麟游县硒盐防治大骨节病四年X线效果观察

麟游县位于陕西省北部黄土高原丘陵沟壑区,1975年和1978年全县大骨节病普查患病率分别为24.0％、28.89％。病情之重,病贫交困居全国之首。今由医学、地学等多学科协作,通过大量调研,认为大骨节病与低硒有关。该县1978年经取样测试人发硒均值0.0735±O.016ppm(28)。土壤、     

补硒防治儿童大骨节病效果的X线观察

为探索防治儿童大骨节病的有效方法,１９８５～１９９４年在甘肃省大骨节病活跃重我吕家拉自然村,采用全民普食硒盐、儿童加服适量硒片的方法进行防治效果的Ｘ线观察。以１３岁以下儿童为观察对象,每年拍摄Ｘ线手片,同时定期检测儿童发硒含量;用Ｘ线阳性检出率及干骺端病变转归修复率作判定依据。结果表明,补硒后儿童发硒由０．０５３μｇ／ｇ升高并稳定在０．２３７μｇ／ｇ以上;儿童病情Ｘ线阳性检出率和干骺阳性率由７０．     

口服亚硒酸钠防治大骨节病X线效果观察

为进一步研究亚硒酸钠防治大骨节病的确切效果,我们参加了省卫生防疫站组织的“口服亚硒酸钠防治大骨节病”协作组。在南岔区晨明乡宝泉村、铁力县朗乡的平山村、达里村和嘉荫县富饶乡的河沿,腰屯,灯照三个村进行口服亚硒酸钠防治大骨节病的 X 线效果观察,现将观察方法和效果报告如下:     

西藏谢通门县碘硒盐防治大骨节病效果观察

目的了解西藏采取碘硒盐干预防治大骨节病的效果.方法 2001～2003年进行了防治前后病区流行病学调查(全民临床普查,4～12岁儿童X线拍片及人体内外环境硒含量测试,防治后每年对4～12岁儿童X线拍片),按国家诊断标准进行诊断,以儿童群体X线病情和X线病例的治疗效果作为防治效果的判定指标.结果 2001～2003年防治点儿童X线检出率下降,干骺端检出率下降明显,X线确诊病例的总有效率为75%,干骺端治愈和好转率为81%.结论碘硒盐干预措施对防治大骨节病有明显效果且简便易行.     

硒盐维生素C治疗大骨节病效果观察

本文报告以119例干骺端早期X线改变的大骨节病儿童为对象,观察比较硒和维生素C治疗效果,表明硒的总有效率达80％,与维生素C组和对照组相比,差异显著(P<0.01)。维生素C组,虽有一定疗效,但与对照组比较,差异不显著(P>0.05)。疗效与时间长短、发硒含量关系密切。硒盐是当前补硒防治大骨节病的理想方法。     

硒防治大骨节病两年X线效果研究及病因学探讨

黑龙江省卫生防疫站于1981年观察证实单纯服用亚硒酸钠即可消除大骨节病干骺端改变之后,本文经过严格的现场实验流行病学方法证明,服硒两年,不仅可使大骨节病干骺端改变得到满意的修复,而且可使其骨端改变者有半数获得明显好转,并有抑制或控制骨端改变进展的效果。现报告如下:     

硒盐防治大骨节病实验小结

山西省晋东南地区是一个大骨节病多发地区,在全区十四个县市中,有六个县为病区,为检验硒在晋东南地区的防治效果,我们选择患者较为普遍的沁源、屯留二县的三个乡,进行了硒盐防治大骨节病的实验,经过一年的观察,现将实验结果报告如下:一、实验方法1、硒盐为食盐中加入亚硒酸钠粉剂,二者比例为60000∶1,试验点服硒盐,对照点     

微量元素锌治疗大骨节病效果的X线观察

本实验观察在陕西省大骨节病高发区耀县4个乡11个村8所小学进行实验。观察对象7～14岁儿童。分组为硫酸锌组,食用硒盐组和硫酸锌硒组及对照组,4组情况比较均衡,可比性好。投药方法:采用北京制药广产硫酸锌粉加赋型剂淀粉制成含量100mg,150mg胶丸,硫酸锌组的观察对象,不分年龄每日100mg,连服半年,硒盐组:按村队户每人统一供应1/6万硒盐0.5kg食用;锌加硒     

