甲母质瘤一例并文献复习

报道一例甲母质瘤并对相关文献进行复习。患者，男，54岁。右手食指指甲增厚、变黄10年。组织病理检查：甲板显著增厚，甲母质细胞V形增生，底端呈条索状伸向真皮，上端呈乳头瘤样伸向甲板，上覆嗜酸性角质增生带，部分乳头瘤顶端见渗出结痂。真皮浅层梭形细胞增生，排列杂乱，间有散在肥大细胞，深部纤维及纤维细胞增生，排列与表皮平行。免疫组化染色：梭形细胞CD34阳性，S-100阴性，FⅩIIIa阴性，CD68阴性，CK7阴性。诊断：甲母质瘤。手术切除肿瘤后随访10个月无复发。     

囊性毛母质瘤1例

毛母质瘤又称钙化上皮瘤，是一种发生于皮内或皮下，向毛母质细胞分化的良性肿瘤，肿瘤表现呈多样性，囊性毛母质瘤临床少见，现将我们诊治的1例囊性毛母质瘤报告如下。     

甲母质细胞癌1例

报道1例甲母质细胞癌。患者女, 76岁, 左手拇指甲下肿物3年。皮肤科检查:左手拇指甲板增厚, 局部呈黄色及黑色, 远端甲板略弯曲, 甲板下可见明显血管扩张, 甲下及甲板外侧缘可见疣状增生。组织病理检查:肿瘤呈团块状向下浸润生长, 团块中央明显角化坏死, 伴较多"鳞状涡"结构及细胞异形, 可见病理性核分裂象。免疫组化示HK31、HK85在鳞状涡区域阳性表达, K6/K16在肿瘤基底部阳性表达, HK75在整个肿瘤区域强阳性表达。诊断:甲母质细胞癌。治疗:手术切除联合3次皮肤光动力治疗, 随访18个月未见复发。     

毛母质瘤

毛母质瘤临床表现多样，无特征性，极易误诊，但其组织病理学改变具有特征性。现报告1例。     

毛母质瘤25例临床分析

毛母质瘤又称毛发基质瘤或钙化上皮瘤，是一种少见的良性肿瘤，以毛发基质上皮或毛母质细胞分化为特点[1]，临床表现形式多样。常因临床医生对其认识不足，导致误诊率高[2]。本文对2008-2013年间我院经病理确诊为毛母质瘤的25例病例进行分析，以增强对毛母质瘤的临床及病理特征的认识，进一步提高临床诊断水平。     

针吸细胞学诊断毛母质瘤86例临床分析

毛母质瘤(pilomatrixoma)是一种临床相对比较少见的良性皮肤附属器肿瘤,此病临床表现多样,常被误诊为皮脂腺囊肿等.但组织病理学诊断并不困难.其针吸细胞学(fine-needle aspiration cytology)诊断国内报道少见.现收集我科于1995年1月-2010年12月间采用针吸细胞学检查并有组织病理学检查诊断对照的86例毛母质瘤病例,报告如下.     

儿童毛母质瘤99例临床与组织病理分析

目的:探讨儿童毛母质瘤临床及组织病理特征。方法:回顾性分析99例经手术治疗的皮肤毛母质瘤患儿临床资料。结果:99例患儿中男49例,女50例,发病年龄4个月～15岁,平均年龄(3.1±2.8)岁,发病部位以面部为主(69.7%)。光镜下可见瘤体主要由影细胞和基底样细胞组成。所有患儿皮损组织病理检查示25例肿瘤间质内可见钙化灶,30例可见纤维组织增生,55例可见炎性细胞浸润,36例可见多核巨细胞。CT示25.0%(8/32)瘤体可见斑点状稍高密度影。所有患儿予手术切除肿物,术后均无复发或恶变。结论:儿童皮肤毛母质瘤临床表现和组织病理特征较为典型,熟练掌握其临床表现、辅助检查及组织病理特征,有助于提高诊断准确率。     

毛母质瘤26例临床分析

目的　总结毛母质瘤的临床和病理特征。方法　分析 2 6例毛母质瘤的临床资料和组织病理检查结果。结果　皮损多为单发结节 ,病理特征是以嗜碱性细胞和影细胞组成的不规则条索或团块。结论　本病较理想的治疗是切开刮除瘤体 ,并完全摘除包膜。     

穿通性毛母质瘤1例报告

穿通性毛母质瘤１例报告胡亚莹（江苏省泰县溱湖医院，２２５５０８）毛母质瘤又称钙化上皮瘤。为一较少见的毛源性肿瘤，而穿通性毛母质瘤更为罕见，今遇到１例，特报告如下：患者男，６７岁，因“头顶部出现碗豆大结节，微痒，搔抓易出血４年”而就诊。自诉４年前头顶部...     

10例毛母质瘤的皮肤镜特征分析

目的:对毛母质瘤的皮肤镜特征进行总结,为提高毛母质瘤的临床诊断率提供一些线索。方法:收集分析行病理学检查及皮肤镜检查的毛母质瘤患者临床资料。结果:共收集10例毛母质瘤患者,其中男5例,女5例,年龄3～22岁。7例(70%)毛母质瘤位于头面部,2例(20%)位于上肢,1例(10%)位于肩颈部。初步临床诊断包括毛母质瘤、皮肤肿物、瘢痕疙瘩、化脓性肉芽肿、表皮囊肿、传染性软疣、皮脂腺增生、Spitz痣,临床诊断符合率仅为20%。毛母质瘤最常见的皮肤镜特征包括黄白色无结构区(90%)、紫红色均质区域(80%)、不规则分枝状血管(60%)及白色条纹(60%)。结论:毛母质瘤初步诊断误诊率高,皮肤镜常见表现为黄白色无结构区、紫红色均质区域、不规则分枝状血管及白色条纹等。     

Malignant tumors of the nail unit

Malignant tumors of the nail unit are rare, often with devastating consequences. The common skin cancers, squamous cell carcinoma (SCC), basal cell carcinoma (BCC), and melanoma, are the malignancies seen arising from the nail unit. Because of the unique properties of the nail unit, these common cancers often have uncommon presentations, resulting in delayed diagnosis and advanced disease. Malignant tumors from other locations may also metastasize to the nail unit. A high level of suspicion and early biopsy allow for successful treatment.     

