贺菊乔教授运用脉管通汤治疗下肢血管疾病验案举隅

贺菊乔,湖南中医药大学第一附属医院主任医师,教授,博士研究生导师,湖南省名中医,第五批全国老中医药专家学术经验继承工作指导老师。擅长各种外科疾病的诊治,衷中参西,学验俱丰,在周围血管病的诊治方面也有较深研究和造诣,疗效卓著。笔者作为贺菊乔名老中医药专家传承工作室课题组负责人跟师侍诊,学有所获,本文就贺菊乔教授运用自拟方脉管通汤治疗下肢血管疾病的经验介绍如下。1血栓性深静脉炎案     

德行天下 医济世人——记我省名中医贺菊乔教授

贺菊乔,男,1953年10月生,湖南省衡山县人。硕士研究生毕业,国家中医药管理局第一批学术继承人。现为湖南中医药大学第一附属医院中医外科主任医师、教授、博士生导师,湖南省名中医。中华中医药学会外治分会副主任委员,中华中医学会外科分会副主任委员,湖南省中医药学会常务理事、湖南省中西医结合学会外科专业委员会主任委员、湖南省中医药学会外科专业委员会主任委员、     

潘智敏教授治疗高血压经验

潘智敏是浙江省中医院主任医师、浙江中医药大学教授、博士生导师、国家级名中医、全国第四批名老中医药学术经验继承指导老师。潘老师从事中医临床工作30余年,诊治内科杂症临床经验丰富,现就其对高血压的诊治经验整理如下。     

继承不泥古 创新不离宗——浙江中医药大学附属第一医院博士生导师潘智敏教授

潘智敏,女,上海市人。现为浙江中医药大学附属第一医院中医内科学主任中医师、教授、博士生导师、浙江省名中医研究院研究员。系全国第四批名中医药专家学术经验指导老师,国家级名中医,潘智敏全国名老中医药专家传承工     

傅汝林全国名老中医药专家传承工作室

正傅汝林,教授,全国名老中医药专家学术经验继承工作指导老师。从事中医临床及科研工作50余年,是第三批及第五批全国名老中医。主要从事中医内科及血液系统疾病的临床及科研工作,在多年的临床工作中积累了丰富的临床经验。为全面整理和研究傅汝林教授的临床经验及学术思想,进一步继承名老中医经验,傅汝林全国名老中医药专家工作室于2011年获批成立。该工作室负责人詹继红教授是全国优秀中医临床人才,工作室现有成员12人,高级职称3人,其中博士1人,硕士7人。该团     

吴熙教授治疗血瘀型输卵管阻塞性不孕症60例临床观察

吴熙教授是全国中医妇科名师,国家级中医专家,笔者有幸作为全国第四批全国名老中医学术经验继承人跟随吴熙教授学习,现将老师治疗输卵管阻塞性不孕症的临床经验结合临床研究总     

胡天成教授解脾困、调肝木治疗小儿抽动症探讨

抽动症属于小儿常见病和难治病。胡天成教授为第五批全国名老中医药专家学术经验传承指导老师,四川省第二批十大名中医,从事临床教学科研工作40多年,擅于儿童抽动症等疾病的中医诊治。本文以"脾主困"立论,探讨导师胡天成教授运用解脾困、调肝木之法治疗小儿抽动症的经验。     

王樟连教授针药结合治疗耳鸣经验

王樟连教授系国家级名中医,第四批全国老中医药专家学术经验继承工作指导老师,擅长运用针灸治疗各种疑难杂症。现总结其针药结合治疗耳鸣经验如下。     

继承不泥古 创新不离宗——浙江中医药大学附属第一医院博士生导师潘智敏教授

潘智敏,女,上海市人。现为浙江中医药大学附属第一医院中医内科学主任中医师、教授、博士生导师、浙江省名中医研究院研究员。系全国第四批名中医药专家学术经验指导老师,国家级名中医,潘智敏全国名老中医药专家传承工作室专家,浙江省中医老年病重点专科学科带头人。兼任中国     

戴裕光教授治疗复发性口疮的经验

戴裕光教授是全国第二、三批中医学术继承工作指导老师,重庆市名中医.在借鉴前人经验的基础上,对复发性口疮的认识和诊治方法形成了自己的特色,疗效也有一定的提高.我们在跟师学习中对此有所体会,特简为记述.     

