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目的:探讨血小板与淋巴细胞比值(platelet to lymphocyte ratio,PLR)对三阴性乳腺癌的临床预后影响及与免疫球蛋白表达的关系。方法:回顾性分析2006年1月至2012年12月于我院乳腺外科住院治疗的134例三阴性乳腺癌患者。临床独立预后因素采用单因素和多因素Cox回归模型分析。术后生存时间和生存曲线比较采用Kaplan-Meier和log-rank方法。结果:PLR是三阴性乳腺癌的独立预后因素,最佳临界值为155.00。PLR<155.00组,术后中位DFS为35.51月,中位OS为55.24月;PLR≥155.00组,术后中位DFS为25.07月,中位OS为35.17月。两组术后DFS和OS比较,差异具有统计学意义(P<0.05)。结论:PLR是三阴性乳腺癌的独立预后因素,具有重复性强、非侵袭性、方便实用等特性,可用于预测三阴性乳腺癌临床预后。 相似文献
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目的:研究弥漫性大B细胞淋巴瘤患者外周血中性粒细胞与淋巴细胞比值(NLR)、血小板与淋巴细胞比值(PLR)及乳酸脱氢酶(LDH)与健康人的差异、不同分期之间的差异,以及三者联合检测的诊断价值。方法:收集我院血液科2018年10月至 2020年10月收治的81例DLBCL患者作为实验组,同期85例健康体检者作为对照组,根据Ann Arbor分期标准将淋巴瘤组患者分为Ⅰ-Ⅱ期(n=27)、Ⅲ-Ⅳ期(n=54),测定外周血NLR、PLR及LDH水平,对比两组及不同分期之间是否存在差异;建立受试者工作特征(ROC)曲线,通过分析曲线下面积(AUC),对比NLR、PLR、LDH以及三者联合对DLBCL的诊断价值。结果:淋巴瘤组81例,NLR、PLR、LDH分别为(3.65±2.55)、(207.73±11.01)、(371.79±63.56)ng/mL,均显著高于对照组(1.96±0.62 ,P<0.05)、(127.88±41.05,P<0.05)、(151.99±43.72,P<0.05)ng/mL,两组之间差异有统计学意义。与Ⅰ-Ⅱ期患者的NLR(3.00±1.63)、PLR(172.99±61.87)、LDH(279.15±19.12)ng/mL水平对比,Ⅲ-Ⅳ期患者NLR(3.98±2.86)、PLR(225.10±25.71)、LDH(418.11±23.83)ng/mL的水平均显著升高,差异有统计学意义(P=0.045,P=0.014,P=0.011)。ROC曲线:NLR以2.44为临界值时对DLBCL的诊断灵敏度、特异性、准确度分别为69.1%、78.8%、74.1%,PLR以168.64为临界值时对DLBCL的诊断灵敏度、特异性、准确度分别为61.7%、87.1%、74.7%,LDH以186.50 ng/mL为临界值时对DLBCL的诊断灵敏度、特异性、准确度分别为75.3%、94.1%、84.9%,三者联合时分别为 80.2%、91.8%、85.5%。四种方法特异度的差异有统计学意义(P=0.022),灵敏度、准确度的差异无统计学意义(P=0.054,P=0.133)。两两比较发现,三者联合的灵敏度高于PLR单独检测(P=0.009),特异性高于NLR单独检测(P=0.027)。NLR、PLR、LDH的曲线下面积分别为0.78、0.788、0.866,三者联合为0.916,显著高于三者单独检测(P<0.05)。结论:与健康人对比,NLR、PLR及LDH在弥漫性大B细胞淋巴瘤患者中显著升高,且与分期有关,三者联合检测可以显著提高对DLBCL的诊断价值。 相似文献
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M Cummings L Merone C Keeble L Burland M Grzelinski K Sutton N Begum A Thacoor B Green J Sarveswaran R Hutson N M Orsi 《British journal of cancer》2015,113(2):311-320
Background:
Variations in systemic inflammatory response biomarker levels have been associated with adverse clinical outcome in various malignancies. This study determined the prognostic significance of preoperative neutrophil:lymphocyte (NLR), platelet:lymphocyte (PLR) and monocyte:lymphocyte (MLR) ratios in endometrial cancer.Methods:
Clinicopathological and 5-year follow-up data were obtained for a retrospective series of surgically treated endometrial cancer patients (n=605). Prognostic significance was determined for overall (OS) and cancer-specific survival (CSS) using Cox proportional hazards models and Kaplan–Meier analysis. Receiver–operator characteristic and log-rank functions were used to optimise cut-offs. NLR, PLR and MLR associations with clinicopathological variables were determined using non-parametric tests.Results:
Applying cut-offs of ⩾2.4 (NLR), ⩾240 (PLR) and ⩾0.19 (MLR), NLR and PLR (but not MLR) had independent prognostic significance. Combining NLR and PLR scores stratified patients into low (NLR-low and PLR-low), intermediate (NLR-high or PLR-high) and high risk (NLR-high and PLR-high) groups: multivariable hazard ratio (HR) 2.51; P<0.001 (OS); HR 2.26; P<0.01 (CSS) for high vs low risk patients. Increased NLR and PLR were most strongly associated with advanced stage (P<0.001), whereas increased MLR was strongly associated with older age (P<0.001).Conclusion:
Both NLR and PLR are independent prognostic indicators for endometrial cancer, which can be combined to provide additional patient stratification. 相似文献5.
