鼻咽癌患者与健康人血清微量元素含量的测定

我们用高频等离子体发射光谱法测定鼻咽癌30例和健康人50例血清的镍、铜、铬、锰、锌、铁的含量。结果,鼻咽癌患者血清镍含量显著地高于健康人,这与我们过去调查(1976～1980)鼻咽癌高发区大米和饮水中镍含量高于低发区,鼻咽癌患者头发镍含量高于健康人等结果一致。鼻咽癌患者的铜及铜/锌比值高于健康人,但血清锰含量却低于健康人,差异均有显著性意义。至于铬、锌和铁的含量,均无显著性差异。比较鼻咽癌患者与健康人血清中微量元素含量,镍和锰与鼻咽癌的发生可能有关。     

食管癌高发区正常人群食管组织与头发微量元素的分布

 目的　探讨食管癌高发区正常人群食管组织与头发中微量元素的变化规律。方法　应用X射线能谱仪扫描电镜及原子吸收分光光度法观测食管癌高发区229例不同年龄正常人食管组织与头发中微量元素含量分布。结果　①食管组织中锌、硒、钼含量随年龄增长逐渐减少,铜、钙、镍及铜锌比值随年龄增长而增高;②头发中钙的变化与食管组织内变化趋势相反,硒的变化无显著差异。结论　在监测食管癌及癌前病变动态变化时,应将食管组织、血清及头发检测结果综合在一起,整体考虑其变化趋势,才能为临床防治食管癌及癌前病变提供准确、可靠的理论依据。     

宫颈癌患者手术前后微量元素含量变化的研究

目的:探讨宫颈癌患者手术前后血清微量元素含量的变化情况.方法:用原子吸收火焰法检测35例宫颈癌患者手术前后的血清微量元素铜、锌、铁、硒、锰、钴、镍、镉的含量.并设24例正常女性作对照,统计分析应用t检验.结果:肿瘤患者血清铜、铜锌比值、镍、镉较正常对照者高;锌、铁、硒、锰、钴却较正常对照者低,P值均为P＜0.01;且与宫颈癌患者的病情和疗效有关,手术前后相比较有显著或非常显著差异,P＜0.05或P＜0.01.结论:血清微量元素的检测可作为监测、判断宫颈癌患者病情和预后的辅助检查.     

宫颈癌患者手术前后微量元素含量变化的研究

目的 :探讨宫颈癌患者手术前后血清微量元素含量的变化情况。方法 :用原子吸收火焰法检测 35例宫颈癌患者手术前后的血清微量元素铜、锌、铁、硒、锰、钴、镍、镉的含量。并设 2 4例正常女性作对照 ,统计分析应用t检验。结果 :肿瘤患者血清铜、铜锌比值、镍、镉较正常对照者高 ;锌、铁、硒、锰、钴却较正常对照者低 ,P值均为P <0 . 0 1;且与宫颈癌患者的病情和疗效有关 ,手术前后相比较有显著或非常显著差异 ,P <0 .0 5或P <0 .0 1。结论 :血清微量元素的检测可作为监测、判断宫颈癌患者病情和预后的辅助检查。     

肺癌与头发微量元素关系的探讨

目的探讨肺癌与头发微量元素之间的关系。方法对肺癌、健康人各50例，用原子吸收分光法，对六种微量元素（硒、铜、锌、锰、铁、镍进行测定，并将单元素比较及致癌／抗癌元素比值和致癌／未明确元素比值来分析与肺癌的关系。结果肺癌组镍、铜和锰的含量明显高于正常组（P＜0．001和P＜0．01），肺癌组镍／锌，铜／锌，镍／硒的比值明显大于正常组（P＜0．01和P＜0．001），肺癌组铜／铁，镍／锰的比值明显低于健康组（P＜0．001和P＜0．01）。结论测定头发六种微量元素的含量对肺癌可能有一定的辅助诊断价值。     

