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1.
Satyendra Khichar Shyama Choudhary Veer Bahadur Singh Priyanka Tater R.V. Arvinda Vivek Ujjawal 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2017,11(1):19-23
Aims
To determine whether elevations of uric acid levels are associated with the cluster of disorders described in metabolic syndrome and to evaluate whether hyperuricemia may be considered a component of this syndrome.Methods
One year case-control study was conducted in Bikaner, Rajasthan, India from January to December 2013. The study population consisted of 200 subjects, 100 with metabolic syndrome (case) and 100 without metabolic syndrome (control) aged between 18 and 80 years, attending OPD at PBM Hospital were studied. Controls were age and sex matched to the cases. Blood tests and all physical variables were examined using standard methods. Subjects were divided into 6 groups according to their possession of 0, 1, 2, 3, 4 or 5 components of the metabolic syndrome. Statistical analysis was done using ANOVA, linear regression analysis and multivariate linear regression model.Results
Mean serum UA level was significantly associated with all components of metabolic syndrome (p < 0.001) and had strong positive correlation (r = +0.66 to +0.77, p < 0.0001) with all of them except serum HDL with which it showed strong negative correlation(r = ?0.71, p < 0.0001). It increased as the number of metabolic factors increased showing a highly significant trend (p < 0.0001). On multivariate regression analysis UA contributed to 66.84% variance of metabolic syndrome.Conclusion
The current multivariate regression analysis clearly infers that uric acid can be considered as a marker and potential modifier of metabolic syndrome. 相似文献2.
Shazia Anjum Manish Bathla Saminder Panchal Gurvinder Pal Singh Manpreet Singh 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(2):135-140
Introduction
Research in the last decade tried to focus on natural and unnatural causes of death in schizophrenic patients, but recent few years has focussed on emerging cardio-metabolic risk factors, as a cause of mortality in such patients.Aim of the study
To assess the determinant of metabolic syndrome in drug naïve schizophrenic patients.Methodology
It was a cross sectional study; 30 indoor patients with diagnosis of schizophrenia were included. Height, weight, waist circumference and Blood pressure assessment was done by using standard protocol. Fasting Blood Glucose (FBG), Triglyceride (TGs), High Density Lipoprotein (HDL) cholesterol, Low Density Lipoprotein (LDL) total cholesterol were measured. International Diabetes Federation (IDF) criteria was considered for establishing metabolic syndrome. Statistical analysis was done by using chi square and ANOVA.Results
Majority of the patients were females; hailing from rural area; unskilled professional; educated up to below primary level; were single and Hindu by religion. Most common metabolic abnormality was low HDL in 76.6%; High TGs in 26.6%; High SBP ≥130 mm Hg in 16.67%; DBP>85 mm Hg in 13.33%; High FBS 10% of the patients.In risk assessment strongest risk factors for metabolic syndrome were high waist circumference, FBS and TGs. BMI, total cholesterol, LDL and VLDL were also observed as a risk factors in drug naïve schizophrenic patients.Conclusion
HDL, FBS, TGs, waist circumference and BMI are all the strong risk factors for development of metabolic syndrome in drug naïve schizophrenia patients. 相似文献3.
Leila Nikniaz Zeinab Nikniaz Nitin Shivappa James R. Hébert 《Primary Care Diabetes》2018,12(5):467-472
Aims
Investigating the association between the dietary inflammatory index (DII®) and metabolic syndrome (MetS) components and liver enzymes in Iranian population.Methods
The present cross-sectional study consist of 606 participants from East-Azarbaijan-Iran. The MetS status was determined using ATPIII NCEP criteria. Moreover, liver enzymes including alanine aminotransferase and aspartate aminotransferase were measured. The DII was calculated according to Shivappa et al. method using a validated quantitative FFQ. Logistic regression was used to determine the association between DII and MetS.Results
About 34.3% of the participants had metabolic syndrome. Higher DII score was significantly associated with MetS [OR: 2.26 (95% CI: 1.03, 4.92)] after adjusting for covariates. After adjustment, participants in the highest quartile of DII score had significantly higher FBG [OR: 2.56 (95% CI: 1.00, 7.05)] compared with the participants in the lowest quartile of DII score. No other significant association was observed between DII and liver enzymes level and other MetS components (P > 0.05).Conclusions
The results showed that the DII score was associated with overall MetS and FBG, after adjusting for all covariates. For precise conclusion there is a need for longitudinal studies with larger sample size and considering more food parameters. 相似文献4.
