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毛细胞黏液样型星形细胞瘤的临床病理学观察 总被引:5,自引:0,他引:5
目的探讨毛细胞黏液样型星形细胞瘤的临床病理学特点。方法观察3例毛细胞黏液样型星形细胞瘤的光镜形态,采用EnVision法免疫组织化学标记胶质纤维酸性蛋白(GFAP)、CD34、Ki-67,并结合文献复习分析其生物学行为。结果3例均为女性,年龄分别为9个月、10岁和19岁。1例发生于视交叉,2例发生于第三脑室(近鞍区部位)。镜下由双极性的梭形细胞组成,间质内含有大量的黏液。肿瘤内的血管明显增生,部分区域内瘤细胞显示以血管为中心性生长。3例切片内均未见到经典型毛细胞星形细胞瘤中的双相性形态,也未见Rosenthal纤维和嗜酸性颗粒小体。免疫标记显示,瘤细胞强阳性表达GFAP,瘤细胞增殖指数(Ki-67)〈1%。CD34标记显示清晰瘤内增生的血管。结论毛细胞黏液样型星形细胞瘤是毛细胞星形细胞瘤的一种独特亚型,在组织学上与毛细胞星形细胞瘤有不同之处,临床上较毛细胞星形细胞瘤更具有侵袭性。部分病例也可发生于儿童和青少年。GFAP标记有助于该瘤的诊断和鉴别诊断。 相似文献
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Tajiri T Tate G Makino M Akita H Omatsu M Enosawa T Hamatani S Masunaga A Kunimura T Mitsuya T Morohoshi T 《Nippon Ika Daigaku zasshi》2011,78(5):305-311
To assist physicians, especially young physicians, in identifying tuberculosis (TB) infection before the terminal stage, we analyzed 7 cases of numerous tuberculous granulomas in multiple organs and compared clinical and autopsy findings between cases. Patients ranged in age from 41 to 86 years at the time of death. The main chief complaint was fever of unknown origin (3 of 7 cases [43%]). The main underlying conditions were liver cirrhosis (2 of 7 cases [29%]) and chronic renal failure (2 of 7 cases [29%]). Two patients (29%) had been given methylprednisolone pulse therapy for various lung disorders. Active TB was not diagnosed before autopsy in 4 of 7 (57%) patients. Calcified lesions indicative of old TB were present in 4 of 7 (57%) patients. Thus, miliary tuberculosis may represent a re-emergence of latent TB infection in these cases. Various histologic features of nonreactive exudative inflammation were seen, along with granulomas containing Langhans giant cells with or without caseous necrosis in hypervascular organs, such as the lung, liver, and bone marrow. Physicians should be mindful of the possibility of miliary TB when older patients with hepatorenal disease and a history of TB infection have undergone immunosuppressive treatment. Active tuberculous infection can depend on the presence of an underlying disease and immunocompromise. 相似文献
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严重急性呼吸综合征临床病理分析 总被引:6,自引:3,他引:6
目的 探讨严重急性呼吸综合征(Severe acute respitatory syndrome,SARS)的病理形态学特点。方法 3例SARS标本为患者支气管镜穿刺活检和切取的肺组织,经HE染色,光镜观察,并用免疫组化S-P法检测SARS患者肺组织CK、CD34、Ⅳ型胶原、CD68、Mac387的表达。结果 SARS患者肺组织病理形态表现为肺泡上皮广泛破坏,Ⅱ型上皮细胞增生。肺泡壁毛细血管内皮细胞肿胀。大部分肺泡腔及肺泡管内透明膜形成。间质有较多的炎细胞浸润,成纤维细胞增生。结论 SARS是一种伴透明膜形成的急性非特异性间质性肺炎。 相似文献
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Malignant cartilaginous tumors of the lung are unusual, and although their occurrence has been reported in the literature in some cases, their separation from other benign cartilaginous tumors of the lung can be very difficult. Four cases of primary chondrosarcomas of the lung are presented. The patients are 2 men and 2 women between the ages of 51 and 69 years. Clinically, the most common symptoms were chest pain, dyspnea, and cough. Two tumors were centrally located, whereas 2 tumors were peripheral. Complete surgical resection was accomplished in all the patients. Histologically, 2 tumors were low grade of the hyaline type, whereas 2 tumors were predominantly myxoid chondrosarcomas. In the 2 myxoid chondrosarcomas immunohistochemical studies for keratin, desmin, smooth muscle actin, and CD31 were negative, whereas S-100 protein shows focal positive staining in both cases. Follow-up showed that one patient with low-grade tumor was alive and well at 36 months, whereas one patient with myxoid chondrosarcoma died 45 days after diagnosis because of surgical complications. Two additional patients were lost to follow-up. Our study highlights the ubiquitous distribution of chondrosarcomas and the histopathologic spectrum that these tumors may show when occurring in the lung. 相似文献