胃癌高低发区不同人群血清微量元素分析

近年来,许多学者对微量元素与肿瘤的研究较多,资料表明,微量元素与肿瘤的发生、发展等有密切关系。我省长乐县是胃癌高发区的男性胃癌死亡率居全国之冠。为探索我省胃癌高发与微量元素关系,本文选择长乐县和福安县胃癌死亡率相差10倍的地区的胃癌病人、非肿瘤病人及健康人血清,测定锰、镍、钴、钼、硒、铜、锌含量作分析。为我省的胃癌防治提供参考。一、对象与方法 1、对象:胃癌病人来自长乐县医院经手术后的病人。共33例,平均年龄54.6岁。非肿瘤病人来自长乐县医院同期住院病人、共42例,平均年龄49.5岁;健康人来自福安县赛歧居民。共42例,平均年龄48岁。     

肝癌患者血清中微量元素的测定研究

近年来,微量元素与恶性肿瘤的关系越来越受到人们的重视,肝癌的发生与发展与微量元素密切相关.测定患者与健康人体内的微量元素含量,可获得许多微量元素与癌症、高血压等疾病的重要信息。为此,我们对38例肝癌患者和20例正常人血清中铜、锌、铁、硒、锰、镍6种微量元素进行了测定,发现血清中这6种微量元素与肝癌相关性较强,现报告如下。     

河北省食管癌高低发区域人体内外环境化学元素含量分析

目的:从土壤化学元素含量分布和人体体液、组织化学元素富集规律,探讨食管癌死亡率地域性分布与化学元素的关系,为食管癌的防治提供科学依据.方法:采用WFX-ID型原子吸收分光光度计测定河北省食管癌高发区磁县和低发区赤城土壤、当地居民唾液、头发、指甲中铜、锌、铁、钙、镁元素含量.结果:1)磁县土壤铜、锌含量分别高于赤城;土壤铁、镁含量和铜/锌比值低于赤城,差异均有统计学意义,t=2.167～25.94,P=0.034～0.000;2)磁县居民唾液铜、铁、镁含量及铜/锌比值均高于赤城,而锌含量低于赤域,t=3.143～9.266,P=0.007～0.000;3)磁县居民头发中铜含量及铜/锌比值高于赤城,铁含量低于赤城,t=2.425～8.663,P=0.013～0.000;4)磁县居民指甲中锌含量高于赤城,t=3.103,P=0.006;而铜/锌比值低于赤城,t=3.542,P=0.006;两地土壤、居民唾液、头发、指甲中钙含量差异均无统计学意义,t=1.954～0.140,P=0.058～0.981.结论:土壤化学元素含量的差异可能是河北省食管癌死亡率呈明显地域性分布的重要因素之一.     

胃食管癌病人头发中9种微量元素含量的测定及临床意义

胃、食管癌病人头发中微量元素铬、镍、锰、锌、铜、铁、镉、硒等九种微量元素用日立180—80原子吸收分光光度计测定,胃癌35例,食管癌6例,良性胃病99例。结果如表1。     

急性白血病与血清、尿、头发的铜、锌、锰、铬和镍关系的研究

本文对38例急性白血病患者在不同时期测定同一天血清,24小时尿及头发中的铜、锌、锰、铬和镍等含量。结果表明:血清中这5种微量元素的含量最能反映这些微量元素变化与病情变化的关系。急白发病初期有血清铜含量的升高,血清锌含量降低。急白发病初期及恶化期均有血清镍含量升高,缓解期则下降。急白在三个时期血清锰含量均降低。急白在三个时期均有铜/锌比值增大和锰/镍比值减少。结果亦表明:血清镍含量与病情变化有伴随性关系,提示测定血清镍含量可作为急白疗效观察的一个指标。微量元素镍与急性白血病的发病可能有着内在的联系。     

人体正常和良恶性组织中8种微量元素的分析

本文报告人体恶性(63例)、良性(64例)和正常(65例)3种组织中8种微量元素测量结呆。证明恶性组织中铜、镍明显高于正常和良性组织,又以胃肠癌显著。栖前者低于后二者,而两组癌无差异。恶性组锌、锰明显低于正常组。其他癌锌降低显著,且锌有恶性<良性<正常的趋势。初步探讨3种组织中微量元素的变化规律和临床意义。     

