MobileMums: A Randomized Controlled Trial of an SMS-Based Physical Activity Intervention

Background  

Postnatal women (<12 months postpartum) are at increased risk of physical inactivity.     

Efficacy and Mediation of a Theory-Based Physical Activity Intervention for African American Men Who Have Sex with Men: A Randomized Controlled Trial

Background

Few trials have tested physical-activity interventions among sexual minorities, including African American men who have sex with men (MSM).

Purpose

We examined the efficacy and mediation of the Being Responsible for Ourselves (BRO) physical-activity intervention among African American MSM.

Method

African American MSM were randomized to the physical-activity intervention consisting of three 90-min one-on-one sessions or an attention-matched control intervention and completed pre-intervention, immediately post-intervention, and 6- and 12-month post-intervention audio computer-based surveys.

Results

Of the 595 participants, 503 completed the 12-month follow-up. Generalized estimating equation models revealed that the intervention increased self-reported physical activity compared with the control intervention, adjusted for pre-intervention physical activity. Mediation analyses suggested that the intervention increased reasoned action approach variables, subjective norm and self-efficacy, increasing intention immediately post-intervention, which increased physical activity during the follow-up period.

Conclusions

Interventions targeting reasoned action approach variables may contribute to efforts to increase African American MSM’s physical activity.

Clinical trial registration

The trial was registered with the ClinicalTrials.gov Identifier NCT02561286.

     

Translating Physical Activity Interventions for Breast Cancer Survivors into Practice: An Evaluation of Randomized Controlled Trials

Background  Although physical activity (PA) interventions have been effective for improving health outcomes in breast cancer survivors, little is known relative to their potential for translation into practice. Purpose  This review was designed to provide a quantitative estimate of the reporting of both internal and external validity in recent studies of PA in breast cancer survivors (BCS). Methods  The Reach, Efficacy/Effectiveness, Adoption, Implementation, and Maintenance (RE-AIM) framework was utilized to assess the reporting of internal and external validity in 25 randomized controlled trials (RCTs) of PA and BCS published between 1998 and 2008. Each trial was evaluated relative to the degree it met criteria for each of the above dimensions. Results  The majority of studies in this review reported dimensions reflecting internal validity. The overall level of detail relative to external validity of PA interventions was rarely reported, limiting the generalizability of study findings. Conclusions  As with many RCTs of health behavior change, detail relative to contextual elements of published PA interventions in BCS is limited. It is recommended that future physical activity interventions in BCS be designed to facilitate scalable and sustainable interventions for improving health outcomes in this population.     

Exploring the Efficacy and Moderators of Two Computer-Tailored Physical Activity Interventions for Older Adults: A Randomized Controlled Trial

Background  

Important health benefits can be derived when low-cost (e.g., computer-tailored) physical activity interventions for older adults demonstrate sustained effects.     

Lifestyle risk factors and infectious disease mortality,including COVID-19, among middle aged and older adults: Evidence from a community-based cohort study in the United Kingdom

In this community-based cohort study, we investigated the relationship between combinations of modifiable lifestyle risk factors and infectious disease mortality. Participants were 468,569 men and women (56.5 ± 8.1, 54.6% women) residing in the United Kingdom. Lifestyle indexes included traditional and emerging lifestyle risk factors based on health guidelines and best practice recommendations for: physical activity, sedentary behaviour, sleep quality, diet quality, alcohol consumption, and smoking status. The main outcome was mortality from infectious diseases, including pneumonia, and coronavirus disease 2019 (COVID-19). Meeting public health guidelines or best practice recommendations among combinations of lifestyle risk factors was inversely associated with mortality. Hazard ratios ranged between 0.26 (0.23–0.30) to 0.69 (0.60–0.79) for infectious disease and pneumonia. Among participants with pre-existing cardiovascular disease or cancer, hazard ratios ranged between 0.30 (0.25–0.34) to 0.73 (0.60–0.89). COVID-19 mortality risk ranged between 0.42 (0.28–0.63) to 0.75 (0.49–1.13). We found a beneficial dose–response association with a higher lifestyle index against mortality that was consistent across sex, age, BMI, and socioeconomic status. There was limited evidence of synergistic interactions between most lifestyle behaviour pairs, suggesting that the dose–response relationship among different lifestyle behaviours is not greater than the sum of the risk induced by each behaviour. Improvements in lifestyle risk factors and meeting public health guidelines or best practice recommendations could be used as an ancillary measure to ameliorate infectious disease mortality.     

