Accuracy of multislice CT angiography for the assessment of in-stent restenoses in the iliac arteries at reduced dose: a phantom study

Objective

We investigated the potential of low-dose CT angiography for accurate assessment of in-stent restenoses (ISRs) of the iliac artery.

Method

A Rando anthropomorphic phantom (Alderson Research Labs, Stanford, CA), custom-made wax simulating hyperplastic tissue and a nitinol stent were used to simulate a patient with clinically relevant iliac artery ISRs. The cylindrical lumen was filled with a solution of iodine contrast medium diluted in saline, representing a patient''s blood during CT angiography. The phantom was subjected to standard- and low-dose angiographic exposures using a modern multidetector (MD) CT scanner. The percentage of ISR was determined using the profile along a line normal to the lumen axis on reconstructed images of 2 and 5 mm slice thickness. Percentage ISRs derived using the standard- and low-dose protocols were compared. In a preliminary study, seven patients with stents were subjected to standard- and low-dose MDCT angiography during follow-up. The resulting images were assessed and compared by two experienced radiologists.

Results

The accuracy in measuring the percentage ISR was found to be better than 12% for all simulated stenoses. The differences between percentage ISRs measured on images obtained at 120 kVp/160 mAs and 80 kVp/80 mAs were below 6%. Patient image sets acquired using low-exposure factors were judged to be of satisfactory diagnostic quality. The assessment of ISR did not differ significantly between image sets acquired using the standard factors and those acquired using the low-exposure factors, although the mean reduction in patient effective dose was 48%.

Conclusion

A reduction in exposure factors during MDCT angiography of the iliac artery is possible without affecting the accuracy in the determination of ISRs.Follow-up in patients treated with peripheral arterial stent implantation is usually performed with clinical examination, ankle–brachial index measurement, exercise testing and proof of patency using duplex ultrasonography. However, digital subtraction angiography (DSA) is still considered to be the best imaging technique for the assessment of in-stent restenosis (ISR) and stent patency in the iliac and proximal superficial femoral arteries following stent implantation as it offers the unique advantage of incorporating diagnostic confirmation and endovascular treatment in a single session. Apart from the relatively high patient radiation burden, the main disadvantage of DSA relates to its invasive nature. DSA is associated with a certain risk for potentially serious complications. Over the last few years, there has been a continuous effort to improve the safety and effectiveness of percutaneous revascularisation in peripheral arterial occlusive disease. A host of technological advances associated with endovascular treatment have been recently developed including novel angioplasty balloons and “shape memory” nitinol stents [1]. Currently, nitinol stents are considered to be the most modern solution for revascularisation of aortoiliac and lower extremity arteries [1]. In addition, the advent of multislice CT angiography during the last few years has provided a non-invasive alternative for the assessment of stented vessels. The use of modern 16- and 64-slice CT systems was recently proven to significantly improve spatial resolution and lumen visualisation, rendering multidetector CT (MDCT) angiography a powerful tool for ISR assessment [2-8].MDCT imaging is considered to be a high-dose diagnostic procedure resulting in absorbed doses to patient tissues of 10–100 mGy. The cumulative dose to patient tissues from multiple CT examinations may often approach or even exceed radiation dose levels known to significantly elevate the probability for cancer induction [9, 10]. MDCT systems are rather complicated systems, and appropriate adaptation of exposure factors to achieve optimisation of the examination is a complex task influenced strongly by the specific diagnostic demands [11]. Given that image quality in modern CT is often higher than that required to achieve diagnostic confidence [12], we felt that it would be interesting to study whether there is any potential for dose reduction in MDCT angiography imaging for ISR assessment. The purpose of the current study was to investigate the effect of reducing the exposure parameters during MDCT angiography on the assessment of clinically relevant ISR in patients with nitinol stents in the external iliac or proximal superficial femoral artery.     