L. Adán-Merino M. Aldeguer-Martínez E. Alonso-Gamarra F. Valentín-Gómez C. Zaera-De la Fuente S. Martín-Chávarri 《Revista de gastroenterologia de Mexico》2018,83(4):470-474
Introduction and aims
Lynch-like syndrome is diagnosed when there is an expression deficit in DNA mismatch repair proteins but a normal genetic study. The behavior and management of that pathology are currently a subject of debate. We present herein the characteristics of patients with Lynch-like syndrome, together with a surveillance proposal.Materials and methods
Immunohistochemistry was carried out on families suspected of presenting with Lynch syndrome. Germline analysis was done if there was loss of mismatch repair protein expression and no BRAF mutation.Results
Of the 148 patients that underwent immunohistochemistry testing, 23 presented with loss of mismatch repair protein expression. Seven of those patients were identified as having Lynch-like syndrome: 3 had colon cancer, 2 had endometrial tumor, and 2 were healthy, with an affected relative. Mean patient age was 56.9 years and only one patient presented with another tumor associated with Lynch syndrome.Conclusions
Until there is a better understanding of the etiology of that heterogeneous entity, intermediate surveillance is an adequate strategy. 相似文献5.
Farhad Gholizadeh Jalal Moludi Ned Lotfi Yagin Mohammad Alizadeh Seyed Mostafa Nachvak Hadi Abdollahzad Khadijeh Mirzaei Mostafa Mostafazadeh 《Primary Care Diabetes》2018,12(4):338-344
Introduction
Prediabetes is considered as an increased risk factor for cardiovascular disease and overt diabetes and is the precursor stage of diabetes. Dietary Diversity Score (DDS) is recognized as an essential factor of a high-quality diet. However, diets with more varieties of food items might increase calorie intake and body weight. Therefore, this study was carried out to determine the association of DDS with metabolic syndrome features in adults with prediabetes.Methods
Three hundred subjects were randomly selected from participants who were undergone diabetes test screening program. Dietary intake was assessed by using a validated semi-quantitative food frequency questionnaire. DDS was calculated by scoring food intake as nine food groups. The 18-items USDA household food securities and International Physical Activity (IPAQ) were also measured. The metabolic syndrome was defined according to the Adult Treatment Panel III.Results
DDS mean for cases and controls were 4.43 and 4.9, respectively (p < 0.005). The prevalence of food insecurity was 67/3% in cases and 55/4% in controls group. The decrease in metabolic syndrome probability was compatible with quartiles of DDS (the quartiles odds ratios: 0.6, 0.5, 0.4, 0.19, P = 0.05). A higher DDS was associated with lower level of fasting blood glucose, HDL-cholesterol, TG and Waist circumference.Conclusion
Lower DDS was associated with high probability of metabolic syndrome and with some features of it, like high fasting blood glucose. Therefore, it seems that increase in dietary diversity scores could prevent the pre diabetes development to overt diabetes. 相似文献6.
Karla Maria Tamez-Torres Pedro Torres-Gonzalez Miguel E. Cervera-Hernandez Barbara Chavez-Mazari Corazon de Jesus Barrientos-Flores Miriam Bobadilla-del-Valle Alfredo Ponce-de-Leon Jose Sifuentes-Osornio 《The Brazilian journal of infectious diseases》2018,22(5)
Objectives
To determine the factors associated with Mycobacterium tuberculosis complex-positive blood culture.Methods
Case-control study. Sociodemographic, clinical and laboratory data were collected from 2000 to 2015.Results
We reviewed medical records of 533 patients with culture-proven tuberculosis, of whom 27.2% (145/533) had blood culture available. Patients with mycobacteremia presented more frequently with abdominal tuberculosis, body mass index <18 kg/m2, and had lower hemoglobin and albumin levels. No differences were observed regarding HIV status.Conclusions
Few studies have reported on the characteristics associated with Mycobacterium tuberculosis complex bacteremia, especially among Human Immunodeficiency Virus-negative patients. Out of 145 tuberculosis-infected patients with blood culture results available, 21 turned out positive. Anemia, hypoalbuminemia, and a body mass index < 18 kg/m2 were associated with mycobacteremia. 相似文献7.