青海省大骨节病病区换粮、补硒防治儿童大骨节病效果观察

目的 观察换粮、补硒对青海省儿童大骨节病的防治效果.方法 2008年对病区7～12岁儿童进行流行病学、临床及右手X线拍片检查,检出X线阳性患者,以村为单位分成3组,贵德县新建坪村为对照组、斜马浪村为换粮组,兴海县上、下鹿圈村为补硒组.防治前和防治后1年对每个观察对象拍摄右手X线片(包括腕骨),同时采集儿童枕部发样,采用2,3-二氨基萘荧光法测定发硒.结果 经过1年防治,对照组X线检出率由4.88%(2/41)升至12.20%(5/41),换粮组X线检出率由17.54%(10/57)降至5.26%(3/57),补硒组X线检出率由13.51%(10/74)降至5.41%(4/74).换粮组10例病人,有7例痊愈,2例稳定,1例进展,无新发病人;补硒组10例病人,有7例痊愈,3例稳定,1例干骺端新发病人;对照组除原有2例病人病情稳定外,有2例干骺端和1例骨端新发病人.换粮组、补硒组防治效果与对照组比较,差异有统计学意义(x2值分别为5.49、4.14,P均＜0.05).对照组、换粮组发硒值防治前为(107.15±42.30)、(125.30±40.30)μg/kg,防治1年后为(108.32±35.67)、(135.38±65.24)μg/kg,升高不明显(t值分别为0.01、0.68,P均＞0.05);补硒组发硒值由防治前的(95.62±43.42)μg/kg明显升高至防治1年后的(197.64±97.08)μg/kg(t=5.41,P＜0.05).结论 换粮、补硒对防治儿童大骨节病有效.     

口服亚硒酸钠防治大骨节病三年效果观察

应用亚硒酸钠防治大骨节病在国内已进行了一些现场实验,其效果报告不尽一致。为进一步验证硒的防治效果,给我省推广硒防工作提供科学依据,我们通过严密的设计和严格的实验方法,于1983年7月至1986年7月在活跃重病区阿坝县安羌乡开展了口服硒亚酸钠三年防治大骨节病的效果观察,现将结果报告如下:     

甘肃省泾川县补硒防治大骨节病20年效果观察

为探索和总结补硒防治大骨节病（KBD）的方法和经验。回顾分析了练范村1980年以来施用硒片和硒盐防治大骨节病20年的X线观察结果，并结合观察同期未使用任何防治措施的邓家峪村儿童X线资料作比较分析，认为硒片防治与儿童KBD患病率下降有关，具有促进干骺端变修复和预防KBD新发的显效果，硒盐防治仍可使病情下降达到控制标准。     

成人大骨节病膝关节间隙的X线观察

Objective To observe and scale knee joint space of the patients who suffered adults' Kaschin-Beck disease (KBD) in Shangzhi City of Heilongjiang Province in order to acquire basic knowledge for upcoming intervention trial. Methods Clinical test was proceeded in adults aged above 40 in Guanghui Village of Shangzhi City in 2007. In typical patients, bilateral knee X-ray was taken and knee joint space was scaled. Three points were chosen on inner and outer epicondyle of each knee and results were recorded. Results There were 307 peoples over the age of 40 in the village. Two hundred eighty-two accepted clinical test, in a rate of 91.9%. Eighty out of 282 suffered KBD, accounting for 28.4%. When the patients' condition became more serious, measurements from flank, middle, inside points on outer epicondyle of joint space presented a narrowing trend [degree Ⅰ: (5.85±0.17), (4.84±0.17), (4.36±0.18)mm; degree Ⅱ: (5.11±0.43), (4.24±0.34), (3.48±0.28)nun; degree Ⅲ: (3.59± 0.78), (3.10±0.56), (2.14±0.62)mm; Fflank,middle,inside= 6.547,5.372,10.302, all P < 0.05], but those on inner epicondyle of joint space did not[degree Ⅰ:(3.66±0.17), (3.47±0.17), (3.73±0.18)mm; degree Ⅱ:(3.55± 0.34), (3.54±0.29), (4.35±0.35)mm; degree Ⅲ: (3.19±0.72), (3.92±0.66), (4.51±0.72)ram; Finside,middle,flank= 0.351,0.356,1.883, all P > 0.05]. Joint space < 5.00 mm were found in 618, among which 363 were measured on inner epieondyle, obviously greater than those measured on outer epicondyle of joint space(255), the difference being statistically signifieant(χ2=9.59, P<0.05). Conclusions Adult cases of KBD occur in Guanghui Village. Knee joint space of adult patients narrows obviously, the more serious, the narrower, especially occurring more obviously on outer epicondyle, but frequently on inner epicondyle.     

