Quadrilateral Space Syndrome: Case Report and Review of the Literature

The quadrilateral space syndrome is defined as tenderness over the quadrilateral space and shoulder pain radiating to the arm, secondary to compression of the axillary nerve and posterior circumflex humeral artery in the quadrilateral space. The symptoms are aggravated by forced abduction and extrenal rotation of the arm. The diagnosis is clinical and is documented by arteriography or angio-MR imaging with dynamic maneuvers. A 30-year-old woman presenting with this syndrome is described here, the differential diagnosis discussed, and the literature reviewed.     

Case Reports: Unusual Cause of Shoulder Pain in a Collegiate Baseball Player

The objective of reporting this case was to introduce a unique cause of shoulder pain in a high-level Division I NCAA collegiate baseball player. Various neurovascular causes of shoulder pain have been described in the overhead athlete, including quadrilateral space syndrome, thoracic outlet syndrome, effort thrombosis, and suprascapular nerve entrapment. All of these syndromes are uncommon and frequently are missed as a result of their rarity and the need for specialized tests to confirm the diagnosis. This pitcher presented with nonspecific posterior shoulder pain that was so severe he could not throw more than 50 feet. Eventually, intermittent axillary artery compression with the arm in abduction resulting from hypertrophy of the pectoralis minor and scalene muscles was documented by performing arteriography with the arm in 120° abduction. MRI-MR angiographic evaluation revealed no anatomic abnormalities. The patient was treated successfully with a nonoperative rehabilitation program and after 6 months was able to successfully compete at the same level without pain.     

Axillary nerve entrapment in the quadrilateral space. Case report

The quadrilateral space syndrome is a recently established entity with seemingly consistent pathological and radiographic features. An example of this syndrome is reported. In this patient, entrapment of the axillary nerve by fibrous bands in the quadrilateral space caused shoulder pain with paresthesias in the upper extremity. Subclavian angiography provided the diagnosis by demonstrating that the posterior humeral circumflex artery, which was normal when the arm was in a neutral position, was occluded when the arm was abducted and externally rotated. Axillary neurolysis through a posterior approach resulted in relief of symptoms.     

The anatomy of the quadrilateral space with reference to quadrilateral space syndrome

Quadrilateral space syndrome is a rare condition in which the contents of the quadrilateral space, the axillary nerve and the posterior circumflex humeral artery, are compressed, leading to vague symptoms of shoulder pain, tenderness over the quadrilateral space on palpation, and teres minor and deltoid denervation. Fibrous bands within the quadrilateral space are often cited in the literature as a cause of compression in quadrilateral space syndrome; however, Cahill and Palmer did not see these bands in cadaveric dissection. These are postulated to cause compression of the quadrilateral space contents in abduction and external rotation of the shoulder. To clarify the anatomic features that may predispose the development of quadrilateral space syndrome, 16 cadaveric shoulders were studied. Dissection revealed that fibrous bands are a common finding in the quadrilateral space, being present in 14 of 16 shoulders. The most common site for a fibrous band was between the teres major and the long head of the triceps. Where the bands were present, both internal and external rotation of the shoulder caused a reduction in the cross-sectional area of the quadrilateral space.     

Neurovascular injuries to the athlete's shoulder: part II

Athletes are at particular risk of compromise of the neurovascular structures of the shoulder-specifically, neurovascular conditions distal to the brachial plexus. These conditions include thoracic outlet syndrome, axillary artery occlusion, effort thrombosis, suprascapular nerve entrapment, quadrilateral space syndrome, and complex regional pain syndrome. When diagnosed properly and in a timely fashion, function of the limb can be preserved. To accomplish this, the physician must possess a detailed understanding of the various clinical presentations, diagnostic techniques, and treatment options.     