Nomograms for predicting prognostic value of inflammatory biomarkers in colorectal cancer patients after radical resection 下载免费PDF全文
Wencheng Yu Ye Xu Xinxiang Li Qingguo Li Sanjun Cai 《International journal of cancer. Journal international du cancer》2016,139(1):220-231
Increasing evidence indicates that inflammation plays a vital role in tumorigenesis and progression. However, the prognostic value of inflammatory biomarkers in colorectal cancer (CRC) has not been established. In this study, a retrospective analysis was conducted in patients with CRC in Fudan University Shanghai Cancer Center (FUSCC) between April 1, 2007 and April 30, 2014, and 5,336 patients were identified eligible. Neutrophil‐to‐lymphocyte ratio (NLR), platelet‐to‐lymphocyte ratio (PLR), lymphocyte‐to‐monocyte ratio (LMR), and albumin/globulin ratio (AGR) were analyzed. Kaplan‐Meier analysis was used to calculate the 5‐year overall survival (OS) and disease‐free survival (DFS). Cox regression analysis was performed to assess the prognostic factors. Nomograms were established to predict OS and DFS, and Harrell's concordance index (c‐index) was adopted to evaluate prediction accuracy. As results, the 5‐year OS was 79.2% and the 5‐year DFS was 56.0% in the cohort. Patients were stratified into 2 groups by NLR (≤2.72 and >2.72), PLR (≤219.00 and >219.00), LMR (≤2.83 and >2.83) and AGR (<1.50 and ≥1.50). Patients with NLR > 2.72, PLR > 219.00, LMR ≤ 2.83 and AGR < 1.50 were significantly associated with decreased OS and DFS (p < 0.001). Multivariate analysis indicated that NLR, LMR and AGR were independent factors of OS (p = 0.047, p = 0.008 and p < 0.001, respectively) and DFS (p = 0.009, p < 0.001 and p = 0.008, respectively). In addition, nomograms on OS and DFS were established according to all significant factors, and c‐indexes were 0.765 (95% CI: 0.744–0.785) and 0.735 (95% CI: 0.721–0.749), respectively. Nomograms based on OS and DFS can be recommended as practical models to evaluate prognosis for CRC patients. 相似文献
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Background:
This study investigated the usefulness of a novel inflammation-based prognostic system, named the COP-NLR (COmbination of Platelet count and Neutrophil to Lymphocyte Ratio), for predicting the postoperative survival of patients with colorectal cancer (CRC).Methods:
The COP-NLR was calculated on the basis of data obtained on the day of admission: patients with both an elevated platelet count (>30 × 104 mm−3) and an elevated NLR (>3) were allocated a score of 2, and patients showing one or neither were allocated a score of 1 or 0, respectively.Results:
Four-hundred and eighty patients were enrolled. Multivariate analysis of clinical characteristics selected by univariate analysis showed that the COP-NLR (1, 2/0) (odds ratio, 0.464; 95% confidence interval, 0.267–0.807; P=0.007) had an association with cancer-specific survival, along with pathology, lymph node metastasis, the serum levels of carcinoembryonic antigen, C-reactive protein and albumin, and the Glasgow Prognostic Score. Kaplan–Meier analysis and log-rank test revealed that the COP-NLR was able to divide such patients into three independent groups (P<0.001).Conclusion:
The COP-NLR is considered to be a useful predictor of postoperative survival in patients with CRC. 相似文献10.
