胃肠道间质瘤病理和临床治疗分析

目的通过对肠道间质瘤患者临床治疗过程的观察分析其病理特点和治疗措施。方法通过对案例的临床特征和病理特点进行差别分析。结果在治疗案例中,S-100阳性3例,阴性44例,阳性率为6．38％;CD34阳性33例,阴性14例,阳性率为70．21％;CD117阳性38例,阴性9例,阳性率为80．85％。CD34和CD117均阳性的为21例,占44．68％。结论CD34与CD117对患者治疗有参考价值。     

Gastro-intestinal patch system for the delivery of erythropoietin.

The absorption of erythropoietin (EPO) from rat small intestine was studied using gastro-intestinal patches (GI-PS) in the presence of absorption enhancers. Surfactants such as a saturated polyglycolysed C8-C18 glyceride (Gelucire 44/14), PEG-8 capryl/caprylic acid glycerides (Labrasol), and polyoxyethylene hydrogenated castor oil derivative (HCO-60) were used as absorption enhancers at 143, 94 and 20 mg/kg, respectively. The absorption of EPO was studied by measuring serum EPO levels by an ELISA method after small intestinal administration of EPO-GI-PS preparation in rats at the EPO dose level of 100 IU/kg. Labrasol showed the highest absorption enhancing effect after intrajejunum administration with maximum serum EPO level of 84.1+/-11.4 mIU/ml while Gelucire 44/14 and HCO-60 showed 43.5+/-9.8 and 26.5+/-2.3 mIU/ml, respectively. The appropriate site for EPO absorption was also investigated. Jejunum was found to be the most efficient absorption site for the absorption of EPO from GI-PS. Using Labrasol as the absorption enhancer and jejunum as the absorption site, the effect of EPO dose on EPO absorption was studied by increasing the EPO dose from 50, to 100, 300 and 600 IU/kg. It was found that 100 IU/kg was the optimum dose with a serum EPO level of 84.1+/-11.4 mIU/ml while escalating doses showed decreases in serum EPO levels 48.3+/-5.6 for 300 IU/kg and 50.6+/-10.3 mIU/ml for 600 IU/kg. The percent bioavailability (BA) of EPO-GI-PS with Labrasol as absorption enhancer was 7.9 at 50 IU/kg, 12.1 at 100 IU/kg, 3.2 at 300 IU/kg and 1.2 at 600 IU/kg. Histological studies showed no adverse effect at the site of administration.     

消化道多发性息肉内镜诊治临床研究

目的：总结消化道多发性息肉内镜治疗经验。方法：以高频电凝切除法及微波切除法对２１６例消化道多发性息肉患者实行内镜下切除。结果：所有息肉均在内镜下得到治疗,治愈率达９８．４％。结论：高频电凝切除法与微波切除法各有利弊,两种方法有互补的作用。只要掌握技巧,正规操作,许多并发症是可以避免的。