藏药"雪莲健骨灵"冲剂防治儿童大骨节病的X线效果观察

目的研究藏药“雪莲健骨灵”防治大骨节病的效果。方法对90例大骨节病患儿口服“雪莲健骨灵”药片5年,并用22例大骨节病患儿作为对照组,以X线拍片观察治疗效果。对大骨节病区正常儿童64例作为预防组,口服“雪莲健骨灵”药片5年,X线拍片观察预防效果。结果“雪莲健骨灵”治疗大骨节病患儿5年,有效率为96.7%,对照组为13.6%;其中治疗组干骺端有效率为96.2%,对照组为15.0%;骨端治疗组有效率为74.2%,对照组为0;治疗组恶化率为0,对照组为13.6%。各项观察指标治疗组与对照组比较,均有显著性意义（P〈0.01）。“雪莲健骨灵”预防大骨节病区64例正常儿童5年,无1例新发患者。对实验点内外环境硒含量检测,病区处于低硒水平,病区人群处于低硒营养状态;“雪莲健骨灵”硒含量很高。结论“雪莲健骨灵”防治大骨节病效果良好,且无毒副作用。其机理既有藏医药补“梅坠”作用,亦与该药硒含量高有关。     

1例大骨节病儿童口服亚硒酸钠前后的X线病理观察

本文首次报告了用切除六趾畸形的方法,动态地观察了大骨节病儿童口服亚硒酸钠前后的 X 线与病理改变。结果表明:1、X 线上见到的干骺端凹陷、硬化、增宽 X 线征在病理上呈明显地软骨坏死;2、服硒七个月,发硒由48.0ppb 提高到315.0ppb,X 线未见病变好转,病理上依然存在软骨坏死;3、硒对大骨节病的软骨坏死未见有明显地修复作用。     

三种不同投硒方法防治儿童大骨节病效果观察

本文报告了采用三种不同投硒方法防治儿童大骨节病的结果。经过三年的防治实验表明,在食用1/6万硒盐的同时加服适量硒片效果最佳,控制了干骺端新发和进展。单服硒片效果次之。这两种防治方法使干骺端阳性率和病情活跃指数逐年下降。单食硒盐效果最差。与空白对照点相比有效率差异性不显著,患病人数,干骺端阳性率及病情活跃指数逐年升高,且趋向活跃。 三年防治结果表明硒对干骺端改变(早期)有肯定的治疗效果,对其他部位也有不同程度的修复效果,但明显低于干骺端的疗效,硒对预防儿童大骨节病新发效果欠佳。     

成人大骨节病膝关节间隙的X线观察

Objective To observe and scale knee joint space of the patients who suffered adults' Kaschin-Beck disease (KBD) in Shangzhi City of Heilongjiang Province in order to acquire basic knowledge for upcoming intervention trial. Methods Clinical test was proceeded in adults aged above 40 in Guanghui Village of Shangzhi City in 2007. In typical patients, bilateral knee X-ray was taken and knee joint space was scaled. Three points were chosen on inner and outer epicondyle of each knee and results were recorded. Results There were 307 peoples over the age of 40 in the village. Two hundred eighty-two accepted clinical test, in a rate of 91.9%. Eighty out of 282 suffered KBD, accounting for 28.4%. When the patients' condition became more serious, measurements from flank, middle, inside points on outer epicondyle of joint space presented a narrowing trend [degree Ⅰ: (5.85±0.17), (4.84±0.17), (4.36±0.18)mm; degree Ⅱ: (5.11±0.43), (4.24±0.34), (3.48±0.28)nun; degree Ⅲ: (3.59± 0.78), (3.10±0.56), (2.14±0.62)mm; Fflank,middle,inside= 6.547,5.372,10.302, all P < 0.05], but those on inner epicondyle of joint space did not[degree Ⅰ:(3.66±0.17), (3.47±0.17), (3.73±0.18)mm; degree Ⅱ:(3.55± 0.34), (3.54±0.29), (4.35±0.35)mm; degree Ⅲ: (3.19±0.72), (3.92±0.66), (4.51±0.72)ram; Finside,middle,flank= 0.351,0.356,1.883, all P > 0.05]. Joint space < 5.00 mm were found in 618, among which 363 were measured on inner epieondyle, obviously greater than those measured on outer epicondyle of joint space(255), the difference being statistically signifieant(χ2=9.59, P<0.05). Conclusions Adult cases of KBD occur in Guanghui Village. Knee joint space of adult patients narrows obviously, the more serious, the narrower, especially occurring more obviously on outer epicondyle, but frequently on inner epicondyle.     