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Neutrophil‐lymphocyte ratio at diagnosis is an independent prognostic factor in patients with nodular sclerosis Hodgkin lymphoma: results of a large multicenter study involving 990 patients 下载免费PDF全文
Tamar Tadmor Luigi Marcheselli Maria Christina Cox Samantha Pozzi Angela Ferrari Luca Baldini Paolo Gobbi Ariel Aviv Giuseppe Pugliese Massimo Federico Aaron Polliack Stefano Sacchi 《Hematological oncology》2017,35(4):561-566
Several studies have demonstrated the prognostic value of neutrophil‐lymphocyte ratio (NLR) in patients with solid tumors and non–Hodgkin lymphoma. In contrast, there is only sparse data on its prognostic role in patients with classical Hodgkin lymphoma (cHL). The aim of our study was to establish whether NLR could serve as an independent prognostic factor in a cohort of 990 patients with nodular sclerosis (NS)‐cHL. After analysis of the log hazard ratio (HR) as a function of NLR, we chose the value 6 as cutoff. Patients with NLR >6 had a worse progression‐free survival and overall survival compared to those with NLR ≤6; 84% vs 75% and 92% vs 88%, at 5 years, with an HR of 1.65 and 1.82, respectively. Multivariate analysis showed that the risk remained high with HR 1.44 and HR 1.54 in progression‐free survival and overall survival, respectively. In summary, our study shows that NLR is a robust and independent prognostic parameter in NS‐cHL, both in early and advanced disease. It is inexpensive and simple to apply. Thus, we conclude that NLR, possibly in combination with the international prognostic score and absolute monocyte count, is a useful guide for physicians treating NS‐cHL patients. 相似文献
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Lymphocyte‐to‐monocyte ratio and neutrophil‐to‐lymphocyte ratio as biomarkers for predicting lymph node metastasis and survival in patients treated with radical cystectomy 下载免费PDF全文
David D'Andrea Marco Moschini Kilian M. Gust Mohammad Abufaraj Mehmet Özsoy Romain Mathieu Francesco Soria Alberto Briganti Morgan Rouprêt Pierre I. Karakiewicz Shahrokh F. Shariat 《Journal of surgical oncology》2017,115(4):455-461
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Roles of Neutrophil/Lymphocyte and Platelet/Lymphocyte Ratios in the Early Diagnosis of Malignant Ovarian Masses 下载免费PDF全文
《Asian Pacific journal of cancer prevention》2014,15(16):6881-6885
Background: The present study aimed to investigate the utility and importance of the various parameters of complete blood count panel for benign-malignant differentiation of adnexal masses. Materials and Methods: This retrospective study involved 316 patients with documented benign and 253 patients with malignant adnexal masses who underwent primary surgical treatment at a tertiary referral center. Prior to the study, all benign and malignant cases were compared within their own groups and then the benign and malignant cases were compared to each other. For all cases, cut-off, sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were calculated for the neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), neutrophil, lymphocyte, platelet and CA-125 parameters, and the results were compared in regards to the groups. Results: NLR, PLR, neutrophil, CA-125, and platelet values were higher in the malignant compared to the benign cases (p<0.01). The lymphocyte value was lower in the malignant cases (p<0.01). No significantdifferences were found for basophils and eosinophils (p > 0.05). For CA-125, the sensitivity, specificity, PPV and NPV for all cases were 78%, 62%, 62% and 78%, respectively. For NLR, they were 65.6%, 72.1%, 65.3%, and 72.3%, and for PLR, 48%, 81%, 67%, and 66%. Additionally, the sensitivity and specificity were 55% and 77% for CA-125, 66% and 58% for NLR, and 61% and 58% for PLR in early malignant cases. Conclusions: NLR and PLR appear to be useful methods that can be applied together with CA-125 due to the relatively high sensitivity values for the malign-benign differentiation of ovarian masses. Although the specificity of these parameters is lower than CA-125, especially in cases with early malignant ovarian pathology, their sensitivity being higher is promising for the early diagnosis of ovarian cancer. It can be used to detect ovarian malignancies in the early stages, and it will increase the treatment options and improve survival rates. 相似文献
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Genetic variants in nucleotide excision repair pathway predict survival of esophageal squamous cell cancer patients receiving platinum‐based chemotherapy 下载免费PDF全文
Ruoxin Zhang Fei Zhou Lei Cheng Alexandria Yu Meiling Zhu Mengyun Wang Zhuanxu Zhang Jiaqing Xiang Qingyi Wei 《Molecular carcinogenesis》2018,57(11):1553-1565
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持续的全身慢性炎症在恶性肿瘤的发生、进展、转移过程中起着重要作用。外周血中性粒细胞与淋巴细胞比值(neutrophil-to-lymphocyte ratio,NLR)和血小板与淋巴细胞比值(platelet-to-lymphocyte ratio,PLR)与多种恶性肿瘤如肺癌、恶性黑色素瘤、消化道恶性肿瘤、肝癌等免疫治疗的预后具有显著相关性,同时NLR和PLR检测具有价格低、创伤小、易获得、可重复性高的特点。研究表明,较高的基线或用药后NLR和PLR水平与患者对免疫治疗的反应、预后均呈负相关,且患者出现免疫治疗抵抗、肿瘤进展或死亡的风险更高,预期无进展生存期(progression free survival,PFS)、总生存期(overall survival,OS)相较于低NLR和低PLR患者更短。该文就NLR和PLR与多种接受免疫治疗的恶性肿瘤患者预后的相关研究作一综述,为寻找针对免疫治疗的最佳预后指标、早期筛选出免疫治疗潜在获益患者以及预测他们的治疗结局提供依据。 相似文献
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M H Kang S-I Go H-N Song A Lee S-H Kim J-H Kang B-K Jeong K M Kang H Ling G-W Lee 《British journal of cancer》2014,111(3):452-460