Physical Activity and Fitness Outcomes of a Lifestyle Intervention for Primary Care Patients with Depression and Anxiety: a Randomised Controlled Trial

Patients currently being treated for depression and/or anxiety were referred by their GP and randomised to a 12-week individually tailored diet and exercise lifestyle intervention or an attention control group. Assessments at baseline and 12 weeks included the Active Australia Survey for self-reported physical activity, chair stands, arm curls and a 3-min step test to measure physical fitness. Intent-to-treat analyses using linear mixed modelling showed both groups significantly improved participation in physical activity and muscular endurance. There were no significant differences in improvement between groups. The only group by time interaction was found for body mass index and indicated greater improvement in the intervention group compared to the attention control group. Motivated patients with depression and/or anxiety may be able to increase their participation in physical activity without regular individual support from an exercise physiologist. Alternate modes of support should be considered.     

Physical Activity, Heath-Related Fitness, and Health Experience in Adults with Childhood-Onset Epilepsy: A Controlled Study

Summary: Purpose: To show any possible associations between childhood-onset epilepsy and physical activity, health-related fitness, and health experience. Methods: A population-based cohort of 176 patients with epilepsy since childhood was monitored for a mean of 35 years. Patients with recurrent, unprovoked epileptic seizures with no associated initial neurologic impairment or disability, termed those with “epilepsy only” (n = 100), were compared with matched controls for self-reported physical activity, health experience, laboratory tests, body mass index, and muscle power tests. Results: On the basis of muscle tests, physical fitness proved to be significantly poorer in patients with “epilepsy only” than in matched controls. During the preceding year, 22% of patients and 24% of controls had reduced their physical activities because of some illness; only 2% reduced their physical activities because of epilepsy. No significant difference was found in blood status, except for a lower serum creatinine level in the patients. Current antiepileptic drug (AED) therapy appeared significantly associated with lower hemoglobin and creatinine levels and higher highdensity lipoprotein values. The patients perceived their health status to be comparable with that of controls, irrespective of physical inactivity, continued seizures, or AED monotherapy. However, patients receiving AED polytherapy perceived their health as rather poor or very poor significantly more often than did controls. Conclusions: Based on objective muscle tests, adults with childhood-onset “epilepsy only” have poorer physical fitness than do matched controls, but they have a feeling of good personal health.     

Lifestyle risk factors,inflammatory mechanisms,and COVID-19 hospitalization: A community-based cohort study of 387,109 adults in UK

We conducted the first large-scale general population study on lifestyle risk factors (smoking, physical inactivity, obesity, and excessive alcohol intake) for COVID-19 using prospective cohort data with national registry linkage to hospitalisation. Participants were 387,109 men and women (56.4 ± 8.8 yr; 55.1% women) residing in England from UK Biobank study. Physical activity, smoking, and alcohol intake, were assessed by questionnaire at baseline (2006–2010). Body mass index, from measured height and weight, was used as an indicator of overall obesity. Outcome was cases of COVID-19 serious enough to warrant a hospital admission from 16-March-2020 to 26-April-2020. There were 760 COVID-19 cases. After adjustment for age, sex and mutually for each lifestyle factor, physical inactivity (Relative risk, 1.32, 95% confidence interval, 1.10, 1.58), smoking (1.42;1.12, 1.79) and obesity (2.05 ;1.68, 2.49) but not heavy alcohol consumption (1.12; 0.93, 1.35) were all related to COVID-19. We also found a dose-dependent increase in risk of COVID-19 with less favourable lifestyle scores, such that participants in the most adverse category had 4-fold higher risk (4.41; 2.52–7.71) compared to people with the most optimal lifestyle. C-reactive protein levels were associated with elevated risk of COVID-19 in a dose-dependent manner, and partly (10–16%) explained associations between adverse lifestyle and COVID-19. Based on UK risk factor prevalence estimates, unhealthy behaviours in combination accounted for up to 51% of the population attributable fraction of severe COVID-19. Our findings suggest that an unhealthy lifestyle synonymous with an elevated risk of non-communicable disease is also a risk factor for COVID-19 hospital admission, which might be partly explained by low grade inflammation. Adopting simple lifestyle changes could lower the risk of severe infection.     

