门腔分流术后不同氨基酸溶液胃肠外营养的对比分析

评价不同氨基酸溶液胃肠外营养对营养支持效果以及肝脏功能和血浆氨基酸谱的影响。方法因门脉高压症住院接受脾切除，限制性门腔静脉侧侧分流术的４０例肝功能ＣｈｉｌｄＡ级患者，随机分为两组：Ｈｅｐａ组和Ｖａｍｉｎ组，每组各２０例。自手术后第１天起两组分别接受等氮，等热卡胃上营养支持８天（Ｈｅｐａ组以Ｈｅｐａ氨基酸溶液 作为氮源，Ｖａｍｉｎ组ＶＡＭＩＮＲＮＰＶＡＤ ＳＧＣＴＩＰＷＫＩＹＷ Ｔ Ｏ ＲＮＯＯＩＤ     

糖尿病患者肾血流与内皮素及降钙素基因相关肽关系

目的为了解内皮素（ＥＴ）及降钙素基因相关肽（ＣＧＲＰ）与糖尿患者不同阶段时肾血流的关系。方法肾彩色多普勒超声检查确定为糖尿病肾血流正常组（Ａ组）１５例、糖尿病肾血流减少组（Ｂ组）１５例，正常对照组１８例。分别采血测定血浆ＥＴ－１和ＣＧＲＰ浓度。结果Ａ组ＥＴ－１水平低于正常对照组（Ｐ＜０．０１），Ｂ组ＥＴ－１水平高于正常对照组（Ｐ＜０．０１）。二组ＥＴ－１水平与肾动脉收缩期峰值血流速度（Ｖｍａｘ）、肾动脉血流量（Ｑ）呈负相关（Ｐ＜０．０１），与尿白蛋白排泄率（ＵＡＥＲ）呈正相关（Ｐ＜０．０５）。二组的ＣＧＲＰ水平均低于正常组（Ｐ均＜０．０１），但Ａ与Ｂ组的ＣＧＲＰ水平差异无显著性（Ｐ＞０．０５）。未发现ＣＧＲＰ水平与Ｖｍａｘ、Ｑ和ＵＡＥＲ呈相关关系。结论ＥＴ－１在糖尿病不同阶段时对肾血流量的病理生理作用可能不同；糖尿病患者呈现低ＣＧＲＰ血症，但它对不同阶段的糖尿病肾血流的影响尚有待探讨。     

不育男性精子数及活动率与体液表皮生长因子的相关性

为了分析体液表皮生长因子（ＥＧＦ）含量与不明原因男性不育之间的相关性，本研究分别收集了３７例男性不育患者的血液、精液和唾液，根据精子计数将患者分成３组：Ａ组：＜２１×１０６／ｍｌ，Ｂ组：２１４０×１０６／ｍｌ，Ｃ组：＞４０×１０６／ｍｌ。根据精子活动率将患者分成４组：Ｉ组：０２０％，Ｉ组：２１％～４０％，ＩＩ组：４１％～６０％，ＩＶ组：６１％～８０％。用放射免疫法测定血浆、精浆和唾液ＥＧＦ浓度。结果：各组血浆ＥＧＦ含量与对照比较无显著差异，Ａ、Ｂ和Ｃ组的唾液ＥＧＦ浓度均显著高于对照（Ｐ＜０．０５），而且Ａ组精浆ＥＧＦ也显著高于对照（Ｐ＜０．０５）。Ｉ、ＩＩ和ＩＶ组的唾液ＥＧＦ浓度都显著高于对照（Ｐ＜０．０５）。对照组的唾液ＥＧＦ含量与精子数量呈显著负相关（ｒ＝－０．８７５，Ｐ＜０．０５）。唾液ＥＧＦ（主要来自颌下腺）与精子发生有相关性。唾液ＥＧＦ浓度异常与不明原因男性不育的关系值得重视。     

