精神分裂症382例七轴诊断分析

目的：探讨精神障碍诊断量表（ＤＳＭＤ）七轴诊断系统对精神分裂症的适用性。方法：选取全国２３家协作单位应用ＤＳＭＤ测试并按ＣＣＭＤ－２诊断的１７种病列患者的资料,由三位经ＤＳＤ及ＣＣＭＤ－２Ｒ、ＩＣＤ－１０等诊断标准训练的精神科医师进行再诊断。对其中ＣＣＭＤ－２Ｆ诊断的３８２例精神分裂症患者的七轴进行分析。结果：ＤＳＭＤ的七轴诊断系统对全面分析精神分裂症患者的总体临床状况是可行的。它既使轴１主要与次     

精神分裂症烟草依赖者的个性比较分析

精神分裂症烟草依赖者的个性比较分析河南省焦作市解放军第１６０医院甘景梨为探讨精神分裂症烟草依赖者的个性特点，本文对１０７例患者进行了比较分析。对象与方法对象为我院住院或门诊就诊经治疗后病情稳定的精神分裂症患者，均符合ＣＣＭＤ－２诊断标准；凡连续吸烟１...     

缺陷与非缺陷型精神分裂症的脑电图分析

精神分裂症缺陷型比非缺陷型具有更多的神经系统软体征 ,提示缺陷型精神分裂症的脑器质性改变更为明显[1 ] 。一般而言脑电图 (ＥＥＧ)是脑细胞功能的最直接反应[2 ] ,据此我们对 6 9例住院精神分裂症患者ＥＥＧ进行了分析比较 ,报告如下。1　对象与方法研究对象 :研究对象为临沂市荣军医院住院的男性精神分裂症患者。符合ＣＣＭＤ— 2—Ｒ关于精神分裂症的诊断标准。均无躯体疾病及神经系统疾病 ,检查合作。使用Ｃａｒ ｐｅｎｔｅｒ关于缺陷型综合征的诊断标准对入组病人进行诊断 ,结果 :缺陷型 30例 ,平均年龄 4 3 5± 9 8岁 ,平均病程 18…     

儿茶酚-O-甲基转移酶Vall58Met和汉族精神分裂症的关联/连锁分析

目的：探讨儿茶酚－Ｏ－甲基转移酶（ＣＯＭＴ）第１５８位密码子从缬氨酸到蛋氨酸的错义突变（Ｖａｌｌ５８Ｍｅｔ）多态性与精神分裂症的关系。方法：在４２个至少包含２名符合ＩＣＤ－１０精神分裂症诊断标准的患病同胞、父母存活的汉族家系中,对ＣＯＭＴＶａｌｌ５８Ｍｅｔ多态标记进行检测。结果：１）ＣＯＭＴ等位基因频度和基因型频度在父母组、非患病同胞组和患病同胞组之间无差异,在三组男女性别之间以及在精神分裂症不     

171例精神分裂症的脑电图分析

１病例资料１７１例均为我院１９９２年～１９９７年门诊病人,男７３例,女９８例,７～５０岁,平均３３岁,临床确诊为精神分裂症,症状符合中国精神疾病分类方案与诊断标准（ＣＣＭＤ－２－Ｒ）中的精神分裂症标准［１］。采用国产１６道脑电图仪,按１０／２０系统放...     

Ⅰ、Ⅱ型精神分裂症WAIS-RC和EPQ测试结果分析

Ⅰ、Ⅱ型精神分裂症ＷＡＩＳ－ＲＣ和ＥＰＱ测试结果分析赵勇杨志学张红深湖北省随州市二医院自Ｃｒｏｗ根据ＨｕｇｈｉｎｇｓＪａｃｋｓｏｎ的阴、阳性症状概念将精神分裂症划分为Ⅰ型（阳性症状为主）和Ⅱ型（阴性症状为主）［１］以来，人们对这两个亚型的临床相和精神...     

老年慢性精神分裂症与Alzheimer病的认知功能筛查结果比较

应用认知功能筛查量表（ＣＡＳＩ）评定４１名正常老人、８５名老年慢性精神分裂症与３５名Ａｌｚｈｅｉｍｅｒ病患者，结果显示老年慢性精神分裂症患者中约一半有认知功能缺损。认知相对保存的分裂症患者的ＣＡＳＩ总分、因子分较正常老人明显减低；认知损害的分裂症患者的认知损害模式与Ａｌｚｈｅｉｍｅｒ病的损害不同。结论：老年慢性精神分裂症患者的认知损害可能具有独特的模式，不同认知结局的精神分裂症可能存在异源性病因。     

