Clinical observation of senile idiopathic nephrotic syndrome treated with integrated traditional chinese and western medicine

Ｓｅｎｉｌｅｉｄｉｏｐａｔｈｉｃｎｅｐｈｒｏｔｉｃｓｙｎｄｒｏｍｅ（ＳＩＮＳ）ｉｓａｄｉｓｅａｓｅｄｉｆｆｉｃｕｌｔｔｏｔｒｅａｔ,ｍｏｒｅｃｏｍｐｌｉｃａｔｅｄａｎｄｐｏｏｒｉｎｐｒｏｇｎｏｓｉｓ．ＦｒｏｍＪａｎｕａｒｙ 1985ｔｏＳｅｐｔｅｍｂｅｒ 1998,ｔｒｅａｔｍｅｎｔｗｉｔｈｉｎｔｅｇｒａｔｅｄｔｒａｄｉｔｉｏｎａｌＣｈｉｎｅｓｅａｎｄｗｅｓｔｅｒｎｍｅｄｉｃｉｎｅ（ＴＣＭ ＷＭ）ｗａｓｕｓｅｄｂｙｔｈｅａｕ ｔｈｏｒｓｔｏｔｒｅａｔ 4 1ｃａｓｅｓｏｆＳＩＮＳｗｉｔｈｓａｔｉｓｆａｃｔｏｒｙ…     

成人原发性肾病综合征中西医结合治疗探讨

目的 :探讨成人原发性肾病综合征 (PNS)中西医结合治疗的方法及效果。方法 :将 64例PNS病人随机分为两组。西医组 3 2例 ,主要用激素治疗 ;中西医结合组 3 2例 ,在西医治疗基础上加用中药治疗。结果 :中西医结合组总有效率 87 5 % ,显著高于西医组的 5 6 3 % (P <0 0 5 )。中西医结合组不良反应发生率及复发率分别为 15 6%和 2 1 9% ,明显低于西医组的 5 9 4%和 5 6 3 % (P <0 0 1)。结论 :中西医结合治疗PNS在增加疗效、减少不良反应及降低复发率方面均明显优于单纯西医组     

中西医结合治疗慢性盆腔炎的疗效分析

目的:研究中西医结合方法治疗慢性盆腔炎的临床疗效.方法:慢性盆腔炎患者共306例,随机分为两组,中西医结合治疗组及单纯西医治疗组,各153例.中西医结合治疗组采用经期抗炎及经间期中药治疗;单纯西医治疗组采用经期抗炎,比较两组患者经治疗后其临床疗效.结果:慢性盆腔炎患者其中西医结合治疗组(治疗组)的临床疗效明显高于西医治疗组(对照组),差异有显著性(P＜0.05).结论:中西医结合治疗慢性盆腔炎的疗效明显高于单纯西医治疗.     

Clinical study on treatment of incipient diabetic nephropathy by integrated traditional Chinese and Western medicine

Ｄｉａｂｅｔｉｃｎｅｐｈｒｏｐａｔｈｙ（ＤＮ）ｉｓｏｎｅｏｆｔｈｅｃｈｉｅｆｃｈｒｏｎｉｃｃｏｍｐｌｉｃａｔｉｏｎｓｏｆｄｉａｂｅｔｅｓｍｅｌｌｉｔｕｓ（ＤＭ）．Ｉｔｉｓｎａｍｅｄａｓｉｎｃｉｐｉｅｎｔｄｉａｂｅｔｉｃｎｅ ｐｈｒｏｐａｔｈｙｗｈｅｎｔｈｅａｌｂｕｍｉｎｅｘｃｒｅｔｉｏｎｒａｔｅ（ＡＥＲ）ｉｓｂｅｔｗｅｅｎ 30 - 30 0ｍｇ 2 4ｈｒｓｕｒｉａａｎｄｄｉａｇｎｏｓｅｄａｓｍｉｃｒｏａｌｂｕｍｉｎｕｒｉａ（1）,ｔｈｅｐｒｏ ｇｒｅｓｓｉｏｎｏｆｄｉｓｅａｓｅｍｉｇｈｔｂｅｒｅｔａｒｄｅｄ…     

