激光光凝治疗大隐静脉曲张围手术期TNF-α和IL-6的水平

目的：检测血管内光凝治疗大隐静脉曲张围手术期血浆白细胞介素-6（IL-6）和肿瘤坏死因子α（TNF-α）的水平。方法：大隐静脉曲张患者110例，其中行血管内激光光凝治疗者43例，行静脉瓣膜环包联合血管内光凝者35例，行大隐静脉高位结扎、分段剥脱治疗者32例。110例患者中有明显皮肤营养障碍者56例。在治疗前及治疗后l，3，7，14d取静脉血，采用放射免疫分析检测血浆内IL-6和TNF-α的水平。另外取正常献血者33例作为对照。结果：皮肤正常大隐静脉曲张患者较正常血浆IL-6和TNF-α水平没有明显改变，而伴有明显皮肤营养障碍和血栓形成患者IL-6和TNF-α皆高于正常。三种术式进行治疗围手术期IL-6和TNF-α均呈现先升高后降低，最后恢复至正常水平的趋势。IL-6和TNF-α水平变化幅度由小到大和恢复到正常水平的顺序为血管内激光光凝治疗组、静脉瓣膜环包联合血管内光凝、大隐静脉高位结扎、分段剥脱治疗组。结论：血浆IL-6和TNF-α水平高低是判断治疗大隐静脉曲张不同手术方式的应激强度大小和病程转归的一种指标。     

血管内光凝治疗大隐静脉曲张围手术期血浆ET-1和NO的水平

目的 :测定血管内激光光凝治疗大隐静脉曲张围手术期血浆内皮素 - 1(ET - 1)和一氧化氮 (NO)的水平。方法 :5 8例大隐静脉曲张患者 ,分为轻、重两组 ,采用激光血管内光凝治疗 ,在治疗后第 1,3,7和 14d取静脉血检测血浆内ET - 1和NO水平 ,检测方法分别为放射免疫分析和Griss法。同时 5 6例大隐静脉曲张患者行传统的大隐静脉高位结扎、分段剥脱治疗 ,同样在治疗后第 1,3,7和 14d检测血浆内ET - 1和NO水平。结果 :大隐静脉曲张患者轻症组ET - 1水平同正常对照组没有明显区别 ,而NO水平高于对照组 ;重症组ET - 1和NO均明显低于正常水平。两种手术方法治疗后血浆ET - 1和NO水平均呈先升高后降低 ,向正常水平接近的变化趋势 ,但血管内光凝组较传统的手术方法ET - 1和NO变化幅度小 ,且提前恢复到正常水平。结论 :ET - 1和NO水平高低是判断手术应激强度大小和病程转归的一种指标。     

次高位大隐静脉结扎联合属支电凝术与传统静脉曲张手术的对比研究

目的：探讨次高位大隐静脉结扎联合自制套管针电凝术治疗大隐静脉曲张的优越性。方法将单下肢大隐静脉曲张患者81例分成改良组(28例)和传统组(53例),分别接受传统手术即大隐静脉高位结扎剥脱术和次高位大隐静脉结扎联合自制简易套管针电凝术,观察疗效。结果改良组的手术时间、出血量、切口数量、切口总长度均小于传统组;术后生活质量评分(CIVIQ)高于传统组,<0.05。结论次高位大隐静脉结扎联合自制简易套管针电凝术即剥除了大隐静脉主干,同时彻底治疗了属支静脉,简便易操作,创伤小恢复快,更加美观,体现了外科的微创发展方向。     

高位加分段结扎治疗大隐静脉曲张

高位加分段结扎治疗大隐静脉曲张高位加分段结扎大隐静脉曲张术，是将大隐静脉及汇集支分别结扎切断，阻断了股静脉内的血液倒流；分段结扎将静脉腔分隔成数段，使血流阻隔，令其静脉血通过交通支汇入深静脉，使大隐静脉废用萎缩。山东临沂矿务局中心医院用该法治疗１６例...     