成人大骨节病膝关节间隙的X线观察

Objective To observe and scale knee joint space of the patients who suffered adults' Kaschin-Beck disease (KBD) in Shangzhi City of Heilongjiang Province in order to acquire basic knowledge for upcoming intervention trial. Methods Clinical test was proceeded in adults aged above 40 in Guanghui Village of Shangzhi City in 2007. In typical patients, bilateral knee X-ray was taken and knee joint space was scaled. Three points were chosen on inner and outer epicondyle of each knee and results were recorded. Results There were 307 peoples over the age of 40 in the village. Two hundred eighty-two accepted clinical test, in a rate of 91.9%. Eighty out of 282 suffered KBD, accounting for 28.4%. When the patients' condition became more serious, measurements from flank, middle, inside points on outer epicondyle of joint space presented a narrowing trend [degree Ⅰ: (5.85±0.17), (4.84±0.17), (4.36±0.18)mm; degree Ⅱ: (5.11±0.43), (4.24±0.34), (3.48±0.28)nun; degree Ⅲ: (3.59± 0.78), (3.10±0.56), (2.14±0.62)mm; Fflank,middle,inside= 6.547,5.372,10.302, all P < 0.05], but those on inner epicondyle of joint space did not[degree Ⅰ:(3.66±0.17), (3.47±0.17), (3.73±0.18)mm; degree Ⅱ:(3.55± 0.34), (3.54±0.29), (4.35±0.35)mm; degree Ⅲ: (3.19±0.72), (3.92±0.66), (4.51±0.72)ram; Finside,middle,flank= 0.351,0.356,1.883, all P > 0.05]. Joint space < 5.00 mm were found in 618, among which 363 were measured on inner epieondyle, obviously greater than those measured on outer epicondyle of joint space(255), the difference being statistically signifieant(χ2=9.59, P<0.05). Conclusions Adult cases of KBD occur in Guanghui Village. Knee joint space of adult patients narrows obviously, the more serious, the narrower, especially occurring more obviously on outer epicondyle, but frequently on inner epicondyle.     

成人大骨节病膝关节间隙的X线观察

Objective To observe and scale knee joint space of the patients who suffered adults' Kaschin-Beck disease (KBD) in Shangzhi City of Heilongjiang Province in order to acquire basic knowledge for upcoming intervention trial. Methods Clinical test was proceeded in adults aged above 40 in Guanghui Village of Shangzhi City in 2007. In typical patients, bilateral knee X-ray was taken and knee joint space was scaled. Three points were chosen on inner and outer epicondyle of each knee and results were recorded. Results There were 307 peoples over the age of 40 in the village. Two hundred eighty-two accepted clinical test, in a rate of 91.9%. Eighty out of 282 suffered KBD, accounting for 28.4%. When the patients' condition became more serious, measurements from flank, middle, inside points on outer epicondyle of joint space presented a narrowing trend [degree Ⅰ: (5.85±0.17), (4.84±0.17), (4.36±0.18)mm; degree Ⅱ: (5.11±0.43), (4.24±0.34), (3.48±0.28)nun; degree Ⅲ: (3.59± 0.78), (3.10±0.56), (2.14±0.62)mm; Fflank,middle,inside= 6.547,5.372,10.302, all P < 0.05], but those on inner epicondyle of joint space did not[degree Ⅰ:(3.66±0.17), (3.47±0.17), (3.73±0.18)mm; degree Ⅱ:(3.55± 0.34), (3.54±0.29), (4.35±0.35)mm; degree Ⅲ: (3.19±0.72), (3.92±0.66), (4.51±0.72)ram; Finside,middle,flank= 0.351,0.356,1.883, all P > 0.05]. Joint space < 5.00 mm were found in 618, among which 363 were measured on inner epieondyle, obviously greater than those measured on outer epicondyle of joint space(255), the difference being statistically signifieant(χ2=9.59, P<0.05). Conclusions Adult cases of KBD occur in Guanghui Village. Knee joint space of adult patients narrows obviously, the more serious, the narrower, especially occurring more obviously on outer epicondyle, but frequently on inner epicondyle.     

