development. This study aimed to test if serum levels of MMP-3, -7, and -9 are correlated with different clinical outcomes in H. pylori-infected subjects and if these are predictive of progression to H. pylori-related gastric cancer.     

Survey of general practitioners' knowledge about <Emphasis Type="Italic">Helicobacter pylori</Emphasis> infection

Background  

Helicobacter pylori, occurring throughout the world and causing gastroduodenal diseases, is one of the most common chronic bacterial agents in humans. The purpose of this study was to measure the general practitioners' (GPs) knowledge and practices pertaining to H. pylori infection.     

<Emphasis Type="Italic">Helicobacter pylori</Emphasis> in a Korean Isolate Expressed Proteins Differentially in Human Gastric Epithelial Cells

Purpose  

The proteins expressed in gastric epithelial cells infected with Helicobacter pylori (H. pylori) may determine the clinical outcome such as chronic gastritis, peptic ulcer, and gastric carcinoma. The present study aims to determine the differentially expressed proteins in human gastric epithelial AGS cells that were infected with H. pylori in a Korean isolate, a cagA+, vacA s1b m2 iceA1 H. pylori by proteomic analysis. The differentially expressed proteins, whose expression levels were more or less than twofold in H. pylori-infected cells, were analyzed.     

Incidence of Esophageal Carcinoma Among Malays in North-Eastern Peninsular Malaysia: An Area with an Exceptionally Low Prevalence of <Emphasis Type="Italic">Helicobacter pylori</Emphasis> Infection

Background  

Obesity, gastroesophageal reflux, and Barrett’s esophagus have all been linked to esophageal adenocarcinoma. In addition, the decline in Helicobacter pylori (H. pylori) infection in affluent societies has also been suggested to be a major factor in the recent rise in the incidence of esophageal adenocarcinoma. If H. pylori infection has a protective role, populations with a naturally low prevalence of H. pylori infection such as the ethnic Malays of Northeastern Peninsular Malaysia should have high rates of esophageal adenocarcinoma.     

Immunohistochemical testing for <Emphasis Type="Italic">Helicobacter Pylori</Emphasis>existence in neoplasms of the colon

Background  

Helicobacter pylori is a common pathogen, and its prevalence varies with socioeconomic conditions (10–80%). It has recently been recognized as a class I carcinogen in relation to gastric cancer. The aim of this study was to investigate the presence of Helicobacter pylori in neoplasms of the colon by immunohistochemical methods.     

Development of corpus atrophic gastritis may be associated with <Emphasis Type="Italic">Helicobacter pylori</Emphasis>-related idiopathic thrombocytopenic purpura

Background  

A strict correlation between Helicobacter pylori eradication and an increase in platelet count has previously been reported in patients with chronic idiopathic thrombocytopenic purpura (ITP). To clarify the pathogenesis of H. pylori-induced ITP and the factors predicting the platelet response to H. pylori eradication therapy, we evaluated the markers of atrophic gastritis in ITP patients.     

The <Emphasis Type="Italic">Helicobacter pylori</Emphasis> duodenal ulcer promoting gene, <Emphasis Type="Italic">dupA</Emphasis>in China

Background  

The prevalence of H. pylori is as high as 60–70% in Chinese population. Although duodenal ulcer and gastric cancer are both caused by H. pylori, they are at opposite ends of the spectrum and as such are considered mutually exclusive. Duodenal ulcer promoting (dupA) gene was reported to be associated with duodenal ulcer development. The aim of this study was to determine the prevalence of dupA gene of Helicobacter pylori in patients with various gastroduodenal diseases and to explore the association between the gene and other virulence factors.     

The overmethylated genes in <Emphasis Type="Italic">Helicobacter pylori</Emphasis>-infected gastric mucosa are demethylated in gastric cancers

Background  

The transitional-CpG sites between weakly methylated genes and densely methylated retroelements are overmethylated in the gastric mucosa infected with Helicobacter pylori (H. pylori) and they are undermethylated in the gastric cancers depending on the level of loss of heterozygosity (LOH) events. This study delineated the transitional-CpG methylation patterns of CpG-island-containing and -lacking genes in view of the retroelements.     

Low prevalence of <Emphasis Type="Italic">H. pylori</Emphasis> Infection in HIV-Positive Patients in the Northeast of Brazil

Background  

This study conducted in Northeastern Brazil, evaluated the prevalence of H. pylori infection and the presence of gastritis in HIV-infected patients.     

Infection with Specific <Emphasis Type="Italic">Helicobacter pylori</Emphasis>-<Emphasis Type="Italic">cag</Emphasis> Pathogenicity Island Strains Is Associated with <Emphasis Type="Italic">Interleukin-1B</Emphasis> Gene Polymorphisms in Venezuelan Chronic Gastritis Patients

Background  

The cag pathogenicity island (cag-PAI) is one of the major virulence factors of Helicobacter pylori, showing considerable geographic variation.     

Molecular and histological evaluation of tumor necrosis factor-alpha expression in <Emphasis Type="Italic">Helicobacter pylori</Emphasis>-mediated gastric carcinogenesis

Purpose  

Helicobacter pylori (H. pylori) is considered to be a major factor contributing to gastric mucosal damage by stimulating mucosal macrophage production of inflammatory cytokines, including tumor necrosis factor-alpha (TNF-α), but the inflammatory responses within the gastric mucosa in vivo are not well known. Therefore, this study was designed to investigate the expression of TNF-α induced by H. pylori infection which is involved in the tumor initiation and promotion of gastric carcinogenesis.     

On the Association Between Soft Drink Consumption and <Emphasis Type="Italic">Helicobacter pylori</Emphasis> Infection

Background  

The association between soft drink (SD) consumption and Helicobacter pylori infection remains unclear.     

Ten-year prospective follow-up of histological changes at five points on the gastric mucosa as recommended by the updated Sydney system after <Emphasis Type="Italic">Helicobacter pylori</Emphasis> eradication

Background  

Atrophic gastritis and intestinal metaplasia (IM) are well known as precancerous lesions of gastric cancer. The present study evaluated the gastric mucosa for 10 years after H. pylori eradication at five points of the stomach as recommended by the updated Sydney system to clarify the relationship between H. pylori eradication and gastric cancer prevention.