幽门螺杆菌与酒渣鼻

酒渣鼻病因复杂,许多因素参与了其发生与发展过程。该病患者的幽门螺杆菌感染率较正常人高,幽门螺杆菌分泌毒素和机体所产生的各种炎症介质可能导致酒渣鼻的发生和发展。综述幽门螺杆菌的生物学特性、与酒渣鼻发生和发展的关系、治疗的影响以及可能的作用机制。     

幽门螺杆菌与酒渣鼻

酒渣鼻病因复杂，许多因素参与了其发生与发展过程。该病患者的幽门螺杆菌感染率较正常人高，幽门螺杆菌分泌毒素和机体所产生的各种炎症介质可能导致酒渣鼻的发生和发展。综述幽门螺杆菌的生物学特性、与酒渣鼻发生和发展的关系、治疗的影响以及可能的作用机制。     

幽门螺杆菌和酒渣鼻发病相关性研究进展

酒渣鼻是发生在颜面中部的一种慢性炎症性疾病,其病因和发病机制尚不明确,近年来幽门螺杆菌感染与酒渣鼻的相关性研究越来越受到国内外学者的重视,现将近几年来的研究进展总结如下。     

酒渣鼻发病机制中微生物的作用

酒渣鼻是一种常见的面部慢性炎症性皮肤病,其发病机制尚不明确,其中微生物起重要作用。蠕形螨虫与酒渣鼻发病有密切相关,可能通过Ⅳ型免疫反应致病。在对蠕形螨虫所携带的细菌的研究中,人们发现奥列伦芽胞杆菌、表皮葡萄球菌可能由蠕形螨虫携带,并与之共同致病;幽门螺杆菌、小肠细菌过度生长等可能在合并消化道症状的酒渣鼻发病中起作用,但其相关性和致病机制并不确切。目前尚未发现痤疮丙酸杆菌、沃尔巴克体与酒渣鼻发病有关。     

幽门螺杆菌和酒渣鼻关系的研究进展

酒渣鼻是发生在中年人鼻部及面部的一种慢性炎症,许多因素参与其发病机制。一些学者认为Hp在酒渣鼻的发病机制中扮演了重要角色,其产生的细胞毒素和细胞因子在酒渣鼻的发生和发展中起着重要作用。本文对Hp和酒渣鼻的关系进行综述。     

幽门螺杆菌感染与皮肤系统疾病的关系

近年来研究发现幽门螺杆菌感染在许多胃肠道外疾病的发病中起一定作用 ,其中皮肤系统许多疾病与幽门螺杆菌感染有关 ,现综述近年来幽门螺杆菌感染与慢性特发性荨麻疹、血管神经性水肿、酒渣鼻及其他皮肤疾病关系的报道     

幽门螺杆菌感染与寻常性银屑病的相关性

目前普遍认为幽门螺杆菌感染与慢性荨麻疹、酒渣鼻等皮肤病有关,但幽门螺杆菌感染与银屑病发病关系的研究不多。为研究寻常性银屑病发病与幽门螺杆菌感染是否存在相关性,我们对103例寻常性银屑病患者进行幽门螺杆菌抗体检测,现报道如下。     

幽门螺杆菌感染与皮肤系统疾病的关系

近年来研究发现幽门螺杆菌感染在许多胃肠道外疾病的发病中起一定作用，其中皮肤系统许多疾病与幽门螺杆菌感染有关，现综述近年来幽门螺杆菌感染与慢性特发性荨麻诊、血管神经性水肿、酒渣鼻及其他皮肤疾病关系的报道。     

幽门螺杆菌感染与酒渣鼻发病的相关性研究

目的探讨幽门螺杆菌感染对酒渣鼻发病的影响并评价幽门螺杆菌(HP)根治治疗对酒渣鼻病人的治疗作用。方法对56例酒渣鼻病人及20例无酒渣鼻的皮炎湿疹类皮肤病患者进行HP检测,酒渣鼻组HP阳性者随机分为A、B两组,A组用幽门螺杆菌根除治疗,B组用维生素B2、B6治疗,停药4周后观察酒渣鼻的疗效,HP阴性者用1%甲硝唑霜(耐瑞)治疗。结果56例酒渣鼻病人HP检出率为76.8%,显著高于对照组检出率45.0%(P<0.05);HP根治疗法对酒渣鼻的总有效率为63.6%,而维生素B疗法的总有效率为14.3%;1%甲硝唑霜治疗酒渣鼻的总有效率为69.3%。结论提示HP感染对酒渣鼻的发生发展起一定的作用,HP根治治疗对酒渣鼻有效,但HP根治治疗能否作为酒渣鼻的常规治疗尚待进一步研究。     

