64例孢子丝菌病临床分析

分析2006年11月至2010年4月我院门诊疑诊抱子丝菌感染病例,利用真菌培养检查和/或皮肤组织病理检查对64例疑诊孢子丝菌病进行统计分析.64例真菌培养阳性(可见孢子丝菌生长),10例皮肤组织病理切片、PAS染色找到真菌孢子或星状体.发病部位主要在裸露部位58例(90.63%),如手部、前臂、面部和小腿等.有明确外伤史11例,皮损类型主要为固定型、皮肤淋巴管型、化脓性肉芽肿卫星型.各种因素(建筑、环境污染、自然灾害等)和腐生菌大量繁殖生长是导致孢子丝菌感染的重要原因,外伤和昆虫叮咬是重要致病条件.     

孢子丝菌病1例

患者男,22岁。右颧部出现无痛性疣状增生物5个月,于2005年2月2日来我所就诊。2004年9月患者右颧部擦伤后未予特殊处理,约1周后自愈。自愈1周后在原部位出现黄豆大结节,高出表面,呈淡红色,2周后结节增至蚕豆大,表面呈黄褐色,粗糙。     

孢子丝菌病1例

患者男,42岁,建筑工人。因右手背结节4个月,于2004年10月来我科就诊。患者4个月前无明显诱因右手背出现1枚黄豆大结节,不痛不痒,未予重视。后皮损逐渐增大,呈环形,边缘隆起,中央结痂。至入院前1个月,右臂又相继出现2枚类似结节,且进行性增大。患者既往体健,发病以来无发热及关节疼痛,否认有药物过敏史。     

孢子丝菌病1例

报告孢子丝菌病1例。     

26例孢子丝菌病临床分析

２６例孢子丝菌病临床分析唐国芬（江苏常州第一人民医院皮肤科，２１３００３）孢子丝菌病是由申克孢子丝菌所致的慢性皮肤病。本文２６例均属于原发皮肤接种性孢子丝菌病，均经服用１０％碘化钾溶液而获临床治愈，随访一年无一例复发。临床资料：２６例患者中男性１２例...     

面部孢子丝菌病1例

患者女,56岁。因面部丘疹、结节2个月,于2006年6月15日来我院就诊。患者2个月前在家中水井打水时,曾被井绳擦破面部皮肤,此后在破损处出现一结节,结节逐渐增大,常有疼痛感,并在初发结节附近出现多个卫星状分布的互不融合的丘疹和结节。在当地医院切除初发结节,组织病理诊断为感染性肉芽肿,未明确病因。给予头孢类抗生素和红霉素治疗无效。     

球形孢子丝菌致面部孢子丝菌病

正患者女,56岁,农民。主诉:右面部红色丘疹、斑块1年。现病史:患者于1年前无明显诱因右颊部出现一个针尖大小红色丘疹,后其周围出现类似几个丘疹,并逐渐增大融合成斑块,部分上覆少量黄色和暗红色痂,无明显瘙痒及疼痛。患者曾于外院就诊,具体诊断不详,未予治疗。后类似皮疹逐渐增多,向下蔓延至颏部     

申克孢子丝菌病3例报告

我科在1998年～2001年发现3例孢子丝菌病,现报告如下。1 病例报告 例1,患者,男,45岁,1998年7月就诊。病史6年,发病前是农民,有外伤史,现为个体户,广东籍。右踝部一鹤鹑蛋大紫红色呈疣状增生样结节,近半年来破溃、糜烂、与皮下粘连。近2个月     

孢子丝菌病研究进展

【摘要】 世界卫生组织将孢子丝菌病归为“被忽视的热带病”，近年来对孢子丝菌病相关的研究逐渐增多，本文从病原体、流行病学、诊断、治疗、疫苗这五个方面综述孢子丝菌病的近期研究进展。     

孢子丝菌病25例临床治疗分析

目的：对近年临床积累的孢子丝菌病例进行临床治疗总结分析。探讨菌子丝菌病的临床、组织病理特点，诊断及有效的治疗方法。方法：对门诊疑为皮肤孢子丝菌病的患者进行真菌学镜检培养和组织病理检查。对确诊病例进行治疗观察。结果：经临床和真菌学检查共25例皮肤孢子丝菌病，病理上按炎性浸润类型的不同，分4型。所有患者确诊后口服10％碘化钾溶液10nd每日3次，大多病例2至2．5个月治愈。结论：本病淋巴管型临床诊断不难，固定型因皮疹形似其他皮肤病易误诊，因此对慢性顽固难治的溃疡及可疑病例应作深部真菌检查培养及时明确诊断。该病治疗首选碘化钾，如单独口服碘化钾效果不明显或皮损面积较大者可考虑联合应用其他抗真菌药物及局部治疗或手术切除。     