大隐静脉传统剥脱术与激光治疗大隐静脉曲张的临床对比分析

目的：比较大隐静脉曲张的传统剥脱术和激光治疗术的治疗效果。方法大隐静脉曲张患者(双侧)36例随机分为两组,每组18例,一组行大隐静脉传统剥脱手术,另一组行大隐静脉高位结扎联合激光腔内闭合术。比较两组术中术后出血量、切口长度、术后住院时间和术后并发症发生率。结果激光治疗组的术中术后出血量、切口长度、术后住院时间较传统静脉剥脱组显著减少(P<0.05)。但两组患者的术后并发症的发生率差异无显著意义(P>0.05)。结论大隐静脉高位结扎联合激光腔内闭合术治疗大隐静脉曲张是一种安全有效的微创手术方法。     

腔内激光联合高位结扎及点式剥脱术治疗大隐静脉曲张23例临床分析

目的:评价腔内激光联合高位结扎及点式剥脱术治疗单纯性大隐静脉曲张的临床疗效.方法:采用腔内激光联合高位结扎或点式剥脱术治疗大隐静脉曲张23例,28条患肢.结果:所有患者术后均恢复良好,无下肢深静脉血栓形成.随访2～10个月,无一例复发.结论:腔内激光联合高位结扎及点式剥脱术治疗大隐静脉曲张,具有安全、有效、微创的优点,值得临床推广应用.     

大隐静脉高位结扎联合点式剥脱术治疗大隐静脉曲张的应用效果观察

目的:探讨对大隐静脉曲张患者采取高位结扎与点式剥脱术联合治疗的效果.方法:选取我院 2021 年5 月至 2022 年 10 月期间收治的 94 例大隐静脉曲张患者作为研究对象,根据住院号将患者分为对照组和观察组(n=47),对照组采用大隐静脉高位结扎联合传统剥脱术治疗,观察组实施大隐静脉高位结扎联合点式剥脱术治疗.经治疗 3 d后,对比两组患者的临床疗效,采用视觉模拟评分法(Visual analogus scale,VAS)评估患者疼痛程度,应用静脉曲张临床严重程度评分表(Venous clinical severity score,VCSS)评估患者病情,应用酶联免疫吸附法检测白细胞介素-6(Interleukin-6,IL-6)、肿瘤坏死因子-α(Tumor Necrosis Factor-α,TNF-α)水平,应用全自动凝血分析仪检测凝血酶原时间(Prothrombin Time,PT)、凝血酶时间(Thrombin Time,TT)、活化部分凝血酶时间(Activated Partial Thromboplastin Time,APTT).结果:观察组治疗有效率显著高于对照组(P＜0.05);观察组VAS评分与VCSS评分均明显低于对照组(P＜0.05);观察组IL-6、TNF-α水平均显著低于对照组(P＜0.05);观察组APTT、PT、TT均长于对照组.结论:在大隐静脉高位结扎的基础上联合点式剥脱术治疗大隐静脉曲张,减轻应激反应与术后疼痛,对患者凝血功能的影响较小     

大隐静脉射频消融术与大隐静脉高位结扎剥脱术治疗静脉曲张的疗效对比

目的比较大隐静脉射频消融术和大隐静脉高位结扎剥脱术治疗静脉曲张的临床疗效。方法回顾性分析2018年9月至2019年5月江苏省中医院收治的70例(93条患肢)下肢大隐静脉曲张患者的临床资料,将行大隐静脉射频消融术和高位结扎剥脱术治疗的患者分别设为观察组和对照组,每组35例(对照组43条患肢,观察组50条患肢)。对比分析2组患者手术时间、恢复时间、切口数量、术后VAS疼痛评分等手术相关情况,比较2组患者手术前后CEAP分级、临床疗效、术后并发症、术后生活质量和满意度评分。结果与对照组相比,观察组所需手术时间、术后首次下床时间、住院时间及恢复时间较短,术中出血量、切口数量较少,术后VAS疼痛评分较低;2组患者CEAP分级构成在术后均比术前显著降低;观察组患者术后并发症总发生率显著低于对照组;观察组患者术后生活质量总评分及各项评分均显著高于对照组;观察组患者对治疗方法的整体评价高于对照组,以上差异均具有统计学意义(P<0.05)。结论大隐静脉射频消融术与大隐静脉高位结扎剥脱术疗效相当,但射频消融术有操作简单、创伤小、恢复快、并发症少且美观等优势,同时可减轻患者痛苦,显著改善术后生活质量,提高患者满意度。     