Comparison of electron-beam and ungated helical CT in detecting coronary arterial calcification by using a working heart phantom and artificial coronary arteries

PURPOSE: To determine the sensitivity and specificity of cardiac gated electron-beam computed tomography (CT) and ungated helical CT in detecting and quantifying coronary arterial calcification (CAC) by using a working heart phantom and artificial coronary arteries. MATERIALS AND METHODS: A working heart phantom simulating normal cardiac motion and providing attenuation equal to that of an adult thorax was used. Thirty tubes with a 3-mm inner diameter were internally coated with pulverized human cortical bone mixed with epoxy glue to simulate minimal (n = 10), mild (n = 10), or severe (n = 10) calcified plaques. Ten additional tubes were not coated and served as normal controls. The tubes were attached to the same location on the phantom heart and scanned with electron-beam CT and helical CT in horizontal and vertical planes. Actual plaque calcium content was subsequently quantified with atopic spectroscopy. Two blinded experienced radiologic imaging teams, one for each CT system, separately measured calcium content in the model vessels by using a Hounsfield unit threshold of 130 or greater. RESULTS: The sensitivity and specificity of electron-beam CT in detecting CAC were 66.1% and 80.0%, respectively. The sensitivity and specificity of helical CT were 96.4% and 95.0%, respectively. Electron-beam CT was less reliable when vessels were oriented vertically (sensitivity and specificity, 71.4% and 70%; 95% CI: 39.0%, 75.0%) versus horizontally (sensitivity and specificity, 60.7% and 90.0%; 95% CI: 48.0%, 82.0%). When a correction factor was applied, the volume of calcified plaque was statistically better quantified with helical CT than with electron-beam CT (P =.004). CONCLUSION: Ungated helical CT depicts coronary arterial calcium better than does gated electron-beam CT. When appropriate correction factors are applied, helical CT is superior to electron-beam CT in quantifying coronary arterial calcium. Although further work must be done to optimize helical CT grading systems and scanning protocols, the data of this study demonstrated helical CT's inherent advantage over currently commercially available electron-beam CT systems in CAC detection and quantification.     

Accuracy and reliability of quantitative measurements in coronary arteries by multi-slice computed tomography: experimental and initial clinical results.

AIM: To evaluate the accuracy of non-invasive measurements within coronary arteries by multi-slice computed tomography (MSCT). We present experimental as well as clinical data. MATERIALS AND METHODS: Silicon tubes simulating coronary arteries (outer diameter 6 mm, lumen diameter within stenotic area 2 mm) were used for experimental studies. Clinical data were derived from 15 patients in whom vessel diameters were assessed by MSCT, intracoronary ultrasound (ICUS) and quantitative coronary angiography (QCA). MSCT were performed in a Somatom Volume Zoom(trade mark)CT system (Siemens, Forchheim, Germany) at 2 collimated slice widths (2.5 mm, 1.0 mm). RESULTS: Outer silicon tube diameters were overestimated by MSCT (6.56 mm +/- 0.32 mm). All measurements revealed significantly better results on 1.0 collimation compared to 2.5 mm collimation (outer diameter: 6.36 mm +/- 0.22 mm vs 6.76 mm +/- 0.27 mm, P < 0.0001; lumen diameters: 1.83 mm +/- 0.14 mm vs 1.51 mm +/- 0.19 mm, P < 0.0001). The comparison of vessel diameters within human coronary arteries revealed comparable results between ICUS and MSCT (4.89 mm +/- 0.67 mm vs 4.91 mm +/- 0.71 mm, P = 0.79, r = 0.79, P < 0.0001). QCA-measurements showed significantly lower results (3.67 +/- 0.71, P < 0.0001, r = 0.62, P < 0.001). CONCLUSIONS: Experimental as well as initial clinical results indicate acceptable reliability and accuracy of quantitative measurements by MSCT, when using thin collimated slice widths. Partial volume effects lead to a systematic overestimation of vessel size. MSCT has the potential to become an important non-invasive diagnostic tool in patients with coronary artery disease.     

