Clinical effect and action mechanism of Weicao Capsule (威草胶囊) in treating gout

Objective： To study the therapeutic effect of Weicao Capsule （威草胶囊, WCC） on gout. Methods： Two hundred gout patients were assigned to two groups. The treated group was treated with WCC and the control group was treated with Tongfengding Capsule （痛风定胶囊）. Both groups were given the respective treatments orally 3 times a day, 2 capsules each time with 2 weeks as one course and all patients received 2 successive courses of treatment. Changes of blood β2- microglobulin （13 2-M）, hemoglobin （Hb）, 24 h urinary protein （24 h UP）, pH value of urine and blood uric acid （BUA） as well as kidney function were observed. Results： After treatment, level of β 2-M got lowered significantly, Hb and 24 h UP, blood urea nitrogen, serum creatinine and the clearance rate of creatinine, as well as blood lipids all improved obviously in the treated group （all P〈0.01）, while these parameters remained unchanged in the control group （P〉0.05）. The pH value of urine was improved in both groups showing an insignificant difference between them （P〉0.05）. BUA was decreased in both groups with a decrease to a larger extent in the treated group （P〈0.01）. The total effective rate was 87% in the treated group, which was superior to that in the control group （62%, P〈0.05）. Conclusion： WCC has a favorable therapeutic effect on gout and its mechanism of action for improving renal function and reducing urinary protein could be related with the lowering of blood β 2-M, BUA and lipids.     

Clinical observation on the efficacy of Xiaoshui decoction (消水方) combined with intrapleural perfusion of cisplatin in treating malignant pleural effusion

Objective： To observe the clinical efficacy of Xiaoshui decoction （XSD,消水方） combined with intrapleural perfusion of cisplatin in the treatment of malignant pleural effusion. Methods： Fifty-one patients with malignant pleural effusion were randomly assigned to two groups. The treated group patients） received oral administration of XSD combined with intrapleural perfusion of cisplatin, and control group （25 patients） was only treated with intrapleural perfusion of cisplatin. The effects of 26 he he short-term efficacy, quality of life scores and clinical symptom scores of malignant pleural effusion were evaluated. Results： The short-term efficacy in the treated group and the control group was 72.0% and 58.3%, respectively, and no significant difference was found （P〉0.05）. In contrast, the quality of life in the treated group was significantly improved compared to that of the control group （P〈0.05）, and so was the symptom remission （P〈0.05）. Conclusions： The combined therapy of XSD and intrapleural perfusion of cisplatin did not show obvious improvement in short-term efficacy, but the therapy remarkably alleviated the symptoms and improved the quality of life of patients.     

The effect of low dose aspirin on the platelet function in patients with acute myocardial infarction (AMI).

To assess the optimal dose of aspirin (ASA) in the treatment of AMI, 60 cases of AMI: 1. admitted within 24 hours after onset of illness, 2. ASA not used within one week before, 3. any other drugs influencing the platelet function also not used during the course of study, were randomized into two groups, 30 cases each: one with conventional therapy as control, the other combined with daily oral ASA 100mg. They were matched in sex, age, infarct site and coexistent conditions (hypertension, diabetes mellitus, hyperlipemia, smoking etc.). The second group was further divided into subgroup I with serum peak CK<1000 U/L and subgroup Ⅱ with serum peak CK>1000 U/L. The parameters of platelet function including plasma TXB_2/6-keto-PGF_(1α), platelet aggregation induced by 5-HT and epinephrine were studied on different days for 3 weeks. Twenty healthy persons were selected for normal value of platelet function.     

Clinical study on effect of Kang’aibao oral liquid in treating 103 patients of malignant tumor) in treating 103 patients of malignant tumor

Objective: To observe the clinical efficacy of Kang’aibao oral liquid (KABL), a Chinese herbal preparation in treating malignant tumor of middle or advanced stage.Methods: A comparative study was done by observing the effect of 103 patients treated with KABL, and another 90 patients treated with chemotherapy at the same time were taken as the control group.Results: The immunologic function, short-term effective rate (complete relieved rate and partial relieved rate), survival quality, 1-, 2- and 3-year survival rate, median survival time, and carcinoembryonic antigen (CEA) declining rate of the KABL group were significantly higher than those of the control group.Conclusion: KABL has the effects of inhibiting tumor growth, prolonging survival time and improving survival quality of tumor patients.     

