Auld Lang Syne: A New Year Brings Awards and a New Cover

“Auld Lang Syne,” a traditional poem used to welcome the New Year, asks rhetorically, “Should old acquaintance be forgot, and never brought to mind?” At Arthroscopy, the answer is a resounding no. We view January as an opportunity to celebrate the abundance and excellence of research published in Arthroscopy. This year, we have decided to spread our applause, approval, and appreciation to recognize both award winners and runners-up, whose distinction in research epitomizes the bounty that is Arthroscopy. In addition, we proudly introduce a new cover.     

Nonoperative and Operative Soft-Tissue,Cartilage, and Bony Regeneration and Orthopaedic Biologics of the Shoulder: An Orthoregeneration Network (ON) Foundation Review

Orthoregeneration is defined as a solution for orthopaedic conditions that harnesses the benefits of biology to improve healing, reduce pain, improve function, and optimally, provide an environment for tissue regeneration. Options include drugs, surgical intervention, scaffolds, biologics as a product of cells, and physical and electro-magnetic stimuli. The goal of regenerative medicine is to enhance the healing of tissue after musculoskeletal injuries as both isolated treatment and adjunct to surgical management, using novel therapies to improve recovery and outcomes. Various orthopaedic biologics (orthobiologics) have been investigated for the treatment of pathology involving the shoulder including the rotator cuff tendons, glenohumeral articular cartilage, glenoid labrum, the joint capsule, and bone. Promising and established treatment modalities include hyaluronic acid (HA); platelet-rich plasma (PRP) and platelet rich concentrates (PRC); bone marrow aspirate (BMA) comprising mesenchymal stromal cells (MSCs alternatively termed medicinal signaling cells and frequently, misleadingly labelled “mesenchymal stem cells”); MSC harvested from adipose, umbilical, or placental sources; factors including vascular endothelial growth factors (VEGF), basic fibroblast growth factor (FGF), platelet-derived growth factor (PDGF), transforming growth factor-beta (TGFβ), bone morphogenic protein (BMP), and matrix metalloproteinases (MMPs); prolotherapy; pulsed electromagnetic field therapy; microfracture and other marrow-stimulation techniques; biologic resurfacing using acellular dermal allografts, allograft Achilles tendons, allograft lateral menisci, fascia lata autografts, and porcine xenografts; osteochondral autograft or allograft); and autologous chondrocyte implantation (ACI). Studies involving hyaluronic acid, platelet rich plasma, and medicinal signaling cells of various origin tissues have shown mixed results to-date as isolated treatments and as surgical adjuncts. Despite varied results thus far, there is great potential for improved efficacy with refinement of current techniques and translation of burgeoning preclinical work.Level of EvidenceLevel V, expert opinion.     

Editorial Commentary: Infographics Engage a Broader Audience Than Traditional Scientific Articles in the Medical Literature: The Latest Social Media Influencer?

Infographics are an evolving medium within the orthopaedic literature and support engagement of a broad audience than traditional scientific articles. Arthroscopy infographics have been published monthly since January 2019 on a range of topics relevant to the readership. Citation numbers have long been used as a metric for quality and relevance of a scientific article, although alternative metrics (altmetrics) are now available to quantify the online activity related to scholarly content. Altmetrics are defined as “metrics and qualitative data that are complementary to traditional, citation-based metrics,” and the altmetric attention score depends on 3 main factors: volume (number of “mentions”), sources (e.g. newspaper, blog, tweet), and author (source of the “mention”, e.g. physician vs journal). Recent research links altmetric scores to citation gains. Infographics are a tool for expanding, educating, and increasing the breadth of medical journal readership.     

Stop Overtreatment,Overdiagnosis, and the Medicalization of “Normal” to Improve Health Care Outcomes. Hippocrasy: The Book

In the 21st century, physician adherence to the Hippocratic Oath “to treat the ill to the best of one’s ability” may require improving our entire health care system. As a result of a wide range of problems, including but not limited to overtreatment, overdiagnosis, inattention to warmth and sympathy, and medicalizing normal, as well failure to attend to prevention, treating the problem, and recognizing what is not known, efficient care delivery and best outcomes may be compromised. A recent book, cleverly titled Hippocrasy: How Doctors Are Betraying Their Oath, courageously calls out evidence of hypocrisy in the health care status quo and, most importantly, includes proposals suggesting how health care might be improved. While the book would benefit from more balance and less bias, improving patient outcomes is a worthwhile goal that readers of Arthroscopy inevitably share.     

