甲状腺细针吸取细胞学检查对儿童甲状腺疾病的诊断价值

目的探讨细针吸取细胞学检查对儿童甲状腺疾病诊断的价值。方法甲状腺肿大患儿１６例，男２例，女１４例，用细针吸取甲状腺组织，放在玻片上经特殊染色后，于光学显微镜下观察细胞形态学的改变。结果１６例患儿共行２０次穿刺，１９次为一次穿刺成功。于光学显微镜下直接作出细胞组织学的诊断。２０次穿刺均无不良反应。结论细针吸取细胞学检查的方法同样可应用于儿童甲状腺疾病的诊断，而且这种方法操作简便，安全。     

细针吸取细胞学检查在儿童甲状腺炎诊断中的应用

目的：　探讨细针吸取细胞学 (FNAC)检查对儿童甲状腺炎的诊断价值。方法：　采用FNAC检查法诊断儿童甲状腺。结果：　经细胞学诊断为甲状腺炎共计 10 0例,经临床治疗及其它实验室检查结果相符的98例(98%),只有2例(2%)在分类上出现误差,而血清学(T3 ,T4 ,TG ,TM ,TSH)检查敏感性则相对较低,桥本氏甲状腺炎为63.1%～73.6%,淋巴细胞性甲状腺炎为26.0%～84.7%,其它血清学检查均无意义。结论：　FNAC检查法吸出细胞成分充足,几乎不含血液成分,有利于甲状腺炎的诊断及分类。     

细针吸取细胞学诊断慢性淋巴细胞性甲状腺炎82例

随甲状腺自身抗体检测和细针吸取细胞学 (FNAC)诊断技术的广泛应用 ,慢性淋巴细胞性甲状腺炎的诊断率明显上升 ,成为儿童甲状腺肿大的常见病因。FNAC检查痛苦小 ,诊断周期短。我院对甲状腺疾病已常规行FNAC检查 ,本文就82例儿童慢性淋巴细胞性甲状腺炎的细胞学结果报道如下。资料与方法一、一般资料　我院 1997年 1月～ 2 0 0 1年 7月收治儿童甲状腺弥散性肿大及结节性病变 6 5 0例。经FNAC诊断为慢性淋巴细胞性甲状腺炎 82例 ,男 10例 ,女 72例 ;年龄 6～ 13岁。肿块直径 0 .6～ 3.0cm ,其中甲状腺疾病阳性家族史 5例。 9例甲状腺局…     

细针穿刺细胞学检查对小儿甲状腺疾病的诊断价值

自1992年7月至2001年12月对262例小儿甲状腺肿大性疾病进行了非抽吸穿刺细胞学检查,其中资料完整的124例,现总结如下。     

细针穿刺细胞学检查对儿童亚急性甲状腺炎的诊断价值

亚急性甲状腺炎因临床表现多样,易误诊和漏诊,自1992年7月至1999年12月对232例小儿甲状腺肿大进行了细针穿刺细胞学检查,其中有7例诊断为亚急性甲状腺炎(亚甲炎),现报告如下。     

细针吸取细胞学检查诊断儿童慢性淋巴细胞性甲状腺炎

慢性淋巴细胞性甲状腺炎(CLT)是甲状腺炎中最多的一种,是儿童及青少年中甲状腺功能减低的最常见原因,我们对11例儿童甲状腺肿大者进行细针吸取细胞学检查(FNAB)确诊为本病,现总结如下。 临床资料 一、一般资料 男1例,女10例,男:女为1:10;年龄8～13岁(平均9.2岁),8～10岁2例,～13岁9例;自发病到确诊时间2个月～1年,平均     

甲状腺细针抽吸细胞学检查对儿童桥本病早期诊断价值探讨

目的探讨甲状腺细针抽吸细胞学检查（ＦＮＡＢ）对儿童桥本病的早期诊断价值。方法对２０例甲状腺肿大患儿进行ＦＮＡＢ检查。结果各种不同的甲状腺疾病组织,在镜下显示不同的细胞学形态。桥本病组织的细胞形态学有其特征性。２例临床诊断为甲亢的患儿经ＦＮＡＢ确诊为桥本病。结论ＦＮＡＢ对早期诊断儿童桥本病有重要价值。     

甲状腺细针穿刺细胞学检查对桥本甲状腺炎的诊断价值

目的　探讨甲状腺非抽吸细针穿刺细胞学 (FNAB)检查对儿童慢性淋巴细胞性甲状腺炎 (HT)诊断价值。方法　对 16 9例弥散性甲状腺肿儿童进行FNAB检查、甲状腺自身抗体测定 ,分别行FNAB诊断和临床诊断 ,并进行随访。结果　 16 9例中 76例诊断为儿童HT ;FNAB初诊准确率 98.6 8% (75 /76 ) ,明显高于临床初诊准确率 80 .2 6 % (6 1/76 ) (P <0 .0 1) ;HT 76例FNAB细胞学表现可分为 3种类型 :以淋巴细胞为主型最多(37/76 ) ,以嗜酸性变型最典型 ,上皮破坏型少见。结论　FNAB检查对诊断儿童HT和细胞学分型有较好的实用价值     

细针穿刺细胞学检查在门诊诊断儿童颈部肿块的应用价值

目的 探讨细针穿刺细胞学检查（fine needle aspiration cytology,FNAC）在儿童颈部肿块诊断的应用价值.方法 总结296例小儿颈部肿块,门诊行细针穿刺后进行细胞学病理诊断.结果 296例病例中,成功作出诊断的有268例,约占88.2％,其中淋巴结反应性增生248例,恶性淋巴瘤6例,梭形细胞肿瘤5例,唾腺来源肿瘤2例,腮裂囊肿2例,甲状舌管囊肿1例,传染性单核细胞增多症1例,颈部淋巴结结核1例,血管瘤1例,钙化上皮瘤1例,33例不能肯定诊断,建议手术活检,最终有11例接受手术,均为淋巴结炎,其余随访.结论 FNAC在儿童颈部疾病诊断中有重要意义,具有快速、便捷、经济、安全、准确的优点,特别适合性质不明的肿块筛查.     

