慢性化脓性中耳炎病原菌及耐药性分析

慢性化脓性中耳炎是一种常见病,临床上患者反复感染、久治不愈,这可能与中耳结构复杂、脓液引流不畅有关,但临床上未能及时选用敏感抗生素进行治疗,是其治疗困难的重要因素之一.为了更好地了解目前慢性化脓性中耳炎的致病菌及耐药情况,以指导临床合理用药,我们对116例慢性化脓性中耳炎患者的耳分泌物进行了细菌培养及耐药分析,报告如下:……     

新疆慢性化脓性中耳炎的病原菌及耐药性分析

目的:研究新疆地区慢性化脓性中耳炎主要致病菌的种类及耐药情况。方法:对住院慢性化脓性中耳炎患者的分泌物进行细菌培养鉴定及药物敏感试验。结果:分离出89株细菌,金黄色葡萄球菌33株(37.1%),铜绿假单胞菌21株(23.6%)。金黄色葡萄球菌对莫西沙星、利奈唑烷、喹努普汀、利福平、替考拉宁、苯唑西林、亚安培南、氨苄西林/舒巴坦、万古霉素、磷霉素有较高的敏感性。所有金黄色葡萄球菌对莫西沙星及利奈唑烷未检出耐药株。铜绿假单胞菌对庆大霉素、头孢哌酮/舒巴坦、哌拉西林/他唑巴坦、丁胺卡那霉素、哌拉西林、头孢他啶、头孢吡肟、妥布霉素有较高的敏感性。结论:金黄色葡萄球菌和铜绿假单胞菌是新疆地区的慢性化脓性中耳炎主要致病菌,临床医生应根据药敏结果合理使用抗生素。     

慢性化脓性中耳炎主要病原菌种类及耐药性分析

目的:研究慢性化脓性中耳炎的主要病原菌种类及耐药性分析,以指导抗生素在该病中的合理应用。方法:对148例患者,采取中耳脓性分泌物进行需氧菌、真菌培养和药物敏感试验。结果:分离出病原菌154株,以金黄色葡萄球菌(57株)和铜绿假单胞菌(32株)为主,真菌10株。金黄色葡萄球菌对利福平、万古霉素和喹诺酮敏感,敏感率分别为100%、100%和87.72%。铜绿假单胞菌对头孢他啶、氨基糖甙类和喹诺酮类敏感,敏感率分别为90.62%、87.50%和90.62%。结论:金黄色葡萄球菌和铜绿假单胞菌是本地区慢性化脓性的中耳炎主要致病菌,二者均对喹诺酮类敏感,金黄色葡萄球菌在慢性化脓性中耳炎致病菌中起重要作用。     

慢性化脓性中耳炎的病原菌及药物敏感性分析

目的 观察慢性化脓性中耳炎患者中耳脓性分泌物的病原菌分布情况及其药物敏感性,以指导临床用药.方法 对123例慢性化脓性中耳炎患者123耳的中耳脓性分泌物进行细菌培养,并对分离的病原菌进行药物敏感试验.结果 123耳标本中分离培养出病原菌103耳,其中细菌99耳,真菌4耳;无细菌生长20耳.以金黄色葡萄球菌(21耳)和铜绿假单胞菌(19耳)为主,其次为表皮葡萄球菌(13耳)和肺炎克雷伯杆菌(10耳)等.不同的细菌有各自的敏感药物谱.结论 金黄色葡萄球菌和铜绿假单胞菌是慢性化脓性中耳炎的主要致病菌,抗菌药物敏感试验对临床用药有指导意义.     

慢性化脓性中耳炎的病原菌及药物敏感性分析

目的 观察慢性化脓性中耳炎患者中耳脓性分泌物的病原菌分布情况及其药物敏感性,以指导临床用药.方法 对123例慢性化脓性中耳炎患者123耳的中耳脓性分泌物进行细菌培养,并对分离的病原菌进行药物敏感试验.结果 123耳标本中分离培养出病原菌103耳,其中细菌99耳,真菌4耳;无细菌生长20耳.以金黄色葡萄球菌(21耳)和铜绿假单胞菌(19耳)为主,其次为表皮葡萄球菌(13耳)和肺炎克雷伯杆菌(10耳)等.不同的细菌有各自的敏感药物谱.结论 金黄色葡萄球菌和铜绿假单胞菌是慢性化脓性中耳炎的主要致病菌,抗菌药物敏感试验对临床用药有指导意义.     