Sara Blanco-Conde Teresa Nebreda-Mayoral Cristina Labayru-Echeverría M. Fe Brezmes-Valdivieso Ramiro López-Medrano Begoña Nogueira-González 《Enfermedades infecciosas y microbiología clínica》2018,36(10):644-647
Introduction
Lady Windermere syndrome (LWS) is a pulmonary disease caused by Mycobacterium avium complex (MAC). The objective of this study is to ascertain its frequency and characteristics in the northern area of the autonomous community of Castile and León.Methods
A retrospective study of patients with MAC isolates in respiratory samples from five public hospitals in the autonomous community over a six-year period, following the ATS/IDSA criteria. The MAC strains were identified by GenoType Mycobacterium reverse hybridisation probes or PCR-RFLP analysis of the hsp65 gene.Results
Of 183 cases of MAC identified, only five women (2.7%) aged 68.8 ± 10.7 years met LWS criteria. In three cases, MAC was isolated jointly and intermittently with other pathogens. Only one patient was treated according to ATS/IDSA criteria.Discussion
LWS remains underestimated, with affected patients representing a significant burden on healthcare resources over long periods of time. As a result, greater microbiological and therapeutic knowledge of the syndrome is needed. 相似文献8.
Carolyn F. Pedley L. Douglas Case Caroline S. Blackwell Jeffrey A. Katula Mara Z. Vitolins 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(3):215-220
Aims
Large-scale clinical trials and translational studies have demonstrated that weight loss achieved through diet and physical activity reduced the development of diabetes in overweight individuals with prediabetes. These interventions also reduced the occurrence of metabolic syndrome and risk factors linked to other chronic conditions including obesity-driven cancers and cardiovascular disease. The Healthy Living Partnerships to Prevent Diabetes (HELP PD) was a clinical trial in which participants were randomized to receive a community-based lifestyle intervention translated from the Diabetes Prevention Program (DPP) or an enhanced usual care condition. The objective of this study is to compare the 12 and 24 month prevalence of metabolic syndrome in the two treatment arms of HELP PD.Materials and methods
The intervention involved a group-based, behavioral weight-loss program led by community health workers monitored by personnel from a local diabetes education program. The enhanced usual care condition included dietary counseling and written materials.Results
HELP PD included 301 overweight or obese participants (BMI 25–39.9 kg/m2) with elevated fasting glucose levels (95–125 mg/dl). At 12 and 24 months of follow-up there were significant improvements in individual components of the metabolic syndrome: fasting blood glucose, waist circumference, HDL, triglycerides and blood pressure and the occurrence of the metabolic syndrome in the intervention group compared to the usual care group.Conclusions
This study demonstrates that a community diabetes prevention program in participants with prediabetes results in metabolic benefits and a reduction in the occurrence of the metabolic syndrome in the intervention group compared to the enhanced usual care group. 相似文献9.
Víctor M. García Nieto Xochitl Illian Pérez Bastida María Salvador Cañibano Victoria E. García Rodríguez Margarita Monge Zamorano María Isabel Luis Yanes 《Nefrología : publicación oficial de la Sociedad Espa?ola Nefrologia》2018,38(3):267-272
Background
Various genetic and environmental factors are involved in urolithiasis. The 2 most common metabolic abnormalities are the increase in urinary calcium and low urinary citrate excretion. The ratio calculated between the concentrations of both substances is a good risk marker for the formation of calcium stones.Objectives
To determine whether the risk of urinary calcium stone formation changes throughout the day in the same patient.Methods
We studied 56 children (23 V, 33 M) to check if they had prelithiasis. Calcium, citrate, and creatinine concentrations were determined in two urine samples collected one before dinner and the other in the morning. It was collected if they had ultrasound stones and if there was a history of urolithiasis in first and/or second degree relatives.Results
In 25 patients (44.6%), renal ultrasound was positive for lithiasis (stones [n = 9] and microlithiasis [n = 16]). Forty of the 56 families (71.4%) had a history of urolithiasis. The percentage of abnormal urinary calcium (28.6%) concentrations and an abnormal calcium/citrate ratio (69.6%) was higher in the first urine of the day. The calcium/citrate ratio was the only studied parameter that was related to a family history of urolithiasis. There were no differences in urinary parameters between patients with and without ultrasound-confirmed kidney stones.Conclusions
Urinary concentrations of calcium and the calcium/citrate ratio vary throughout the day. Urine produced at night has a higher risk of urinary calcium stone formation. 相似文献10.