梗阻性黄疸时胆道内压力和门静脉血流与IL-2、sIL-2R及T淋巴细胞亚群变化的关系探讨

为探讨梗阻性黄疸患者败血症的发生机理，研究了３７例梗阻性黄疸（Ａ组）和９０例胆囊结石（Ｂ组）患者的胆道内压力、门静脉血流速度与白细胞介素－２（ＩＬ－２）、可溶性白细胞介素－２受体（ｓＩＬ－２Ｒ）及Ｔ淋巴细胞亚群的关系。Ａ组又分为急诊手术组（Ａ１）、择期手术组（Ａ２）、＞６０岁组（Ａ３）和＜６０岁组（Ａ４）４个亚组。结果显示：Ａ及Ａ１～４各组术前ＣＤ３＋、ＣＤ４＋、ＣＤ８＋值均显著低于术后１０天值（Ｐ＜０．０５或Ｐ＜０．０１），ｓＩＬ－２Ｒ显著高于术后１０天值（Ｐ＜０．０１）。Ａ１组术前ｓＩＬ－２Ｒ极显著高于Ａ及Ａ２～４组（Ｐ＜０．０１）。相关分析显示胆道内压力与ＩＬ－２、ＣＤ３＋、ＣＤ４＋及ＣＤ８＋呈负相关，与ｓＩＬ－２Ｒ呈正相关（Ｐ＜０．０１），门静脉血流速度与ＩＬ－２呈正相关（Ｐ＜０．０１）。由此表明梗阻性黄疸感染与宿主细胞免疫功能降低密切相关。     

狼疮肾炎患者血与尿白细胞介素-8测定的临床意义

目的　探讨血清和尿中白细胞介素８（ Ｉ Ｌ８） 水平变化在系统性红斑狼疮（ Ｓ Ｌ Ｅ） 及狼疮肾炎（ Ｌ Ｎ） 中的临床意义。方法　采用 Ｅ Ｌ Ｉ Ｓ Ａ 法对４７ 例 Ｓ Ｌ Ｅ 患者（ 含３７ 例 Ｌ Ｎ） 、１３ 例原发性慢性肾小球肾炎和１４ 例正常对照进行血清和尿中 Ｉ Ｌ８ 水平检测,比较分析其与 Ｓ Ｌ Ｅ 活动指数（ Ｓ Ｌ Ｅ Ｄ Ａ Ｉ） 、肾脏损害的相关关系。结果　 Ｓ Ｌ Ｅ 患者血清 Ｉ Ｌ８ 水平活动期为５５３ ｐｇ／ｍｌ（ 中位数,下同） 静止期为２６３８ ｐｇ／ｍｌ,明显高于正常对照组２０５４ ｐｇ／ｍｌ（ Ｐ ＜ ０００１） ,并且活动期高于静止期（ Ｐ ＜ ００５） ,血清 Ｉ Ｌ８ 水平与 Ｓ Ｌ Ｅ Ｄ Ａ Ｉ正相关（ ｒ ＝ ０６００３ , Ｐ ＜ ００５） ; Ｓ Ｌ Ｅ 患者尿 Ｉ Ｌ８ 显著高于正常对照组２０６７ｐｇ／ｍｌ（ Ｐ＜ ００５） ,且 Ｌ Ｎ 组２５２９ ｐｇ／ｍｌ 明显高于 Ｓ Ｌ Ｅ 无肾炎组为２１１ ｐｇ／ｍｌ 及原发性慢性肾小球肾炎组１９４１ ｐｇ／ｍｌ（ Ｐ 值均＜ ００５） ;肾脏组织病理狼疮活动指数（ Ａ Ｉ） 高者其血清、尿 Ｉ Ｌ８ 水平显著高于 Ａ Ｉ低者（ Ｐ ＜ ００５） 。结论　血清 Ｉ Ｌ     

山莨菪碱对ARDS的氧输送及血流动力学改变的作用

早期、大剂量山莨菪碱治疗外科术后成人呼吸窘迫综合征（ＡＲＤＳ），观察病程第１￣４天氧输送与血流动力学等指标。治疗组用山莨菪碱＋常规治疗，对照组用常规治疗。结果：第２￣４天治疗组Ｃｌ、ＤＯ２、ＶＯ２、Ｏ２Ｅｘｔ、ＰａＯ２／ＦｉＯ２分别显著高于对照组（Ｐ〈０．０５）；Ａ－ａＤＯ２、ＰＶＲＩ显著低于对照组（Ｐ〈０．０５）。ＶＯ２与ＤＯ２呈直线相关（ｒ＝０．５８，Ｐ〈０．０５）。治疗组８例死亡１例，对照组     