食管癌高低发区饮用水微量元素谱的多元分析

背景与目的： 研究食管癌高低发区饮用水中微量元素谱(Trace elements,TE),为食管癌(Esophageal cancer,EC)病因提供研究依据。材料与方法：采集食管癌高低发地区的饮用水样,用高频电感耦合等离子体发射光谱法(Inductively coupled plasma_atomic emission spectgrometry,ICP_AES)测定13种元素(Cd, Co, Cr, Cu, Fe, Mn, Mo, Ni, Pb, Se, Sr, V, Zn)含量,并进行t检验、相关分析、建立回归方程。 结果： 检测发现食管癌高低发区的水样中的微量元素谱不同,Fisher判别法,其识别准确率为93％。 结论： 不同环境水中微量元素对食管癌发生率有影响。     

Research on serum levels of retinol, α-tocopherol β-carotene,and 12 elements in gastric dysplasia and gastric cancer patients

Serum levers of retinol, α-tocopherol, β-carotene and elements (Zn, Cu, Mn, Ca, Mg, Cr, Co, Cd, Mo, Se) were determined in 45 gastric cancer and 41 gastric dysplasia patients, and 48 normal subjects. The results showed that β-carotene and Se, Co were lower in gastric cancer patients than that in gastric dysplasia patients or in normal subjects, Ni and Cr levels were lower and Mn, Ca and Cd were higher in gastric cancer than in dysplasia patients. Zn, Fe, Cr, Cd were lower and Mn, Ca, Mg, Mo levels were higher in gastric cancer patients than in normal. The differences mentioned are statistically significant. The stepwise discriminant analysis of 10 variables (Mn, Fe, Ca, Cr, Mo, Co, Cd, Se, α-tocophrol, β-carotene) were used in identifying gastric cancer, with 100% of the positive rate. The potential protective effect of β-carotene and Se against gastric cancer is an interesting postulate. We suggest that optimum supplement of β-carotene and Se might will be beneficial to gastric dysplasia patients in preventing the development of gastric cancer.     

土壤微量元素背景值与癌症关系的主成分分析

目的 :探讨土壤微量元素含量与癌症发病率间的关系。方法 :测定癌症高发区江苏省扬中市土壤中Cu、Pb、Zn、Ni、Cr、As、Se、Co、V、Mn、F等 11种微量元素的含量 ,应用主成分分析法提取出贡献率大的主成分与 1991- 1999年癌症发病率做多重回归分析。结果 :土壤 11种微量元素间存在较强相关性 ,应用主成分分析法提取出第一主成分与癌症发病率拟合线性回归方程 ,显示土壤微量元素含量与胃癌、肝癌及全部癌发病率均呈负相关 ,其中Se元素作用最强。结论 :土壤微量元素 ,特别是Se元素的含量可能在癌症发生中起重要作用。     

Trace elemental analysis of normal, benign hypertrophic and cancerous tissues of the prostate gland using the particle-induced X-ray emission technique.

Trace elemental analysis was carried out in the tissue samples of normal, benign hypertrophic and carcinoma prostate using the particle-induced X-ray emission technique. A proton beam of 3 MeV energy was used to excite the samples. The elements Cl, K, Ca, Ti, Cr, Mn, Fe, Ni, Cu, Zn, Se, and Br were identified and their concentrations were estimated. It is observed that in benign tissues the concentrations of Cl, K, Zn, and Se are lower (P<0.05) and those of Cr, Fe, Ni, and Cu are higher (P<0.05 ) than in normal tissues. The concentrations of K, Ca, Zn, Se, and Br are lower (P<0.01) and those of Ti, Cr, Mn, Fe, Ni, and Cu are significantly higher (P<0.0005) in cancerous tissues than in normal tissues. Free radicals generated by elevated levels of Cr, Fe, Ni, and Cu possibly initiate and promote prostate cancer by oxidative DNA damage. The excess Cu levels in cancerous tissues support the fact that Cu promotes cancer through angiogenesis. The higher levels of Fe observed in cancerous tissues might be a consequence of tumor growth through angiogenesis. Significantly higher levels of Ni and Cr observed in carcinoma tissues support the well-established role of Ni and Cr as carcinogens. It is likely that the observed low levels of Zn and Se in cancerous tissues lead to the development of prostate cancer owing to a decrease in antioxidative defense capacity and impaired immune function of cells and also suggest that the inability to retain high levels of Zn and Se may possibly be an important factor in the development and progression of malignant prostate cells. In order to substantiate the observed elevated or deficient levels of trace elements in initiating, promoting, and inhibiting prostate cancer, several cellular and molecular studies are required.     