Thoracic outlet syndrome caused by first rib hemangioma

We report a case of first rib hemangioma that caused thoracic outlet syndrome. A 50-year-ole woman who was admitted to our hospital with a clinical diagnosis of thoracic outlet syndrome presented with fullness and easy fatigue of her right arm. Her right arm discomfort was associated with intermittent engorgement of superficial veins over the shoulder girdle. A chest radiograph revealed an enlargement of the anterior aspect of the first rib with fine bony trabeculations. Computed tomography scan showed contrast enhancement over the enlarged rib. Our tentative preoperative diagnosis was a benign first rib hypertrophic change, such as an old fracture with exuberant callus formation. A right-arm venogram revealed a patent subclavian vein with an extrinsic compression, which occluded on arm abduction. The findings of neural conduction studies of both upper extremities were symmetric and normal. The patient agreed to surgery because of the occlusive condition of the subclavian vein on arm abduction and progressive arm weakness in recent months. Segmental transection of the offending portion of the enlarged first rib was complicated by difficulty in isolating the whole length of the compressed but normal-appearing subclavian vein by our initial transaxillary and infraclavicular approaches because the medial aspect of the subclavian vein was obstructed by the enlarged first rib, which extended medially to the junction of the right jugular and subclavian veins. Successful segmental transection of the enlarged first rib was finally accomplished by combined transaxillary, infraclavicular, and supraclavicular approaches. A moderate amount of rib bleeding from resection ends was noted during segmental resection of the enlarged first rib, resulting in local hematoma formation. A 470-mL bloody discharge was collected from the vacuum ball inserted via the transaxillary route during her 12-day hospitalization. Pathologic examination revealed an intraosseous hemangioma. The patient had a prolonged course to partial recovery of her arm numbness, but signs of venous compression were much improved at 6 months' follow-up. Although hemangioma is benign, its hypervascular nature may cause catastrophic intraoperative bleeding.     

Unusual case of thoracic outlet syndrome caused by a neurilemmoma in the pectoralis minor space

A 34-year-old man presented with a 5-year history of paraesthesia of the right palm and the right middle and ring fingers. This paraesthesia was exacerbated by elevation of the right arm. A tumour was palpable in the subclavicular fossa. As magnetic resonance imaging (MRI) indicated a neurogenic tumour originating from the brachial plexus, a diagnosis of thoracic outlet syndrome caused by a neurilemmoma in the pectoralis minor space was made. Pathological examination showed the tumour to be a benign neurilemmoma. There have been only three previous case reports of neurilemmomas as causes of thoracic outlet syndrome worldwide, and this is the first report of a neurilemmoma originating from the lateral fascicles of the brachial plexus in the pectoralis minor space causing thoracic outlet syndrome.     

Axillary nerve injury: diagnosis and treatment

Axillary nerve injury is infrequently diagnosed but is not a rare occurrence. Injury to the nerve may result from a traction force or blunt trauma applied to the shoulder. The most common zone of injury is just proximal to the quadrilateral space. Atraumatic causes of neuropathy include brachial neuritis and quadrilateral space syndrome. The vast majority of patients recover with non-operative treatment. Baseline electromyographic and nerve conduction studies should be obtained within 4 weeks after injury, with a follow-up evaluation at 12 weeks. If no clinical or electromyographic improvement is noted, surgery may be appropriate. The results of operative repair are best if surgery is performed within 3 to 6 months from the injury. Surgical options include neurolysis, nerve grafting, and neurotization. The results of repair of axillary nerve injuries have been good compared with treatment of other peripheral nerve lesions, due to the monofascicular composition of the nerve and the relatively short distance between the zone of injury and the motor end-plate.     

Quadrilateral space syndrome: diagnosis, pathology, and treatment

Quadrilateral space syndrome is an infrequent, recently established neurovascular compression syndrome affecting young active adults. With this syndrome, the neurovascular bundle, consisting of the posterior humeral circumflex artery (PHCA) and the axillary nerve, is compressed by fibrotic bands as it traverses the quadrilateral space. Symptoms result from compression of the axillary nerve, not from PHCA occlusion. Because of the vague, often nonspecific, clinical presentation of patients with quadrilateral space syndrome, diagnosis is challenging and requires a high index of suspicion from the orthopedist. Subclavian arteriography confirms the diagnosis. Treatment is usually conservative; operative management is reserved for selected patients. A posterior approach with detachment of the deltoid and teres minor muscles is recommended for surgical decompression and for lysis of fibrous tissue. We report two cases of persistent quadrilateral space syndrome in young adults, treated surgically, with 2-year follow-up. In the present report, diagnostic criteria, pathology, management, operative technique, and recent literature are also reviewed.     

Isolated teres minor atrophy: manifestation of quadrilateral space syndrome or traction injury to the axillary nerve?