68例大隐静脉激光治疗围手术期并发症分析

目的探讨应用大隐静脉高位结扎联合腔内激光治疗大隐静脉曲张,围手术期常见并发症及其处理。方法自2012年1月~2013年1月,68例患者的97条大隐静脉病变血管,应用大隐静脉高位结扎联合腔内激光治疗。结果本组68例行大隐静脉高位结扎联合腔内激光治疗手术,均治愈出院,无1例死亡或有严重并发症,住院时间3~15d,平均(5.5±2.6)d,无伤口感染,术后57条患肢(58.76%)存在不同程度的下肢肿胀,2~4d后消失。78条患肢(80.41%)有局部感觉异常,82条患肢(84.53%)沿大隐静脉或分支走向可触及硬结感,经随诊复查,2~8w症状逐渐消退。1条患肢(1.03%)出现皮肤损伤。结论大隐静脉高位结扎联合腔内激光治疗手术是一种安全有效的方法,操作成功率和近中期效果确切,可作为大隐静脉曲张的首选治疗方法,治疗同时注意预防局部并发症。     

大隐静脉曲张手术几点体会

大隐静脉曲张的主要原因是静脉壁的先天性薄弱,静脉内持续性高压以及大隐静脉和交通支静脉瓣失灵。因此,手术应将大隐静脉高位结扎,剥脱,结扎交通支,切除曲张的静脉团。对此有几点体会。     

Level of functioning of siblings and parents of probands of varying degrees of retardation

A further analysis of already published data supports the position that retardates of low ability level less frequently have retarded siblings, retarded parents, and parents low in occupational level than do retardates higher in ability level. The analysis supports the position that there are two types of retarded individuals, persons retarded as a result of gene or chromosomal anomalies, brain injury, etc., who more frequently occur in the lower-level retardate group, and persons whose retardation represents polygenic segregation, who more frequently occur in the higher-level group.     

局部注射辛伐他汀对骨质疏松大鼠股骨髁骨小梁的改建效应

背景：局部注射具有成骨作用的辛伐他汀,可显著增加骨质疏松大鼠股骨颈及股骨髁部的骨密度及力学强度,分析局部注射辛伐他汀对股骨髁骨小梁的影响。 目的：进一步研究骨质疏松大鼠股骨内局部注射辛伐他汀对股骨髁骨小梁的影响。为将辛伐他汀应用于临床骨质疏松局部治疗提供实验基础。 方法：18只雌性SD大鼠双侧卵巢切除后3个月,制备大鼠骨质疏松模型。实验大鼠随机数字表法均分为3组,分别在实验大鼠的右侧股骨髓腔内单次注射辛伐他汀溶液5 mg、10 mg,对照组单纯注射空白载体。分别在注射后1个月处死大鼠并取材。Micro-CT扫描并定量分析骨组织形态变化。 结果与结论：给药后1个月,Micro-CT扫描结果显示,辛伐他汀治疗组的骨微结构参数如骨皮质厚度、骨小梁密度及连接率明显优于对照组。说明疏松骨骼单次注射小剂量辛伐他汀可显著促进股骨髁部骨小梁改建,改善骨骼微结构,可为强化局部、防治骨质疏松骨折的新选择进一步提供实验基础。     

石斛属民族药用植物的分类及生药学研究

中药石斛早在《神农本草经》中就被列为上品,其应用历史悠久,具有养阴生津、补肾益气、润喉护嗓、活血明目、抗癌防老等功效。本文对国内外石斛属民族药用植物的分类及生药学研究进行了综述。     

