Solitary testicular myofibroma: a case report and review of the literature

Myofibromas are benign mesenchymal neoplasms of myofibroblastic origin. Most present as solitary lesions at any age, but the presentation of multiple lesions in newborns and infants is known as infantile myofibromatosis. Multicentric lesions commonly involve soft tissues and bone and may involve internal organs, where they are associated with an unfavorable prognosis. Solitary lesions involving the viscera are rare. We report a case of a 3-month-old male infant with a left testicular mass detected during an evaluation for suspected torsion. The patient underwent orchiectomy, revealing a nodular mass with grossly evident foci of necrosis. Histologically, the lesion exhibited small fascicles of plump eosinophilic, smooth muscle actin-positive spindle cells, alternating with larger areas of primitive cells with vesicular nuclei and scant cytoplasm arranged around a hemangiopericytoma-like vasculature. To our knowledge, this is the first report of a myofibroma localized within the testis.     

鼻腔平滑肌肉瘤1例及文献复习

目的:探讨鼻腔平滑肌肉瘤(leiomyosarcoma,LMS)的临床病理特征及鉴别诊断.方法:观察1例鼻腔原发LMS的临床表现、组织学特征和免疫组化特点,并复习相关文献.结果:患者,男,62岁,因左鼻塞流涕2月余入院,术后结果显示肿瘤由梭形细胞束组成,细胞核呈卵圆形或短梭形,两端钝圆,部分细胞核仁肥胖,胞浆嗜酸性,染色质粗糙;细胞核异型性明显,核分裂3~5个/10HPF,间质可见粘液变性,部分区域可见坏死.免疫组化显示瘤细胞SMA、Vimentin、Calponin和Desmin均(+).结论:平滑肌肉瘤是鼻及鼻窦部分少见的软组织恶性肿瘤,侵袭性较高,临床预后较差.     

Solitary intrapulmonary cystic lymphangioma in an infant: a case report with literature review

Lymphangioma rarely presents as a solitary pulmonary lesion. We encountered a case of solitary cystic lymphangioma and present its clinicopathologic and immunohistochemical findings. A 2-month-old boy was referred to the hospital after developing a persistent cough. Chest X-ray showed a large cyst in the right lung. Under the preoperative diagnosis of bronchogenic cyst, he underwent right lower lobectomy at the age of 11 months. The resected specimen contained a 5.5-cm septate cystic lesion. Microscopically, the lesion consisted of a large cystic space and interconnected slit-like spaces surrounding bronchovascular islands. The cyst was lined by a monolayer of flat cells with focal multinucleated giant cells. Immunohistochemically, the cells lining the cystic lesion were positive for D2-40, Prox1, CD34, and CD31, and weakly positive for VEGFR-3, but were negative for AE1/3, HMB45, VEGF-A, VFGF-C, VEGFR-1. Differential diagnoses included lobar or interstitial emphysema, bronchogenic cyst, congenital pulmonary airway malformation and alveolar adenoma. D2-40 and Prox1 were useful in differentiation and in determining the extent of the lesion. A review of the literature found only 15 cases of solitary pulmonary lymphangioma. In younger patients, the lesions tend to occupy more of the lung. Focal giant cell reaction has not been described in the reported papers.     

Solitary fibrous tumor of the vagina: a case report with review of the literature

Solitary fibrous tumor, initially described in the pleura, is now known to occur in various extrathoracic sites. However, its occurrence in the female genital tract, especially the vagina, is extremely rare. The authors report here a case of a well-circumscribed vaginal spindle cell nodule in a 48-year-old woman with features consistent with solitary fibrous tumor. The diagnosis was established histologically by the varying pattern with hypocellular fibrous areas alternating with hypercellular areas and hemangiopericytoma-like areas and, immunohistochemically by the strong positive reaction for CD34 and Bcl2 with a negative reaction for all other spindle cell and epithelial markers. The differential diagnosis is discussed and a review of the literature is presented.     