Imaging factors influencing spine and cord measurements by CT: a phantom study

Metrizamide computed tomography (CT) of the spine allows evaluation of the contents and measurement of the size of intracanalicular structures. The relative size (linear and area measurements) of spinal structures can be changed by varying imaging factors or the density of intrathecal contrast material. Two phantoms, one consisting of rods embedded in a plastic cylinder and the other of a vertebral body with a central rod simulating spinal cord, were evaluated with varying imaging factors (window width and window level) and different contrast concentrations within the surround. It was found that wide window widths allowed the most consistent measurements independent of window level, that a window level midway between the CT number of rod and surround would facilitate uniform measurements independent of window width, and that the use of high concentrations of contrast material (high CT number) in the surround, in combination with a wide window width, was most effective in establishing consistent measurements.     

Quality control within the multicentre perfusion CT study of primary colorectal cancer (PROSPeCT): results of an iodine density phantom study

Objectives

To assess the cross-centre consistency of iodine enhancement, contrast-to-noise ratio and radiation dose in a multicentre perfusion CT trial of colorectal cancer.

Materials and methods

A cylindrical water phantom containing different iodine inserts was examined on seven CT models in 13 hospitals. The relationship between CT number (Hounsfield units, HU) and iodine concentration (milligrams per millilitre) was established and contrast-to-noise ratios (CNRs) calculated. Radiation doses (CTDI_vol, DLP) were compared across all sites.

Results

There was a linear relationship between CT number and iodine density. Iodine enhancement varied by a factor of at most 1.10, and image noise by at most 1.5 across the study sites. At an iodine concentration of 1 mg ml^?1 and 100 kV, CNRs ranged from 3.6 to 4.8 in the 220-mm phantom and from 1.4 to 1.9 in the 300-mm phantom. Doses varied by a factor of at most 2.4, but remained within study dose constraints. Iterative reconstruction algorithms did not alter iodine enhancement but resulted in reduced image noise by a factor of at most 2.2, allowing a potential dose decrease of at most 80 % compared to filtered back projection (FBP).

Conclusions

Quality control of CT performance across centres indicates that CNR values remain relatively consistent across all sites, giving acceptable image quality within the agreed dose constraints.

Key Points

? Quality control is essential in a multicentre setting to enable CT quantification. ? CNRs in a body-sized phantom had the recommended value of at least 1.5. ? CTDIs and DLPs varied by factors of 1.8 and 2.4 respectively.     

Value of multislice CT coronary arteries calcification scoring in the prediction of coronary arteries pathology in chronic kidney disease patients

PurposeTo determine the value of multislice CT coronary artery calcification (CAC) scoring in the prediction of future cardiac events in known chronic kidney disease (CKD) patients using conventional coronary angiography as the standard reference.Patients and methodsFifty-eight patients with CKD on hemodialysis underwent CT CAC scoring using multislice scanner and conventional coronary angiography. Results of CAC scoring were compared to the findings of conventional coronary angiography.ResultsMean CAC scoring in patients with significant coronary arteries stenotic lesions was higher than in patients with no significant coronary arteries stenotic lesions with significant difference (P < 0.001).Mean patient CAC scoring was strongly correlated with the number of coronary arteries with significant stenotic lesions (r = 0.910).ConclusionCT CAC scoring is a non-invasive technique which can be used in the evaluation and follow up of CKD patients’ coronary arteries without the use of contrast medium reducing the number of invasive coronary angiography needed.     