Medical Device and Pharmaceutical Industry Employees as Medical Research Publication Authors

As an editorial policy, medical device and pharmaceutical industry employees are generally permitted to publish original scientific research in Arthroscopy journal but are not permitted to publish systematic reviews. All authors complete the International Committee of Medical Journal Editors Form for Disclosure of Potential Conflicts of Interest, which are thoughtfully considered by our reviewers and editors and readers. In accord with the American Academy of Orthopaedic Surgeons, we believe that “manufacturers of medical devices, biologics, drugs, and other items use(d) in the care of the patient…play an important role in…the development of new technologies. This collaborative effort ensures that patients have the best outcomes through the invention and testing of new technology, research, and evaluation of existing technology.” Our peer-review process mitigates against bias including but not limited to commercial bias in the interpretation of scientific research data. In the end, our goal is to publish the best science, and as above, industry plays “an important role in…(t)his collaborative effort.”     

Arthroscopy,Sports Medicine,and Rehabilitation (ASMAR): A New,Open Access,Electronic Journal

Arthroscopy, Sports Medicine, and Rehabilitation (ASMAR) is our new, open-access, electronic, companion journal to Arthroscopy and Arthroscopy Techniques. While there is already “so much to read, so little time,” bearing in mind the context that some submissions are not accepted for publication in Arthroscopy despite admirable quality, the necessity of ASMAR becomes clear.     

Health Research Titles and Guidelines Improve Impact and Article Acceptance Rates

The peer-reviewed publication of Arthroscopy, Arthroscopy Techniques, and Arthroscopy, Sports Medicine, and Rehabilitation is the result of a team effort. Our assistant editors-in-chief are a notable part of this team who are specifically credited for, among other contributions, leadership in organizing, creating, and publishing a series of pearls, templates, and checklists for health research authors as well as reviewers, editors, and readers. These articles and tools are available under drop-down menus on the Arthroscopy journal home page. Our series of research pearls concludes with 2 articles on the weighty impact of journal article titles and on instruments to improve research publication quality.     

My Kind of Town (Chicago Is): Content Collections Optimize Learning Related to the 2018 AANA Annual Meeting

The 2018 Arthroscopy Association of North America Annual Meeting represents an opportunity to deepen one's understanding of a wide variety of topics. Arthroscopy journal readers have diverse practices and interests, and the meeting is designed to accommodate individual needs. The constructivist learning theory provides that scholars learn in many different ways. Thus, to enrich your learning experience, selected recently published Arthroscopy articles are suggested to supplement material presented at the meeting. The articles are collated on our web site in Content Collections, to allow meeting participants to prepare and to allow those unable to attend to remain engaged. We offer suggestions and encourage readers to customize their own learning experience.     

Nonoperative and Operative Soft-Tissue and Cartilage Regeneration and Orthopaedic Biologics of the Knee: An Orthoregeneration Network (ON) Foundation Review

Orthoregeneration is defined as a solution for orthopedic conditions that harnesses the benefits of biology to improve healing, reduce pain, improve function, and optimally, provide an environment for tissue regeneration. Options include: drugs, surgical intervention, scaffolds, biologics as a product of cells, and physical and electro-magnetic stimuli. The goal of regenerative medicine is to enhance the healing of tissue after musculoskeletal injuries as both isolated treatment and adjunct to surgical management, using novel therapies to improve recovery and outcomes. Various orthopaedic biologics (orthobiologics) have been investigated for the treatment of pathology involving the knee, including symptomatic osteoarthritis and chondral injuries, as well as injuries to tendon, meniscus, and ligament, including the anterior cruciate ligament. Promising and established treatment modalities include hyaluronic acid (HA) in liquid or scaffold form; platelet-rich plasma (PRP); bone marrow aspirate (BMA) comprising mesenchymal stromal cells (MSCs), hematopoietic stem cells, endothelial progenitor cells, and growth factors; connective tissue progenitor cells (CTPs) including adipose-derived mesenchymal stem cells (AD-MSCs) and tendon-derived stem cells (TDSCs); matrix cell–based therapy including autologous chondrocytes or allograft; vitamin D; and fibrin clot. Future investigations should standardize solution preparations, because inconsistent results reported may be due to heterogeneity of HA, PRP, BMAC, or MSC preparations and regimens, which may inhibit meaningful comparison between studies to determine the true efficacy and safety for each treatment.     