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Yamakawa K Iwasaki H Ohjimi Y Kikuchi M Iwashita A Isayama T Naito M 《Pathology, research and practice》2001,197(7):499-506
We describe five cases of tumoral calcium pyrophosphate dihydrate crystal deposition disease (CPPDCD) and discuss the clinical, radiological and pathological features. Patients included 4 males and 1 female, ranging in age from 49 to 70 years (median, 63 yrs). The wrist was involved in two patients. The thumb, palmar aspect of the proximal phalanx of the middle finger and dorsum of the carpal bone of the hand were involved in one patient each. In one patient, a preoperative diagnosis of chondrosarcoma had been made. Macroscopically, the lesion was a circumscribed whitish-gray mass with a more or less chalky appearance, measuring between 1.0 to 6.2 cm (median, 2.5 cm). Histologically, all five lesions contained areas of calcification with crystal deposits and chondroid metaplasia. The majority of crystals were rhomboid in shape, characteristic of CPPD, but some needle-shaped crystals were also identified, which resembled urate crystals. A review of the 54 reported cases of tumoral CPPDCD including our series indicated that they could be divided into two categories based on anatomic location: central (head and neck) type (n = 33) and distal (extremity) type (n = 21). Patients of these two groups were not different with respect to age and gender, but those with the central type often presented with a painful mass (15 patients, 46%), or neurological disturbances (11 patients, 33%). Patients with the distal type presented with a painless mass or swelling (12 patients, 57%), but none had neurological signs, although 8 (38.1%) presented with acute attack similar to tophaceous gout. Tumoral CP-PDCD should be differentiated from tophaceous gout, tumoral calcinosis, and malignant or benign tumors. 相似文献
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目的观察卵巢黏液性肿瘤中附壁结节的临床表现、组织病理学和免疫表型特征,强调诊断标准并探讨病因机制。方法分析3例卵巢黏液性肿瘤中附壁结节的临床资料、组织学形态及其免疫学表型,并复习相关文献。结果3例卵巢黏液性肿瘤中附壁结节的病例1为良性的肉瘤样附壁结节,以两种细胞成分为主:其一为纤维组织细胞样单核细胞,呈卵圆形或梭形,部分细胞形态较一致、温和,部分细胞出现高度的核异型性,核分裂多见并可见病理性核分裂象;另一种细胞为散在分布的破骨样巨细胞,常围绕于小的出血腔隙周围。病变中见出血坏死区,并伴明显的炎症反应背景;病例2为恶性的肉瘤性附壁结节,其组织学形态与肉瘤样附壁结节极其相似,但体积大,并出现血管浸润。该2例中的单核细胞表达vimentin,灶性表达AE1/AE3,多核巨细胞表达CD68为主。病例3为恶性的化生性癌性附壁结节,其中的瘤细胞为化生性或低分化癌成分,以表达上皮性标记如AE1/AE3和CK7为主,同时也表达vimentin。结论卵巢黏液性肿瘤中附壁结节为罕见的伴发病变或肿瘤,具有广泛的病理形态图像谱,不同类型的卵巢黏液性肿瘤中附壁结节有完全不同的预后及治疗原则,正确的诊断具有重要的临床意义。 相似文献
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脂肪母细胞瘤44例临床病理分析 总被引:7,自引:0,他引:7
目的 探讨脂肪母细胞瘤的临床、病理及预后。方法 对 4 4例脂肪母细胞瘤临床资料、病理切片和随访结果进行分析。结果 脂肪母细胞瘤 ,手术切除时的平均年龄为 (2 0 8± 14 6 )个月 ,患儿最大 5岁 ,男性多于女性。病变多发生于四肢、头颈部、腰背部及腋部。复发率 18 2 % ,弥漫型明显多于局限型。肿瘤最大径多为 3~ 7cm ,切面比脂肪瘤灰白。镜下见未成熟和成熟的脂肪组织小叶由丰富毛细血管、小静脉的狭窄纤维间隔分割 ,伴不同程度的黏液样基质。结论 脂肪母细胞瘤需与黏液脂肪肉瘤、纤维脂肪肉瘤和婴儿纤维性错构瘤相鉴别。脂肪母细胞瘤生物学行为完全良性 ,虽有局部复发 ,但从无转移及恶变 ,治疗方法主要为局部切除 相似文献
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血管肌纤维母细胞瘤16例临床病理分析 总被引:5,自引:1,他引:4