血栓调节蛋白与肝细胞癌门静脉癌栓的关系

目的　了解血栓调节蛋白（ｔｈｒｏｍｂｏｍｏｄｕｌｉｎ,ＴＭ） 在肝细胞癌（ＨＣＣ） 病人血浆中的水平,探讨ＴＭ 与ＨＣＣ门静脉癌栓形成及侵袭和转移的关系。方法　采用酶联免疫吸附（ＥＬＩＳＡ） 夹心法,检测４５ 例ＨＣＣ病人和６ 例肝良性占位病人的术前和术后血浆ＴＭ 水平。结果　术前ＨＣＣ组血浆ＴＭ水平（１０±６）ｎｇ／ｍｌ 明显高于肝良性占位组（６．１ ±２．２）ｎｇ／ｍｌ,Ｐ＜ ０．０５;单发肝癌结节组（１２ ±６）ｎｇ／ｍｌ和无门静脉癌栓组（１１±６）ｎｇ／ｍｌ 明显高于多发肝癌结节组（８ ±５）ｎｇ／ｍｌ 和门静脉癌栓组（７ ±５）ｎｇ／ｍｌ,Ｐ＜ ０．０５;而ＴＭ 高低与肝癌大小、包膜是否完整、病理分化程度、ＡＦＰ值及肝癌伴肝硬化程度无关,各组比较Ｐ＞０．０５。肝良性占位组术前ＴＭ（６±２）ｎｇ／ｍｌ 与切除术后（５ ．９ ±１ ．８）ｎｇ／ｍｌ 相比差异无显著性,Ｐ＞０ ．０５ ;肝癌组术前（１０ ±５）ｎｇ／ｍｌ 与切除术后（８ ±４）ｎｇ／ｍｌ 相比差异有显著意义,Ｐ＜０ ．０５。结论　ＨＣＣ病人血浆中ＴＭ 水平可升高,ＴＭ 在抗ＨＣＣ门静脉癌栓形成过程中发挥重要作用。     

慢性肾功能衰竭血浆P物质,心钠素与肾功能的关系

目的了解慢性肾功能衰竭（ＣＲＦ）患者血浆Ｐ物质（ＳＰ）、心钠素（ＡＮＰ）含量变化与肾功能的关系。方法采用放射免疫分析法检测正常对照组及ＣＲＦ组血液透析前后ＳＰ、ＡＮＰ，同时测定血清肌酐（Ｓｃｒ）。结果（１）透析前ＳＰ显著高于正常对照组（Ｐ＜００１），透析后ＳＰ高于透析前（Ｐ＜００５）；ＳＰ透析前与Ｓｃｒ呈正相关（ｒ＝０６６，Ｐ＜００５），ＳＰ透析后与Ｓｃｒ呈负相关（ｒ＝－０４６，Ｐ＜００５）；（２）透析前ＡＮＰ显著高于对照组（Ｐ＜００１），透析后ＡＮＰ显著低于透析前（Ｐ＜００５），ＡＮＰ透析前后与Ｓｃｒ呈正相关（ｒ＝０８２，Ｐ＜００５）；（３）透析前后ＳＰ变化值与ＡＮＰ变化值呈负相关（ｒ＝－０４８，Ｐ＜００５）。结论ＣＲＦ患者血浆ＳＰ、ＡＮＰ含量的变化与肾功能的改变有较明显的相关性。     

慢性肾功能衰竭患者血清及尿白细胞介素－8的检测及意义

目的了解慢性肾功能衰竭（ＣＲＦ）患者血清及尿ＩＬ－８水平的变化及意义。方法双抗体夹心ＥＬＩＳＡ法。结果ＣＲＦ患者血清及尿中ＩＬ－８的含量均显著高于正常对照组（Ｐ＜０．００１），但与Ｓｃｒ无明显相关性（ｒ＝－０．２７，Ｐ＞０．０５和ｒ＝－０．０５，Ｐ＞０．０５）。结论ＣＲＦ仍存在比较严重的免疫炎症反应，此可能为肾小球功能受损的重要原因之一。     

P53基因突变结合术前肿瘤标志物检测对结直肠癌患者预后的评估

目的　进一步了解肿瘤标志物与基因检测在判断结直肠肿瘤患者预后中的价值。方法　对５４ 例结直肠癌患者,术前取血检测结直肠相关抗原血清癌胚抗原（ＣＥＡ） 、ＣＡ１９９ 水平,同时取手术切除标本,应用聚合酶链反应单链构像多肽性法（ＰＣＲＳＳＣＰ） 检测Ｐ５３ 基因第５ － ８ 外显子。结果　Ｐ５３ 基因突变率为４４－４ ％（２４／５４） ,在Ｐ５３ 基因突变患者中,ＣＥＡ阳性率明显高于Ｐ５３ 基因未突变者（ Ｐ＜ ０－０５）,而术前ＣＥＡ（ ＋） 及肿瘤标本Ｐ５３ 基因突变者多发生复发或远处转移（ Ｐ＜０－０５）。结论　术前ＣＥＡ（＋ ）及肿瘤标本中Ｐ５３ 基因突变者临床预后差,这不但说明了术前测定肿瘤标志物同样存在临床实用价值,而且对于术后如何制订合理的、优化的治疗方案、如何进一步有效地加强临床随访工作均有一定的参考价值。     