Clinical study of shengxue mixture (生血合剂) in treating aplastic anemia

Ａｐｌａｓｔｉｃａｎｅｍｉａ（ＡＡ）ｉｓａｃｏｍｍｏｎｄｉｓ ｅａｓｅｏｆｂｌｏｏｄｓｙｓｔｅｍｔｈａｔｉｓｃｈａｒａｃｔｅｒｉｚｅｄｂｙｐａｎｃｙｔｏｐｅｎｉａｄｕｅｔｏｈｅｍａｔｏｐｏｉｅｔｉｃｄｉｓｏｒｄｅｒ．ＡｎｄｒｏｇｅｎｈａｓｂｅｅｎｔｈｅｍａｉｎｔｈｅｒａｐｙｔｏｔｒｅａｔＡＡ,ｂｕｔｉｔｓａｐｐｌｉｃａｔｉｏｎｗａｓｌｉｍｉｔｅｄｂｅｃａｕｓｅｏｆｉｔｓｔｏｘｉｃｉｔｙａｎｄｓｉｄｅ ｅｆｆｅｃｔｓｕｃｈａｓｌｉｖｅｒｆｕｎｃ ｔｉｏｎｄａｍａｇｅ．Ｗｅｔｒｅａｔｅｄ 84ｐａｔｉｅｎ…     

Clinical study on effect of Astragalus Injection (黄芪注射液) and its immuno-regulation action in treating chronic aplastic anemia

Objective:To observe the clinical effect of Astragalus Injection(黄芪注射液,AI) and its immuno-regulatory action in treating chronic aplastic anemia(CAA).Methods:Sixty patients with CAA were randomly assigned to two groups equally,both were treated with Stanozolol three times a day,2 mg each time through oral intake,but AI was given additionally to the patients in the treated group once a day via intravenous dripping.All were treated for 15 days as one therapeutic course and the whole medication lasted for more than 4 months totally,with follow-up adopted.The clinical effi cacy was estimated and the changes of T-lymphocyte subsets in peripheral blood as well as the serum levels of tumor necrosis factor-α(TNF-α) and interleukin-2(IL-2) were observed.Results:The total effective rate in the treated group was 83.3%(25/30),which was higher than that in the control group 66.7%(20/30),showing significant difference between them(P<0.05).Levels of hemoglobin,WBC,reticular cell and platelet were elevated in both groups after treatment,but the improvement was signif icantly better in the treated group than that in the control group with respect to the former three indexes(P<0.05).The level of CD4 increased and that of CD8 decreased signifi cantly after treatment in the treated group(P<0.05),which showed significant difference as compared with those in the control group(P<0.05).Levels of serum TNF-α and IL-2 lowered after treatment in both groups,but signifi cance only showed in the treated group(P<0.05).The degree of proliferation in bone marrow got raised signifi cantly and the percentage of non-hemopoietic cells reduced signifi cantly in the treated group after treatment,also showing significant difference to those in the control group(P<0.05).Conclusion:AI could promote the recovery of hemopoietic function,which might be through improving T-lymphocyte subsets and reducing the release of negative regulatory factors such as TNF-α and IL-2 to alleviate the inhibition on hemopoietic function.     