Carola Saure Carolina Caminiti Julieta Weglinski Fernanda de Castro Perez Soledad Monges 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(2):81-85
Introduction
Duchenne muscular dystrophy (DMD) is a severe muscular disease characterized by progressive loss of functional muscle mass followed by changes in body composition.Aim
To describe body composition, resting energy expenditure (REE), and metabolic disorders in DMD patients followed-up at a tertiary care center. To analyze the association with type of steroid and ambulatory status, and to compare obese DMD patients with patients with multifactorial obesity.Population and methods
A prospective, observational, cross-sectional study was conducted. Anthropometric measurements were taken, evaluating body composition with bioelectrical impedance analysis (BIA), REE with indirect calorimetry, and biochemical parameters in all DMD patients seen between June 2013 and April 2014.Results
63 boys between 5.4 and 18.7 years of age were evaluated. Diagnosis of obesity ranged from 28% measuring body mass indexZ-score (BMIZ-score) to 70% using percentage of fat mass (%FM). Patients who had lost gait had a significantly higher %FM than those in whom gait was preserved (72% vs 46%, p < 0.05).Insulin resistance was present in 29% associated with BMI Z-score and waist circumference and 40% had dyslipidemia associated with %FM, both of which were steroid independent. In obese DMD patients REE was lower than predicted and also lower than controls, and persist when dividing the patients into ambulators and non-ambulators.Conclusions
A high prevalence of obesity was observed. BMI-Z-score underestimates the degree of FM. No correlation was found between steroid type and body composition or metabolic disorders. No differences were found in REE between ambulators and non-ambulators. Obese DMD patients have a lower REE than controls. 相似文献11.
H. Kahal A. Aburima B. Spurgeon K.S. Wraith A.S. Rigby T. Sathyapalan E.S. Kilpatrick K.M. Naseem S.L. Atkin 《Diabetes & metabolism》2018,44(5):431-436
Aim
Strict glycaemic control has been associated with an increased mortality rate in subjects with type 2 diabetes (T2DM). Here we examined platelet function immediately and 24 hours following induced hypoglycaemia in people with type 2 diabetes compared to healthy age-matched controls.Methods
Hyperinsulinaemic clamps reduced blood glucose to 2.8 mmol/L (50 mg/dl) for 1 hour. Sampling at baseline; euglycaemia 5 mmol/L (90 mg/dl); hypoglycaemia; and at 24 post clamp were undertaken. Platelet function was measured by whole blood flow cytometry.Results
10 subjects with T2DM and 8 controls were recruited. Platelets from people with T2DM showed reduced sensitivity to prostacyclin (PGI2, 1 nM) following hypoglycaemia. The ability of PGI2 to inhibit platelet activation was significantly impaired at 24 hours compared to baseline in the T2DM group. Here, inhibition of fibrinogen binding was 29.5% (10.3–43.8) compared to 50.8% (36.8–61.1), (P < 0.05), while inhibition of P-selectin expression was 32% (16.1–47.6) vs. 54.4% (42.5–67.5) (P < 0.05). No significant changes in platelet function were noted in controls.Conclusion
Induced hypoglycaemia in T2DM enhances platelet hyperactivity through impaired sensitivity to prostacyclin at 24 hours. 相似文献12.