Clinical Evaluation of Integrative Chinese and Western Medicine in Treating SARS

Objective:To evaluate the effective treatment with integrative Chinese and western medi-cine(ICWM)of severe acute respiratory syndrome(SARS).Methods:The 65 cases of SARS patientswere treated with ICWM and 37 cases with western medicine(WM)alone as the control in our hospitalfrom March 11 to April 30,2003.The results were analyzed,with T subset profile tested for all the 102patients.Results:Sixty-five cases of SARS patients treated with ICWM included 52 mild cases of whom 51cases were cured(98.1％)and no patient died.As to the 13 severe cases in this group,9 were cured(69.2％)and 2 died(15.4％).Of the 37 cases treated with WM alone,16 out of the 18 common cases werecured(88.9％)and 10 out of the 19 severe cases were cured(52.6％),with the other 9 died(47.4％).Comparison between the two groups(P=0.061)showed the difference was close to the value for statisti-cal significance.But considering that the number of samples was small,more cases are needed fot furtherstudy.The immune function examination:in cases     

中西医结合治疗缺血性脑卒中的成本效益分析

Objective:To evaluate the cost-effectiveness of combining Chinese medicine(CM)with Western medicine(WM)for ischemic stroke patients.Methods:Hospitalization summary reports between 2006 and 2010from eight hospitals in Beijing were used to analyze the length of stay(LOS),cost per stay(CPS),and outcomes at discharge.Results:Among 12,009 patients(female,36.44%;mean age,69.98±13.06 years old),a substantial number of patients were treated by the WM_Chinese patent medicine(CPM)_Chinese herbal medicine(CHM)(38.90%);followed by the WM_CPM(32.55%),the WM(24.26%),and the WM_CHM(4.15%).With adjustment for confounding variables,LOS of the WM_CPM_CHM group was about 10 days longer than that of the WM group,and about 6 days longer than that of the WM_CPM group or the WM_CHM group(P0.01);CPS of the WM_CPM_CHM group was United States dollar(USD)1,288 more than that of the WM group,and about USD600 more than that of the WM_CPM group or the WM_CHM group(P0.01).Compared with the WM group,odd ratio(OR)of recovered and improved outcome of the WM_CPM_CHM group was the highest[OR:12.76,95%confidence intervals(CI):9.23,17.64,P0.01],OR of death outcome of the WM_CPM_CHM group was the lowest(OR:0.08,95%CI:0.05,0.12,P0.01).There was no significant difference between LOS,CPS and OR of the WM_CPM group and those of the WM_CHM group(P0.05).Cost/effectiveness and incremental costeffectiveness ratio of the WM_CPM_CHM group were robustly higher than those of the WM group.Conclusion:Compared with WM alone,supplementing CPM and CHM to WM provides significant health benefits of improving the chance of recovered and improved outcome,and reducing the death rate,at an expense of longer LOS and higher CPS.     

咳喘脐贴治疗咳嗽变异性哮喘31例

目的观察咳喘脐贴治疗咳嗽变异性哮喘(CVA)的疗效。方法61例CVA患儿随机分为治疗组31例,对照组30例,均口服博利康尼片每次0.1 mg.kg-1,每日3次;酮替芬片<3岁者每次0.5 mg,每日2次口服,≥3岁者每次1 mg,每日2次口服,疗程2周;治疗组另加咳喘脐贴敷神阙穴,每日1贴,7 d为1个疗程,用1~2疗程。结果治疗组显效22例(70.97%),对照组显效13例(43.33%),两组显效率有显著性差异(P<0.01)。咳嗽平均消失时间治疗组为6.32±3.50 d,对照组为10.90±7.19 d,两组比较有显著性差异(P<0.01)。结论咳喘脐贴治疗CVA止咳时间明显缩短,疗效显著。     

对冲性重型颅脑损伤双侧去骨瓣减压疗效分析

目的:探讨双侧去骨瓣减压开颅术治疗双侧对冲性重型颅脑损伤(DHSCI)的治疗效果.方法:将52例DHSCI患者随机分为治疗组和对照组,每组26例.治疗组给予双侧去骨瓣减压开颅术治疗,对照组给予标准单侧外伤大骨瓣减压窗手术治疗.观察两组急性脑膨出和切口疝发生情况,记录术后1,3,5d颅内压情况,术后随访3个月评价临床疗效.结果:治疗组急性脑膨出和切口疝发生率分别为15.4％(4/26)和26.9％(7/26),均显著低于对照组的57.7％(15/26)和61.5％(16/26),两组比较差异有统计学意义(P＜0.01);治疗组术后1,3,5d颅内压[(21.54±3.15),(17.43±2.93),(15.92±2.91) mmHg均分别显著低于对照组[(30.20±4.16),(29.73±4.06),(24.10±3.01) mmHg](均为P＜0.05);治疗组临床治疗有效率为50.0％(13/26),显著高于对照组的23.1％(6/26)(P＜0.05);治疗组病死率为19.2％(5/26),显著低于对照组的42.3％(11/26)(P＜0.05).结论:双侧去骨瓣减压开颅术治疗DHSCI疗效明显优于标准单侧外伤骨瓣减压窗手术,可以减少急性脑膨出和切口疝的发生,患者预后良好.     

