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The effects of an ethanol extract of the plant Sophora flavescens Ait. on cardiac arrhythmias induced by coronary artery ligation in rats, and by aconitine infusion in mice, were studied. Pretreatment with intravenous injection of the extract, 120 mg/kg, significantly reduced the incidence and delayed the onset of ventricular tachycardia in rats subjected to ligation of the left coronary artery. The time of onset of both initial cardiac arrhythmias and persistent ventricular tachycardia induced by aconitine infusion in mice was also significantly prolonged. These preliminary findings suggest that the ethanol extract of Sophora flavescens Ait. possesses antiarrhythmic activity. 相似文献
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苦参提取物体外抗菌实验研究 总被引:6,自引:0,他引:6
目的:探讨苦参总生物碱、总黄酮提取物及其混合物的体外抗菌效果。方法:采用液体二倍稀释法分析苦参总生物碱、苦参总黄酮提取物及其混合物对金黄色葡萄球菌、大肠埃希菌、福氏志贺菌、乙型副伤寒杆菌、铜绿假单胞菌、白色葡萄球菌、痢疾杆菌和柠檬色葡萄球菌的抗菌作用,并测定最小抑菌浓度(MIC)和最小杀菌浓度(MBC)。结果:苦参总生物碱对以上菌株的MIC分别为:9.00、3.38、8.25、9.00、4.50、13.50、6.75、7.13mg.mL-1,MBC分别为:13.50、14.25、8.25、9.00、14.25、14.25、13.13、14.25mg.mL-1;苦参总黄酮对以上菌株的MIC分别为3.00、2.63、3.56、3.38、1.50、2.44、3.56、2.35mg.mL-1,MBC分别为14.25、12.75、7.13、13.50、13.50、12.75、12.75、13.13mg.mL-1;苦参总生物碱与总黄酮混合物对以上菌株的MIC分别为:2.25、2.07、3.28、3.94、1.22、2.44、2.07、1.97mg.mL-1,MBC分别为9.00、13.13、6.75、6.38、13.88、7.50、6.38、7.13mg.mL-1。结论:苦参总生物碱和总黄酮提取物对上述菌株存在体外抑菌和杀菌活性,混合物呈现一定协同作用。 相似文献
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目的:研究茉莉根醇浸膏对小鼠的镇痛作用。方法:采用醋酸扭体法、热板法、热水浴法、尾根加压法进行茉莉根醇浸膏对小鼠的镇痛实验研究。结果:茉莉根醇浸膏可明显抑制ip0.6%冰醋酸诱发的小鼠扭体反应,最大抑制率为44.38%;药物对热板模型小鼠痛阈无显著影响;药物高剂量能显著提高热水浴刺激的小鼠痛阈(P<0.05);药物可明显提高小鼠尾根受机械刺激的痛阈(P<0.01)。结论:茉莉根醇浸膏对小鼠扭体实验、小鼠尾根加压实验及小鼠热水浴甩尾实验均显示较好的镇痛作用,但对热板实验无镇痛作用。 相似文献
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目的确定苦参的适宜采收期。方法采取定株分期采集化验的方法。结果秋分至小雪前采收苦参碱含量较高,分别为11月20日采收,含量为3.1%,9月20日采收,含量为2.98%,而3月19日,5月20日,7月20日采收的苦参碱含量相对低。结论秋分至封冻前为苦参的适宜采收期。 相似文献
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The impact of a herbal extract with excitatory modulator activity in the management of asthma was studied. An open and selective 3-year follow-up of 14 chronic refractory asthmatics aged between 22 and 70 was used. Participants received an extract of Sophora flavescens Ait. Medication use, a diary card of symptoms and respiratory function were recorded. The study was retrospective and all patients gave written informed consent. The quality of life, clinical symptoms and respiratory function improved during all periods of measurement. The use of inhaled corticosteroid and beta-agonists were reduced or eliminated. There were no significant adverse reactions reported. Therefore the extract of S. flavescens as an excitatory modulator appears to be a safe and may be an effective alternative treatment for refractory chronic asthma. 相似文献
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目的:综述近年来有关苦参有效成分的定量分析方法和药代动力学的研究进展。方法:介绍并评价苦参有效成分的定量分析方法及药代动力学研究技术。结果:滴定法、薄层扫描法及酸性染料比色法用于苦参有效成分的分析均具有一定的局限性。高效液相色谱法及高效毛细管电泳法具有灵敏、准确、重现性好,适用性强等特点。结论:目前苦参的研究有一定基础,液-质联用技术广泛应用于苦参有效成分分析研究。 相似文献
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玉竹乙醇提取物对心梗后心力衰竭大鼠血流动力学的影响 总被引:2,自引:1,他引:2