José Luís Martins Tiago Adrega Luís Santos Vera Afreixo Jesus Viana José Santos 《Revista portuguesa de cardiologia》2018,37(8):645-653
Introduction
Behavioral and emotional factors are triggers of cardiovascular events (CVEs). It is uncertain whether soccer fans, particularly individuals with coronary artery disease (CAD), are at increased risk for CVEs.Objectives
To assess the effect of watching soccer matches in patients with known CAD on the incidence of CVEs according to the match result.Methods
We prospectively assessed 82 male soccer fans with a history of acute coronary syndrome during 23 matches of the 2015/2016 season. Each individual was assessed by Holter monitoring on the day of their team's match and on the control day. The primary endpoint was the composite of death, stroke, reinfarction, angina or sustained arrhythmia. Secondary endpoints assessed were episodes of non‐sustained supraventricular or ventricular arrhythmia and mean heart rate (HR).Results
Participants’ mean age was 61 ± 10 years. Compared with the control day, despite a significant increase in HR (p < 0.001) that was independent of the result (p > 0.97), the number of CVEs did not differ according to the result (p > 0.05). Moreover, the number of non‐sustained episodes of supraventricular and ventricular arrhythmia did not differ when stratified according to the match result (p > 0.05).Conclusions
The match result was not associated with a difference in incidence of CVEs in patients with a past history of CAD, with ischemic and arrhythmic substrate, who watched soccer matches on television. 相似文献13.
Pedro Méndez-Chacón Nicolás Riccobelli María P. Dionisi Emilio Sánchez-Álvarez Fernando Bardales-Viguria Carla Méndez-Chacón Rodríguez Jorge B. Cannata-Andía José L. Fernández-Martín 《Nefrología : publicación oficial de la Sociedad Espa?ola Nefrologia》2018,38(3):279-285
Background
Mineral and bone metabolism disorders are common complications in haemodialysis patients that present significant geographical variability.Objectives
The objective of this study was to assess these disorders for the first time in haemodialysis patients from Peru.Methods
The study included 1551 haemodialysis patients from 55 centres affiliated with the Social Health System of Peru in the city of Lima. Demographic data, comorbidities, treatments and biochemical parameters were collected from each patient. Serum calcium, phosphorus and PTH levels were categorised according to the recommended ranges in the KDOQI and KDIGO guidelines.Results
The mean age of the patients was 59.5 ± 15.6 years, with a mean time on haemodialysis of 58.0 ± 54.2 months. All patients were dialysed with a calcium concentration in the dialysis fluid of 3.5 mEq/l and 68.9% of patients were prescribed phosphate-binding agents (98.4% of them calcium carbonate). A high percentage of patients showed serum calcium above, and serum phosphorus below, the recommended ranges in the KDOQI guidelines (32.8% and 37.3%, respectively). More than half of the patients had serum PTH values below the recommended ranges of both the KDOQI and KDIGO guidelines (56.4% and 51.6%, respectively).Conclusions
Patients included in this study were younger than those from other studies and showed both hypophosphataemia and suppressed PTH, probably due to an excessive calcium overload through dialysis fluid and the use of calcium-containing phosphate binding agents. 相似文献14.
M. Koubaa F. Smaoui S. Gargouri H. Ben Ayed K. Rekik I. Abid I. Maaloul J. Feki C. Marrakchi M. Ben Jemaa 《La Revue de médecine interne / fondée ... par la Société nationale francaise de médecine interne》2018,39(5):326-331
Objectives
Ocular tuberculosis is a rare form of extra pulmonary tuberculosis. It represents 1–2% of all clinical forms. The aim of this work was to focus on diagnostic and therapeutic characteristics of ocular tuberculosis.Methods
We report a case series of 14 patients with ocular tuberculosis seen in an infectious diseases department between 2006 and 2015. The diagnosis was retained on clinical data and a positive tuberculin skin test or interferon-gamma release assay.Results
The patient's mean age was 40.7 ± 9 years. The most common clinical presentation was uveitis (11 patients and 16 eyes). An extra ocular involvement was associated in three patients. The mean duration of antitubercular therapy was 10 ± 2.5 months. Corticosteroid therapy was associated in 11 cases. The outcome was favorable in all cases. Two patients had maintained visual sequelae.Conclusion
Ocular tuberculosis is a rare disease but still remains a diagnostic problem. It should be considered in case of any chronic ocular symptoms, especially in endemic countries. Early management can improve the visual prognosis. 相似文献15.