Study on Treatment of Polycystic Ovarian Syndrome with Infertility by Combined Therapy of Chinese Herbal Medicine and Compound Cyproterone Acetate

Objective: To evaluate the effect of combined therapy of Chinese herbal medicine and compound cyproterone acetate (CPA) in treating non-obesity polycystic ovarian syndrome (PCOS) and to explore its mechanism in improving withdrawal ovulation. Methods: Eighty-six patients of non-obesity P-COS, typed as Shen-deficiency with blood stasis Syndrome or Shen-deficiency with Phlegm-Dampness Syndrome by Syndrome Differentiation in traditional Chines medicine, were randomly divided into three groups: (1) The TCM group (n = 26) was treated with Chinese drugs for 6 menstrual cycles; (2) The western medicine (WM) group (n=30) was treated with 1 tablet of CPA for 21 days, with the treatment beginning from the 5th day of menstruation. The treatment was given for 3 menstrual cycles by repetitious medication, which stopped and restarted on the 5th day of withdrawal bleeding. Then the ovulation promoting therapy was applied by using clomifene citrate and human chorionic gonadotropin (CC/hCG) for 3 menstrual cycles; (3) T     

恶性肿瘤化疗患者血小板参数的实验观察

目的:探讨恶性肿瘤化疗患者血小板参数的变化及临床意义。方法:使用血细胞分析仪测定115例术后恶性肿瘤化疗患者和46例术后非化疗患者的血小板参数,并与正常对照组比较。结果:恶性肿瘤化疗患者的平均血小板体积MPV、血小板体积分布宽度PDW和大血小板比值P-LCR均明显低于正常对照组MPV:8.37±0.77fl对8.70±0.67fl,P<0.05;PDW:9.622±1.47fl对10.27±1.29fl,P<0.01;P-LCR:0.157±0.05对0.176±0.04,P<0.05,血小板(Plt)明显高于正常对照组,249.86±92.23×109/L对219.95.00±52.62×109/L,P<0.05,与非化疗患者比较明显降低(P<0.05),血小板无差异(P>0.05);非化疗患者MPV、PDW和P-LCR较正常对照组均无显著性差异P>0.05;Plt明显高于正常对照组(P<0.05);血小板数>300×109/L的化疗患者的MPV、PDW和P-LCR与血小板数<300×109/L的化疗患者比较均明显降低(P<0.01)。结论:恶性肿瘤化疗患者血小板参数的测定对观察其骨髓抑制状况和病情估计有一定的临床意义。     

尿激酶角膜接触镜辅助羊膜移植治疗严重角膜烧伤的临床研究

目的:探讨尿激酶和角膜接触镜对急性期严重角膜烧伤羊膜重建的临床治疗可行性和疗效.方法:对63例(65眼)严重角膜烧伤的患者,随机对其中33眼作为治疗组,采用尿激酶(0.5 ml,3 000 U)球结膜下注射,每日1次,连续7-10 d,择机羊膜移植术并配戴软型角膜接触镜,共10-15 d,其余32眼作为对照组,羊膜眼表...     

Therapeutic Effect of Integrative Traditional Chinese and Western Medicine on 51 SARS Patients and Its Influence on Their TLymphocyte Subsets

Severeacuterespiratorysyndrome(SARS)isanewlyariseninfectiousdiseasewithrespiratorytractasthechiefpathwayoftransmission.Thisisespecial lytrueforSARSpatientsofseveretypeduetoitsse riouscondition,whichresultsinhighmortalityandgreatdifficultiesinitstreatment.InordertoexploretheeffectivewaysintreatmentofSARS,clinicalstudiesontreatmentofSARSbyintegrativeChineseandwesternmedicine(ICWM)havebeencarriedoutbytheauthorsandthepreliminarysummaryisre portedasfollows.METHODSClinicalMaterials　　 T…     