精神分裂症与社会心理应激因素

本文应用ＣＣＭＤ－Ⅱ对精神分裂症病人在发病前一年内的应激事件进行分析，结果发现，精神分裂症病人应事件显著比正常人多，首次发病前遇到的生活事件较为严重，只有负性应激事件才与精神分裂症有关，且患者中以内向性格者居多。     

不同攻击行为的精神分裂症患者人格特征分析

在各类精神疾病患者中 ,精神分裂症攻击行为的发生率最高 ,本研究把攻击行为分为一般攻击行为和凶杀致死行为。前者包括打人、骂人、毁物、伤人及自伤 ;后者指在疾病期杀人致死者。采用病例对照分析方法 ,使用ＭＭＰＩ测量 ,从而探讨精神分裂症攻击行为患者的个性特征。对象　一般攻击组 :入组标准 (1)符合ＣＣＭＤ -3精神分裂症的诊断标准 ,(2 )无脑器质性疾病和躯体疾病 (3 )入院前后有明显的打人、骂人、伤人及自伤、毁物行为 (4 )小学以上文化程度。共入组 5 1例。凶杀组 :入组标准 (1)符合ＣＣＭＤ-3精神分裂症的诊断标准 ,(2 )无脑器…     

WAIS—RC简式用于精神病人的效度分析

目的：对ＷＡＩＳ－ＲＣ简式进行效度检验,以探讨其在精神病人中的应用价值。方法：被试全部为住院精神病人,其中精神分裂症和躁郁症患者各５０例,均符合ＣＣＭＤ－２－Ｒ诊断标准。每个被试完成ＷＡＩＳ－ＲＣ全式测验,全式智商由所有言语及操作分测验计算,简式智商采用回归法换算。结果：二合一与全式智商的相关为０．７３～０．９４,四合一为０．８３～０．９７,六合一均在０．９５以上。精神分裂症患者简式与全式智商均值的差异非常显著,而躁郁症患者除ＰＩＱ外也有显著性差异。结论：同国外多数研究结果不一致,不支持ＷＡＩＳ－ＲＣ简式用于精神病人。     

Primary interaction between antibody and components of Alternaria. I. Immunology and chemical characteristics of labeled antigens.

Components were isolated from Alternaria tenuis and its culture filtrate, and were radiolabeled with 123-I. The labeled antigenic components had a high polysaccharide content as determined by staining patterns following electrophoresis in polyacrylamide gels and by inactivation with sodium metaperiodate. A primary binding test was employed to detect and measure serum antibodies to the components from A. tennuis. This procedure was more sensitive in detecting antibodies that bound to antigens than were comparable tests dependent upon precipitin types of reactions. The labeled components of A. tenuis cross-reacted or shared antigens with 3 other species of molds: Stemphylium sp., Curvularia sp., Aspergillus fumigatus, but not with a variety of other fungal and nonfungal materials.     

Sources of dependency in asthmatic children

The question of whether childhood asthma produces increased dependency is examined. Dependency scores of 60 asthmatic and non-asthmatic children with the same familial-constitutional allergic predisposition were divided into “low-dependent” and “high-dependent” groups. In each group, asthmatic and non-asthmatic children with the same familial-constitutional allergic predisposition were compared statistically for significant psychological differences. Dependency was not found to be associated with the severity of asthma, but was associated with family relationship patterns.     

Administration of local anesthetics to patients with a history of prior adverse reaction

The clinical histories of 71 patients evaluated for suspected local anesthetic (LA) allergy were reviewed retrospectively. The clinical histories were classified into (1) immediate generalized reactions (15%), (2) localized swelling at the injection site (25%), (3) nonspecific systemic symptoms (42%), and (4) other histories (17%). Serial dilutional intradermal skin tests were performed with mepivacaine, lidocaine, and procaine in 59 patients. There were 5 skin test--positive patients found, and each had a positive reaction to an LA to which, by history, they had not reacted. In 50 patients, when an LA was subsequently required, a subcutaneous challenge was performed with an LA chosen for chemical nonsimilarity. No significant reactions were observed in this group. Three patients tolerated a challenge with an LA to which they were skin test--positive. These data indicate (1) the low incidence of reactions compatible with a systemic IgE-mediated mechanism by history in patients referred for evaluation of LA allergy, (2) the lack of specific and clinically relevant information provided by dilutional skin tests, and (3) the apparent safety and usefulness of careful challenge with an alternative LA.     