Mohamed Larbi Hamlaoui Ammar Ayachi Aoulia Dekaken Adel Gouri 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(1):1-4
Aims
The aim of this study is to evaluate the prevalence of the metabolic syndrome and its compounds in subjects with different thyroid status.Materials and methods
A prospective cross-sectional study was conducted in the internal medicine department at El Okbi Hospital of Guelma (East of Algeria) from January 2014 to September 2015. Eighty six patients attending the specialist consultation for suspected thyroid disorders were included in the study. Gender; blood pressure; body mass index; and serum levels of fasting glucose, total cholesterol (TC), high-density-lipoprotein cholesterol (HDL-C), low-density-lipoprotein cholesterol, and triglyceride were compared between subjects with hypothyroidism, hyperthyroidism and euthyroidism.Results and conclusion
Thyroid dysfunction was found in 59.3% (n = 42) patients, hypothyroidism (45.3%) was the major thyroid dysfunction followed by hyperthyroidism (14.0%). Overall, the prevalence of metabolic syndrome was 48.8% (n = 42). Subjects with hypothyroidism had significantly higher level of BMI, WC, TC, LDL-C, and higher prevalence of abdominal obesity (84.6%, p < 0.01) and hypertension (51.2%, p < 0.05). The hyperthyroid group had significantly lower level of TC, LDL-C and HDL-C but a higher level of SBP and UA. Furthermore, abdominal obesity, hypertension and low HDL-C level were the most common metabolic syndrome compounds found in the hyperthyroid group compared to the euthyroid group. We found a positive association between TSH level and the prevalence of the metabolic syndrome. 相似文献16.
Background
Adherence to pharmacotherapy reduces symptoms of asthma and rhinitis, however, little is known of its impact on school performance.Objective
To evaluate the impact of pharmacotherapy in absenteeism and school performance in a child population.Methods
A cross-sectional study, carried out in eight schools. All participants and their parents were given a questionnaire assessing parameters related to respiratory diseases and pharmacotherapy. Data on school performance was obtained from the academic history of each child who participated in the study. Adherence to pharmacotherapy was classified as a correct use of therapy for more than five days per week.Results
1109 children agreed to participate. Students were divided into two groups: symptomatic (36%) and asymptomatic (63%). The symptomatic group had a higher frequency of school absenteeism (1 vs. 3.1 days/year/patient p < 0.01) and lower academic performance (failed: 20% vs. 33% p < 0.01). After dividing the symptomatic group between adherents and non-adherents to the pharmacotherapy, the group of adherents had a similar school performance to the asymptomatic group and it was significantly different from the no-adherent group.Conclusion
Respiratory symptoms are associated with poor school performance and with an increase in school absenteeism, but adherence to pharmacotherapy can reduce these negative impacts in children. 相似文献17.
Dina Bento Nuno Marques Pedro Azevedo João Guedes João Bispo Daniela Silva José Amado Walter Santos Jorge Mimoso Ilídio de Jesus 《Revista portuguesa de cardiologia》2018,37(11):889-897
Introduction
Major bleeding is a serious complication of acute coronary syndrome (ACS) and is associated with a worse prognosis. The CRUSADE bleeding score is used to stratify the risk of major bleeding in ACS.Objective
To assess the predictive ability of the CRUSADE score in a contemporary ACS population.Methods
In a single‐center retrospective study of 2818 patients admitted with ACS, the CRUSADE score was calculated for each patient and its discrimination and goodness of fit were assessed by the area under the receiver operating characteristic curve (AUC) and by the Hosmer‐Lemeshow test, respectively. Predictors of in‐hospital major bleeding (IHMB) were determined.Results
The IHMB rate was 1.8%, significantly lower than predicted by the CRUSADE score (7.1%, p< 0.001). The incidence of IHMB was 0.5% in the very low risk category (rate predicted by the score 3.1%), 1.5% in the low risk category (5.5%), 1.6% in the moderate risk category (8.6%), 5.5% in the high risk category (11.9%), and 4.4% in the very high risk category (19.5%). The predictive ability of the CRUSADE score for IHMB was only moderate (AUC 0.73).The in‐hospital mortality rate was 4.0%. Advanced age (p = 0.027), femoral vascular access (p = 0.004), higher heart rate (p = 0.047) and ticagrelor use (p = 0.027) were independent predictors of IHMB.Conclusions
The CRUSADE score, although presenting some discriminatory power, significantly overestimated the IHMB rate, especially in patients at higher risk. These results question whether the CRUSADE score should continue to be used in the stratification of ACS. 相似文献18.