Clinical study of sudden deafness treated with integrated traditional Chinese and Western medicine

Objective: To explore the mechanisms of integrated traditional Chinese and western medicine (TCM-WM) in treating sudden deafness.Methods: One hundred and forty-six patients suffered from sudden deafness were divided into two groups, 64 cases in the treated group were treated with TCM-WM therapy and the other 82 cases treated with western medicine alone for control.Results: The total effective rate of the treated group was 92.19%, that of the control group was 75.61%. The difference between the two groups was significant,P < 0.01.Conclusion: The TCM-WM therapy is very effective in treating sudden deafness. Its mechanism might be: (1) Decrease of the blood viscosity and increase of the red blood cell’s tenacity, so that the blood stream could pass through unimpededly. (2) Decrease of the plasma TXA₂ level and increase of the PGI₂ level, to benefit the blood supply for inner ear. (3) Increase of the activity of SOD and clearing away the free radicals so as to reduce the damage to the inner ear.     

更昔洛韦治疗小儿咽-结合膜热的临床研究

目的 :探讨更昔洛韦治疗小儿咽 结合膜热疗效。方法 :将 12 0例咽 结合膜热随机分为两组 ,更昔洛韦组、病毒唑组各 6 0例。更昔洛韦组给予更昔洛韦 10mg·kg·d- 1 静滴 ,每日 1次治疗 ;病毒唑组给予病毒唑 10mg·kg- 1 ·d- 1 静滴 ,每日 1次治疗。两组均计数发热天数及结合膜炎治愈天数 ,同时观察药物的毒副作用。结果 :更昔洛韦组平均发热天数为 (2 .0 2± 0 .4 2 )d ,明显少于病毒唑组 (4 .87± 0 .38)d(P <0 .0 1)。眼结合膜炎持续时间 ,更昔洛韦组为 (3.4 5± 0 .76 )d ,明显少于病毒唑组 (5 .74± 0 .82 )d(P <0 .0 1)。两组药物治疗过程中仅少数病人表现轻度恶心、呕吐等副作用 ,停药后症状缓解。结论 :更昔洛韦治疗咽 结合膜热疗效显著 ,明显优于病毒唑。     

中西医结合治疗早期2型糖尿病肾病的临床观察

目的探讨中西医结合治疗早期2型糖尿病肾病的疗效。方法62例患者按随机原则分为两组，治疗组在采用西药有效控制血糖水平的基础上加用具有益气养阴、活血化瘀功效的中药参芪益肾汤治疗；对照组则采用单纯西药治疗，两组均治疗3个月，并同时观察两组治疗前后症状，体征及实验室相关指标。结果总有效率治疗组为87．5％，对照组为60％，两组比较有显著性差异（P〈0．05）。24h尿白蛋白排泄率，血糖，血脂等指标治疗组治疗后均较治疗前有显著改善（P〈0．05或P〈0．01）。结论中西医结合治疗早期2型糖尿病肾病疗效明显优于单纯西药治疗。     

Clinical Study on Long-Term Treatment of Ankylosing Spondylitis with Integrative Medicine

Ａｎｋｙｌｏｓｉｎｇｓｐｏｎｄｙｌｉｔｉｓ（ＡＳ）ｉｓａｒｈｅｕｍａｔｉｃｄｉｓｅａｓｅｗｉｔｈｈｉｇｈｉｎｃｉｄｅｎｃｅ，ｉｎｄｕｃ ｉｎｇｄｉｓａｂｉｌｉｔｙａｎｄｉｎｖａｄｉｎｇｔｈｅｓｐｉｎａｌａｘｉａｌｊｏｉｎｔａｓｉｔｓｃｈｉｅｆｃｈａｒａｃｔ     

大承气汤加味治疗粘连性肠梗阻疗效观察

目的:观察大承气汤加味在肠梗阻治疗中的疗效。方法:将94例肠梗阻患者分治疗组51例,对照组43例。对照组予西医保守治疗;治疗组在西医治疗基础上予大承气汤加味胃管注入。结果:治疗组总有效率及痊愈率分别为90.2%和68.6%,明显高于对照组的74.4%和41.9%(P<0.05及P<0.01);无效转手术率治疗组明显低于对照组(9.8%vs 25.6%,P<0.01);肛门排气时间治疗组明显短于对照组(40.04±10.72)h vs(53.39±8.08)h,P<0.01;住院时间治疗组明显短于对照组(7.14±1.51)天v(s9.37±1.99)天,P<0.01;治疗72h后,外周血C-反应蛋白(CRP)治疗组明显低于对照组(P<0.01),白细胞计数(WBC)两组无差异(P>0.05)。结论:承气汤加味灌胃结合西医保守治疗在肠梗阻治疗中疗效显著,值得临床推广应用。     