Saffron （Crocus sativus L.） and major depressive disorder： a meta-analysis of randomized clinical trials

Due to safety concerns and side effects of many antidepressant medications, herbal psychopharmacology research has increased, and herbal remedies are becoming increasingly popular as alternatives to prescribed medications for the treatment of major depressive disorder （MDD）. Of these, accumulating trials reveal positive effects of the spice saffron （Crocus sativus L.） for the treatment of depression. A comprehensive and statistical review of the clinical trials examining the effects of saffron for treatment of MDD is warranted. OBJECTIVE： The purpose of this study was to conduct a meta-analysis of published randomized controlled trials examining the effects of saffron supplementation on symptoms of depression among participants with MDD. SEARCH STRATEGY： We conducted electronic and non-electronic searches to identify all relevant randomized, double-blind controlled trials. Reference lists of all retrieved articles were searched for relevant studies. INCLUSION CRITERIA： The criteria for study selection included the following： （1） adults （aged 18 and older） with symptoms of depression, （2） randomized controlled trial, （3） effects of saffron supplementation on depressive symptoms examined, and （4） study had either a placebo control or antidepressant comparison group. DATA EXTRACTION AND ANALYSIS： Using random effects modeling procedures, we calculated weighted mean effect sizes separately for the saffron supplementation vs placebo control groups, and for the saffron supplementation vs antidepressant groups. The methodological quality of all studies was assessed using the Jadad score. The computer software Comprehensive Meta- analysis 2 was used to analyze the data. RESULTS： Based on our pre-specified criteria, five randomized controlled trials （n = 2 placebo controlled trials, n = 3 antidepressant controlled trials） were included in our review. A large effect size was found for saffron supplementation vs placebo control in treating depressive symptoms （M ES = 1.62, P 〈 0.001）, revealing that saffron supplementation significantly reduced depression symptoms compared to the placebo control. A null effect size was evidenced between saffron supplementation and the antidepressant groups （M ES = -0.15） indicating that both treatments were similarly effective in reducing depression symptoms. The mean Jadad score was 5 indicating high quality of trials. CONCLUSION： Findings from clinical trials conducted to date indicate that saffron supplementation can improve symptoms of depression in adults with MDD. Larger clinical trials, conducted by research teams outside of Iran, with long-term follow-ups are needed before firm conclusions can be made regarding saffron＇s efficacy and safety for treating depressive symptoms.     

Association between intervertebral disc degeneration and disturbances of blood supply to the vertebrae

Low back pain is a common public health problem in western industrialized societies and the world as well.Studies indicate that the prevalence rate ranges to 35%, with around 10% of patients from 12% becoming chronically disabled. It also places an enormous economic burden on society. Although the exact cause of low back pain has yet to be defined, intervertebral disc degeneration is considered a major source of it. Since patients with degenerative discs are often asymptomatic, the mechanisms of it are still unclear.     

Relevance of muscle biopsy for diagnosing multifocal motor neuropathy

Multifocal motor neuropathy （MMN） is a rare,.focal,inflammatory,demyelinating disease of the peripheral nerves with pure motor involvementJ MMN is clinically characterized by slowly progressive,asymmetric,distal,upper limb predominant weakness,in the absence of sensory disturbances） Weakness is usually multifocal and connected to a distinct motor nerve,such as the musculocutaneous nerve resulting in biceps weakness,the posterior interosseus nerve resulting in finger drop,the median,ulnar,or radial nerve resulting in dexterity problems or grip weakness,or the peroneal nerve resulting in a foot drop.Onset of clinical manifestations is between 20 and 50 years of age.The prevalence of MMN is reported as 1-2 per 100 000.2 MMN is three times more frequent in men as compared to women.     

痘苗病毒天坛株的减毒与其作为疫苗载体研究进展

1痘苗病毒天坛株的历史天花是人类历史上最可怕的传染病之一。天花由天花病毒（variola virus）引起,人是该病毒的惟一宿主。人感染天花病毒后的死亡率达到30%~40%[1]。世界上公认的对天花最早的准确记录来自中国,晋代药学家葛洪于公元430年左右,在《肘后备急方》中对天花有清楚的描述[1]。     

WHO西太区与世界中医药学会联合会中医名词术语国际标准比较研究：八纲辨证（三）

The Chinese characters 寒 and 热, 虚, and 实 are quite common concepts in Chinese language. However in traditional Chinese medicine （TCM）, they are used as four principles in syndrome differentiation. In terms of translation, 寒 and 热 are very easy to understand and can be simply translated as ＂cold＂ and ＂heat＂. But the transla- tion of 虚 and 实 used to be a problem. For a quite long time in translation practice,     

Chinese herbal medicine Xinfeng Capsule in treatment of rheumatoid arthritis： study protocol of a multicenter randomized controlled trial