Neoadjuvant chemoradiotherapy combined with TME in treatment for locally advanced low rectal cancer (LALRC)

Neoadjuvant chemoradiotherapy combined with TME in treatment for locally advanced low rectal cancer (LALRC)@郁宝铭$Dept Surg,Ruijin Hosp,Shanghai 2nd Med Univ,Shanghai 200025     

Protective effect of panaxatriol on function of hypothalamus-pituitary-testes system in rats irradiated with large dose of X-rays

<正> The present study observed the protective effect of panaxatriol on the function of hy-pothalamus - pituitary - testes system after whole body irradiation with 5 Gy X -rays in male rats. The rats were given panaxatriol intraperitoneally once a day (5mg/day) for 14 days beginning from 24 h before the irradiation. The results showed that hypothalamic L-Enk (P<0. 01) and pituitary (3 - EP(P<0. 05) and testicular cAMP (P<0. 01) contents and serum testosterone level (P<0. 01) were all decreased significantly,while serum FSH level (P<0. 01) increased significantly in single irradiation groups compared with the normal control. However, the above - mentioned indices all approached to the normal control levels in irradiation plus panaxatriol groups. These suggest thhat panaxatriol may weaken the decrement of hypothalamic and pituitary opioid peptide contents, testicular cAMP content and serum TS level and the increment of serum FSH level after the rats being irradiated, and that panaxatriol may have protective fu     

Clinical efficacy and safety of Gubitong Recipe (骨痹通方) in treating osteoarthritis of knee joint

Objective:To observe the therapeutic efficacy and safety of Gubitong Recipe(骨痹通方,GBT) in treating osteoarthritis(OA) of knee joint.Methods:Ninety patients with knee osteoarthritis were equally assigned, according to a randomizing digital table,to the treatment group and the control group.The treatment group was treated with GBT Decoction one dose every day and the control group with glucosamine sulfate 500 mg thrice a day,respectively,for eight successive weeks.Besides,diclofenac sodium could be given as...     

Study on clinical effect and mechanism of Jianpi Qingre Huayu Recipe (健脾清热化瘀方) in treating patients with gastric ulcer

Objective： To study the effects of Jianpi Qingre Huayu Recipe （健脾清热化瘀方, JQH） in curing gastric ulcer and to preliminarily probe into its pathogenic mechanism, Methods： Fifty patients with gastric ulcer of Pi （脾）-insufficiency and stasis-heat syndrome type were assigned to the treated group （30 patients） and the control group （20 patients）. They were treated respectively with JQH and Ranitidine. At the same time, another group consisting of 20 healthy persons was set up for normal control. The clinical effect on gastroscopic figure and traditional Chinese medicine （TCM） syndrome were observed. Changes of T-cell subsets and interleukin-8 （IL-8） in serum as well as IL-8 in mucosa around the gastric ulcer were determined before and after treatment by flow cytometry and ELISA. Results： Comparison of the total effective rate on gastroscopic figure in the treated group and the control group （86.7% vs 80.0%） showed insignificant difference, but the cure rate and markedly effective rate in the former （50.0% and 20.0%） was higher than that in the latter （40.0% and 15.0%） respectively. Comparison of the total effective rate on TCM syndrome in the treated group and in the control group （96.7% vs 70.0%） showed insignificant difference, but the cure rate and markedly effective rate in the former （63.3% and 23.3%） was higher than that in the latter （50.0% and 20.0%） respectively. Serum levels of CD3^＋, CD4^＋, CD8^＋ got restored to normal range in the treated group after treatment but it was not so in the control group. IL-8 level in gastric mucosa was improved in both groups but the improvement in the treated group was better. Cenclusien： JQH could effectively treat gastric ulcer and partly reduce its recurrence through improving patients＇ immune function.     

