乙双吗啉、乙亚胺治疗银屑病诱发急性白血病16例报告

乙双吗啉、乙亚胺治疗银屑病诱发急性白血病１６例报告楼金星，杨科，秦似龙，肖丽华，戴光熙，李静华，沈鹏，张泓，张伟华，李殿青，刘伟，曹春，贺才标，宋爱民，李治中，王克强，刘汉棠，陈振华，孙丽敏近年来选用乙双吗啉、乙亚胺治疗银屑病而致白血病屡有报道。虽然...     

超巨大胸腔内肿瘤1例报告

患者女，56岁，因胸闷憋喘3年，加重2周于2005年1月30日入院，查体：一般情况差，颜面部肿胀，颈静脉怒张，胸廓不对称，左侧饱满，语颤消失，叩诊实音，呼吸音不能闻及，右侧语颜减弱，呼吸音低，双下肢肿胀。心电监测示心率120次/分左右，呼吸30次/分，SaO2 74%，胸部CT可见左侧胸腔内巨大软组织阴影，不仅占满整个左侧胸腔，纵隔，并且累及右侧胸腔，纵隔内血管，心脏明显右移，右肺被压缩。     

卵巢平滑肌瘤1例

患者，女性，１９岁，未婚，学生。近两年月经紊乱，经量减少，周期４０～６０天，末次月经１９９７年６月１３日，因停经３个月来院求诊，门诊拟卵巢畸胎瘤于１９９７年９月９日收入院治疗，患者以往体健，月经规则，量中。查体：一般情况好，Ｔ：３６．５℃，Ｐ：８０次／分，Ｒ：２０次／分。ＢＰ：１２／８ｋＰａ，心肺（－），肝脾（－），腹平软，于耻骨联合上方可触及拳头大小肿块，质硬，表面高低不平，活动欠佳，无压痛。肛检：子宫前位，偏小，狭长形，质地中等，活动度好，无压痛，子宫后方可触及一拳头大小肿块、性质与腹部触诊…     

脾脏原发性恶性淋巴瘤一例

1 病例报告 患者妇女．25岁，1999年10月体检时发现脾脏占位性病变，逐渐增大，于2000年4月17日入院治疗，无发热，消瘦，腹胀等不适症状，体检：腹部平软，无压痛，未及腹块，肝脾肋下未及，肝肾区叩痛（一），全身浅表淋巴结无肿大，B超未脾区，边界尚清，后腹膜未见异常密度块影，提示脾脏占位病变，     

巨大先天性多囊肾一例

患者，男性，34岁，因头痛、头晕4年，血尿20天，发热10天入我院。查体：双肾明显增大，左肾内侧超过中线，下极达骼峡水平，表面不光滑，硬，有压痛。手术所见：左肾巨大，囊状。逐行左肾肿块切除术。病理检查：巨大囊状肿物一个，体积34cmX21cmXllcm，表面灰黄灰红，多囊泡状，质中等，重4400克，有包膜。切面：多囊状，囊大小不一，内含陈旧性出血液及血凝块，部分是淡黄色液体，囊之间为纤维结缔组织。镜下见多个囊腔，囊大小不一，囊内有出血，囊肿壁由薄层纤维结缔组织构成，内村扁平上皮，部分立方上皮，肾组织萎缩，未见肾小球。诊…     

国产重组人白介素-1 1衍生物Ⅰ期耐受性及临床疗效观察

目的：观察肿瘤患者对重组人白介素-11衍生物的耐受性，不良反应的表现与剂量的关系。确定向Ⅱ期临床研究推荐的剂量，并初步观察临床疗效。方法：rhIL-11剂量分7级，由初始剂量10μg/kg开始逐级增加，每剂量水平3例共12例（16例次），rhIL-11衍生物每1mg加入1ml生理盐水，皮下注射，连续给药10天。结果：患者的主要不良反应为肌肉关节疼痛，乏力，发热，四肢颜面部水肿，头痛，睾丸触痛，心慌，球结膜充血，皮肤瘙痒，头晕，头眠要不良反应为肌肉关节疼痛，乏力，发热，四肢颜面部水肿，头痛，睾丸触痛，心慌，球结膜充血，皮肤瘙痒，头晕，失眠等，7例血小板降低的患者治疗后血小板恢复正常，总有效率100%。结论：肌肉关节疼痛，乏力为主要的剂量限制性生物对化疗所致的血小板降低有效。     

双侧卵巢畸胎瘤切除术人工再造卵巢成功1例

患者，女，23岁，未婚，因发现下腹部包块8个月，迅速增大1个月，于1994年8月1日妇检及门诊盆腔B超检查“卵巢畸胎瘤”收入院。患者近半年月经周期改变，经期延长，即为六＞关天，时有痛经，常有膀眈压迫感，即有尿频尿急症状。体检：T36．SC，P80次／分，Bp12／skPa，发育正常，营养中等，全身浅表淋巴结不大，心肺正常，肝脾未及，下腹部隆起，于平脐处可及一巨大包块，质硬，无明显压痛，移动性浊音阴性。妇检：外阴少许血性分泌物。肛诊：子宫前位，正常大小，于子宫左后方可及一巨大囊实性包块，约为25cmX20cmX18cm，包块上界至平…     