肝硬变门静脉高压患者门腔静脉搭桥分流术前后血浆氨基酸谱的分析

作者于１９９４年４月至１９９５年５月对１０例肝硬变门静脉高压和１０例无肝病胃肠手术患者进行了血浆氨基酸谱检测。１０例门静脉高压患者行８ｍｍ口径人工血管门腔搭桥分流术。分别于分流术前、术后即刻、术后１天、术后３天测定周围动脉、周围静脉、门静脉及肝静脉血浆氨基酸谱，胃肠手术组则于手术开始及术后３天测定。结果显示：胃肠组与分流组术后氨基酸水平均比术前下降，但分流组下降明显。支链氨基酸与芳香氨基酸之比（ＢＣＡＡ／ＡＡＡ）在分流术前小于２，对照则大于３，术前术后两组变化均不明显。在分流组患者肝静脉血中的ＢＣＡＡ及ＡＡＡ含量无论手术前后均高于其它部位；分流术后即刻ＢＣＡＡ及ＡＡＡ均比术前减少，其中ＢＣＡＡ中缬氨酸、亮氨酸减少明显。术后３天ＢＣＡＡ和ＡＡＡ恢复至术前水平。提示：小口径门体分流术对患者氨基酸谱变化无明显影响。术后氨基酸暂时下降可能与手术应激及肝功受损有关     

Multiple system organ failure in postburn: characteristics of plasma amino acid profiles

The purpose of this study was to investigate the levels of various plasma amino acids in 30 burned patients (76.83 +/- 14.4% TBSA, with III. 42.16 +/- 27.95% TBSA) and identify the alterations in plasma profiles characteristic of patients who later developed MSOF (n = 16) versus those who did not developed MSOF (n = 14). The levels of amino acids were analyzed by use of individual amino acid and the ratio of BCAA (Branched-Chain Amino Acid) to AAA (Aromatic Amino Acid) and Phe to Tyr. The results showed that: (1) The patients who developed MSOF later had significantly lower levels of Pro, Gly Arg, Val, Leu, Ile, and BCAA/AAA, and higher values of Phe, Trp, Tyr, and Phe/Tyr than those who did not develop MSOF. (2) The incidence rate of MSOF increased as the ratio of BCAA/AAA decreased. When the ratio lower than 1.5, eight of ten patients developed MSOF. (3) The higher of the values of Phe/Tyr, the more of the incidence of MSOF. When Phe/Tyr was higher than 2.0, six of seven developed MSOF. These data suggested that: (1) Both BCAA/AAA and Phe/Tyr were the indices of prognosis available in severe trauma patients. (2) Alterations in metabolism as reflected in plasma amino acids patterns were thus critical indicators of MSOF. (3) Liver may be the earliest involved and the most severe injured organ in multiple system organ failure.     

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目的 探讨Hepa氨基酸溶液对非肝硬化和肝硬化肝癌病人行肝切除术后肠外营养的应用价值。方法 2002年2～5月对22例肝癌病人行肝切除术，术后接受含有Hepa氨基酸溶液的肠外营养6d，根据是否合并肝硬化分为两组，非肝硬化组7例，肝硬化组15例。术前和术后第7天抽血测定肝功能、血糖、前白蛋白、转铁蛋白和CD3、CD4、CD8、CD56。结果 术后第7天，非肝硬化组血清AST、ALT比肝硬化组恢复快，但血清ALP、TBIL比肝硬化组高，且肝硬化组血清ALB明显高于非肝硬化组；血清前白蛋白，转铁蛋白水平均降低，但非肝硬化组降低更明显；非肝硬化组外周血CD56降低明显。结论 Hepa氨基酸溶液更适合用于肝硬化肝癌术后的肠外营养。     

Changes of plasma amino acid profiles following total hepatectomy under veno-veno bypass in dogs