成人大骨节病膝关节间隙的X线观察

Objective To observe and scale knee joint space of the patients who suffered adults' Kaschin-Beck disease (KBD) in Shangzhi City of Heilongjiang Province in order to acquire basic knowledge for upcoming intervention trial. Methods Clinical test was proceeded in adults aged above 40 in Guanghui Village of Shangzhi City in 2007. In typical patients, bilateral knee X-ray was taken and knee joint space was scaled. Three points were chosen on inner and outer epicondyle of each knee and results were recorded. Results There were 307 peoples over the age of 40 in the village. Two hundred eighty-two accepted clinical test, in a rate of 91.9%. Eighty out of 282 suffered KBD, accounting for 28.4%. When the patients' condition became more serious, measurements from flank, middle, inside points on outer epicondyle of joint space presented a narrowing trend [degree Ⅰ: (5.85±0.17), (4.84±0.17), (4.36±0.18)mm; degree Ⅱ: (5.11±0.43), (4.24±0.34), (3.48±0.28)nun; degree Ⅲ: (3.59± 0.78), (3.10±0.56), (2.14±0.62)mm; Fflank,middle,inside= 6.547,5.372,10.302, all P < 0.05], but those on inner epicondyle of joint space did not[degree Ⅰ:(3.66±0.17), (3.47±0.17), (3.73±0.18)mm; degree Ⅱ:(3.55± 0.34), (3.54±0.29), (4.35±0.35)mm; degree Ⅲ: (3.19±0.72), (3.92±0.66), (4.51±0.72)ram; Finside,middle,flank= 0.351,0.356,1.883, all P > 0.05]. Joint space < 5.00 mm were found in 618, among which 363 were measured on inner epieondyle, obviously greater than those measured on outer epicondyle of joint space(255), the difference being statistically signifieant(χ2=9.59, P<0.05). Conclusions Adult cases of KBD occur in Guanghui Village. Knee joint space of adult patients narrows obviously, the more serious, the narrower, especially occurring more obviously on outer epicondyle, but frequently on inner epicondyle.     

成人大骨节病膝关节间隙的X线观察

目的 观察成年大骨节病患者膝关节间隙改变情况,为进一步进行的干预试验做基础准备.方法 2007年在黑龙江省尚志市光辉村对40岁以上的成人进行大骨节病临床检查,典型病例拍摄双侧膝关节X线片,测量关节间隙.每个膝关节内、外上髁关节面各取外、中、内3个点,记录测量结果.结果 病村40岁以上人口307人,本次检查282人,检查率为91.9%,检出Ⅰ度以上病例80人,占28.4%.外上髁外、中、内3个部位测量值随着病情的加重明显降低[Ⅰ度分别为(5.85±0.17)、(4.84±0.17)、(4.36±0.18)mm,Ⅱ度分别为(5.11±0.43)、(4.24±0.34)、(3.48±0.28)mm,Ⅲ度分别为(3.59±0.78)、(3.10±0.56)、(2.14±0.62)mm;F外=6.547,F中=5.372,F内=10.302,P均<0.05];而内上髁内、中、外3个部位的测量值并没有出现相同的趋势[Ⅰ度分别为(3.66±0.17)、(3.47±0.17)、(3.73±0.18)mm,Ⅱ度分别为(3.55±0.34)、(3.54±0.29)、(4.35±0.35)mm.Ⅲ度分别为(3.19±0.72)、(3.92±0.66)、(4.51±0.72)mm;F内=0.351,F中=0.356,F外=1.883,P均>0.05].关节间隙<5.00 mm的测量点共618个,内上髁关节面测量点(363个)明显多于外上髁关节面(255个),二者比较差异有统计学意义(χ2=9.59,P<0.05).结论 光辉村成年大骨节病病例较多;伴随病情加重患者膝关节间隙呈变窄趋势,尤以外上髁表现明显;但患者以内上髁狭窄病变为多见.