CT仿真内窥镜技术的模型研究

目的　系统分析主要扫描参数对CT仿真内窥镜 (CTVE)图像质量的影响 ,寻找可获得较好图像质量的扫描参数组合。评价CTVE对不同大小、形态的模拟病变的分辨能力 ,进一步确定图像的真实性。方法　应用不同扫描参数分别对不同组别模拟病变的模型进行扫描 ,观察图像质量及模拟病变的分辨情况。结果　准直器宽度、螺距、重叠重建率及重建方式的变化均会不同程度地影响CTVE图像质量。在准直器宽度≤ 3mm、螺距 1.0～ 2 .0、重叠重建率 6 0 %、标准 (STD)重建方式的参数范围内可获得较满意的图像质量 ,并具有可分辨微小结构及较真实显示结构形态的能力。结论　适当选择扫描参数、有效分辨伪影及变形 ,CTVE技术将成为显示空腔脏器病变及结构的有效方法之一。     

Relative density measurements in a simple lung phantom by Compton backscatter

Compton backscatter of 60 keV gamma radiation from a simple lung phantom has been used to measure changes in "lung" density. It was shown how introduction of a small volume of air can increase as well as decrease the count. Radiation scattered from the "chest wall" was prevented from entering the detector by careful choice of geometry. The remaining count increased linearly with "lung" density. The relative increase of count rate with density was entirely independent of "chest wall" thickness. With our apparatus a change of 0.01 kg/L in "lung" density produced a change in count rate of 2.2%.     

Abdominal multislice CT for obese patients: effect on image quality and radiation dose in a phantom study

RATIONALE AND OBJECTIVES: To evaluate the effect of a modified abdominal multislice computed tomography (CT) protocol for obese patients on image quality and radiation dose. MATERIALS AND METHODS: An adult female anthropomorphic phantom was used to simulate obese patients by adding one or two 4-cm circumferential layers of fat-equivalent material to the abdominal portion. The phantom was scanned with a subcutaneous fat thickness of 0, 4, and 8 cm using the following parameters (detector configuration/beam pitch/table feed per rotation/gantry rotation time/kV/mA): standard protocol A: 16 x 0.625 mm/1.75/17.5 mm/0.5 seconds/140/380, and modified protocol B: 16 x 1.25 mm/1.375/27.5 mm/1.0 seconds/140/380. Radiation doses to six abdominal organs and the skin, image noise values, and contrast-to-noise ratios (CNRs) were analyzed. Statistical analysis included analysis of variance, Wilcoxon rank sum, and Student's t-test (P < .05). RESULTS: Applying the modified protocol B with one or two fat rings, the image noise decreased significantly (P < .05), and simultaneously, the CNR increased significantly compared with protocol A (P < .05). Organ doses significantly increased, up to 54.7%, comparing modified protocol B with one fat ring to the routine protocol A with no fat rings (P < .05). However, no significant change in organ dose was seen for protocol B with two fat rings compared with protocol A without fat rings (range -2.1% to 8.1%) (P > .05). CONCLUSIONS: Using a modified abdominal multislice CT protocol for obese patients with 8 cm or more of subcutaneous fat, image quality can be substantially improved without a significant increase in radiation dose to the abdominal organs.     

Dose reduction in multislice CT by means of bismuth shields: results of in vivo measurements and computed evaluation

Purpose

We investigated the amount of patient dose reduction in the thyroid, lens of the eye and the breast when using bismuth protections in multislice computed tomography (CT) exams as well as their influence on the quality of diagnostic images.

Materials and methods

The radiation dose was measured by using thermoluminescence dosimeters. The study was conducted on the two CT scanners installed in our radiology department (64 and eight slices). The shield effects on the CT image were evaluated by measuring the signal-to-noise ratio in a phantom and in vivo, and by verifying the presence of artefacts on patients’ images. The obtained organ-dose reduction factors were used to evaluate the effects of shielding on the effective dose.

Results

The shielding attenuation ranged from 30% to 60% depending on the CT scan protocols and organs. The difference between shielded and unshielded signal-to-noise ratio was statistically significant but within the standard requirements for quality assurance. Results were in agreement with the radiologists’ perception of image quality. The use of the shields allowed up to 38% reduction of effective dose.