Patients with advanced liver disease demonstrate characteristic plasma amino acid abnormalities. The response of plasma amino acid patterns after liver transplantation in those patients is unknown. Mongrel dogs were subjected to two experimental models, that is, one is total hepatectomy under veno-veno bypass as an assumption of an hepatic phase in liver transplantation and the another is splenectomy as control. In control group, BCAA/AAA ratio rose gradually during operation. The levels of methionine, glycine and alanine were significantly lower at 4 hours. In hepatectomized dogs, BCAA/AAA ratio fell gradually after total hepatectomy. The levels of amino acids except BCAA were higher than preoperative value. Increase of alanine was the most remarkable early after total hepatectomy. It was derived not only from the lack of glucose-alanine cycle but also from increased synthesis due to degradation of the BCAA in muscle.     

The effects of altered hepatic energy metabolism as reflected by the blood ketone body ratio on plasma aminogram after the abdominal surgery]

The blood ketone body ratio (KBR), which reflects the liver mitochondrial redox state, and the plasma aminogram were measured postoperatively in 85 patients who underwent abdominal surgery at our Department. When the KBR of the patients was less than 0.4, the plasma concentrations of the total amino acids (TAA), the aromatic amino acids (AAA) and the branched chain amino acids (BCAA) were increased significantly compared with those when it was more than 0.7. The plasma concentrations of threonine, serine, glutamine, alanine, valine, asparagine, ornithine, glycine, cystine, methionine, leucine, tyrosine, phenylalanine, tryptophan, lysine and histidine were increased significantly when the KBR was less than 0.4 compared with those when it was more than 0.7. The molar ratios (MR) which indicate the ratio of BCAA to AAA were decreased significantly when the KBR was less than 0.4 compared with those when it was more than 0.7. In the 4 cases of prolonged decrease of KBR to less than 0.4 for 4 to 11 days postoperatively, the concentrations of the plasma amino acids listed above increased day by day. These phenomena suggest that the AAA and alanine, which are metabolized mainly by the liver, become hard to be metabolized when the KBR is less than 0.4. Furthermore, the increase in the other amino acids including BCAA, which are mainly metabolized by the peripheral tissue, may indicate an increase in peripheral proteolysis and a deterioration in the peripheral amino acids metabolism when the KBR is less than 0.4. The gradual postoperative increase in amino acids in those cases of prolonged decrease of KBR to less than 0.4 suggests that the decrease in the KBR, indicating a deterioration in the hepatic energy metabolism, precedes the increase in the plasma concentration of amino acids.     

The role of alanine in the nitrogen conserving quality of the branched-chain amino acids in the postinjury state

In a recent study from this laboratory the improved nitrogen-conserving quality of the branched chain amino acids (BCAA) in the post-traumatic state was demonstrated. A number of properties have been ascribed to the BCAA which may be responsible for these effects. In order to elucidate which of these properties ascribed to the BCAA is responsible for this nitrogen-sparing effect, three groups of rats were infused with 8% dextrose, 3% alanine in 5% dextrose, or 3% solution of all the branched-chain amino acids (100% BCAA) in 5% dextrose after undergoing laparotomy and jugular vein cannulation. The groups of animals receiving 100% BCAA showed less negative nitrogen balance and lost less weight than the animals receiving isocaloric 8% dextrose. The group receiving 100% BCAA had a significantly better nitrogen balance than the alanine group. The plasma and muscle amino acid pattern of the 100% BCAA is more nearly normal as compared with the other groups suggesting decreased amino acid efflux from muscle. That the group receiving 100% BCAA showed better nitrogen balance than the alanine group combined with the near normal plasma and muscle amino acid pattern in the 100% BCAA group suggests that the mechanism of the improved nitrogen-conserving quality of the BCAA in the post-traumatic state is not only through increased alanine production and gluconeogenesis by BCAA infusion, but is probably a combination of the BCAA being used as energy substrate in the muscle, serving as a substrate for alanine production and gluconeogenesis and blockage of amino acid efflux from the muscle.     

Administration of balanced or BCAA-enriched amino acid solution in septic rats. Effects on protein synthesis in the liver.