2010-2020年广西新发现麻风病例流行病学特征分析

目的:分析2010-2020年广西新发现麻风病例的流行特征。方法:描述性分析2010-2020年广西全区在全国麻风防治管理信息系统中上报的新发现麻风病例的病历资料。结果:2010-2020年,广西麻风新发病例年发现率从0.13/10^(5)降至0.06/10^(5),年均下降7.1%;共发现新发麻风病例499例,其中男333例,女166例,平均年龄(44.16±16.87)岁,儿童病例12例(2.4%);2级畸残98例(19.6%),平均延迟期为27个月,早期发现比例为31.9%。发现方式以皮肤科就诊为主(347例,占69.5%),通过接触者检查发现占8.8%,传染源来自家内的病例占27.3%。14个市均有新发病例报道,百色、河池、崇左3个市报告的病例数占广西病例总数的51.9%。结论:广西新发现麻风病例数呈下降趋势,但新发病例的平均延迟期较长,需加强接触者检查、皮肤科医师培训等工作以便早期发现病例。     

Eyelid sporotrichosis: Unique clinical findings in 72 patients

Sporotrichosis on the eyelids is uncommon and has been rarely reported. As the largest series of 72 adults and children with eyelid sporotrichosis from Jilin ?P??rovince in China, this study provides useful information for the improved diagnosis and treatment of sporotrichosis.     

Three cases of sporotrichosis with numerous fungal elements

Three cases of sporotrichosis with numerous fungal elements were reported. Clinically these cases showed nodules to plaques with ulceration. Histologically, they showed unusual features, including histiocytic granuloma in the upper to middle dermis which contained few neutrophils but were surrounded by lymphocytes and epithelioid cells. There was no formation of an abscess. Fungal elements were found in abundance in the histiocytic granuloma, mainly in the form of oval or round spores of varying sizes, some of them produced germ tubes. No asteroid bodies were found. The spores stained positively with HE and PAS, and, in case 1, with anti-Sporothrix schenckii antiserum. All three cases had been treated with topical corticosteroid ointment. In one case, after the topical corticosteroid treatment was stopped, the histological pattern returned to the usual features seen in sporotrichosis, and fungal elements decreased significantly. This unusual histological pattern was also observed in a specimen from a healthy control infected with Sporothrix schenckii and treated with steroid ointment. These histological and fungal patterns may be possibly induced by the local immunodeficiency following topical steroid treatment.     

A familial occurrence of sporotrichosis

A grandfather and granddaughter suffering from sporotrichosis were reported. It is thought that they might have been infected from the same source of Sporothrix schenckii (S. schenckii).     

A case of cutaneous disseminated sporotrichosis

We described a case of cutaneous disseminated sporotrichosis. The condition was diagnosed based on isolation and identification of Sporothrix schenckii from the lesions. The patient was otherwise normal, including a negative HIV test. The blood culture did not grow S. schenckii. However, spores were detected in the biopsy histological sections and stained positively with PAS staining and ConA and LCA lectin histochemistry.     

婴儿孢子丝菌病一例

患儿,女,10个月。右侧面部斑块8个月。皮肤科查体：右侧面部一横条状红色斑块,上可见黄白色鳞屑、少许褐色结痂。真菌培养阳性,形态学鉴定为孢子丝菌。诊断：固定型孢子丝菌病。治疗：给予盐酸特比萘芬片50 mg日1次口服,萘替芬酮康唑乳膏日2次外用,治疗12周后其上痂屑脱落,但斑块缩小不明显。     

2010-2019年广西梅毒流行特征分析

目的:了解广西梅毒流行特征和趋势,为制定防控策略提供依据.方法:对广西2010-2019年通过中国疾病预防控制信息系统传染病监测信息系统报告的梅毒病例资料进行描述性分析.结果:2010-2019年,广西梅毒年报告发病率由82.41/105降至37.24/105,年均下降8.45％;一期和二期梅毒报告发病率年均下降22....     

A case of lymphangitic sporotrichosis occurring on both forearms with a published work review of cases of bilateral sporotrichosis in Japan

The patient, 56-year-old man who was working as a clerk and a farmer, presented with nodules that had appeared on the dorsa of both his hands 3 months earlier. At the first examination, there were multiple dark-red nodules scattered on the fingers, dorsa and wrists of both hands. The nodules were up to 3 cm in diameter and had crusts in the incenters. The patient was suspected to suffer from prurigo and was subsequently treated with topical steroid, but the nodules did not respond. Therefore, a skin biopsy and fungal culture were performed, and the patient was finally diagnosed as having bilateral multiple sporotrichosis. He was then successfully treated with local thermotherapy and oral potassium iodide. Bilaterally-distributed lymphangitic sporotrichosis is very rare and often difficult to diagnose. Careful attention is required to avoid misdiagnosis.     

1998-2018年陕西省麻风流行特征分析

目的：了解1998-2018年陕西省麻风流行趋势和流行特征,为开展麻风防治工作提供理论依据。方法：通过全国麻风防治管理信息系统（LEPMIS）收集陕西省1998-2018年麻风病历资料,对麻风发现率、患病率和病例基本情况进行描述性分析。结果：1998-2018年陕西省新发现麻风病例共计477例,年平均发现率为0.070/10万,年平均患病率为0.305/10万;病例平均发现年龄为46.71岁;男女比为2.46:1;多菌型（MB）399例,占83.6% ;II级畸残共148例,畸残率为31.03%;新发现病例平均延迟期为62.01个月。结论：陕西省新发麻风病例依然存在畸残比高、延迟期长和高龄化等情况,应进一步加强低流行状态下麻风的监测,减少传播和畸残的发生。