Digital Monitoring of Sleep,Meals, and Physical Activity for Reducing Depression in Older Spousally-Bereaved Adults: A Pilot Randomized Controlled Trial

ObjectivesTo evaluate the feasibility and acceptability of a behavioral intervention and explore its impact on depression symptom burden among older spousally-bereaved adults.MethodsParticipants were age ≥60 years, bereaved ≤8 months, and at high risk for depression. Participants were randomized to 12 weeks of digital monitoring of sleep, meals, and physical activity; digital monitoring plus health coaching; or enhanced usual care and followed for 9 months for new-episode depression.ResultsWe enrolled 57 participants, 85% of eligible adults and 38% of all adults screened. We observed high levels of adherence in both digital monitoring (90%) and health coaching (92%); 88% of participants were retained. In linear mixed-effects models, depression symptoms significantly decreased, but the interaction between time and intervention was not significant.ConclusionA behavioral intervention that uses both digital monitoring and motivational health coaching is feasible and acceptable to older bereaved adults.     

Aerobic Training Efficacy in Inflammation,Neurotrophins, and Function in Chronic Stroke Persons: A Randomized Controlled Trial Protocol

Background: Neuroinflammation is an important part of stroke pathophysiology and has both detrimental and beneficial effects after stroke. Besides that the enhancement of neurotrophins seems to be related to improvements in stroke recovery. Evidences suggest that exercise plays a role in modulating anti-inflammatory and neurotrophic effects. However, little is known about its impact in stroke survivors, mainly in chronic stroke. The purpose of this study is to investigate the efficacy of moderate-intensity treadmill exercise in changing inflammatory mediators, interleukin-6 (IL-6), soluble tumor necrosis factor receptors I and II (sTNFRI, sTNFRII), interleukin-10 (IL-10), and brain-derived neurotrophic factor (BDNF) levels in chronic stroke patients. The secondary objective is to investigate the effects of training in improve mobility and exercise capacity. Methods: This is a randomized controlled trial. Chronic stroke patients will be randomized to an experimental or control group, and will receive group interventions three times per week, over 12 weeks. The experimental group will receive moderate-intensity (60%-80% of maximum heart rate reserve) treadmill exercise. Control group will perform walking training on the ground (<40% of maximum heart rate reserve). Primary outcomes include IL-6, sTNFRI, sTNFRII, IL-10, and BDNF levels. Secondary outcomes include mobility and exercise capacity. Outcomes will be measured at baseline, postintervention, and at the 4-week follow-up. Discussion: The findings of this trial have the potential to provide important insights regarding the effects of an aerobic physical program in the inflammatory process and in the neuronal plasticity in stroke persons and its impact on mobility and exercise capacity.     

Lifestyle factors and risk of stroke in Seoul, south Korea

Background and purpose: The importance of stroke risk factors, especially lifestyle associated ones, may differ among different ethnic groups. The purpose of the present study is to elucidate the risk factors for stroke in Seoul, Korea. Subjects and Methods: Three-hundred four stroke patients and 249 age-matched controls were studied. Patients were divided into those with cerebral infarction (CI) and intracerebral hemorrhage (ICH). Using a structured interview, we assessed risk factors for stroke including lifestyle-associated factors: hypertension (HT); diabetes mellitus (DM); cigarette smoking; alcohol drinking; sodium intake; salt taste preference; physical activity and exercise; consumption of vegetables, fat, fish and fruits; body mass index; total body fat; and skinfold thickness of triceps, subscapular, and abdomen. The results were compared between patients and controls, and between CI and ICH. Results: There were 232 CI and 72 ICH. Multivariate logistic regression analyses revealed the following independent risk factors; for CI in men, HT, DM, high sodium intake, low intake of vegetables, and excessive abdominal skinfold thickness; for ICH in men, HT, heavy alcohol drinking, high sodium intake, excessive abdominal skinfold thickness, and low fat consumption; for CI in women, excessive abdominal skinfold thickness, and low fat consumption; for CI in women, HT, high sodium intake, excessive abdominal skinfold thickness, decreased triceps skinfold thickness, and lack of recent physical exercise. On subgroup comparison, DM was found to be a discriminant risk factor favoring CI (v ICH) in women. Conclusion: Our results showed that in Seoul, Korea, HT is the strongest risk factor for CI and ICH, and high sodium intake, lack of exercise, and central body fat deposition are relatively important factors related to stroke, whereas factors such as cigarette smoking, hypercholesterolemia, and body mass index are not. Low consumption of fat and heavy alcohol drinking appear to be related to the occurrence of ICH. Risk factors for stroke may differ among different ethnic groups and guidelines for stroke prevention should be based on a correct understanding of them.     