Malignant nasal paraganglioma: a case report and review of the literature

A rare case of malignant nasal paraganglioma is described. A 30 year old female patient presented with a one year history of bilateralnasal obstruction, nasal deformity and recurrent epistaxis. CT scan demonstrated an enhancing mass occupying both nasal cavities, right maxillary antrum and anterior ethmoid sinus. Histopathologic diagnosis was malignant paraganglioma. A total maxillectomy with excision of growth was performed. Post-operative radiotherapy and chemotherapy was given but patient expired before the completion of therapy. Nose being a rare site for paragangliomas, these lesions present a diagnostic challenge to histopathologists and clinicians alike. A review of the four previously described malignant nasal paragangliomas is also presented.     

Solitary extramedullary plasmacytoma of the adrenal gland: a rare case report with review of the literature

Plasmacytomas are monoclonal plasma cells proliferations originating either in localized osseous tissue or in soft tissue (extramedullary plasmacytoma, EMP). Although many such lesions are found in the bone marrow, fewer arise in extramedullary tissue. A solitary EMP involving the adrenal gland is extremely rare, with only 7 cases having been reported in the literature thus far. Here, we describe a rare case of solitary EMP in the right adrenal gland of a 26-year-old man that was managed by retroperitoneal laparoscopic resection, with no recurrence during 6-year follow-up.     

Solitary neurofibroma of the mesentery: report of a case and review of the literature

Neurofibromas of the gastrointestinal tract are usually associated with neurofibromatosis type 1 (Nfl), or they are exclusive manifestations of the so-called "familial intestinal neurofibromatosis". Gastrointestinal neurofibromas can rarely occur as sporadic lesions in the jejunum and stomach, and only exceptionally in the mesentery. A critical review of the literature revealed that only seven cases of solitary neurofibromas (SNFs) of the mesentery (six in the ileal mesentery; one in the gastrocolic mesentery) have been reported in patients without stigmata of Nf1. We report the clinicopathologic features of an additional case of SNF of the ileal mesentery, incidentally found in a patient with an advanced gastric carcinoma. Since there is increasing evidence that some patients may have some features of Nf1, including dermal or nodular SNFs alone - limited to one or more body segments - (segmental Nf1), the possibility that SNFs of the mesentery may also represent a segmental manifestation of Nf1 is postulated.     

Solitary fibrous tumor of the larynx: a case report and review of the literature

Solitary fibrous tumors are relatively rare mesenchymal neoplasms that were originally described as pleural- or peritoneal-based lesions. Although they were considered a form of mesothelioma, subsequent investigation failed to reveal mesothelial differentiation. Characterization of their histologic and immunohistochemical features, as well as identification in a multitude of nonmesothelial-based locations has further served to distinguish these lesions from the more diffuse and aggressive mesothelioma. Reports of solitary fibrous tumor in the larynx are extremely rare. We report a case of solitary fibrous tumor of the larynx in a 38-year-old man.     

前列腺孤立性纤维瘤一例报道并文献复习

患者男,33岁。因尿痛、尿线变细、尿后滴沥不尽约1个月于2003年11月入院。CT检查提示:盆腔左侧膀胱直肠间占位性病变,考虑来源前列腺(图1)。查血前列腺特异性抗原(PSA)8.29ng/ml,Fpsa/PSA0.15。直肠指诊:前列腺增大约6cm×5cm,质地中等,无压痛,中央沟存在,表面光滑饱满,境界清,无结节。初步诊断:前列腺肿瘤。图1盆腔CT扫描示前列腺增大病理检查:大体检查:前列腺根治标本,大小9cm×8cm×6cm,切面实性,灰白灰黄色,质地中等。表面似有纤维性假包膜(图2)。光镜观察:肿瘤细胞为短梭形、圆形或卵圆形,胞质量少,淡红染,核圆形、卵圆形,核染色…     