目的探讨血管肌纤维母细胞瘤(angiomyofibroblastoma,AMF)的临床病理、免疫组化特征、组织来源以及鉴别诊断。方法通过16例AMF的临床表现、病理形态和免疫组化研究,并结合文献复习,总结AMF的临床病理、免疫组化特征及鉴别诊断。结果16例AMF,大体境界清楚,无包膜,可见一层假纤维膜包绕;组织学上呈疏松水肿样,丰富薄壁海绵样血管,肿瘤细胞多样性,梭形及上皮样细胞多见,常围绕血管排列呈疏密交替分布特征。免疫组化结果:瘤细胞desmin及vimentin呈弥漫强阳性表达,actin、CD34、ER和PR染色稍弱、呈灶状分布,而S-100蛋白、NF和CK均阴性。结论AMF临床上多无明显症状;发病部位以女性外阴及盆腔最多见,但全身多处部位也可见;其生物学行为及组织来源尚无定论;术前很难确定诊断AMF,需与侵袭性血管黏液瘤、富于细胞性血管纤维瘤等相鉴别。 相似文献
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The clinicopathologic and immunohistochemical features of three metastasizing fibrous histiocytomas of the skin are presented. The first patient had a 1.3-cm nodule in the right thigh, with right inguinal lymph node metastases 19 years later. The second patient, who had a 3-cm nodule excised from his left thigh and inguinal lymph node metastasis after 4 months, had a favorable outcome 14 years after local radiotherapy and chemotherapy. The third had a 2-cm nodule in his neck, which recurred 16 months later. Four months later, cervical lymph node metastases were found. The patient was alive and well 26 months after initial surgery. All three primary skin tumors involved the dermis and subcutis, appeared well-delineated but nonencapsulated, were associated with some degree of epidermal hyperplasia, and showed features of aneurysmal/atypical or cellular fibrous histiocytoma. The number of mitoses ranged from 6 to 11 per 10 high-power fields. Recurrences and metastases showed morphologic features similar to primary lesions. Tumor cells were positive, at least focally, for CD 68, Ki-M1p, and Factor XIIIa, and occasionally for smooth muscle actin. Desmin, CD 34, S-100 protein, and cytokeratin stainings were negative. Primary neoplasms, recurrences, and metastases showed a Mib-1 labeling index of 10% or less. Cellular, aneurysmal, and atypical (pseudosarcomatous) fibrous histiocytomas of the skin can metastasize, yet they often show a protracted clinical course. Risk factors for metastatic dissemination include large size, high cellularity, aneurysmal changes, marked cellular pleomorphism, high mitotic activity, tumor necrosis, and repeated local recurrences. 相似文献
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Sean K. Lau Lawrence M. Weiss Peiguo G. Chu 《Virchows Archiv : an international journal of pathology》2009,454(2):189-194
While focal myxoid areas are occasionally observed in solitary fibrous tumors, neoplasms of this type exhibiting extensive
myxoid change are considered exceedingly uncommon. Due to their rarity, the biologic behavior of myxoid solitary fibrous tumor
has not been determined. Three cases of myxoid solitary fibrous tumor are described in order to better characterize the clinical
and pathologic features of this uncommon variant of solitary fibrous tumor. The tumors occurred in one man and two women,
with ages of 37, 47, and 58 years, respectively. Sites of involvement included the retroperitoneum, pelvis, and soft tissue
of the neck. Histologically, all cases were characterized predominantly by the presence of myxoid stroma comprising 70% to
100% of the tumor. The tumor cells were predominantly spindled in all cases, and arranged randomly, in loose fascicles, or
in anastomosing strands imparting a microcystic/reticular appearance. The lesional cells had a bland cytologic appearance
and low mitotic count. All tumors lacked necrosis and areas of increased cellularity. By immunohistochemistry, all cases were
