Correction de l’hypoxémie d’exercice chez le BPCO : variabilité des réponses, enjeux et problèmes posés dans le cadre de la réhabilitation respiratoire

Aim

To define in chronic obstructive pulmonary disease patients (COPD) moderately hypoxemic in resting conditions, if controlled acute oxygen supplementation was always able to increase exercise tolerance when partial oxygen saturation SpO₂ was corrected.

Results

In hyperoxia, endurance time (T_LIM) was significantly and consistently increased in 14 COPD (+68%) and decreased in seven others (–36%). These two subgroups exhibited no difference in resting values or in their disease severity. COPD with a decreased T_LIM under hyperoxic conditions had an abnormal response to O₂: unchanged cardiac output and ventilation, increased breathing frequency.

Conclusion

This work shows that acute O₂ supplementation responses in COPD are not univocal, either on exercise tolerance or cardio-respiratory variables typically affected by hyperoxia.