慢性肝炎及肝硬化患者血钙浓度的分析

目的:观察慢性肝炎与肝硬化患者血钙浓度变化,以及肝硬化Child-pugh分级与血钙浓度关系。方法:对190例慢性肝炎及肝硬化患者做血钙浓度测定,同时设正常对照组90例。结果:在本组研究中,正常对照组、慢性肝炎组血钙浓度均值相近(P>0.05),肝硬化组血钙浓度均值(1.94±0.22)mmol/L明显低于肝炎组。血钙浓度<2.03mmol/L者,慢性肝炎组30.4%,肝硬化组73.5%,两组比较有显著性差异(P<0.01)。随着Child-pugh积分的增高,肝硬化程度加重,血钙浓度逐渐降低,A、B、C级之间比较有显著性差异(P<0.01)。结论:血钙浓度可作为判断肝炎与肝硬化肝功能减退的重要指标。     

温阳通络方对硬皮病成纤维细胞Ⅰ、Ⅲ型胶原及MMP-1mRNA的影响

目的：观察温阳通络方对系统性硬皮病（SSc）患者皮肤成纤维细胞Ⅰ、Ⅲ型胶原mRNA及MMP-1mRNA的影响。方法：12例SSc患者分成SSc对照组（初诊未治疗者）、西药组、中药组和中西药联合组,每组3例。除对照组外,其他三组分别给予青霉胺和强的松、温阳通络方煎剂、青霉胺和强的松加温阳通络方煎剂口服,疗程2个月。SSc对照组在治疗前取血分离血清备用;西药组、中药组和中西药联合组治疗2个月后取血分离血清。另取正常及SSc患者皮肤进行成纤维细胞原代培养并以上述血清处理,正常对照组不予处理,然后提取总RNA,以设计的引物逆转录生成cDNA,然后PCR扩增、凝胶电泳后图像分析Ⅰ、Ⅲ型胶原及MMP-1mRNA表达。结果：与正常皮肤比较,SSc皮肤成纤维细胞Ⅰ、Ⅲ型胶原及MMP-1mRNA表达量明显增多（P〈0.01）;与SSc对照组比较,20%含药血清处理后各组Ⅰ、Ⅲ型胶原mRNA表达量明显减少（P均〈0.01）;中药组Ⅰ、Ⅲ型胶原mRNA表达量显著高于西药组和中西药组（P均〈0.01）,中西药组显著低于西药组（P〈0.01）;各组间SSc皮肤成纤维细胞MMP-1mRNA表达量差异无统计学意义（P〉0.05）。结论：SSc患者皮肤成纤维细胞胶原合成量增加,温阳通络方在一定程度上干扰SSc患者皮肤成纤维细胞I、III型胶原mRNA表达,而对MMP-1干预作用不明显。     

培哚普利对慢性稳定型冠心病合并舒张功能不全患者的影响

目的探讨培哚普利(雅施达)对慢性稳定型冠心病合并舒张功能不全患者的临床影响。方法将106例患有慢性稳定型冠心病合并舒张功能不全患者,随机分成治疗组(52例)和对照组(54例)。2组患者均给于冠心病常规治疗,其中治疗组患者加用培哚普利4～8mg/d,疗程6月。疗程结束后,采用运动平板试验和彩色多普勒心脏超声,评价患者的临床症状与左心室舒张功能指标的改善情况。结果治疗组总有效率优于对照组(69.4%比52.9%,P<0.01);治疗组治疗后运动耐量增加[(6.3±2.4)met和(9.5±1.8)met,P<0.01)];左心室舒张功能指标除LVPW、LVEF外均有改善(P<0.05～0.01),而对照组在治疗前后无明显差异(P>0.05),左室舒张功能指标除AcTe、DcTe、IRT有改善外(P<0.05),其余均无显著改善(P>0.05)。结论培哚普利能减少慢性稳定型冠心病患者的缺血症状,增加其运动耐量,纠正左心室舒张功能不全,从而改善其预后。