positive for CD34, CD99, and bcl-2, and negative for keratin, epithelial membrane antigen, desmin, actin, smooth muscle actin,
and S-100 protein. To date, all cases have followed a benign course without evidence of recurrence or metastasis with a follow-up
duration ranging from 50 to 87 months. The data suggest that myxoid solitary fibrous tumors are associated with an indolent
clinical course and favorable prognosis. 相似文献
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Sugeshnee Pather Diane MacKinnon Rushen S. Padayachee 《Annals of diagnostic pathology》2013,17(1):80-84
Plasmablastic lymphoma (PBL) is an aggressive high grade non-Hodgkin lymphoma which occurs predominantly in adult patients who are concomitantly afflicted with HIV infection. In contrast to several reports and studies of PBL in adult patients, PBL has very rarely been reported in pediatric patients. This article hereby provides collaborative clinicopathologic information of de novo PBL diagnosed in 3 pediatric patients with concomitant HIV infection. Cognizance of this rare tumor in the pediatric population coupled with antiretroviral therapy and prompt initiation of multimodality treatment may, in the future, facilitate improved outcome in pediatric patients with PBL. 相似文献
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Casiraghi O Martinez-Madrigal F Pineda-Daboin K Mamelle G Resta L Luna MA 《Annals of diagnostic pathology》2004,8(4):189-197
We studied 19 cases of chondroid tumors of the larynx: two chondrometaplastic nodules, two chondromas and 15 chondrosarcomas (including two dedifferentiated chondrosarcomas). One of chondromas recurred 18 months after resection because of inadequate surgical treatment. Chondrosarcomas were separated as low-grade (nine cases), intermediate (three cases), high-grade (one case), and dedifferentiated (two cases) according to histologic appearance. Chondrosarcomas are nearly always histologically low grade, make up the largest numbers of the neoplasms, and arise from the cricoid cartilage. Conservative surgical management, when possible, is advocated to preserve the larynx. Chondrometaplastic nodules are to be distinguished from chondrosarcoma and the rarely occurring chondroma. The nodules are not neoplastic and have a low to nil recurrent potential. 相似文献
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The clinical and pathologic features of 26 primary pulmonary sarcomas were analyzed. Fourteen patients were male and 12 were female; ranging in age from 18 to 75 years (mean, 48 yr). The tumors measured from 0.9 cm in greatest diameter to filling the entire hemithorax. Thirteen tumors were in the left lung and nine in the right lung; one was bilateral, two were in the pulmonary artery, and the location of one tumor was not available. The histologic diagnoses were malignant fibrous histiocytoma (7), synovial sarcoma (6), malignant peripheral-nerve sheath tumor (3), leiomyosarcoma (3), angiosarcoma (2), intimal sarcoma (2), fibrosarcoma (2), and one case of epithelioid hemangioendothelioma. Immunohistochemical and ultrastructural examination supported these diagnoses. Morphologically, the differential diagnosis often included sarcomatoid carcinoma or desmoplastic malignant mesothelioma Patients were treated with surgery, chemotherapy, radiation therapy, or a combination of these. Follow-up was available for 22 patients and ranged from 2 to 