Conclusions

Use of bismuth shields significantly decreases both organ and effective radiation dose, with a consequent reduction in health risk for the patient, quantified in 1.4 fewer cases of radiation-induced tumours every 5 years in our centre (12,100 exams/year), in agreement with the risk factors proposed by Publication 60 of the International Commission on Radiological Protection (ICRP). The relative inexpensiveness of these protections, their easy application and their substantial lack of influence on image quality suggest their massive introduction into routine clinical practice.     

Optimal scanning protocol of multislice CT virtual intravascular endoscopy in pre-aortic stent grafting: in vitro phantom study

OBJECTIVE: To investigate the optimal scanning protocol for multislice computed tomography angiography (MSCT) in pre-aortic stent grafting observed with virtual intravascular endoscopy (VIE). MATERIALS AND METHODS: The study was performed on a human abdominal aortic phantom which was housed in a perspex container, filled with contrast medium having CT attenuation similar to that used in the patient's abdominal CT scan. A series of scans were performed on a four-slice multislice CT scanner with the scanning protocols as follows: section thickness of 1.3, 3.2 and 6.5 mm, pitch value of 0.875, 1.25 and 1.75 with reconstruction intervals of 50% overlap. The degree of stair-step artifacts was measured at three different locations, superior mesenteric artery (SMA), renal ostium and the normal abdominal aorta. Standard deviation (S.D.) of the signal intensity measured on surface shaded images was used to determine the image quality. Radiation dose was also recorded in each scanning protocol. RESULTS: The VIE images showed that image quality was not dependent on pitch and section thickness in the visualization of renal ostium and SMA, whereas it was dependent on these two factors at the level of the normal aorta (p<0.05). It was noticed that when section thickness reached 6.5 mm the SMA and renal ostia became distorted. Radiation dose measured in 1.3 mm protocols was significantly higher that those measured in other section thicknesses (p<0.05). CONCLUSION: The scanning protocol of section thickness 3.2 mm, pitch 1.25 with a reconstruction interval of 1.6 mm was recommended as it allows optimal visualization of VIE images of aortic ostia, generation of fewer artifacts and less radiation dose.     

Overlapping cross-sections significantly improve the reproducibility of coronary calcium measurements by electron beam tomography: a phantom study

PURPOSE: We conducted phantom studies to investigate whether overlapping cross-sections and volumetric scoring would significantly improve interscan reproducibility of electron beam tomography (EBT) for coronary artery calcium quantification. METHOD: Fifteen phantoms simulating various amounts of coronary calcification were scanned in five different positions with a slice thickness of 3.0 mm and a table feed of 3.0, 2.5, and 2.0 mm. For the conventional "Agatston score" and a "volume score" (total volume of calcified lesions), interscan variabilities were compared between the three image acquisition protocols. RESULTS: Agatston score variability was significantly lower for the 2.0 mm table feed than for the 3.0 or 2.5 mm table feed (3.0 mm: 22.9 +/- 10.3%; 2.5 mm: 13.6 +/- 8.2%; 2.0 mm: 8.9 +/- 5.5%). Volume score variability was significantly lower for 2.5 and 2.0 mm table feed than for 3.0 mm table feed (3.0 mm: 21.7 +/- 11.0%; 2.5 mm: 10.9 +/- 5.9%; 2.0 mm: 9.8 +/- 5.9%). CONCLUSION: Overlapping cross-sections, especially in combination with volumetric scoring, significantly improved interscan reproducibility of EBT calcium quantification in a phantom study.     