幽门螺杆菌感染与酒渣鼻发病关系的探讨

酒渣鼻是一种发生于面中部的慢性炎症，影响美观，病因不明，有人研究认为其发病可能与幽门螺杆菌（HP）感染有关。为探讨HP感染在酒渣鼻发病中的作用，我们对酒渣鼻患者采用^14C-尿素呼吸试验检测HP，同时对健康人群HP进行了检测，并对HP阳性者采用根除治疗观察皮疹变化，现将结果报道如下。     

幽门螺杆菌感染与酒渣鼻的关系分析

目的探讨幽门螺杆菌(HP)感染与酒渣鼻的关系。方法对55例酒渣鼻患者的血清HP-IgG抗体浓度、消化道症状及抗HP治疗的疗效进行了分析,并以30例正常人作对照。结果酒渣鼻患者的血清抗体浓度明显高于对照组,经抗HP治疗后取得了很好的疗效。结论HP感染与酒渣鼻的发生及加重有关。     

Helicobacter pylori eradication treatment reduces the severity of rosacea

BACKGROUND: A higher prevalence of Helicobacter pylori infection in rosacea patients than in healthy controls has been reported. OBJECTIVE: The aim of this study was to investigate the effect of H. pylori eradication therapy in patients with rosacea. METHODS: Twenty-five rosacea patients and 87 age- and sex-matched healthy controls were included in this study. We detected IgG and IgA antibodies against H. pylori in both groups. An upper gastrointestinal endoscopy and a rapid urease test were performed on the 13 patients with rosacea who accepted this procedure. Amoxicillin 500 mg 3 times daily, metronidazole 500 mg 3 times daily, and bismuth subcitrate 300 mg 4 times daily were administered to patients positive for H. pylori. The severity of rosacea was scored before and after treatment. RESULTS: There was no statistical difference in seropositivity in either group. In H. pylori-positive rosacea patients there was a significant decrease in the severity of rosacea at the end of the treatment as compared with the initial scores. CONCLUSION: Our findings suggest that H. pylori may be involved in rosacea and that eradication treatment may be beneficial.     

The seroprevalence of Helicobacter pylori and nitric oxide in acne rosacea

BACKGROUND: Acne rosacea is a dermatosis with unknown etiology. Some studies have reported a high prevalence of Helicobacter pylori infection in acne rosacea. Other studies have reported a decrease in the severity of the lesions of acne rosacea after eradication of H. pylori. H. pylori is a Gram-negative bacterium which colonizes the gastric mucosa and increases the synthesis of oxygen radicals, such as superoxide and proinflammatory cytokines. These cytokines have been demonstrated to stimulate the synthesis of the inflammatory species nitric oxide (NO). In this study, we examined the role of NO in the possible effect of H. pylori in acne rosacea. METHODS: Thirty-three acne rosacea patients were included in the study and the control group comprised 20 healthy individuals. The levels of immunoglobulin G antibodies against H. pylori in the serum samples were measured using the enzyme-linked immunoabsorbent assay method. Measurement of nitrate was performed using chemiluminescence in accordance with the method described by Braman and Hendrix (Braman RS, Hendrix SA. Nanogram nitrite and nitrate determination in environmental and biological materials by vanadium(iii) reduction with chemiluminescence detection. Anal Chem 1989; 61: 2715-2718). For statistical analysis, the t-test was used. RESULTS: The seropositivity of H. pylori in acne rosacea patients was found to be high; however, the serum nitrate levels were found to be normal. CONCLUSIONS: The results of the study indicate that the inflammatory species NO, which has been hypothesized to be associated with H. pylori, has no role in the inflammatory mechanism of acne rosacea.     

幽门螺杆菌细胞毒素相关蛋白A与酒渣鼻的相关性

目的探讨幽门螺杆菌(HP)细胞毒素相关蛋白A(CagA)与酒渣鼻发生的关系。方法使用酶联免疫法测定76例酒渣鼻患者及31例健康对照者的血清CagA-Hp抗体,并检测CagA-Hp阳性及阴性情况下IL-8,TNF-α,VEGF水平。结果酒渣鼻组血清CagA-Hp阳性率为71.05%,对照组为22.58%,两组差异有显著性(P<0.05)。CagA-Hp阳性的酒渣鼻患者血清IL-8,TNF-α水平高于CagA-Hp阴性者(P<0.05)。CagA-Hp抗体水平与酒渣鼻病情轻重呈正相关。抗HP治疗可促进酒渣鼻的恢复。结论CagA-Hp阳性菌株感染与酒渣鼻的发生有关,是其发病的危险因素。     