183 months (mean, 45 mo). Fourteen patients are free of disease, four died of disease, three are alive with disease, and one died of surgical complications. A variety of sarcomas, especially malignant fibrous histiocytoma and synovial sarcoma, arise within the pulmonary parenchyma. These tumors have the potential to behave aggressively but can be cured by resection, with or without adjuvant therapy. Immunohistochemistry and electron microscopy can be helpful in distinguishing primary pulmonary sarcoma from other tumors in the differential diagnosis. 相似文献
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Synovial sarcomas arising in unexpected locations may lead to diagnostic challenges. In this report, we describe 3 cases of synovial sarcoma that manifested clinically as primary pericardial lesions. All 3 cases occurred in men in their fourth decade. Fever, cough, chest pain, and chest distress were the most common symptoms. Histologically, 2 of the tumors were spindle cell monophasic, and 1 tumor was biphasic. By immunohistochemical studies, the tumor cells were positive for cytokeratins and epithelial membrane antigen. In addition, the tumor cells displayed focal immunoreactivity for calretinin, cytokeratin 5/6, and HBME-1, resulting in the initial interpretations of malignant mesotheliomas. None of the 3 cases were diagnosed correctly until subsequent molecular cytogenetic assays demonstrated the presence of SYT gene rearrangements. As there are overlapping morphologic features between pericardial synovial sarcoma and mesothelioma, molecular analysis is essential for differential diagnoses. 相似文献
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恶性颗粒细胞瘤临床病理、免疫组化和超微结构观察 总被引:6,自引:0,他引:6
目的:探讨恶性颗粒细胞瘤的病理学诊断和鉴别诊断要点及组织学起源。方法:对3例恶性颗粒细胞瘤进行临床病理、免疫组化及超微结构观察研究。结果:男性2例,女性1例,平均年龄为49岁。部位分别为颈部1例,右大腿2例。其中2例分别于术后2年半及7年复发,并伴有区域淋巴结转移。组织学上3例与良性颗粒细胞瘤十分相似,局部区域出现梭形瘤细胞,空泡状核及明显的核仁,其中1例在肿瘤的周边部可见到瘤细胞与外周神经束支之间有直接移行关系。免疫酶标结果显示瘤细胞强阳性表达S-100蛋白和神经特异性烯醇化酶(NSE),1例电镜检测显示胞浆内充满膜包被复合性溶酶体。结论:对临床明显恶性而组织学上却极似良性的恶性颗粒细胞瘤,以下几点能提示恶性诊断:(1)肿瘤超过4cm;(2)核分裂象超过2个/10HPF;(3)核呈空泡状并有明显的核仁;(4)出现梭形瘤细胞;(5)有肿瘤性坏死。此外,免疫组化标记及超微结构观察有助于鉴别诊断及揭示组织学起源。 相似文献
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We describe the characteristic clinical and pathologic findings of three cases of constrictive bronchiolitis. All three patients were middle-aged women with chronic respiratory illness characterized by chronic cough, dyspnea, mild to severe obstructive pulmonary dysfunction, relatively normal chest radiographs with occasional peribronchial infiltration, and lack of response to bronchodilators or prednisolone. The patients also had medical diseases such as non-Hodgkin's lymphoma and hyperprolactinemia in case 1 and 3, respectively. None of the patients smoked cigarettes and had clinical evidence of recent viral lower respiratory tract infection. Histologic study by open lung biopsy revealed a spectrum of changes ranging from active cellular bronchiolitis to obliterative peribronchiolar fibrosis. The intervening interstitial and alveolar areas showed no remarkable lesion. Immunohistochemically, the bronchiolar or peribronchiolar inflammatory infiltrates mainly comprised of mixed T- and B-lymphocytes. It may be possible that the active form of constrictive bronchiolitis is initiated by attendant lymphocytic inflammation of the airways, which is followed by fibrous obliteration of bronchioles. 相似文献