Diphenylhydantoin Sensitivity. A Syndrome Resembling Infectious Mononucleosis with a Morbilliform Rash and Cholestatic Hepatitis

Summary: Diphenylhydantoin sensitivity. A syndrome resembling infectious mononucleosis with a morbilliform rash and cholestatic hepatitis.     

Immunophenotypic Profile in Acute Infectious Mononucleosis Mimicking Malignant Lymphoproliferative Disorder: A Case Report and Review of Literature

Infectious mononucleosis is characterized by an intensive lymphoproliferation with atypical forms which sometimes resemble with acute leukemia or malignant lymphoproliferative diseases. Flow cytometric analysis of lymphocytes shows a typical phenotype but unawareness of it may lead to misdiagnosis of malignant lymphoproliferative diseases. Herewith we present an immunophenotypic profile in a case of acute infectious mononucleosis and review of literature.     

Blind Pouch Syndrome: A Case Report

The blind pouch syndrome is associated with a spectrum of diseases affecting the gastrointestinal tract that includes: malabsorption, ulceration, bleeding, and perforation. The clinical signs and symptoms of anemia, weight loss, abdominal pain, vomiting, and intermittent intestinal obstruction can be found. Occasionally, constipation or more often diarrhea is an important manifestation. A case report of this entity with related radiological and pathological findings secondary to a side-to-side anastomosis is presented and discussed.     

The "Infectious Mononucleosis Cell" A Cytochemical Study

The abnormal cells in the peripheral blood of patients with infectious mononucleosis were studied by available histochemical technics and with immunofluorescent and autoradiographic technics. The findings indicated a closerelationship of these cells to lymphocytes, although the strong acid phosphatase reaction observed in the infectious mononucleosis (IM) cells wasnot usually seen in normal lymphocytes, but rather in monocytes and reticulum cells. There was no evidence of antibody production by the IM cells ofthe peripheral blood.

Studies of the lymph nodes showed two abnormal cell types: one, similarto the IM cells in the peripheral blood but more immature, and the second,a primitive cell with various indications of immunologic competence.

Submitted on February 28, 1963 Accepted on July 8, 1963     

Fine Structure of Leukocytes in Infectious Mononucleosis: In Vivo and In Vitro Studies

The peripheral blood mononuclear cell population in patients with heterophile positive infectious mononucleosis is comprised of small and mediumsized lymphocytes, monocytes, increased numbers of lymphoid-plasma (LP)cells, and large lymphocytoid cells with abundant polysomes. Cell-lines derived from these patients contain a spectrum of cells of the lymphoid plasmacell series. These cultures are morphologically indistinguishable from Burkittlymphoma and leukemic suspension cultures. A large portion of the cellspresent in these continuous suspension cultures have fine structural featuressimilar to phytomitogen stimulated lymphocytes, and to cells implicated inthe immune response.

Submitted on November 26, 1968 Accepted on February 26, 1969     

Brief Note Lymphocyte RNA Synthesis in Infectious Mononucleosis: The Response to Phytohemagglutinin in Vitro

Circulating lymphocytes were isolated from normal individuals and frompatients with IM. IM lymphocytes synthesized RNA at 10 times the rate ofnormal lymphocytes. A 1-hour exposure to PHA did not result in the stimulation of 4 to 30S RNA synthesis which occurs in a similarly treated normallymphocyte. RNA synthesis in IM lymphocytes actually appeared to be depressed by this short exposure to PHA.

Submitted on March 9, 1966 Accepted on May 20, 1966     

进一步提高急性呼吸窘迫综合征的诊治策略

急性呼吸窘迫综合征 (Acuterespiratorydistresssyndrome ,ARDS)是由多种因素引起的急性进行性非心源性肺水肿和低氧血症综合征 ,是急性肺损伤(ALI)的严重阶段。在加强医疗病房 (ICU )中是一种常见的重症患者 ,费用大 ,病死率高。 1972年美国国立卫究院 (NIH)的报告 ,美国每年约有 15万患者发生ARDS ,年发病率为 6 5 / 10万。ARDS的病死率介于 10 %～ 90 %之间。近几年病死率虽有下降 ,病死率大约 4 0 %左右 ,仍然提示ARDS的发病率和病死率很高 ,其主要原因是ALI/ARDS诊断和治疗的认识不够。ARDS的诊断2 0 0 0年中华医学会呼…     

Rotational Atherectomy in Acute Coronary Syndrome: A Meta-Analysis

BackgroundThe use of rotational atherectomy (RA) in percutaneous coronary intervention (PCI) of acute coronary syndrome (ACS) is considered relatively contraindicated. There have been several observational studies showing RA use in ACS, however, no systemic studies have been undertaken. We sought to evaluate the feasibility and outcomes of RA PCI in ACS by performing a meta-analysis.MethodsWe searched PUBMED, EMBASE, CINAHL, and Cochrane Central Register of Clinical Trials for any studies that evaluated the role of RA PCI in ACS. The outcomes analyzed were all-cause mortality, cardiac mortality, short and long-term major adverse cardiac events (MACE), procedural complications and cardiac perforations.ResultsThere was a total of 8 retrospective studies with a total population of 1237 with a median follow up of 23 months. The median age of the included patient was 73. Angiographic success rate was 97.4%. The rate of all-cause mortality and cardiac mortality were 5% (range 1–12%, p < 0.001, I² = 92%) and 2% (range 0–5%, P = 0.03, I² = 58%) respectively. In-hospital MACE and long-term MACE were 7% (range 3–13%, p < 0.001, I² = 87%) and 29% (range 21–37%, p = 0.21, I² = 34%) respectively. The incidence of total procedural complications was noted to be 7% (range 2–14%, p < 0.001, I² = 90%). Rate of perforation was 1% (range 0–1%, p = 0.9, I² = 0%).ConclusionOur results show that RA PCI is feasible in ACS with comparable procedural complications and short-term MACE, but with a higher long-term MACE rate compared to RA PCI in routine cases.