Nonoperative and Operative Bone and Cartilage Regeneration and Orthopaedic Biologics of the Hip: An Orthoregeneration Network (ON) Foundation Hip Review

Orthoregeneration is defined as a solution for orthopaedic conditions that harnesses the benefits of biology to improve healing, reduce pain, improve function, and, optimally, provide an environment for tissue regeneration. Options include drugs, surgical intervention, scaffolds, biologics as a product of cells, and physical and electromagnetic stimuli. The goal of regenerative medicine is to enhance the healing of tissue after musculoskeletal injuries as both isolated treatment and adjunct to surgical management, using novel therapies to improve recovery and outcomes. Various orthopaedic biologics (orthobiologics) have been investigated for the treatment of pathology involving the hip, including osteonecrosis (aseptic necrosis) involving bone marrow, bone, and cartilage, and chondral injuries involving articular cartilage, synovium, and bone marrow. Promising and established treatment modalities for osteonecrosis include nonweightbearing; pharmacological treatments including low molecular-weight heparin, prostacyclin, statins, bisphosphonates, and denosumab, a receptor activator of nuclear factor-kB ligand inhibitor; extracorporeal shock wave therapy; pulsed electromagnetic fields; core decompression surgery; cellular therapies including bone marrow aspirate comprising mesenchymal stromal cells (MSCs aka mesenchymal stem cells) and bone marrow autologous concentrate, with or without expanded or cultured cells, and possible addition of bone morphogenetic protein-2, vascular endothelial growth factor, and basic fibroblast growth factor; and arterial perfusion of MSCs that may be combined with addition of carriers or scaffolds including autologous MSCs cultured with beta-tricalcium phosphate ceramics associated with a free vascularized fibula. Promising and established treatment modalities for chondral lesions include autologous platelet-rich plasma; hyaluronic acid; MSCs (in expanded or nonexpanded form) derived from bone marrow or other sources such as fat, placenta, umbilical cord blood, synovial membrane, and cartilage; microfracture or microfracture augmented with membrane containing MSCs, collagen, HA, or synthetic polymer; mosaicplasty; 1-stage autologous cartilage translation (ACT) or 2-stage ACT using 3-dimensional spheroids; and autologous cartilage grafting; chondral flap repair, or flap fixation with fibrin glue. Hip pain is catastrophic in young patients, and promising therapies offer an alternative to premature arthroplasty. This may address both physical and psychological components of pain; the goal is to avoid or postpone an artificial joint.Level of EvidenceLevel V, expert opinion.     

AANA20: The 2020 Annual Meeting of the Arthroscopy Association of North America

Arthroscopy, Arthroscopy Techniques, and Arthroscopy, Sports Medicine, and Rehabilitation will be in attendance in force at the 2020 Annual Meeting of the Arthroscopy Association of North America (AANA20). Program highlights and innovations include surgery simulcasts, “Great Debates,” award-winning papers, Feature Lectures, and sessions glimpsing what is On the Horizon—and perhaps over and beyond.     

Proper Evaluation of Bone Loss Determines Shoulder Instability Indications and Outcomes

One of the most-read articles published in the history of Arthroscopy: The Journal of Arthroscopic and Related Surgery is “Evolving Concept of Bipolar Bone Loss and the Hill-Sachs Lesion: From ‘Engaging/Non-Engaging’ Lesion to ‘On-Track/Off-Track’ Lesion” by Di Giacomo, Itoi, and Burkhart. This 2014 article is a modern classic and has inspired a plethora of recent research as well as infographics published in Arthroscopy. We now understand, to the great benefit of patients, that proper evaluation of bone loss determines shoulder instability surgical indications and outcomes.     