Effect of Lidan Granule (利胆冲剂) on bile lithogenesis in patients with choledocholithiasis combined with cholecystolithiasis

ABSTRACT Objective： To observe the effect of Lidan Granule （利胆冲剂, LDG） on bile lithogenic tendency and biliary 33.5 kd vesicular protein （VP） and to explore its mechanism. Methods： Sixty patients with choledocholithiasis combined with cholecystolithiasis were randomly assigned to the LDG treated group, the sodium cholate treated group for positive control, and the untreated control group, 20 patients in each group. The 4 bile lithogenic trend indexes, including lithogenic index （LI）, unconjugated bilirubin percent （UCB%）, unconjugated bilirubin saturation index （BSI） and Z-value, were determined before and after treatment. The content of VP in bile was determined as well. Results： Before treatment, the LI, UCB%, BSI and Z-value in the LDG treated group were 1.298 ± 0.265, 34.72 ± 2.96, 0.353± 0.093 and 0.556 ± 0.499, respectively, which was decreased after the 2-week treatment to 0.926± 0.208, 8.93± 1.19, 0.154 ± 0.056 and 0.257± 0.211, respectively （all P〈0.05）. Meantime, the content of VP was also lowered from 0.050 ± 0.005 g/L to 0.032 ± 0.005 g/L. However, no significant change in any of the above-mentioned indexes was found in the other two groups. Conclusion： LDG could effectively suppress bile lithogenic trend and reduce 33.5 kd VP in bile.     

Observation on efficiency of Jiangtang (降糖) capsule in treating diabetes mellitus type 2 with hyperlipidemia

Ａｒｔｅｒｉｏｓｃｌｅｒｏｓｉｓｉｓａｍａｊｏｒｃｏｍｍｏｎｖａｓｃｕ ｌａｒｄｉｓｏｒｄｅｒｏｆｄｉａｂｅｔｅｓｍｅｌｌｉｔｕｓ（ＤＭ）,ａｎｄａｓｔｈｅｌｉｆｅ ｓｐａｎｏｆＤＭｐａｔｉｅｎｔｓｐｒｏｌｏｎｇｅｄ,ｔｈｅｉｎ ｃｉｄｅｎｃｅｉｎｃｒｅａｓｅｄ,ａｒｔｅｒｉｏｓｃｌｅｒｏｔｉｃｃｏｒｏｎａｒｙｈｅａｒｔｄｉｓｅａｓｅ（ＣＨＤ）ａｎｄｃｅｒｅｂｒｏｖａｓｃｕｌａｒｄｉｓ ｅａｓｅｓｈａｖｅｂｅｃｏｍｅｔｈｅｐｒｉｎｃｉｐａｌｃａｕｓｅｓｏｆｄｅａｔｈｏｆＤＭ．Ｔｈｅｒｅｆｏｒｅ,ｉｍ…     

Clinical observation on the treatment of male neoplastic anemia with Yixuesheng capsule (益血生胶囊) combined with recombination human erythropoietin

Objective:To explore the efficacy and mechanism of Yixuesheng capsule(益血生胶囊,YXS) combined with recombination human erythropoietin(RHE) in treating male neoplastic anemia(NA).Methods: Sixty-five patients were randomized into two groups,the 33 patients in the treated group treated with a combined therapy of YXS and RHE,and the 32 in the control group treated with RHE alone,all for 12 weeks.Related clinical indexes,including hemoglobin(Hgb),red blood cell(RBC),hematocrit(HMC),testosterone(T),estradiol (E_2)...     

Effect of Tiaozhi Yanggan Decoction (调脂养肝汤) in treating patients with non-alcoholic fatty liver

Objective:To observe the clinical efficacy and safety of Tiaozhi Yanggan Decoction (调脂养肝汤,TZYGD)in treating non-alcoholic fatty liver.Methods:One hundred and thirty-eight patients were enrolled and randomized into two groups according to the random number table in a ratio of 3:1,with 8 cases eventually dropping out.The symptoms,signs,liver function markers, blood lipids,iconographic indices and clinical comprehensive efficacy after a 12-week treatment course were assessed in 101 patients treated with TZYGD in the treated group and 29 patients treated with Thiola in the control group.Results:The total effective rate in the treated group and the control group was 81.19% and 68.97%,respectively,showing a significant difference between the two groups with the former being significantly higher than the latter(P<0.05).Moreover,the improvements in the symptoms,signs,liver function,blood lipids and iconographic indices in the treated group were favorable with no serious adverse reactions.Conclusion:TZYGD is effective and highly safe in treating non-alcoholic fatty liver.     