CT of a bronchial phantom. Factors affecting appearance and size measurements

In order to determine the most appropriate window settings for viewing CT of the bronchial tree, we performed CT of a bronchial phantom consisting of air-filled tubes measuring from 3.1 to 12.7 mm, oriented at varying angles relative to the scan plane, surrounded by water or air, and with scan collimation of 10 mm, 5 mm, and 1.5 mm. Using a computer program to graphically display CT number relative to the distance across the tube's lumen, it was found that a window mean of -150 H accurately estimated the internal diameter of tubes surrounded by water, at all angles, when collimation was 5 mm or 1.5 mm. With 10-mm collimation, tube diameter was slightly underestimated for tubes 9.5 mm or less when oriented 30 degrees or more from perpendicular to the plane of scan. At lower window settings and window widths of 500 H or less, all tube's diameters were significantly underestimated. At -150 H, with tubes parallel to and centered in the scan plane, 5-mm and 1.5-mm collimation were most accurate; with decentering of 4 mm, 10-mm collimation better showed the tube's lumen. When surrounded by air, tube wall thickness was best estimated using a window mean of -450 H.     

Non-invasive characterisation of coronary lesion morphology and composition by multislice CT: first results in comparison with intracoronary ultrasound

The reliable non-invasive detection of coronary artery disease (CAD) is a prime goal for future developments in clinical cardiology. In addition to the documentation of high-grade stenoses, the detection of vulnerable plaques is of major importance for risk stratification and early treatment to prevent plaque rupture. Recently, a new generation of fast spiral CT has been introduced using a multi-slice technique (MSCT), which is the first real quantum leap in CT since the introduction of spiral CT in the early 1990s. We report on non-invasive differentiation of coronary plaque morphology by MSCT in patients with lesions in the proximal left anterior descending artery (LAD). The results were compared with the findings of intracoronary ultrasound (ICUS). The ICUS and MSCT scans were analysed in 6 patients scheduled for ICUS-guided PTCA. One target lesion was selected in each patient. On ICUS, two lesions were classified as soft, two as intermediate and two as calcified according to established criteria based on echogenicity. By multislice CT, density measurements (expressed in Hounsfield Units, HU) were performed at 16 randomly selected areas within the plaques. The two soft plaques showed a mean density of 6+/-28 and -5+/-25 HU, the two intermediate plaques of 83+/-17 and 51+/-19 HU, and the two calcified plaques of 489+/-372 and 423+/-111 HU. To our knowledge, this is the first report on non-invasive characterisation of coronary lesions by MSCT. Plaque composition could be clearly differentiated and classified according to the ICUS results by determining tissue density within the lesions. Thus, this new technology holds promise for non-invasive risk assessment in patients with known or suspected CAD since also rupture-prone soft coronary lesions can be detected by use of this new technique.     

Value of 3D-volume rendering in the assessment of coronary arteries with retrospectively ECG-gated multislice spiral CT

PURPOSE: To assess the diagnostic value and measurement precision of 3D volume rendering technique (3D-VRT) from retrospectively ECG-gated multislice spiral CT (MSCT) data sets for imaging of the coronary arteries. MATERIAL AND METHODS: In 35 patients, retrospectively ECG-gated MSCT of the heart using a four detector row MSCT scanner with a standardized examination protocol was performed as well as quantitative X-ray coronary angiography (QCA). The MSCT data was assessed on segmental basis using 3D-VRT exclusively. The coronary artery diameters were measured at the origin of each main coronary branch and 1 cm, 3 cm and 5 cm distally. The minimum, maximum and mean diameters were determined from MSCT angiography and compared to QCA. RESULTS: A total of 353 of 525 (67.2%) coronary artery segments were assessable by MSCT angiography. The proximal segments were more often assessable when compared to the distal segments. Stenoses were detected with a sensitivity of 82.6% and a specificity of 92.8%. According to the Bland-Altman method the mean differences between QCA and MSCT ranged from -0.55 to 1.07 mm with limits of agreement from -2.2 mm to -2.7 mm. CONCLUSION: When compared to QCA, the ability of 3D-VRT to quantitatively assess coronary artery diameters and coronary artery stenoses is insufficient for clinical purposes.     

CT virtual intravascular endoscopy assessment of coronary artery plaques: A preliminary study

Purpose

The purpose of this study was to investigate the potential value of CT virtual intravascular endoscopy (VIE) in the visualization and assessment of coronary plaques in patients suspected of coronary artery disease.