中药蜈蚣对小鼠胚胎发育的影响

孕鼠１６１只随机分组，在孕期第７－１１天给实验组分别以５００ｍｇ／（ｋｇ．ｄ）（蜈蚣１组）及１０００ｍｇ／（ｋｇ．ｄ）（蜈蚣２组）的中药蜈蚣煎剂灌胃，至孕期１８天记录各组孕鼠和胎鼠的发育情况。结果表明：蜈蚣１，２两组致畸作用明显，死胎，吸收胎比例升高；蜈蚣２组胎鼠和孕鼠的体重均下降，堕胎作用显著，与对照组比较，差异均有非常显著意义（Ｐ＜０．０１）。     

The PLC/PRF/5 human hepatoma cell line. I. Reevaluation of the karyotype

The karyotype of the PLC/PRF/5 (Alexander) human hepatoma cell line was identified at passage +/- 110, prior to attempting in situ hybridization studies to determine the chromosomal localization of the hepatitis B virus (HBV) DNA integration sites. The karyotype was established by means of G-, Q-, and sequential C-banding techniques. Multiple consistent numerical and structural abnormalities were detected. These were compared with the original published unbanded karyotype of this cell line (at passage less than 25) and also with a previously published banded karyotype (at passages 60-90). Despite minor differences in the compared banded karyotypes (which are probably interpretational), the concordance in modal number and morphological karyotypic similarities over the course of 10 years indicate that this cell line is stable in vitro.     

The effect of combining subtherapeutic concentrations of different ionophorous antibiotics on anticoccidial action in chickens

The mode of action of polyether, ionophorous drugs against Eimeria infections in chickens was studied by feeding subeffective doses of drugs separately and in combination, in comparison with the full dose of each drug. Thus, monensin, lasalocid and salinomycin (50, 35 and 30 ppm, respectively) were compared with a full dose of the same drugs. The combinations of ionophorous antibiotics were as effective in controlling Eimeria tenella and E. acervulina infections as the single antibiotic mixed in the feed at recommended prophylactic concentrations. When intracellular sporozoites of E. tenella were treated with the drugs in vitro, the effects on morphology were similar, regardless of which drug was used.The additive effects of these drugs in the chicken, and their similar effects on intracellular sporozoites suggest that they have a similar mode of action on Eimeria sporozoites, despite differences in ion selectivity.     

Cerebrospinal fluid amine metabolites, tryptophan and clinical parameters in depression. Part 2. Psychopathological symptoms

The group of 33 severely depressed female patients was divided into 3 equally large subgroups, separately according to their CSF 5-HIAA, HVA, tryptophan and total plasma tryptophan, and the severity of 17 operationally defined psychopathological symptoms was compared between the subgroups containing the highest and lowest biochemical values. Nonparametric statistical testing yielded significant results on several symptoms, when the subgroups were formed from CSF 5-HIAA and HVA. There was only one significant symptom difference between subgroups separated by CSF tryptophan and a few other differences by plasma tryptophan level. The results indicate that lumbar CSF metabolites correlate more with certain individual symptoms than with the global severity of depression.     

Viloxazine plasma concentrations and clinical response

Eleven patients suffering from primary depressive illness were treated with 300 mg/d of viloxazine for 29 days. Blood samples were collected at weekly intervals and severity of depression assessed using the Hamilton depression rating scale. Mean plasma viloxazine level for all patients during the trial was 1.20 micrograms/ml and ranged from 0.40 to 2.70 micrograms/ml. No simple relationship between plasma concentration and amelioration score was observed at day (rs = -0.02), day 22 (rs = -0.29) or day 29 (rs = 0.09). No significant difference in plasma concentrations between responders and non-responders was observed at day 29. Side effects were not correlated with plasma concentrations.     

Cerebrospinal fluid amine metabolites,tryptophan and clinical parameters in depression: Part 1. Background variables

5-Hydroxyindoleacetic acid, homovanillic acid, and tryptophan were measured in the lumbar cerebrospinal fluid of 33 female patients with severe hospitalized depression. Total plasma tryptophan was also determined in blood samples taken simultaneously at the time of lumbar puncture. Twelve clinical parameters were recorded using operational definitions for variables not measurable in physical units, and were compared in patient subgroups containing individuals with the highest and the lowest metabolite levels.Only age proved to be significantly higher in patients with low CSF 5-HIAA, and body height showed the same tendency. The lack of other significant differences indicates that there are no close relations between these clinical parameters and the biochemical variables except the two mentioned above.     

赛庚啶对大鼠脑损伤脑皮质和脑微血管中5—HT含量的影响

采用高效液相色谱－电化学检测器检测大鼠（１８０只）脑损伤后脑皮质及脑微血管中５－ＨＴ含量变化，并选用５－ＨＴ受体阻断剂赛庚啶治疗，观察其对脑损伤后脑皮质及脑微血管５－ＨＴ水平变化的影响。结果表明：脑损伤后５－ＨＴ水平显著升高，神经细胞和脑微血管内皮病理变化与５－ＨＴ代谢改变有密切关系，赛庚啶可显著降低脑皮质及脑微血管中５－ＨＴ含量，并减轻脑继发性损害。