膝关节骨性关节炎的关节镜治疗体会

目的我科自2001～2005年4月对59例67膝的骨性关节炎（0A），进行关节镜检查及镜下清理术。方法镜检：膝关节骨性关节炎伴不同程度滑膜炎，滑膜皱壁粘连纤维片，关节软骨不同程度破坏。镜下清除增生滑膜，松解粘连，去除剥脱软骨、修复关节面。结果随访2月～4年，平均1.5年，术后综合评估2月～1年，优良率94％；1～2年，优良率79.2％；2年以上优良率54.8％。结论关节镜对膝关节骨性关节炎诊断能提供了比较全面的资料，并对骨性关节炎早期有良好疗效，具有创伤小、恢复快、并发症少和重复治疗等优点。     

Pathways of the realization of immunomodulating effects of neurotransmitters

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 115, N ^o 4, pp. 401–404, April, 1993     

Anatomical study of distribution of valves of the cutaneous veins of adult''s limbs

Since the cutaneous veins of the four limbs have been used as autogenous grafts in the treatment of cardiovascular disorders, knowledge of distribution of the valves is increasingly required depending upon the use. In the gross anatomical study of distribution of valves of the trunci venae, there has been argument about locational relationships between the venous roots and the valves in the vicinity of the roots and the inter-valvular distance. However, there have been only few reports discussing detailed information about valves of the cutaneous veins of the four limbs. The authors observed patterns of distribution of the cutaneous venous valves of the four limbs of cadavers prepared for practice in anatomy. The following parts were excised from each cadaver: the cephalic, basilic, and the great saphenous veins, which originate from the acral venous network and flow into the proximal deep veins, and the venous roots communicating with these veins. An incision was made on each excised vein in the direction of the long axis under observation with a stereoscopic microscope, and the inter-valvular distance and the distance between the valve and the orifice of venous root in the vicinity of the valve were measured. The inter-valvular distance varied with type of the truncus venae, and it varied according to area even in the same truncus venae.     

Characterization of sterols of three digenetic trematodes of buffalo

Sterols of three digenetic trematodes were isolated and characterized by infrared and 1H nuclear magnetic resonance spectroscopies, and gas-liquid chromatography and gas chromatography-mass spectrometry. Sterols identified were cholesterol, cholestanol, 24-methylcholesterol, 24-methylcholestanol, 24-ethyl-22-dehydrocholesterol, 24-ethyl-22-dehydrocholestanol, 24-ethylcholesterol and 24-ethylcholestanol.     

Mechanisms of generation of slow components of bioelectric activity in diagnostics of functional state of the gastrointestinal tract

New electrophysiologic devices were used for the diagnostics of the state of excitable structures in the gastrointestinal tract and correction of their motor functions. Bioelectrical and biomechanical activities form the basis of functioning of internal organs. The mechanisms of generation of slow bioelectrical activity that are important for clinical and physiological studies are described. One of these mechanisms is a capacitance parametric transducer converting the energy of contractions into specific electric signals reflecting muscle functions. Another mechanism results from slow oscillations of resting potentials of interrelated excitable cells in large neuromuscular structures of internal organs. The elaborated procedure is efficient for preventing early postoperative paresis of the gastrointestinal tract. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 128, No. 10, pp. 448–452, October, 1999     

胃小弯侧血管弓的MDCT解剖

目的：研究正常胃小弯侧血管弓及其属支血管的多排螺旋CT表现。方法：回顾性分析51例正常成人的上腹部CT资料,观察胃小弯侧血管弓及其属支血管的显示情况、血管弓形态及其与胃壁的关系。结果：51例均显示胃小弯侧血管弓,血管弓贲门部属支、胃体部属支和幽门部属支分别显示46例、15例和10例;血管弓与胃壁紧邻41例。结论：MDCT检查可良好显示正常胃小弯侧血管弓及其属支血管。     

Assessment of the efficacy of treatment of hemangiomas

Assessment of the aftereffects of cryoexposure and ultrahigh-frequency cryoexposure on hemangioma tissue of various types, cavernous and squamous, showed a higher cryogenic effect in hemangiomatous tissue preexposed to ultrahigh-frequency waves. A quantitative criterion is proposed for assessing the efficacy of the studied methods of exposure. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, N ^o 6, pp. 669–672, June, 1995