The 2022 Orthopaedic Surgery Residency Match Leaves Many Qualified Candidates Unmatched

Orthopaedic surgery has always been a popular and competitive field, but in 2022, approximately 40% of applicants for orthopaedic surgery residency positions did not successfully match, despite their immense talent and commitment. This is a failure of the system, not the medical student applicants, and there is no evident solution. In fact, the problem is expected to get worse, as many of the approximately 600 unmatched 2022 applicants are expected to apply again next year, further flooding the pool. Reflecting on the results of the 2022 Orthopaedic Surgery Residency Match, we feel incredibly fortunate and humbled to serve as orthopaedic surgeons with a subspecialty interest in Arthroscopy, Arthroscopy Techniques, and Arthroscopy, Sports Medicine, and Rehabilitation.     

Tools to Improve Scientific Research

The mission of Arthroscopy is to provide authoritative, current, peer-reviewed clinical and basic science information regarding arthroscopic and related surgery. In addition, with a goal of improving the quality of the scientific research published in our journal and others, we develop and publish research pearls, statistical guides, article checklists and templates, and related tools. In sum, this effort allows our cadre of editors, reviewers, authors, and readers to strive to improve in our ability to create and critically analyze medical literature of the greatest merit. Our ultimate ambition is to publish more perfect articles with conclusions on which readers can rely.     

Nonoperative and Operative Soft-Tissue and Cartilage Regeneration and Orthopaedic Biologics of the Foot and Ankle: An Orthoregeneration Network Foundation Review

Orthoregeneration is defined as a solution for orthopaedic conditions that harnesses the benefits of biology to improve healing, reduce pain, improve function, and optimally, provide an environment for tissue regeneration. Options include drugs, surgical intervention, scaffolds, biologics as a product of cells, and physical and electromagnetic stimuli. The goal of regenerative medicine is to enhance the healing of tissue after musculoskeletal injuries as both isolated treatment and adjunct to surgical management, using novel therapies to improve recovery and outcomes. Various orthopaedic biologics (orthobiologics) have been investigated for the treatment of pathology involving the foot and ankle (including acute traumatic injuries and fractures, tumor, infection, osteochondral lesions, arthritis, and tendinopathy) and procedures, including osteotomy or fusion. Promising and established treatment modalities include 1) bone-based therapies (such as cancellous or cortical autograft from the iliac crest, proximal tibia, and/or calcaneus, fresh-frozen or freeze-dried cortical or cancellous allograft, including demineralized bone matrix putty or powder combined with growth factors, and synthetic bone graft substitutes, such as calcium sulfate, calcium phosphate, tricalcium phosphate, bioactive glasses (often in combination with bone marrow aspirate), and polymers; proteins such as bone morphogenic proteins; and platelet-derived growth factors; 2) cartilage-based therapies such as debridement, bone marrow stimulation (such as microfracture or drilling), scaffold-based techniques (such as autologous chondrocyte implantation [ACI] and matrix-induced ACI, autologous matrix-induced chondrogenesis, matrix-associated stem cell transplantation, particulated juvenile cartilage allograft transplantation, and minced local cartilage cells mixed with fibrin and platelet rich plasma [PRP]); and 3) blood, cell-based, and injectable therapies such as PRP, platelet-poor plasma biomatrix loaded with mesenchymal stromal cells, concentrated bone marrow aspirate, hyaluronic acid, and stem or stromal cell therapy, including mesenchymal stem cell allografts, and adipose tissue-derived stem cells, and micronized adipose tissue injections.Level of EvidenceLevel V, expert opinion.     