This article prospectively determines through magnetic resonance imaging (MRI) the incidence of isolated teres minor atrophy and its gender and age distribution, and documents associated findings related to the rotator cuff, labroligamentous complex, and quadrilateral space. Two hundred seventeen consecutive shoulder MRI examinations performed over a 3-month period were prospectively reviewed and evaluated for isolated teres minor atrophy. Twelve (5.5%) patients had non-compressive isolated teres minor atrophy. Ninety-two percent (n=11) of these patients had rotator cuff or labroligamentous complex tears. No patients had an associated mass within the quadrilateral space. The average patient age was 60 years and 11 of the 12 patients were male. Isolated teres minor atrophy on MRI is most commonly seen in older patients who do not fit the expected clinical presentation of quadrilateral space syndrome. The anatomical relationship of the teres minor nerve to the joint capsule and the frequency of associated shoulder injuries in these patients raises the possibility of an association between humeral decentering and teres minor atrophy. Quadrilateral space syndrome would appear to be a very rare cause of isolated teres minor atrophy.     

Quadrilateral space syndrome: a case report

Quadrilateral space syndrome is a rare entity caused by isolated compression of the axillary nerve in the quadrilateral space. A twenty-seven-year-old male patient presented with a poorly localized shoulder pain and point tenderness on the posterior aspect of the shoulder. Magnetic resonance imaging showed a fibrous band causing quadrilateral space syndrome. Surgical excision of the fibrous band was performed and the axillary nerve was released. The patient became symptom-free after surgical decompression.     

The treatment of thoracic outlet syndrome: a comparison of different operations

Although transaxillary first rib resection is one of the popular treatments for thoracic outlet syndrome today, recurrences and nerve injuries have led to investigation of other operations that might reduce complications and improve results. This article compares the results of transaxillary first rib resection with (1) scalenectomy (anterior and middle) and (2) supraclavicular first rib resection with scalenectomy. Between 1964 and 1987, 668 primary operations were performed for thoracic outlet syndrome on 491 patients. Seventy-one percent were women. Eight-six percent gave histories of neck trauma, often a whiplash injury (traumatic thoracic outlet syndrome); 4.5% had cervical ribs. Common symptoms included paresthesia in the hands (90%); arm pain (80%); neck pain (86%); and occipital headaches (69%). On physical examination, tenderness over the scalene muscles and duplication of symptoms with the arms abducted to 90 degrees in external rotation were present in over 90% of patients. By use of life-table analysis methods, success after surgery was found to be the same for all operations: 91% to 93% at 3 months; 76% to 79% at 1 to 2 years; 70% to 73% at 3 to 5 years; and 69% to 72% at 5 to 10 years. After rib resection plexus injuries occurred in 2.6%, with partial disability in 0.5%. No plexus injuries occurred after scalenectomy, but temporary phrenic nerve palsy occurred in 4.4%. Scalenectomy is as successful an operation as first rib resection for traumatic thoracic outlet syndrome and has fewer serious complications.(ABSTRACT TRUNCATED AT 250 WORDS)     

选择进胸取膈神经移位路径的应用解剖学研究

目的 为选择进胸取膈神经移位治疗臂丛神经根性损伤的移位路径提供解剖学依据。方法 对29侧尸体标本，观测进胸获取膈神经，经不同路径移位可到达的上臂部位。结果 进胸取膈神经经肋间引出胸腔作移位时，经第二肋间腋前线处引出的膈神经远端，距肱骨内外髁连线的距离最近，平均为上臂长度的38.6%(左侧）和52.4% (右侧）。膈神经丛颈部抽出经胸腔外移位时，沿臂丛神经行径置于锁骨后方的膈神经远端，距上臂内髁的距离最近，平均为上臂长度的25.9%(左侧）和39.0%(右侧）。结论 上述两种路径分别为进胸取膈神经经肋间和经胸腔外移位，修复上臂部神经的最短路径。     

Thoracic Outlet Syndrome Masquerading as Coronary Artery Disease (Pseudoangina)