急性白血病患者血清微量元素谱分析

采用ＤＣＰ－ＡＥＳ检测了４０例急性白血病（初发１８例，化疗后２２例）血清中锌、铜、铁、硒、镍、钛等１５种元素含量。结果显示：初发急性白血病患者血清锌、铁、硒、镍、钛均降低，铜、钙、镁、铜／锌比值均升高。化疗达ＣＲ后，血清锌、铜、铜／锌、硒均可正常，而化疗后ＮＲ组上述元素无改变。血清钙、镍、钛化疗后ＣＲ和ＮＲ组均无改善。表明微量元素与急性白血病转归相关。     

包头地区乳腺肿瘤及其复发转移的血清微量元素变化研究

目的探讨9种微量元素与乳腺肿瘤的关系。方法采用原子吸收分光度计对81例健康女性志愿者、94例乳腺良性肿瘤患者、93例乳腺癌患者手术前后和38例乳腺癌复发转移患者血清中Fe、Zn、CU、Mn、Pb、Cd、Cr、Ni、Mo的含量进行测定。结果血清Fe、Zn、Cu、Mn、Pb随乳腺肿瘤病情加重呈明显升高趋势,与乳腺癌呈正相关,而Mo随病情的加重明显降低,与乳腺癌呈负相关。结论有6种微量元素与乳腺肿瘤的发病有显著关系,其中Fe、Zn、Cu、Mn、Pb可能是乳腺癌的危险因素,而Mo为乳腺癌的保护因素。     

Pattern recognition on the trace element spectrum in gastric cancer and peptic ulcer

The trace element spectrum of gastric tissue and whole blood specimens from gastric cancer and peptic ulcer patients was recognized with pattern recognition technique in order to obtain the chemical information of gastric cancer. Thirty specimens were obtained from cancer patients in each of the 58 gastric tissues and 54 whole blood specimens. Five pathological types were divided into two groups: peptic ulcer and dysplasia as the ulcer group; well-differentiated, undifferentiated and mucinous carcinoma as the cancer group. The accuracy of recognizing the several spectra was 90%: nine trace element spectra (Cu, Zn, Ni, Co, Cr, Cd, Mn, Fe and Mg) for the tissue specimens from the cancer and ulcer groups; six (Cu, Zn, Mn, Co, Cr and Cd) for dysplasia and well-differentiated adenocarcinoma tissues; five (Cu, Ni, Cr, Cd and Fe) for the whole blood specimens from these two groups and six (Cu, Zn, Cr, Cd, Fe and Ni) for the whole blood specimens from dysplasia and peptic ulcer (including 10 normal individuals). The data were treated by non-linear mapping method and calculated by TRS-80 III type microcomputer.     

微量元素铜锌硒,抗氧化酶类,维生素E与恶性肿瘤的关系

本文作者对６７例恶性肿瘤患者同时作了血清铜（ＳＣｕ）、锌（ＳＺｎ）、硒（ＳＳｅ）含量和血红细胞超氧化物歧化酶（ＲＢＣ－ＳＯＤ）、谷胱甘肽过氧化物酶（ＧＳＨ－Ｐｘ）活性及维生素Ｅ、丙二醛（ＭＤＡ）含量测定。     

回族血清中微量元素含量与胃癌的相关性研究

目的探讨回族血清中微量元素含量与胃癌的关系。方法采用原子吸收分光光度法对回族胃癌患者和回族非胃癌对照人群血清中锌(Zn)、铜(Cu)、铁(Fe)、镁(Mg)、钙(Ca)、锰(Mn)、镍(Ni)元素含量进行检测,并用SPSS统计软件对实验结果进行配对t检验分析。结果回族胃癌病例组血清中Cu、Cu/Zn、Mn均比对照组高,而Zn、Fe、Ca、Mg、Ni的含量低于对照组。配对t检验结果显示,血清中Cu、Zn、Cu/Zn、Ca、Mg含量差异有统计学意义(P<0.05)。结论回族胃癌的发生、发展与血清内微量元素变化密切相关。高Cu、Cu/Zn比值高以及低Zn、低Ca、低Mg是回族胃癌发生的危险因素。