Building better bone: The weaving of biologic and engineering strategies for managing bone loss

Segmental bone loss remains a challenging clinical problem for orthopaedic trauma surgeons. In addition to the missing bone itself, the local tissues (soft tissue, vascular) are often highly traumatized as well, resulting in a less than ideal environment for bone regeneration. As a result, attempts at limb salvage become a highly expensive endeavor, often requiring multiple operations and necessitating the use of every available strategy (autograft, allograft, bone graft substitution, Masquelet, bone transport, etc.) to achieve bony union. A cost‐sensitive, functionally appropriate, and volumetrically adequate engineered substitute would be practice‐changing for orthopaedic trauma surgeons and these patients with difficult clinical problems. In tissue engineering and bone regeneration fields, numerous research efforts continue to make progress toward new therapeutic interventions for segmental bone loss, including novel biomaterial development as well as cell‐based strategies. Despite an ever‐evolving literature base of these new therapeutic and engineered options, there remains a disconnect with the clinical practice, with very few translating into clinical use. A symposium entitled “Building better bone: The weaving of biologic and engineering strategies for managing bone loss,” was presented at the 2016 Orthopaedic Research Society Conference to further explore this engineering‐clinical disconnect, by surveying basic, translational, and clinical researchers along with orthopaedic surgeons and proposing ideas for pushing the bar forward in the field of segmental bone loss. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:1855–1864, 2017.

     

Orthopaedic Musculoskeletal Biologics Research Impacts Patient Care: The First Annual Arthroscopy Orthobiologics Virtual Special Issue

Orthobiologics can modify symptoms and improve healing in a variety of musculoskeletal conditions as a part of office-based care or as an adjunct to surgery. Orthobiologics harness the benefits of naturally derived blood components, autologous tissue, and growth factors to reduce inflammation and optimize the host-healing environment. The Arthroscopy family of journals seeks to positively influence evidence-based clinical decision-making by publishing peer-reviewed biologics research. This special issue contains recent influential articles strategically chosen to positively impact patient care.     

Arthroscopy and Musculoskeletal Biologics

Orthopaedic biologics holds great promise. Absent peer-reviewed clinical musculoskeletal research, orthobiologics indications and treatment recommendations will remain opaque. In a Call for Papers, Arthroscopy; Arthroscopy Techniques; and Arthroscopy, Sports Medicine, and Rehabilitation editors invite authors to submit clinical musculoskeletal biologics original scientific research, and technical notes with video. Each year, the top articles will be awarded inclusion in an annual Biologics Special Issue. Future investigators and current readers could follow the science while being mindful of the regulatory environment.     

3D printing and its applications in orthopaedic trauma: A technological marvel

Background

With rapid emergence of 3D printing technology, surgeons have recently started to apply this for nearly all areas of orthopaedic trauma surgery. Computed tomography or magnetic resonance images of trauma patients can be utilized for making graspable objects from 3D reconstructed images. Patient specific anatomical models can thereby be created. They enhance surgeon's knowledge of their patients' precise patho-anatomy, regarding both traumatized bones and soft tissue as well as normal areas, and therefore help in accurate preoperative planning. 3D printed patient specific instrumentation can help to achieve precise implant placement, and better surgical results. Most importantly, customized implants, casts, orthoses and prosthetics can be manufactured to match an individual's anatomy. Three dimensional (3D) printing, also called as ‘additive manufacturing’ and ‘rapid prototyping’ is considered as the “second industrial revolution”, and this appears to be especially true for orthopaedic trauma surgery.

Editorial Commentary: A Model for Shoulder Rotator Cuff Repair and for Basic Science Investigations

“Breaking the fourth wall” is a theater convention where the narrator or character speaks directly to the audience. As an Assistant Editor-in-Chief, as I comment on a recent basic science study investigating rotator cuff repair, I break the fourth wall and articulate areas of basic science research excellence that align with the vision that we hold for our journal. Inclusion of a powerful video strengthens the submission. We prefer to publish clinical videos in our companion journal, Arthroscopy Techniques, and encourage basic science video submissions to Arthroscopy. Basic science research requires step-by-tedious-step analogous to climbing a mountain. Establishment of a murine rotator cuff repair model was rigorous and research intensive, biomechanically, radiographically, histologically, and genetically documented, a huge step toward the bone-to-tendon healing research summit. This research results in a model for both rotator cuff repair and the pinnacle of quality, basic science research.