Uncommon presentation of pigmented paraungual basal cell carcinoma on the first toe treated with total excision

Basal cell carcinomas (BCCs) are the most common types of skin neoplasm. The finger, toe, and nail unit are uncommon and rare locations of BCC. Only a few patients with foot BCC have been reported, and ungual BCC is even less frequent. We present a patient with a BCC on the left first toe. Clinically, it appeared as a brown‐colored plaque with an irregular border on the nail fold and dorsum of the left thumb. Histopathological findings were consistent with the pigmented type of BCC. Surgical approach with subsequent full thickness mesh graft led to a complete remission. Follow‐up at 10 months revealed a functionally and cosmetically acceptable outcome. The clinical presentation of nail unit BCC is variable, and nonspecific manifestations occur more frequently. Our case stated the necessity of histopathologic examination in ulcerous lesions resistant to topical treatment.     

内脏恶性肿瘤的皮肤表现

内脏恶性肿瘤的皮肤表现按病理生理学特点可分为两类:肿瘤的直接效应和间接效应.肿瘤的直接效应是指恶性肿瘤转移灶生长影响周围器官或组织;间接效应即副肿瘤性皮肤病.文中复习了皮肤转移瘤的临床特点及常见的副肿瘤性皮肤病.皮肤表现可能是患者潜在肿瘤的首发临床表现.因此,认识肿瘤的皮肤表现,将有助于潜在肿瘤的早期发现.     

Multiple Granular Cell Tumors and Growth Hormone Deficiency in a Child

Granular cell tumor is an uncommon benign tumor occurring on the skin as a single nodule. Multiple tumors are very rare, particularly in children. We describe a child with multiple granular cell tumors on the skin in association with growth hormone deficiency. The occurrence of multiple granular cell tumors in association with other clinical manifestations in childhood is discussed.     

常见非黑素细胞性皮肤肿瘤皮肤镜特征与组织病理表现的对应关系专家共识

【摘要】 皮肤镜在皮肤病诊疗中的应用日益广泛,大多数皮损皮肤镜下结构特征与组织病理学表现有对应关系,因此皮肤镜可作为皮肤病临床和病理之间联系的桥梁。本共识详细阐述非黑素细胞性皮肤肿瘤的皮肤镜特征和组织病理的对应关系,希望有助于皮肤镜被更为规范、高效、精准地应用,为临床诊断和治疗决策提供有价值的临床信息。     

Cutaneous manifestations of breast carcinoma

The incidence of breast carcinoma cutaneous manifestation in patients with breast carcinoma is 23.9%. The most common sites of breast carcinoma cutaneous manifestation are the chest wall and abdomen, but they can occur at the extremities and in the head/neck region. Due the high incidence of breast carcinoma, these cutaneous manifestations are the most common metastases seen by dermatologists. In clinical practice, cutaneous metastases show a wide range of clinical manifestations. Nodules are the most common presentation, but several other patterns are described below.     

某些皮肤转移癌的临床及病理分析

目的：为了研究皮肤转移癌的临床及病理特征。方法：选择了18例皮肤转移癌，对临床、病理进行分析。结果：皮损以红色斑块或多发结节最常见。躯干和颈部是常见的转移部位，下肢转移较少。转移灶的组织类型是腺癌(77．8％)和鳞癌(22．2％)。组织学上皮肤转移癌与原发肿瘤相同。女性最常见的原发肿瘤是乳腺癌(41．7％)，男性常见的原发肿瘤是肺癌、鼻咽癌、直肠癌、肾癌。结论：皮肤转移癌提示预后较差。     

Hereditary cancer syndromes of the skin

Hereditary cancer syndromes are a group of disorders characterized by a genetic susceptibility to the development of malignant tumors. Multiple cancers in the family or an abnormally early onset for the given cancer may suggest an underlying inherited predisposition. Awareness of their associated dermatologic manifestations can facilitate early detection of risk for neoplasms. This article provides an update on the clinical features, diagnostic criteria, and the use of genetic analysis in the detection of causative mutations of those hereditary cancer syndromes with cutaneous manifestations.     

皮肤转移癌的临床分析

目的：研究临床较少见的恶性肿瘤皮肤转移患者的临床表现及治疗预后。方法：采用临床资料的回顾分析方法，分析恶性肿瘤皮肤转移主要临床表现、病理分类、原发癌肿部位和接受治疗情况及生存时间等。结果：皮肤转移首发多在躯干，以多发结节肿块型为主；皮肤转移发现时有其他脏器转移者29例。病理以低分化癌(21／51)、腺癌(23／51)多见。51例中位生存期8个月，接受治疗者10个月。近期治疗效果未分化癌好，低分化癌生存期长。原发乳腺癌生存时间最长，肝癌最短。结论：皮肤转移为恶性肿瘤多脏器转移之一，预后差。合理有效的综合治疗仍可减轻症状、延长生存期、提高生活质量。     

Letter: Two cases of metastases to the scalp bone mimicking epidermoid cyst

Metastatic skin tumors present with a variety of clinical manifestations. We herein present two cases of metastases to the scalp, invading the skull, which showed epidermoid cyst-like appearances.