Lívia D. Akl Ana L.R. Valadares Monica Jacques de Moraes Aarão M. Pinto-Neto Bianca Lagrutta Lúcia Costa-Paiva 《The Brazilian journal of infectious diseases》2017,21(3):263-269
Objectives
To determine the prevalence of metabolic syndrome (MetS) and its associated factors in a group of HIV-infected middle-aged women.Methods
Cross-sectional study including 273 HIV-infected climacteric women of 40–60 years of age under care in two HIV outpatient reference centers in Brazil. Metabolic syndrome diagnosis was based on 2006 International Diabetes Federation criteria. Sociodemographic, clinical and behavioral factors were evaluated as well as HIV infection-related parameters.Results
Mean age was 47.7 years; 59.1% of women were premenopausal, 91% were on antiretroviral therapy. Current CD4 count was >500 cells/mm3 in 61.7%, current viral load undetectable in 76.9% of women, and a quarter had previous diagnosis of aids. The prevalence of metabolic syndrome in the subgroup of menopausal women was 46.9%. Univariate analysis showed an association between metabolic syndrome and age ≥50 years (p = 0.002), schooling <8 years (p = 0.003), post-menopause (p < 0.001), body mass index (BMI) >25 kg/m2 (p < 0.001), and FSH ≥40 mIU/mL (p = 0.002). In the multivariate analysis only increased BMI (PR = 1.09; 95% CI: 1.05–1.13; p < 0.001) and FSH levels ≥40 mIU/mL (PR = 1.66; 95% CI: 1.14–2.40; p = 0.008) maintained statistical significance. There was no association between PI use or any other factor related to HIV-infection and MetS in any of the analyses performed.Conclusion
High BMI and FSH levels compatible with menopause were the only factors associated with MetS in these middle aged HIV-infected women. In the context of well-controlled, early treated HIV infection, traditional rather than HIV-related factors were associated with MetS. 相似文献19.
María Isabel Pacheco-Tenza José Antonio Ruiz-Maciá María Navarro-Cots Joan Gregori-Colomé José María Cepeda-Rodrigo Jara Llenas-García 《Enfermedades infecciosas y microbiología clínica》2018,36(1):24-28
Introduction
Strongyloides stercoralis infection is more prevalent in tropical regions but autochthonous cases have been reported in Spain, mainly in La Safor (Valencia). The objective is to describe the strongyloidiasis cases registered in a regional hospital of Alicante province (Spain) and to determine if they were autochthonous cases.Methods
Retrospective study of all diagnosed cases of strongyloidiasis in Vega Baja Hospital (Orihuela, Alicante) between January 1999 and March 2016.Results
A total of 10 cases were found, four of which were autochthonous cases. Two of them presented with a hyper-infection syndrome, with a fatal outcome. All autochthonous cases were in patients ≥ 69 years old with gastrointestinal, cutaneous, and/or respiratory symptoms. Serology was positive in the 8 cases studied. Larvae were found in histopathological samples of the gastrointestinal tract of three patients.Conclusions
We communicate the first autochthonous cases of strongyloidiasis in the region of Vega Baja. Screening programs should be implemented, especially in immunosuppressed patients or patients under chronic corticosteroid treatment. 相似文献20.
Per Lundberg Rune Andersson Elizabeth S. Machado Tomaz Pinheiro da Costa Cristina Barroso Hofer 《The Brazilian journal of infectious diseases》2018,22(5):412-417