Old and new targets of antibacterial therapy

Currently available antibiotics target bacterial cell wall synthesis, protein synthesis, or DNA replication. Antibiotics that are structurally unrelated sometimes have common targets. Mutations in these common targets frequently give rise to bacteria that are resistant to multiple antibiotics. The impact of these bacteria in clinical situations is increasing whereas development of effective antibiotics for their treatment is not keeping pace. This emerging crisis in clinical care has led to intense efforts in new antibiotic development. Both improvements in currently available classes of antibiotics as well as discovery of completely novel ones are being aggressively sought. In this review, the mechanisms of action of available antibiotics will be discussed with emphasis on newly developed drugs. Also, some of the potential new targets of antibiotic therapy in the future will be highlighted.     

高龄胃癌患者全胃切除术的围手术期处理

目的：探讨高龄胃癌患者全胃切除的囤手术期处理。方法：回顾性分析1995年至2004年60岁以上高龄胃癌患者34例,其中全胃切除 Roux—y空肠代胃术5例,全胃切除 改良布朗Ⅱ式空肠代胃术29例。结果：围手术期无死亡病例,出现并发症10例,24例平稳度过围手术期。结论：高龄胃癌患者行全胃切除术围手术期处理对于手术成功率很重要。高龄并不是手术绝对禁忌证。     

老年牙病413例患者分析

目的 统计分析广元市老年牙痛患者牙病种类及其治疗,为老年人群牙病防治工作提供必要的信息.方法 采集2000～2007年在广元市第一人民医院口腔科就诊的413例老年患者的临床资料进行统计分析.结果 413例中龋病、牙周病发病率,牙缺失率及缺失牙修复率较高.结论 广元市需进一步完善口腔保健服务体系,加大老年人群口腔健康知识教育力度以降低牙病患病率,提高牙病治疗率.