慢性化脓性中耳炎病原菌检查及药物敏感试验

慢性化脓性中耳炎为耳科常见疾病,病原学检查以往曾有报道,不同时期感染菌群及药物敏感试验时有变化[1～3].我科1996-1998年对112例慢性化脓性中耳炎患者中耳腔脓液做需氧菌、真菌培养及细菌药物敏感试验,报道如下.     

慢性化脓性中耳炎的病原菌监测及耐药性研究

为更好地了解目前慢性化脓性中耳炎的菌种分布及耐药谱，我们对１９９９年１月至２０００年１２月收治的２８０例慢性化脓性中耳炎患者的耳分泌物进行了 病原菌培养，监测病原菌对抗生素的耐药性，报告如下。１　材料与方法１．１　临床资料　患者中耳流脓多在３个月以上，慢性化脓性中耳炎２８０例中，男１５２例，女１２８例，平均３８．５岁。由临床医师用无菌生理盐水湿润的消毒棉拭子在患者中耳、外耳道深部采集脓性分泌物，置无菌管内立即送检。１．２　试剂与质控菌株　培养基购自杭州天和微生物试剂有限公司，药敏纸片购自北京天坛…     

慢性化脓性中耳炎的病原菌及耐药性分析

研究慢性化脓中耳炎主要病原菌的种类及对抗生素的耐药情况。方法：对162例慢性化脓性中耳炎患者的耳分泌物进行细菌培养,对分离的病原菌进行药物敏感试验。结果：分离出病原菌183株,以金黄金葡萄球菌（63株）和铜绿假单胞菌（57株）为主,金黄色葡萄球菌对青霉素和红霉素的耐药经分别为100％和71．4％,对氨基糖甙类、氟喹诺酮类和头孢头抗生素敏感性较高;铜绿假单胞菌对氨苄西林、头孢类抗生素耐药率较高,对氟喹诺酮类、氨基糖甙类抗生素敏感。结论：金黄色葡萄球菌和铜绿假单胞菌是济南地区慢性化脓性中耳炎的主要致病菌,二者对青霉素类抗生素有较高的耐药率。临床医师不仅凭经验,而应根据细菌培养和药敏结果用药,以防耐药菌株产生。     

慢性化脓性中耳炎细菌培养及药物敏感试验103例报告

1997年 11月至 1999年 3月 ,我们对 10 3例、10 9耳慢性化脓性中耳炎的脓液进行细菌培养和药物敏感试验 ,现将结果报告如下。1　资料与方法1 1　一般资料　 10 3例中 ,男 5 7例 ,女 46例 ,3～ 71岁 ,10岁以下者居多 ,病程 1至 6 5年。1 2　培养方法　用 75 %酒精棉球清洁外耳道口 ,用灭菌试管内的无菌棉签 ,取外耳道深部或鼓室内的脓液 ,涂布于血琼脂平板上 ,采用需氧环境 36℃ ,恒温箱内培养 2 4ｈ ,再根据血平板生长菌落形态和各菌种特异性进行鉴别分类 ,然后采用Ｋ -Ｂ氏法 ,在ＭＨ培养基上 ,用抗生素纸片观察抑菌情况。2　结　果　　 10…     

慢性化脓性中耳炎细菌培养分析

本文报告了１７５例（耳）慢性化脓性中耳炎患者术前的细菌培养结果。其中１５２例（８６．８６％）有细菌生长。共检出细菌３１种，１６０株。均做了临床常用的抗生素敏感试验。我们认为，多种致病菌感染及不合理应用抗生素是造成本病治疗困难的因素之一。评价了细菌培养和药物敏感试验在治疗本病中的作用和地位。     

Pattern of chronic suppurative otitis media

This observational study was conducted to know the bacteriological pattern of chronic suppurative otitis media. For this 110 patients of Chronic Suppurative Otitis Media (CSOM) were selected from January 2006 to December 2007 at the out patient department of Otolaryngology and Head Neck surgery, BSMMU and Dhaka Medical College Hospital, Dhaka. Among the 110 patients unilateral involvement was 76.36% and bilateral involvement was 23.64%. Ninety percent patients presented with tubotympanic variety and 10% patients presented with attico-antral variety. Bacteriologically pure growth was found in 79.09% cases, mixed growth in 10.91% cases, no growth in 10% cases. Only aerobic bacteria were isolated in the present series. Pseudomonas aeruginosa was the most common organism (43.68%) isolated in pure culture followed by staphylococcus aureus 27.59%, E. coli 10.35%, Kleibsiella spp. 9.19%, proteus spp. 8.04%. Amikacin was the most effective antibiotic followed by Gentamycin, Ciprofloxacin, Ceftazidime, Cetriaxone. Before giving therapy bacterial growth and sensitivity pattern is to be known where facilities are available.     