儿童甲状腺结节的诊断与治疗

儿童甲状腺结节患病率低于成人,但恶性病变发生率较高,预后也不同于成人,故对其诊断、鉴别诊断及治疗方案进行探讨尤为重要.目前对患儿甲状腺结节的诊断方法主要包括患者病史采集、体格检查、实验室检查、超声检查以及细针穿刺吸取活组织检查(fine-needle aspiration biopsy,FNAB),其中以超声及FNAB检查更为重要,超声检查不仅能对病变进行准确的定位,而且还能提供病变的大小、边界、血流等重要信息.通过FNAB则可以直接获取病变内部细胞进行分析,进一步提高诊断的准确性.甲状腺结节良恶性判别是关键,良性甲状腺结节性病变以保守治疗为主,恶性病变需采取更激进的治疗方式,如甲状腺次全切除、全腺叶切除以及区域淋巴结清扫等,此外还可以给予放射性131 I以及药物进行辅助治疗.     

Fine Needle Aspiration Cytology in Advanced Pediatric Tumors

Eighty-one children with clinically suspected malignant tumors were subjected to percutaneous fine needle aspiration cytology (FNAC) at the Pathology Department of the National Institute of Child Health, Jinnah Postgraduate Medical Centre, Karachi, from August 1986 through July 1987. There were 47 malignant diagnoses including lymphoma, neuroblastoma, nephroblastoma, Ewing's sarcoma, and leukemia. Histological findings confirmed the FNAC diagnoses in 36 cases in which a subsequent incisional biopsy or surgically removed specimen was available. FNAC results were confirmed in all benign cases. In 10 advanced cases of NonHodgkin's lymphoma, surgery was not possible because of marked malnourishment. One false negative and no false positive result was encountered. Forty-eight were females and thirty-three males. FNAC can be a quick, effective, and inexpensive alternative to open biopsy, particularly in advanced cases of malignancy in undernourished children where anesthesia and immediate surgery are contraindicated.     

Hyperfunctioning Thyroid Nodules in Children and Adolescents

ABSTRACT. Eight children and adolescents, seven female and one male, aged 7.1 to 15.0 years, referred over a 12-year period for a solitary mass in an otherwise normal thyroid gland, exhibited a hyperfunctioning nodule on thyroid scintiscan. Tracer uptake in the surrounding thyroid tissue was reduced or completely suppressed, but could be restored after TSH stimulation. Only one patient had mild clinical hyperthyroidism with normal T4 but increased T3 serum levels and blunted TSH responsiveness to TRH. A similar hormonal pattern suggestive of subclinical hyperthyroidism was found in three other subjects who were clinically euthyroid. One patient initially euthyroid progressed to subclinical hyperthyroidism two years later. In the whole group a significant negative relationship was found between serum T3 level and TRH-stimulated TSH peak (r= -0.829, p<0.02). All the patients underwent selective surgery after a 3-month to 2-year period of follow-up. Microscopic examination was consistent with adenoma in seven patients, while in one case a well-encapsulated papillary adenocarcinoma was found. Though hyperfunctioning nodules are seldom malignant, their surgical removal must be recommended when they become thyrotoxic, exceed 3 cm or show progressive enlargement.     

Fine Needle Aspiration Cytology (FNAC) of the Testes in Childhood Acute Lymphoblastic Leukemia and Non-Hodgkin's Lymphoma: Preliminary Report

Eighteen patients with childhood acute lymphoblastic (ALL) or non-Hodgkin's lymphoma (NHL) in remission and 2 patients with ALL in suspected testicular relapses were studied by testicular fine needle aspiration cytology (FNAC). Well-preserved testicular cells, both singly and in small clusters, were considered indicative of an adequate aspiration. Of 18 patients in remission, 17 had at least one adequate sample from each testis and one showed evidence of leukemic infiltrate. None of these patients experienced a relapse during a median follow up of 4 years. In 2 other patients with clinically suspected testicular relapses, the smears from fine needle aspirates contained numerous malignant lymphoid cells that could be readily distinguished from seminiferous tubular cells. The observations indicate that FNAC is a promising new approach to study testicular conditions in childhood ALL and NHL. A larger prospective study and accumulation of additional follow-up data is required before a definitive evaluation of the technique can be made.     

B超引导下穿刺活检术对儿童实体肿瘤的诊断价值探讨

目的 探讨超声导向穿刺活检术在诊断儿童实体肿瘤中应用的可行性和可靠性。方法采用自动同步负压活检取样装置在B超引导下行穿刺活检术。结果15例均获成功，取材成功率100％。组织标本符合病理学检查14例，穿刺检出阳性率为93．3％。无一例出血、感染及肿瘤破溃等并发症。结论超声引导自动活检术是一种安全准确，快速可靠的病理诊断方法。