Clinical Observation of Tiaojining Recipe (调激宁冲剂) in Combination with Corticosterone in Infantile Primary Nephrotic Syndrome

Clinical Observation of Tiaojining Recipe (调激宁冲剂) in Combination with Corticosterone in Infantile Primary Nephrotic Syndrome@李荣辉@彭征屏@魏佑莲@冀晓华     

Clinical Assessment on Treatment of Hyperlipidemia with Pushen Capsule (蒲参胶囊)

Objective: To explore the therapeutic effect of Pushen capsule (PSC, 蒲参胶囊) in treating primary hyperlipidemia. Methods: Two hundred and forty patients with primary hyperlipidemia were randomly divided into two groups, the 120 patients in the treated group treated with PSC (4 capsules, tid) and the 120 patients in the control group treated with Zhibituo tablet (脂必妥, 3 tablets, tid), and they were administered at the same time with Zhibituo placebo. The therapeutic course for both groups was 4 weeks. The therapeutic effect and the effects on blood lipids and viscosity were observed. Results: The effective rate in thetreated group was 76. 3%, which was significantly higher than that in the control group (48. 7% , P< 0. 01). PSC showed a significant lowering effect on TC, TG and LDL-C and raising effect on HDL-C, and the effect in lowering TG was significantly better than that of Zhibituo (P<0.01). PSC also showed a certain effect in decreasing whole blood viscosity of both high-sheared and low-shear     

Evaluation of the Clinical Efficacy of Qingqiao Capsule (清窍胶囊) in Treating Patients with Secretory Otitis Media

Secretory otitis media (SOM) , alsocalled non-suppurative otitis media and glueear ,etc .,is a frequently encountered dis-ease in the middle ear in clinics . Especiallyin children of 2 -7 years old,the incidencereached 7 .3 % to 30 .7 %(1). However ,itwould decrease along the increase of age .Itis characterized by retention of exudativefluid in the middle ear but shows no acuteinfectious manifestation. A long-lastingSOM often causes hearing i mpairment . Ifuntreated or i mproperly treated,i…     

Effect of Tang No.1 granule (糖1号方) in treating patients with impaired glucose tolerance

Objective： To observe the therapeutic effect of Tang No.1 granule （糖1号方, T1G） in treating patients with impaired glucose tolerance （IGT）. Methods： One hundred and forty patients with IGT and with Pi （脾）-Wei （胃） dampness-heat syndrome type were assigned randomly according to their visiting sequence into two equal groups. The control group received only general knowledge about IGT, but to the treated group, based on current knowledge available, T1G was given additionally for 6 months. Changes in related laboratory indexes, including fasting plasma glucose and insulin （FPG and FINS）, plasma glucose 2 h after meal （2hPG）, glycosylated hemoglobin （HbAlc）, serum triglyceride （TG）, low density lipoprotein cholesterol （LDL） and insulin resistance index （HOMA-IR）, were observed. Results： The levels of FPG, 2hPG, HbAlc, FINS, TG and HOMA-IR were significantly decreased after treatment in the treated group, showing a significant difference compared to the control group （P〈0.01）. Among them, HbAlc decreased from 7.08±1.41% to 6.56±1.29% in the treated group, while in the control group, it decreased from 7.02±1.37% to 6.93±1.31%. The level of LDL was also reduced in the treated group after treatment （P〈0.05）. In the treated group, 13 out of 68 patients （19.12%） had their glucose tolerance reversed to normal, while in the control group, only 2/64 （3.1%） got it reverse; a comparison between the two groups in terms of reversion rate showed a significant difference （P〈0.01）. No severe adverse reaction was found in the therapeutic course. Conclusions： T1G has good clinical effect as a treatment intervention for IGT, as it could improve glycometabolism, significantly depress the levels of post-prandial blood sugar and blood lipids, alleviate clinical symptoms of patients, and effectively cut-off and reverse the yielding and development of diabetes mellitus.