慢性化脓性中耳炎骨导听阈特点分析

目的对慢性化脓性中耳炎(SCOM)患者的骨导听力损失情况进行总结和回顾行分析,探讨SCOM骨导听阈损伤情况.方法 320例患者均未接受过耳科手术治疗,对侧耳为正常耳(作对照耳),其中男11 4例,女196例;年龄12～61岁,平均34岁,病程3月～50年,平均21.16年.所有病例均采用GSI-68纯音测听仪在隔音室对患者和正常耳进行听力测试,并对骨导听阈的平均值进行统计学处理,对影响骨导听阈的因素做相关分析.结果所有患者中有201例(62.81%)发生骨导听阈损害.500～4000 Hz每个频率的骨导听力均有损失,主要损害在2000～4000 Hz的骨导听力损害程度与年龄、病程和病变程度有关.结论慢性化脓性中耳炎可以导致骨导听力损失,原因是综合性的.     

Extracranial complications of chronic suppurative otitis media

The aim of this study was to find out the pattern of extracranial complications of CSOM cases who attended to the department of ENTD, Mymensingh Medical College Hospital during the period from July'1999 to June' 2001. Different types of extracranial complications of CSOM were presented here. A total of 100 cases, diagnosed clinically and radiologically were included in the study of which 66 were male and 34 were female giving a male to female ratio of 1.94 : 1 (p < 0.05). Majority cases (53) were in the age group of 11- 20 years followed by the age group of below 10 years where there were 30 cases. Majority (64) cases came from low socio-economic class. The number of different types of extracranial complications of CSOM were as follows: mastoid abscess 57, discharging sinuses 28, purulent labyrinthitis 07, Bezold's abscess 04, fascial nerve paralysis 03 and zygomatic abscess 01. In all cases of CSOM Cholesteatoma were detected. In 14 cases, Cholesteatoma were associated with granulation tissue/polyp. Modified radical mastoidectomy were performed in all cases. On analyzing the findings of the present study it was observed that mastoid abscess were the predominant extracranial complications of CSOM, affecting mostly the male population of 11 - 20 years age group coming from low socio-economic class.     

Microbiology of chronic suppurative otitis media in Singapore

The objective of the study was to study the microflora and the antibiograms of patients with chronic suppurative otitis media (CSOM) in Singapore. Ninety patients with CSOM were prospectively studied. They had chronic ear discharge and had not received antibiotics for the previous five days. Swabs were taken, and cultured for bacteria. Antibiotic testing was done using modified Kirby Bauer disk diffusion method. In addition to the usual antibiotics, the three most common topically available antibiotics (chloramphenicol, gentamicin and neomycin) were tested. There were 135 positive cultures for organisms from the 90 patients. The most common causal organisms isolated were Pseudomonas aeruginosa (33.3%) and Staphylococcus aureus (33.3%) followed by coagulase negative Staphylococcus (21.1%). Fungi accounted for 8.8% of isolates while 6.6% were anaerobes. Of the three antibiotics commonly available as topical eardrops, gentamicin has the highest susceptibility rate (82.6%), followed by neomycin (67.8%) and chloramphenicol (62.8%).     

慢性化脓性中耳炎微生物学相关研究

慢性化脓性中耳炎(CSOM)是耳鼻咽喉头颈外科常见疾病之一,是中耳及乳突内不可逆慢性炎症改变。截至目前本病的发病原因和机制尚不完全明确,其病因复杂,发病与多种因素有关,主要包括感染、咽鼓管功能障碍及免疫功能不健全等。其中病原菌感染是引起CSOM最重要、最直接的外源性致病因素。目前,随着抗生素的广泛应用,CSOM病原菌对抗生素的敏感性逐渐降低,其病原菌组成也发生着变化。因此,尽早检测CSOM中病原菌及明确其药物敏感性,对临床治疗CSOM具有重要的指导意义。本文通过查阅近年国内外相关文献,就CSOM病原菌分布及其耐药性研究、病原菌检测和抗菌药物合理应用的部分相关问题作一介绍。     

儿童慢性化脓性中耳炎126耳分析

目的 :探讨儿童慢性化脓性中耳炎的临床特点及易发生的并发症 ,以提高诊断和治疗儿童慢性化脓性中耳炎的水平。方法 :回顾分析慢性化脓性中耳炎 12 6耳的临床资料。结果 :儿童慢性化脓性中耳炎并发症高于成人 ,松弛部穿孔胆脂瘤发生率为 6 8.9%,术前影像学检查胆脂瘤误诊率为 15 .6 %。结论 :治疗儿童慢性化脓性中耳炎手术方式应根据具体情确定。