Materials and methods

20 (13 men, 7 women, mean age 54 years) consecutive patients with suspected coronary artery disease undergoing 64-slice CT angiography were included in the study. Four main coronary artery branches were assessed with regard to the presence of coronary plaques based on 2D axial, multiplanar reformation, 3D volume rendering and VIE visualizations. The coronary plaques were characterized into calcified, noncalcified and mixed plaques. The intraluminal appearances of these coronary plaques were demonstrated with VIE images and correlated with 2D and 3D images to determine the diagnostic value of VIE for the assessment of the plaques.

Results

VIE was able to identify and demonstrate the intraluminal appearances of coronary plaques in 18 patients involving 32 coronary artery branches which were shown as an irregularly intraluminal protruding sign in extensively calcified plaques and smooth protruding appearance in noncalcified or focally calcified plaques. An irregular intraluminal appearance was also noticed in the presence of mixed plaques due to variable components with different CT attenuations contained within the plaques. VIE accurately confirmed the degree of coronary stenosis or occlusion despite the presence of heavy calcification.

Conclusion

VIE could be used as a complementary tool to conventional CT visualizations for the analysis of luminal changes and assessment of disease extent caused by the coronary plaques.     

Influence of a lipid-lowering therapy on calcified and noncalcified coronary plaques monitored by multislice detector computed tomography: results of the New Age II Pilot Study

PURPOSE: Multislice detector computed tomography (MSCT) is an accurate noninvasive modality to detect and classify different stages of atherosclerosis. The aim of the New Age II Study was to detect coronary lesions in men without established coronary artery disease (CAD) but with a distinct cardiovascular risk profile. We also sought to assess the effect after 1 year of a lipid-lowering therapy (LLT) using 20 mg of atorvastatin. METHODS: Forty-sixe male patients (mean, 61 +/- 10 years) with an elevated risk for CAD (PROCAM score >3 quintile) without LLT were included. Native and contrast-enhanced scans were performed in all patients. A total of 27 of 46 patients received a follow-up scan (after 488 +/- 138 days). Coronary plaque burden (CPB) was assessed volumetrically. RESULTS: The prevalence of CAD was 83% (38/46 patients), and 11% (5/46) without coronary calcifications still had noncalcified plaques. Total cholesterol and low-density lipoprotein cholesterol levels decreased significantly under LLT (225 +/- 41 mg/dL vs. 162 +/- 37 mg/dL, P < 0.0001 and 148 +/- 7 mg/dL vs. 88 +/- 5 mg/dL, P < 0.001, respectively). On follow-up, calcium score and CPB remained unchanged (Agatston score: 261 +/- 301 vs. 282 +/- 360; CPB: 0.149 +/- 0.108 vs. 0.128 +/- 0.075 mL, P > 0.05), whereas mean plaque volume of noncalcified plaques decreased significantly from 0.042 +/- 0.029 mL versus 0.030 +/- 0.014 mL (P < 0.05, mean reduction 0.012 +/- 0.017 mL or 24 +/- 13%). CONCLUSIONS: Statin therapy led to a significant reduction of noncalcified plaque burden that was not reflected in calcium scoring or total plaque burden. This finding might explain the risk reduction after the initiation of statin therapy. Using multislice detector computed tomography, physicians have the potential to monitor medical treatment in patients with coronary atherosclerosis.     

Impact of different window settings on colon polyp measurements with CT virtual colonoscopy: a phantom study

The aim of this study was to evaluate the impact of window settings on measurement of colon polyps with CT virtual colonoscopy with experiment. Twenty-four artificial polyps' diameter were measured and scanned 10 times with identical scan parameters using a 64-multidetector computed tomographic scanner. The diameter of each polyp was measured using lung window and abdominal soft tissue window settings and compared with the actual diameter. The lung window setting offers accurate measurement of colon polyps.