Forty-four patients presenting with chest pain suggesting coronary artery disease had normal exercise stress tests and selective coronary angiography and subsequently were found to have an unsuspected thoracic outlet syndrome. Thirteen additional patients had both significant coronary artery disease and thoracic outlet syndrome. Esophageal and pulmonary disease were ruled out and the diagnosis of brachial plexus compression in the thoracic outlet established by a reduction of the ulnar nerve conduction velocity (UNCV) below normal, the normal value being 72 meters per second. Clinical improvement from thoracic outlet compression resulted either from physical therapy if the UNCV's were above 55 m./sec, or from transaxillary surgical extirpation of the first rib if the UNCV's were below 55 m./sec. Thirteen patients with coronary artery disease and thoracic outlet syndrome required therapy for both problems before improvement ensued. Although the usual symptomatology for thoracic outlet syndrome involves pain and paresthesias of the shoulder, arm, and hand, the chest wall is frequently involved. If the chest pain is predominant with minimal shoulder-hand symptoms, the diagnosis is not suggested clinically and can only be established by the high index of suspicion, positive UNCV reduction, and a normal coronary angiogram. Pathways of pain in angina pectoris and afferent stimuli originating from brachial plexus compression at the thoracic outlet stimulate the same autonomic and somatic spinal centers that induce referred pain to the chest wall and arm.     

Thoracic outlet syndrome in whiplash injury.

Thirty-five cases of thoracic outlet syndrome complicating whiplash or cervical strain injury were studied. Thirty cases had confirmation by the demonstration of slowed ulnar nerve conduction velocity (UNCV) through the thoracic outlet. Two distinct groups of patients were found. An acute group, seen an average of 3 1/2 months post injury, had severe neck pain with often mild or incidental thoracic outlet syndrome. A chronic group, with symptoms persisting more than 2 years after cervical injury, often had thoracic outlet symptoms as the predominant complaint. This study suggests that the arm aches and parethesias seen in association with both acute and chronic cervical strain injury are most often secondary to thoracic outlet syndrome.     

Sibson筋膜导致胸廓出口综合症

本文分析了1987～1995年手术治疗45例胸廓出口综合症病人，经手术证实引起胸廓出口综合症之主要病因中除通常所述的斜角肌病变、预肋、胸小肌出点处病变和肋锁间隙病变外。还有一种病因，即胸膜上筋膜（Sibson筋膜）卡压臂丛下干而导致胸廓出口综合症。其中7列行手术探查肘，未发现其他卡压因素，仅发现臂丛下手表面覆盖一层薄的筋膜，遂对此筋膜进行了松解，术后症状明显缓解，因此认为此膜系卡压因素。     

Thoracic outlet syndrome of pectoralis minor etiology mimicking cardiac symptoms on activity: a case report

Thoracic outlet syndrome is the result of compression or irritation of neurovascular bundles as they pass from the lower cervical spine into the arm, via the axilla. If the pectoralis minor muscle is involved the patient may present with chest pain, along with pain and paraesthesia into the arm. These symptoms are also commonly seen in patients with chest pain of a cardiac origin. In this case, a patient presents with a history of left sided chest pain with pain and paraesthesia into the left upper limb, which only occurs whilst running. The symptoms were reproduced on both digital pressure over the pectoralis minor muscle and on provocative testing for thoracic outlet syndrome. The patient’s treatment therefore focused on the pectoralis minor muscle, with a complete resolution of symptoms. This illustrates that not all cases of chest pain with associated arm symptoms that occur on physical activity are of cardiac origin.     

Paralabral cyst: an unusual cause of quadrilateral space syndrome.

A paralabral cyst arising from a detached inferior glenoid labral tear was shown by magnetic resonance imaging (MRI) to dissect into the quadrilateral space, resulting in a compressive neuropathy of the axillary nerve. Three consecutive MRI examinations were performed over a 5-year period in a 47-year-old man with a long history of worsening shoulder pain. The MRI examinations revealed a slowly enlarging paralabral cyst extending into the quadrilateral space with progressive atrophy of the teres minor muscle.     

Mycotic aneurysm of the distal aortic arch caused by Aspergillus.

We describe an unusual case of a thoracic aortic aneurysm caused by Aspergillus. A 70-year-old man underwent prednisolone and Ara-C treatments for a myelodysplastic syndrome. Blood examination revealed pancytopenia. Under these treatments, an aneurysm presented at the distal aortic arch. He underwent resection of the aneurysm with a graft repair covered by a pedicled omentum flap, followed by prolonged administration of micafungin and itraconazole for a mycotic aneurysm. The postoperative course was favorable without complications. Serum C-reactive protein became negative and he was discharged 2 months after the surgery. However, 4 months after the surgery, he died from worsening of the myelodysplastic syndrome. The prognosis for patients with mycotic aneurysms is poor due to their immunocompetent condition arising from underlying diseases. Therefore, in addition to prompt treatment with antifungal agents combined with surgical debridement, control of the underlying disease is essential for improving the outcome.