目的:探讨玉竹乙醇提取物对心梗后心衰大鼠血流动力学的影响并进行量效关系的研究。方法:70只清洁级健康成年SD大鼠随机分为5组,即假手术组,模型组,玉竹大、中、小剂量组,造模成功后尾iv不同剂量玉竹乙醇提取物,测定用药后不同时点(0,5,10,20,30min)大鼠心率(HR),左室收缩压最大压(LVSP),左室舒张末压(LVDP),左心室压力最大上升速率(+dp/dtmax),左心室压力最大下降速率(-dp/dtmax),并分别进行组内及组间相同时段的比较。结果:玉竹大、中剂量组用药5min后开始HR减慢、LVSP明显下降,+dp/dtmax、-dp/dtmax减慢,LVDP明显上升,20~30min以后基本恢复正常,小剂量组只在10min时出现明显改变,并且HR未见明显变化。结论:玉竹具有负性肌力、负性频率作用,并随剂量增大呈现出一定的量效关系;小剂量时负性肌力为主,随着剂量增大,负性肌力作用增强,同时出现负性频率作用。 相似文献
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目的:对苦参不同组织部位中总生物碱与五种单体生物碱进行含量测定。方法:采用酸性染料比色法和高效液相色谱法分析苦参不同组织部位中总生物碱含量以及五种单体生物碱的含量。结果:苦参各组织部位中,五种单体生物碱含量总计依次为:韧皮部29.62mg/g,木质部20.90mg/g,髓部13.29mg/g,木栓层4.885mg/g;总生物碱含量依次为:韧皮部35.14mg/g,木质部33.12mg/g,髓部31.46mg/g,木栓层含量低于线性范围。结论:苦参各组织部位中五种单体生物碱和总生物碱含量高低依次为:韧皮部>木质部>髓部>木栓层。 相似文献
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J Yamahara M Mochizuki H Fujimura Y Takaishi M Yoshida T Tomimatsu Y Tamai 《Journal of ethnopharmacology》1990,29(2):173-177
The effect of a methanol extract of Sophora flavescens root was examined on gastric ulcers induced in rats by HCl/ethanol in order to substantiate its reputed protective properties. Oral doses of 1 g/kg completely suppressed ulceration. Results suggest that oral administration of 50 mg/kg of vexibinol, a flavanol found in the extract, inhibited ulceration more effectively than spizofurone at 100 mg/kg. 相似文献
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Different species of Crataegus, commonly called Hawthorn, were reported to possess wide pharmacological effects on the cardiovascular system. In the present study, chloroform, ethylacetate and methanol (70%) extracts of the flowering tops of Crataegus meyeri A. Pojark. were studied. The extracts were tested on the incidence and severity of arrhythmias induced by a period of myocardial ischaemia in open-chest anaesthetized male Wistar rats. Infusion of a hydroalcohol extract (1 mg/kg/min) resulted in a significant decrease in the total number of ventricular ectopic beats (from 1494 +/- 362 in the control to 634 +/- 102), mainly by reduction of beats occurring as ventricular tachycardia. A chloroform extract (1 mg/kg/min) also reduced the total number of ventricular ectopic beats but this reduction was due to the decrease of single extrasystoles. A significant reduction in the time spent for ventricular fibrillation was seen by the hydroalcohol and ethylacetate extracts. There were no significant changes in the heart rate and blood pressure during the extract infusion. However, bolus injection of all the extracts caused a significant reduction in the blood pressure. Thus, the extracts of Crataegus meyeri have a hypotensive and a potential antiarrhythmic action on ischaemic myocardium and may possess active principles. 相似文献
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目的:探讨中西医结合治疗房颤的临床疗效。方法:将76例房颤患者随机分为对照组和观察组,对照组患者给予乙胺碘呋酮片,观察组在对照组治疗基础上给予纠颤复律汤(药物组成:党参20 g,酸枣仁20 g,苦参20 g,丹参15 g,延胡索15 g,麦冬15 g,五味子15 g,炙甘草10 g)治疗,每日1剂,4周为1个疗程。治疗1个疗程后对两组患者的临床疗效、平均复律时间进行观察和比较。结果:与对照组相比,观察组有效率明显升高、平均复律时间明显缩短(P〈0.05)。结论:中西医结合治疗房颤临床疗效显著,并能显著改善患者的生活质量。 相似文献
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家兔静注回生饮注射液(HSI),可显著推迟肾上腺素(Ad)诱发的心肌缺血性损伤的发生时间,显著缩短损害持续时间;HSI在150mg/kg剂量下不能推迟垂体后叶素(PAH)诱发的心肌缺血性损害的发生时间,但可非常显著地缩短损害持续时间;可显著降低哇巴因(Oua)诱发的室速(VT)、室颤(VF)发生率与死亡率;可显著提高乌头碱(AC)致颤阈,并显著降低AC诱发的VF发生率与死亡率;HSI在150mg/kg剂量下不能降低CaCl_2所致的家兔心肌损害的死亡率,但可显著提高CaCl_2阈剂量,降低VF发生率,延长存活时间。以上结果表明HSI有显著预防家兔心肌损害作用。 相似文献
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