Etiopathogenesis, classification, and current trends in treatment of rosacea

Rosacea is a common chronic dermatosis characterized by varying degrees of flushing, erythema, telangiectasia, edema, papules, pustules, ocular lesions, and phymas. Etiology and pathogenesis of rosacea are still unknown. Many possible causes have been described as inducing the disease or contributing to its manifestation, such as genetic predisposition, abnormal vascular reactivity, changes in vascular mediating mechanisms, Helicobacter pylori infection, Demodex folliculorum infestation, seborrhea, sunlight, hypertension, and psychogenic factors. However, none of these factors has been proved. Rosacea shows a wide spectrum of clinical presentations, which vary over time and with age. Successful management of rosacea requires careful patient evaluation and individualized therapy with appropriate variations and modifications, as the severity of the disorder fluctuates. In mild cases of rosacea, patients are instructed to avoid sun, to apply sun-protective creams, and to avoid facial irritants and other triggers that provoke symptoms. At later stage, drug therapy is often necessary. The disease commonly requires long-term treatment with topical or oral medicaments. Surgical correction may be required for rhinophyma and telangiectasia. We reviewed the current literature on the aspects of the pathogenesis, diagnostic criteria, and treatment options for rosacea.     

Ocular rosacea and treatment of symptomatic Helicobacter pylori infection: a case series

Rosacea is a chronic inflammatory skin disease characterized by recurrent episodes of facial flushing, erythema, papules, pustules, and telangiectasia. More than half of all rosacea patients may have ocular symptoms. Rosacea is associated with certain digestive diseases, such as gastritis, hypochlorhydria, or a number of jejunal mucosal abnormalities, and many patients have Helicobacter pylori infection. The role of Helicobacter pylori has often been a subject of investigation; these studies show conflicting results. Here we present results of the effects of treatment given for H. pylori eradication in seven patients with ocular rosacea that, at the same time, had clinical and serological evidence of H. pylori infection. Six weeks after completion of the treatment, all patients experienced improvement of their rosacea symptoms. Ocular disease responded better than cutaneous rosacea.     

幽门螺杆菌感染与酒渣鼻的相关性

为了研究幽门螺杆菌(HP)感染与酒渣鼻的相关性 ,研究了42例酒渣鼻患者的血清HP IgG浓度、消化道症状及抗HP治疗的疗效 ,并以33例寻常痤疮作对照。发现酒渣鼻患者的血清抗体及消化道症状阳性率及抗HP治疗的疗效明显高于对照组 ,且6例接受胃镜及组织学检查的酒渣鼻患者的检查结果均显示有异常。结果提示 ,HP感染与酒渣鼻可能存在一定的相关性。     

Rosacea: a cutaneous marker of Helicobacter pylori infection? Results of a pilot study

Given the long purported anecdotal association between rosacea and gastrointestinal disease, the discovery that Helicobacter pylori causes gastritis and duodenal ulcer disease has led to a hypothesized role for this organism in the aetiology of rosacea. We conducted a case-series study of 49 patients to assess the potential association between severity of rosacea and direct and serological evidence of H. pylori infection. Patients were classified by severity into non-inflammatory erythematotelangiectatic or inflammatory/papulopustular rosacea and were tested for current H. pylori infection and evidence of previous exposure. Positive 13C-urea breath test and ELISA tests were more likely to be observed in patients with inflammatory rosacea, although not statistically significantly so (OR = 3.0, p = 0.15 and OR = 2.9, p = 0.16, respectively). However, the proportion of patients who tested positive in both assays (versus negative in at least one) was even higher in the inflammatory rosacea group and neared statistical significance (OR = 4.5, p = 0.06). This pilot study provides sufficient evidence suggestive of a positive association between the severity of rosacea and the presence of H. pylori to warrant further research.     

Effect of treatment of Helicobacter pylori infection on rosacea.

OBJECTIVE: To evaluate the clearing and intensity of symptoms of rosacea 60 days after the treatment of Helicobacter pylori infection. DESIGN: Randomized, double-blind, placebo-controlled clinical trial. SETTING: The dermatology section of a large multispecialty clinic in the North Central United States. PARTICIPANTS: Men and women older than 25 years with active signs of rosacea who tested positive for H pylori with both the rapid whole blood test and the urea breath test. INTERVENTION: Treatment of H pylori infection with 14-day therapy using clarithromycin. 500 mg orally 3 times a day, and omeprazole, 40 mg orally once a day. MAIN OUTCOME VARIABLES: The extent and intensity of rosacea as measured by the number of papules and pustules and the extent and intensity of erythema and telangiectasia. RESULTS: Three hundred twenty patients presented with rosacea. For 50 patients, the results of a urea breath test were positive for H pylori, and 44 patients were enrolled in the study. Rosacea abated in almost all patients, but none were cured. Notably, lessening of rosacea for patients treated for H pylori was not significantly better than for the control cohort. CONCLUSIONS: Rosacea abated in most participants in this study, whether they were in the treatment or the control cohort. There was no statistical difference when the results of active treatment were compared with those of placebo. Treating H pylori infection has no short-term beneficial effect on the symptoms of rosacea to support the suggested causal association between H pylori infection and rosacea.