Familial carcinoma of the ovary. Case report.

A patient was successfully treated by surgery, progestogens and chlorambucil for a poorly differentiated cystadenocarcinoma of the ovary. Four of her relatives had died of ovarian cancer; it was ascertained that two of them also had poorly differentiated cystadenocarcinoma.     

Herlyn-Werner syndrome. Case report

The following study shows a syndrome which is commonly not diagnosed by gynaecologists. It was first described from Herlyn-Werner in 1971. In Bulgaria the same was described by I. Karagjosov in 1983 as a part of Herlyn-Werner-Wunderlich Syndrome.     

Case report on SHORT syndrome.

The acronym SHORT was first used by Gorlin et al. (1975) and Sensenbrenner et al. (1975) to define a recognizable pattern of features, consisting of Short Stature, Hyperextensibility of joints and/or inguinal Hernia, Ocular depression, Rieger anomaly, and Teething delay. Other features characteristic of the syndrome included intrauterine growth retardation (IUGR), slow weight gain, frequent illness, triangular face, anteverted ears, telecanthus, deeply set eyes, wide nasal bridge, hypoplastic alae nasi, chin dimple, micrognathia, clinodactyly, partial lipodystrophy, hearing loss, functional heart murmur, delayed bone age, delayed speech, normal intellect, glucose intolerance, and insulinopenic diabetes. To our knowledge 19 cases of SHORT syndrome have been reported (Gorlin et al., 1975; Sensenbrenner et al., 1975; Aarskog et al., 1983; Toriello et al., 1985; Lipson et al., 1989; Schwingshandl et al., 1993; Verge et al., 1994; Bankier et al., 1985; Brodsky et al., 1996; Sorge et al., 1996; Haan and Morris, 1998). We report the twentieth patient diagnosed with SHORT syndrome who presented with growth retardation, sensorineural hearing loss, and minor dysmorphic features, consistent with the phenotype described for this syndrome.     

Thirty-eight kilograms ovary cystoadenoma. Case report and literature review

A clinical case of a patient with a giant tumoration of the ovary appears, that went to the external consultation declaring progressive picture of abdominal distension, postprandial fullness and general weakness. The diagnosis was elaborated as much by clinical and paraclinical methods (USG and RX) as well as by pathological anatomy; and the handling consisted firstly of puncture-drainage and later by laparotomy with the extraction of the same one. The gross weight of the tumoration was of 38 kg and the histopathologic study was of cystoadenoma serum giant of the left ovary. Evolution of the patient was satisfactory having a favorable prognosis, returning normally to her habitual activities.     

Klippel-Trenaunay syndrome and pregnancy. Case report

The Klippel-Trenaunay syndrome is a rare congenital disorder consisting of: cutaneous vascular nevi, varicose veins or venous malformations and hypertrophy of soft tissue and bone, affecting one or more limbs. The morbidity of the disease is associated with vascular anomalies. Pregnancy is discouraged because this rare disease puts a pregnant woman in an increased obstetric risk, due to pregnancy can exacerbate complications. The pregnancy has been reported rarely in patients with Klippel-Trenaunay syndrome, although the incidence is unknown. Until 2006 there have been only 17 reported cases of pregnancy in patients with Klippel-Trenaunay syndrome in the literature in English. We report the case of the second pregnancy of 22 years old woman with this disease.