Total hepatic protein synthesis was measured in vivo with a flooding-dose technique, and the production of total secreted proteins, albumin, complement component C3, and seromucoid fraction was measured in perfused livers of septic rats that received one of three different solutions infused intravenously; Group 1 received 16.4% dextrose; Group 2 received Aminosyn (25% BCAA) in 10.6% dextrose, and Group 3 received Freamine HBC (45% BCAA) in 10.6% dextrose. All solutions were isocaloric, and the amino acid solutions were isonitrogenous. The solutions were administered for 18 or 48 hours after the induction of sepsis. There were no significant differences in mortality rates in the three treatment groups. The negative nitrogen balance seen in the dextrose-infused animals was reversed to the same degree by the two different amino acid solutions. There were no significant differences in hepatic protein synthesis rates in vivo between the three groups of rats. Synthesis rates of secreted proteins in perfused liver were similar in the different treatment groups in the 18-hour experiments, whereas in the 48-hour experiments, synthesis rates of total secreted proteins, C3, and the serumucoid fraction were higher in Group 1 than in Groups 2 and 3. The results suggest that administration of an amino acid solution improves nitrogen balance in sepsis, but that this effect is not caused by stimulated hepatic protein synthesis. The nitrogen-sparing effect during sepsis of a branched chain amino acid (BCAA)-enriched solution does not seem to be superior to that of a balanced amino acid solution.     

The effect of enriched branched chain amino acid solution on amino acid metabolism during perioperative total parenteral nutrition support

A prospective, randomized clinical study was performed in patients underwent subtotal gastrectomy or hemicolectomy. Patients were randomly divided into two groups receiving standard amino acid solution (23% BCAA) or a solution enriched with branched chain amino acid (41% BCAA). Preoperative postprandial plasma amino acid levels were used as base line. The amino acid concentrations in plasma between control group (A) and study group (B) were compared during perioperative period. The dynamics of postoperative plasma amino acid profile of the two groups were similar except that plasma BCAA concentrations were very high in group B. In both groups, the levels of plasma glutamine, alanine, tyrosine, lysine, threonine, arginine, asparagine, and cystine decreased, whereas the levels of plasma methionine, phenylalanine, and tryptophan increased. The solution of 41% BCAA was not found to be superior to standard 23% BCAA in normalizing the disorder of plasma amino acid spectrum during the period of TPN support. The differences of urinary amino acid excretion including 3-MHIS and nitrogen balance between the two groups were not statistically significant. Also the results showed more severe disorder of plasma amino acid profile caused by 41% BCAA solution than by standard solution of 23% BCAA.     

Effets sur la protéolyse musculaire et générale du brûlé d'une solution enrichie en acides aminés ramifiés

In order to assess the effects of a branched chain amino acid (BCAA) enriched solution on urinary nitrogen loss and muscle protein breakdown, 22 burnt patients were randomly divided into two groups immediately after hospital admission : 11 patients received a 22% BCAA amino acid solution, 11 patients received a 41% BCAA amino acid solution. Nitrogen intake was 0.2 g per day during the first 4 days in each group. Urinary total nitrogen, urinary creatinine and urinary 3,methylhistidine (3,MeHis) were measured for 4 days. Nitrogen balance, 3,MeHis/nitrogen ratio and 3,MeHis/creatinine ratio were calculated in each group. The two groups were compared using Student's test. Nitrogen, creatinine and 3,MeHis urinary excretion, and nitrogen balance were not significantly different in the two groups, except for urinary nitrogen on day 3 which was slightly higher in the 41% BCAA group. The 3,MeHis/nitrogen ratio on day 1, day 2 and during the whole study period, as well as the 3,MeHis/creatinine ratio on day 2, were significantly lower in the 41% BCAA group. These results were in agreement with a decrease in muscle/whole body urinary nitrogen excretion. However, no beneficial effect upon nitrogen loss or nitrogen balance was shown by using the 41% BCAA rich amino acid solution.     

腹部外科血瘀证患者血浆氨基酸谱与血瘀兼证关系的研究

目的：探讨腹部外科血瘀证各兼证型的氨基酸代谢。方法：对３６例腹部外科血瘀证患者行血浆氨基酸谱分析。结果：气滞血瘀组支链氨基酸（ＢＣＡＡ）、芳香氨基酸（ＡＡＡ）含量以及支链氨基酸／芳香氨基酸（ＢＣＡＡ／ＡＡＡ）比值与对照组无差异,气虚血瘀组ＢＣＡＡ较对照组明显降低,ＢＣＡＡ／ＡＡＡ比值显著降低,湿热血瘀组ＢＣＡＡ及ＡＡＡ均明显增高。结论：腹部外科血瘀证各兼证型氨基酸代谢不同,临床工作中应充分认识以提