BACKGROUND： Rheumatoid arthritis （RA）, as a common systemic inflammatory autoimmune disease, affects approximately 1 in 100 individuals. Effective treatment for RA is not yet available because current research does not have a clear understanding of the etiology and pathogenesis of RA. Xinfeng Capsule, a patent Chinese herbal medicine, has been used in the treatment of RA in recent years. Despite its reported clinical efficacy, there are no large-sample, multicenter, randomized trials that support the use of Xinfeng Capsule for RA. Therefore, we designed a randomized, double-blind, multicenter, placebo-controlled trial to assess the efficacy and safety of Xinfeng Capsule in the treatment of RA. METHODS AND DESIGN： This is a 12-week, randomized, placebo-controlled, double-blind, multicenter trial on the treatment of RA. The participants will be randomly assigned to the experimental group and the control group at a ratio of 1：1. Participants in the experimental group will receive Xinfeng Capsule and a pharmaceutical placebo （imitation leflunomide）. The control group will receive leflunomide and an herbal placebo （imitation Xinfeng Capsule）. The American College of Rheumatology （ACR） Criteria for RA will be used to measure the efficacy of the Xinfeng Capsule. The primary outcome measure will be the percentage of study participants who achieve an ACR 20% response rate （ACR20）, which will be measured every 4 weeks after randomization. Secondary outcomes will include the ACR50 and ACR70 responses, the side effects of the medications, the Disease Activity Score 28, RA biomarkers, quality of life, and X-rays of the hands and wrists. The first four of the secondary outcomes will be measured every 4 weeks and the others will be measured at baseline and after 12 weeks of treatment. DISCUSSION： The result of this trial will help to evaluate whether Xinfeng Capsule is effective and safe in the treatment of RA. TRIAL REGISTRATION： This trial has been registered in ClinicalTrials.gov. The identifier is N CT01774877.     

The role of central nervous system on hypoglycemia and the feasibility of the brain theory in traditional Chinese medicine on treatment of diabetes mellitus

The central nervous system （CNS） plays a key regulatory role in glucose homeostasis. In particular, the brain is important in initiating and coordinating protective counterregulatory responses when blood glucose levels fall. This may due to the metabolic dependency of the CNS on glucose, and protection of food supply to the brain. In healthy subjects, blood glucose is normally maintained within a relatively narrow range. Hypoglycemia in diabetic patients can increase the risk of complications, such as heart disease and diabetic peripheral neuropathy. The clinical research finds that the use of traditional Chinese medicine （TCM） has a positive effect on the treatment of hypoglycemia. Here the authors reviewed the current understanding of sensing and counterregulatory responses to hypoglycemia, and discuss combining traditional Chinese and Western medicine and the theory of iatrogenic hypoglycemia in diabetes treatment. Furthermore, the authors clarify the feasibility of treating hypoglycemia on the basis of TCM theory and CNS and have an insight on its clinical practice.     

Gene expression profiles of ERCC1, TYMS, RRM1, TUBB3 and EGFR in tumor tissue from non-small cell lung cancer patients

Background Personalized medicine becomes essential in lung cancer treatment, however lung-cancer-related gene expression profiles in Chinese patients remain unknown. In this study, the correlation of gene expression profiles and clinical characteristics in non-small-cell lung cancer （NSCLC） was investigated. Methods Seventy-six Chinese patients with NSCLC were enrolled in the study to investigate mRNA expression profiles of excision repair cross complement group 1 （ERCC1）, thymidylate synthetase （TYMS）, ribonucleotide reductase （RRM1）, class Ill 13-tubulin （TUBB3）, and epidermal growth factor receptor （EGFR） genes and their correlation with patient clinical characteristics. A novel liquidchip technology was used to detect mRNA expression levels in formalin fixed paraffin embedded tumor pathology samples. The relationships between gene expression and clinical characteristics were assessed using the Mann-Whitney test. Results ERCC1 mRNA levels were higher in tumors from patients with metastatic disease than patients with non- metastatic disease （P=-0.021）, and higher in adenocarcinomas than squamous cell carcinomas （P=0.006）. Increased TUBB3 mRNA expression levels were found in patients with performance status （PS） 1 in comparison with PS 0 （P=0.049）, with poorly differentiated tumors in comparison with tumors that were moderately and well differentiated （P 〈0.000 1）, and with advanced stage in comparison with early stage disease （P 〈0.000 1）. Conclusions ERCC1 mRNA levels were higher in metastatic adenocarcinoma NSCLC; TUBB3 mRNA levels were significantly higher in poorly differentiated tumors and in advanced stage NSCLC, which indicates the poor prognosis.