大蒜抑制与逆转实验性胃癌及癌前病变的研究

观察大蒜对甲基硝基亚硝基胍（ＭＮＮＧ）诱发大鼠腺胃胃癌及癌前病变影响，ＭＮＮＧ组，预防组，治疗组分别诱发腺瘤１５例，９例，３例，不典型腺癌１３例，５例，６例，息肉２３例，１６例，１１例，不典型息肉２１例，１７例，７例，微囊２４例，２１例，１７例，不典型微囊１６例，８例，３例，重度不典型增生２３例，１３例，９例，粘膜肉瘤２３例，６例，５例，浸润癌１９例，３例，４例，加用大蒜的预防与治疗组均有显著性差     

同安县肝癌高危人群筛检的应用研究

同安县肝癌高危人群筛检的应用研究薛常镐，钟文玲，陈铁晖，孙昌盛，郑英杰，张作英，陈增春，肖锦榕康天尝，郑君玉，洪作艺，陈晓鹭，张基础，蒋明全，洪金进国内肝癌高发现场的一些研究表明，肝癌高危人群筛检能发现肝癌早期病人，为早期治疗提供机会，是高发现场实现...     

82例晚期肺癌临床治疗体会

８２例晚期肺癌临床治疗体会河南省南阳地区医院肿瘤科徐素梅，梅廷兰，方怡先，张成辉，仝运科，贾文惠，刘青娥，刘玉芝，庄玉林指导柴群立近年来，肺癌的发病率不断上升，而肺癌的起病隐匿，发展快，早期不易诊断，能适应手术的病人只２０％左右。所以，化疗已成为晚期...     

Oncogénétique et psycho-oncologie, une collaboration recommandée...

Résumé: La possibilité depuis 1994, de connaître la probabilité individuelle de développer certains cancers a permis de proposer de nouvelles modalités de prévention, de traitements et contribué au développement actuel de loncogénétique. Une meilleure connaissance des répercussions psychologiques tant pour les patients que pour les apparentés est désormais possible et limplication des psycho-oncologues dans ce cadre de la réalisation des tests prédictifs, recommandée. La mission de «messager» qui incombe au «cas-index» doit faire lobjet dune attention particulière. La complexité de linformation et la dimension paradoxale que peut avoir parfois la communication à propos des choix, rend difficile lévaluation de la qualité du consentement. La situation particulièrement délicate dune aide à la décision à légard de la chirurgie prophylactique, exige une collaboration étroite des généticiens et des psycho-oncologues.Les soins de support en oncologie     

The role of papillomaviruses in human cancers

This review comprehensively evaluates the influence of gene-gene, gene-environment and multiple interactions on the risk of colorectal cancer (CRC). Methods of studying these interactions and their limitations have been discussed herein. There is a need to develop biomarkers of exposure and of risk that are sensitive, specific, present in the pathway of the disease, and that have been clinically tested for routine use. The influence of inherited variation (polymorphism) in several genes has been discussed in this review; however, due to study limitations and confounders, it is difficult to conclude which ones are associated with the highest risk (either individually or in combination with environmental factors) to CRC. The majority of the sporadic cancer is believed to be due to modification of mutation risk by other genetic and/or environmental factors. Micronutrient deficiency may explain the association between low consumption of fruit/vegetables and CRC in human studies. Mitochondrial modulation by dietary factors influences the balance between cell renewal and death critical in colon mucosal homeostasis. Both genetic and epigenetic interactions are intricately dependent on each other, and collectively influence the process of colorectal tumorigenesis. The genetic and environmental interactions present a good prospect and a challenge for prevention strategies for CRC because they support the view that this highly prevalent cancer is preventable.     

Antifungal combination therapy in localized candidosis

A mouse model of localized candidosis in air-filled subcutaneous cysts imitating thrush has been developed. We have now tested various antifungal combinations in this animal model. Flucytosine (5-FC) + amphotericin B (Amph B) showed the highest efficacy, a clear additive or even synergistic effect was seen. The combination of 5-FC + imidazole or triazole derivative was less efficacious, an additive effect was rare. The combination of 5-FC + Amph B was also tested against Candida albicans strains showing various degrees of 5-FC-resistance. A significant reduction in 5-FC-resistant mutants was seen after the treatment with the combination.     

Les génériques en cancérologie: à molécule identique, médicaments identiques? Les biosimilaires, des super-génériques?