甲状腺孤立性纤维性肿瘤1例报道并文献复习

目的探讨甲状腺孤立性纤维性肿瘤的临床病理学特点。方法对1例甲状腺孤立性纤维性肿瘤进行组织学和免疫组织化学观察,并复习相关文献。结果患者女性,于甲状腺右叶触及一肿块。光镜下见肿块境界清楚,梭形及卵圆形的肿瘤细胞排列成条束状、短席纹状,其间含有胶原纤维束,肿瘤细胞间散在少量大小不一的滤泡。肿瘤细胞CD34和bcl-2均呈阳性。结论孤立性纤维性肿瘤发生于甲状腺者较为罕见,并且临床中其生物学行为仍然未能确定,有必要长期随访。     

Basal cell adenoma of nasal septum: report of a case and review of literature

Basal cell adenoma is an uncommon benign salivary gland neoplasm, presenting isomorphic basaloid cells with a prominent basal cell layer. Basal cell adenoma arising from the nasal septum is exceptionally rare. Reports on positron emission tomography with 2-deoxy-2-fluorine-18-fluoro-D-glucose (18FDG-PET) imaging for basal cell adenoma are limited. Here, we present the case of a 49-year-old man who had the symptoms of intermittent repeated bleeding from the left nose for half a year. 18FDG-PET scaning showed increased accumulation of 18FDG with its characteristic benign pathology has a potential to malignancy. After removal of the mass, the patient became symptom free. Pathology showed basal cell adenoma. The evidence of active and growing cells was present in the specimen.     

Solitary extramedullary plasmacytoma of the breast with serum monoclonal protein: a case report and review of the literature

A case of a solitary extramedullary plasmacytoma of the breast in a 73-year-old woman is reported. This is the second case of solitary breast plasmacytoma reported in the world literature. Plasmacytomas of the breast are extremely rare, especially those that are not associated with myelomatosis or disseminated disease. An associated monoclonal protein was present in the serum and was immunologically identical to the immunoprotein found in the tumor cells. The subject of extramedullary plasmacytomas in the breast is reviewed and discussed.     

Solitary fibrous tumor of small bowel mesentery with postoperative bowel obstruction: a case report and review of literature

Solitary fibrous tumor (SFT) which is an extremely rare clinical entity has been reported infrequently. Most commonly it is distinguished into pleural and extrapleural forms, with same morphological resemblance. There has been many literatures reported regarding extrapleural form of SFT but few cases of SFT originating from small bowel mesentery have been reported till now. We here report one case of SFT of small bowel mesentery with some eventful postoperative bowel obstruction and literature review.     

Painless angioleiomyoma: a case report with review of literature

A 55 year old male, who presented with a painless swelling of six months duration on his thigh, was clinically diagnosed to have a benign soft tissue neoplasm. Histological examination of the excision biopsy specimen revealed a benign tumour of the vascular smooth muscle, which was diagnosed as angioleiomyoma. Angioleiomyomas are painful lesions that can occur anywhere in the body. We present this case for its atypical clinical presentation and discuss its histologic features with a review of literature.     

Xanthogranuloma of the oral cavity in adult. A case report and review of the literature

A case of xanthogranuloma arising in the palatal gingiva of the maxilla in a 38-year-old Japanese male was investigated. Histopathological findings of the excised lesion were indistinguishable from the xanthogranulomas in infants and children (juvenile xanthogranuloma), and like those in the young, the present case was not associated with abnormalities of serum lipids and was not associated with other lesions. A review of the English literature yielded only two histopathologically documented cases of xanthogranuloma in the oral cavity, arising in young patients. A case of xanthogranuloma of oral cavity in an adult was not documented previously.     

Blastomatous tumor with teratoid features of nasal cavity: report of a case and review of the literature

A case of blastomatous tumor with teratoid features is presented. The polypoid mass was observed in the left nasal cavity of a 72-year-old man. Histologically, the lesion was composed of neuroepithelial cells with blastomatous appearance, cystic squamous nests filled with keratin materials, many mucous glands, complex tubular and glandular structures with edematous fibroblastic stroma. Sinonasal neoplasms including teratoid components and immature neuroepithelium are exceedingly rare. We suggest that the term 'immature teratoma' is more suitable than blastoma or blastomatous tumor when there is no carcinomatous or sarcomatous component besides the immature neuroepithelium and teratoid elements.