Six-Month Outcomes from Living Well with Diabetes: A Randomized Trial of a Telephone-Delivered Weight Loss and Physical Activity Intervention to Improve Glycemic Control

Background

Intensive lifestyle intervention trials in type 2 diabetes contribute evidence on what can be achieved under optimal conditions, but are less informative for translation in applied settings.

Purpose

Living Well with Diabetes is a telephone-delivered weight loss intervention designed for real-world delivery.

Methods

This study is a randomized controlled trial of telephone counseling (n?=?151) versus usual care (n?=?151); 6-month primary outcomes of weight, physical activity, HbA1c; secondary diet outcomes; analysis was by adjusted generalized linear models.

Results

Relative to usual care, telephone counseling participants had small but significantly better weight loss [?1.12 % of initial body weight; 95 % confidence interval (CI) ?1.92, ?0.33 %]; physical activity [relative rate (RR)?=?1.30; 95 % CI, 1.08, 1.57]; energy intake reduction (?0.63 MJ/day; 95 % CI, ?1.01, ?0.25); and diet quality (3.72 points; 95 % CI, 1.77, 5.68), with no intervention effect for HbA1c (RR?=?0.99; 95 % CI, 0.96, 1.01).

Conclusions

Results are discussed in light of challenges to intervention delivery.     

A Review of Physical Activity Measures Used Among US Latinos: Guidelines for Developing Culturally Appropriate Measures

Background  As the US population continues to grow and diversify, there is a need for progressive physical activity measurement and cross-cultural research. Studies suggest that US Latinos are among the most sedentary of ethnic groups compared to others; however, study findings may be biased given that some measures may not be culturally sensitive for assessing behaviors that are not characterized as leisure time physical activity. Purpose  The primary objective of this review was to identify and evaluate measures used to quantify physical activity among US Latinos. Methods  A review of the literature was performed and studies examining levels of physical activity among Spanish and English speaking Latinos were documented. This process involved identifying existing guidelines for the purpose of culturally adapting and/or translating (into Spanish) physical activity measures for the Latino population. These guidelines were used as the minimal criteria for the evaluation of the 13 identified measures of physical activity. Results  Of these 13 measures, four were available in English and nine were available in Spanish. One English measure met the guidelines for being culturally adapted for assessing physical activity among Latinos. There were no Spanish measures that met all the guidelines for physical activity assessment among Spanish-speaking Latinos. Lastly, the identified guidelines for developing culturally appropriate measures were improved to advance physical activity measurement among ethnic and cultural groups. Conclusion  Future research should merit the use of culturally appropriate guidelines to increase the understanding of physical activity patterns in the USA. Electronic supplementary material  The online version of this article (doi:) contains supplementary material, which is available to authorized users.     

A Systematic Review of Randomized Controlled Trials on the Effectiveness of Computer-Tailored Physical Activity and Dietary Behavior Promotion Programs: an Update

Background

A review update is necessary to document evidence regarding the effectiveness of computer-tailored physical activity and nutrition education.

Purpose

The purpose of this study was to summarize the latest evidence on the effectiveness of computer-tailored physical activity and nutrition education, and to compare the results to the 2006 review.

Methods

Databases were searched for randomized controlled trials evaluating computer-tailored physical activity and nutrition education aimed at primary prevention in adults, published from September 2004 through June 2011.

Results

Compared to the findings in 2006, a larger proportion of studies found positive effects for computer-tailored programs compared to generic or no information, including those for physical activity promotion. Effect sizes were small and generally at short- or medium-term follow-up.

Conclusions

The results of the 2006 review were confirmed and reinforced. Future interventions should focus on establishing larger effect sizes and sustained effects and include more generic health education control groups and objective measurements of dietary behavior.     

Impact of a Community-Based Frailty Intervention Among Middle-Aged and Older Prefrail and Frail Homeless Women: A Pilot Randomized Controlled Trial

Interventions are needed to address frailty and other behaviors (e.g., drug and alcohol use) among prefrail and frail homeless women (P/FHW). The purpose of this pilot randomized controlled trial (RCT) was to compare the efficacy of a Frailty Intervention (FI) versus a Health Promotion (HP) program among P/FHW (N?=?32). Structured instruments assessed sociodemographics, individual, situational, health-related, and behavioral factors. While program differences were not statistically significant with the main outcome variables, medium-to-large effect sizes were found in favor of the HP program as it relates to physical and overall frailty, as well as, any drug use, alcohol use, and drug dependency. Based on these findings, it is critical to strengthen the HP program to optimize all domains of frailty (e.g., physical, psychological, and social) and substance use for P/FHW.