Résumé: Les biosimilaires vont bientôt voir leur apparition en Europe. Comment un laboratoire peut-il aborder le développement de son dossier dAMM? Quelles sont les bases légales et les recommandations officielles? Comment la similarité et/ou le caractère générique peuvent-ils être démontrés? Les règles sont-elles identiques à celles des produits chimiques conventionnels pour lesquels, notamment en cancérologie, il existe des médicaments génériques? Comment faire pour que la sécurité et lefficacité des médicaments biosimilaires soient assurées pour les patients?     

Cancer immunotherapy

Unprecedented progress has seen made in the last decade in the field of cancer immunotherapy. The recent approval of nivolumab （Opdivo）, the first anti-programmed cell death-1 （PD-1） antibody, for metastatic melanoma in Japan, marked a milestone in the rapidly advancing field of cancer immunotherapy. Nivolumab together with ipilimumab （Yervoy）, the anti-cytotoxic T-lymphocyte-associated antigen-4 （CTLA-4） antibody, are the first 2 drugs in the class of ＂immune checkpoint inhibitors＂ that have delivered impressive responses in patients with metastatic melanoma and renal cell cancer （RCC） as well as a variety of solid tumors.     

Effect of tumor therapeutic irradiation on the mechanical properties of teeth tissue

Tumor irradiation of the head-neck area is accompanied by the development of a so-called radiation caries in the treated patients. In spite of conservative therapeutic measures, the process results in tooth destruction. The present study investigated the effects of irradiation on the demineralization and remineralization of the dental tissue. For this purpose, retained third molars were prepared and assigned either to a test group, which was exposed to fractional irradiation up to 60 Gy, or to a non-irradiated control group. Irradiated and non-irradiated teeth were then demineralized using acidic hydroxyl-cellulose gel; afterwards the teeth were remineralized using either Bifluorid12 or elmex gelee. The nanoindentation technique was used to measure the mechanical properties, hardness and elasticity, of the teeth in each of the conditions. The values were compared to the non-irradiated control group. Irradiation decreased dramatically the mechanical parameters of enamel and dentine. In nonirradiated teeth, demineralization had nearly the same effects of irradiation on the mechanical properties. In irradiated teeth, the effects of demineralization were negligible in comparison to non-irradiated teeth. Remineralization with Bifluorid12 or elmex gelee led to a partial improvement of the mechanical properties of the teeth. The enamel was more positively affected by remineralization than the dentine.     

Consultation multidisciplinaire pour les patients atteints d’une pathologie tumorale (carcinome infiltrant ou lésion précancéreuse) liée à HPV : la consultation multidisciplinaire papillomavirus

Given the recent increase in the number of human papillomavirus (HPV)-induced cancers in other locations than gynaecological, the number of patients with two cancers at distinct sites, and because of the lack of exhaustive data, we decided to create a multidisciplinary network around an HPV consultation at the Georges-Pompidou European Hospital (HEGP). This network aims to set up the best tools for detecting HPV-associated “multisite” precancerous lesions in order to determine the possible impact of dedicated care for this at-risk population. This monthly consultation was created at the HEGP in June 2014. It is currently organized around five consultations: gynaecological, ENT, urological, digestive and immunological. Every patient who has been diagnosed with HPV-related cancer and whose care is provided at the HEGP is offered this particular follow-up: systematically, once the initial lesion has been treated, the patient is convened annually for a day during which it benefits from the consultations mentioned above. A consultation with a psychologist is systematically proposed. Local samples are taken at each site: a cytological examination, the analysis of known predictive and prognostic virological markers are carried out. This study fits more broadly in a theme of clinical and fundamental research around cancers related to HPV.     

Differentiation state and invasiveness of human breast cancer cell lines

Summary Eighteen breast cancer cell lines were examined for expression of markers of epithelial and fibroblastic differentiation: E-cadherin, desmoplakins, ZO-1, vimentin, keratin and ₁ and ₄ integrins. The cell lines were distributed along a spectrum of differentiation from epithelial to fibroblastic phenotypes. The most well-differentiated, epithelioid cell lines contained proteins characteristic of desmosomal, adherens and tight junctions, were adherent to one another on plastic and in the basement membrane matrix Matrigel and were keratin-positive and vimentin-negative. These cell lines were all weakly invasive in anin vitro chemoinvasion assay. The most poorly-differentiated, fibroblastic cell lines were E-cadherin-, desmoplakin- and ZO-1-negative and formed branching structures in Matrigel. They were vimentin-positive, contained only low levels of keratins and were highly invasive in thein vitro chemoinvasion assay. Of all of the markers analyzed, vimentin expression correlated best within vitro invasive ability and fibroblastic differentiation. In a cell line with unstable expression of vimentin, T47D_CO, the cells that were invasive were of the fibroblastic type. The differentiation markers described here may be useful for analysis of clinical specimens and could potentially provide a more precise measure of differentiation grade yielding more power for predicting prognosis.