天芪降糖胶囊治疗2型糖尿病60例临床观察

目的 :研究天芪降糖胶囊治疗 2型糖尿病的有效性及安全性。方法 :采用前瞻性随机双盲对照试验的方法 ,应用天芪降糖胶囊治疗 2型糖尿病 60例 ,于治疗前后检测空腹及餐后 2 h血糖、2 4h尿糖定量、糖化血红蛋白、胰岛素、C-肽水平及中医证候变化、血象、肝肾功能等 ,以观察疗效及安全性。结果 :天芪降糖胶囊治疗 2型糖尿病总有效率 86.67% ,显效率 31 .67% ,中医证候疗效总有效率 95 .0 0 % ,显效率 60 .0 0 % ,与对照组相似。天芪降糖胶囊治疗后病人血糖、2 4 h尿糖、糖化血红蛋白均有显著下降 ,与对照组相比差异有显著性 ( P<0 .0 5 ) ,而胰岛素及 C-肽水平无变化。未见血象及肝肾功能异常。结论 :天芪降糖胶囊是有效安全治疗 2型糖尿病的药物     

降糖胶囊对2型糖尿病的治疗作用

目的:评价降糖胶囊对2型糖尿病的临床疗效.方法:50例2型糖尿病患者随机分为试验组和对照组,试验组给予降糖胶囊1.5 g,tid,对照组给予玉泉丸9 g,tid,均为餐前口服,疗程4～8 wk.用药前后检查空腹血糖(FPG)、餐后2 h血糖(h2PG).部分病例进行血浆胰岛素(IRI)和血脂[总胆固醇(TC),三酰甘油(TG),高密度脂蛋白胆固醇(HDL-C)]的检测.结果:与对照组比较,降糖胶囊治疗后症状有明显改善,血糖、血脂较治疗前明显下降,总有效率达87%.结论:降糖胶囊用于治疗2型糖尿病具有较好的疗效.     

益津降糖胶囊治疗2型糖尿病42例

目的　观察益津降糖胶囊治疗糖尿病的临床疗效。方法　选择新确诊的 2型糖尿病 42例 ,服用益津降糖胶囊 12周 ,自身对照治疗前后空腹血糖 (FBG)、餐后 2h血糖 (PBG)、糖化血红蛋白 (HbA1c)、总胆固醇 (TG)、甘油三酯(TC)、高密度脂蛋白 (HDL)、低密度脂蛋白 (LDL)等变化。结果　与基础值比较 ,治疗 12周FBG、PBG、HbA1c水平均有下降 (P <0 .0 1,P <0 .0 5 ) ;益津降糖胶囊降低FBG、PBG、HbA1c的有效率分别为 78.6%、83 .3 %、45 .2 % ;TG和TC与治疗前比较有显著差异 (P <0 .0 5 )。结论　益津降糖胶囊能有效地降低血糖 ,改善血脂。     

降糖胶囊加格列喹酮对糖尿病的疗效研究

目的:研究降糖胶囊(CRH)加格列喹酮对Ⅱ型糖尿病的降糖作用、临床疗效及毒副作用。方法:152例Ⅱ型糖尿痛患者随机分成3组,分别给予格列喹酮、降糖胶囊及格列喹酮和降糖胶囊,在治疗后不同时间对患者进行空腹血糖、胰岛素、C肽、糖化血红蛋白、甘油三酯、总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇及餐后2 h血糖测定,以评价这些处理措施对Ⅱ型糖尿痛的治疗效果。结果:三种处理方法均能有效降低空腹血糖及餐后2 h血糖;但格列喹酮与降糖胶囊联合应用可明显提高治疗有效率(与格列喹酮组和降糖胶囊组比较,P<0.05)。单独应用格列喹酮对血脂代谢无影响,但对胰岛素抵抗有一定改善;单独运用降糖胶囊或将降糖胶囊与格列喹酮联合应用不但能有效改善患者胰岛素抵抗,恢复患者胰岛功能,患者的血脂代谢异常也出现了明显的改善。联合应用降糖胶囊与格列喹酮未发现明显的毒副作用。结论:降糖胶囊与格列喹酮联合应用治疗Ⅱ型糖尿病具有良好的协同作用,无明显的毒副作用,且对于防止Ⅱ型糖尿病的并发症如脂类代谢异常具有良好作用。     

中医药预防糖尿病并发症

目的：探讨中医药治疗糖尿病的临床疗效。方法：对50例确诊的2型糖尿病患者随机分为治疗组30例，对照组20例。结果：治疗组总有效率为88．5％，高于对照组的总有效率（85．0％），两者比较无显著性差异（P〉0．05）。两组空腹血糖及餐后2h血糖均下降。血脂改变以治疗组明显。结论：治疗2型糖尿病时酌加活血化瘀之品，不失为辨病施治的上策，对2型糖尿病并发症防治更为重要。     

珍芪降糖胶囊治疗2型糖尿病疗效观察

珍芪降糖胶囊由黄芪、生地黄、黄精、麦门冬、天花粉、石斛、山药等组成,具有益气养阴,清热生津之功,主治消渴病属于气阴两虚兼虚热之证的糖尿病。为观察珍芪降糖胶囊治疗2型糖尿病的疗效,将243例患者随机分为2组,治疗组184例,对照组59例,治疗组口服珍芪降糖胶囊;对照组口服降糖宁胶囊。疗程4周。结果:与治疗前比较,治疗组和对照组均能改善糖尿病患者的临床症状(P<0.01),降低患者的空腹血糖及餐后2h血糖(P<0.01),治疗组和对照之间无显著差异。结论:珍芪降糖胶囊可改善2型糖尿病患者的临床症状,降低患者的空腹血糖和餐后2h血糖。     

金芪降糖片治疗2型糖尿病临床观察

目的:探讨分析金芪降糖片治疗2型糖尿病临床疗效。方法:受试前检查空腹血糖和餐后2h血糖水平,分别给予金芪降糖片和安慰剂服用,3次/d,7片/次,饭前30min即服。连续服用3周,于第1周末、第2周末、第3周末复查空腹血糖和餐后2h血糖含量。结果:金芪降糖片与对照组综合比较评估,金芪降糖片组的总有效率为90.0%,对照组总有效率为40.0%,两组比较差异有统计学意义(P<0.05)。结论:金芪降糖片效果优于安慰剂,其降糖效果显著,且未出现任何不良影响,因此,其可作为临床上治疗糖尿病的有效手段。     

丹蛭降糖胶囊改善老年2型糖尿病患者胰岛B细胞功能临床观察

目的:观察丹蛭降糖胶囊对老年2型糖尿病胰岛B细胞功能的影响.方法:两组均服用降糖药物格列齐特,治疗组同时加服丹蛭降糖胶囊,疗程均为12周.观察两组临床疗效,及治疗前后空腹血糖(FPG)、餐后2 h血糖(2hPG)、糖基化血红蛋白(HbA1c)、空腹胰岛素(FIns)、胰岛素敏感指数(HOMA IS)、胰岛素抵抗指数(HOMA IR)的变化情况,并进行对比分析.结果:治疗组总有效率为90.6%,对照组总有效率为85.7%,两组疗效无显著性差异(P>0.05).两组治疗后FPG、2hPG、HbA1c、FIns、HOMA IS、HOMA IR均有改善,但两组治疗后FPG、2hPG、HbA1c比较无显著性差异(P>0.05),而FIns、HOMA IS、HOMA IR治疗组较对照组改善明显(P<0.05,P<0.01).结论:丹蛭降糖胶囊对老年2型糖尿病患者有促进内源性胰岛素分泌,改善胰岛B细胞功能,改善胰鸟素抵抗的作用.     

空气净化对老年Ⅱ型糖尿病的疗效探讨

目的 :探讨空气净化对老年Ⅱ型糖尿病患者的疗效。方法 :对 4 8例老年Ⅱ型糖尿病患者应用MKJ型空气洁净器进行每日 2 4h空气净化 1个月 ,对照组 4 3例行运动疗法 ,分别于治疗后 1,2 ,3和 4周抽血查空腹血糖、餐后 2h血糖、糖化血红蛋白、胰岛素含量 ,并进行比较。结果 :实验组患者空腹血糖、餐后 2h血糖在净化后第 3周、糖化血红蛋白在净化后第 4周下降明显 ,胰岛素在净化后第 4周上升明显 (P <0 .0 1)。上述指标在第 4周的变化与对照组比较无显著性差异。病程在 2年以内的患者净化有效率为 89.7% ,病程在 2年以上者有效率为 6 6 .7%。另有 17例患者 (35 .4 % )的降糖药物用量有所减少。结论 :对老年Ⅱ型糖尿病患者行空气净化能有效降低空腹血糖、餐后 2h血糖、糖化血红蛋白水平 ,改善胰岛素的敏感性。其疗效与运动疗法相似。     

消栓胶囊治疗2型糖尿病伴高黏血症患者的临床观察

目的　观察消栓胶囊对 2型糖尿病伴高黏血症患者血生化指标的影响。方法　将符合诊断标准的糖尿病患者随机分为两组 ,均给予降糖治疗 ,观察组在此基础上加服消栓胶囊 ,观察两组患者治疗前、后血黏度、血小板聚集率、纤维蛋白原 (FIB)、空腹血糖 (FBG)、餐后 2h血糖 (2h -PBG)、糖化血红蛋白 (HbA1c) ,空腹胰岛素(FINS)、IL- 6等指标的变化。结果　治疗后观察组患者上述指标与对照组比较差别均有显著性意义 (P <0 0 5或0 0 1)。结论　消栓胶囊可以降低 2型糖尿病伴高黏血症患者的血糖、血脂水平     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.     

Scientific principles and rigorous processes should be followed in developing clinical guidelines for therapeutic interventions of integrative medicine

A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care（~＇4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.