牙源性钙化上皮瘤（骨外型）一例报告

牙源性钙化上皮瘤（骨外型）一例报告王林康，杨学财牙源性钙化上皮瘤是一种少见的局部浸润性肿瘤，多见于颌骨内，骨外极少见，１９５８年由国外首先报道，将其描述为一独立类型的牙源性肿瘤，我科１９９５年收治一例，报道如下。病例介绍：患者，女，３４岁，因＂左颌下...     

骨外型牙源性钙化上皮瘤1例

牙源性钙化上皮瘤(calcifying epithelial odontogenic tumor,CEOT)亦称Pindborg瘤,是一种良性、生长缓慢、但有局部侵袭性的牙源性上皮肿瘤,发病率占所有牙源性肿瘤的0.4%~3%,据文献报道称,该瘤多发生于颌骨内磨牙区(94%),骨外型极少见(6%)。现将我科收治的一例骨外型CEOT报告如下。     

牙源性钙化上皮瘤2例

牙源性钙化上皮瘤（CEOT）是一种具有局部浸润性生长特点的良性牙源性上皮性肿瘤,可分为骨内型（中央型）、骨外型（外周型）两种,后者罕见。本文报道2例牙源性钙化上皮瘤,并结合文献探讨其临床、影像表现特点。     

钙化上皮瘤及牙源性钙化上皮瘤的临床病理分析

目的：探讨钙化上皮瘤及牙源性钙化上皮瘤的临床表现、诊断及外科处理原则。方法：对13例钙化上皮瘤和4例牙源性钙化上皮瘤患者的临床资料进行回顾性分析。结果：所有患者均经手术治疗。钙化上皮瘤患者平均年龄11．2岁,小于10岁者占69．2％（10例）;位于头颈部8例（61．5％）,四肢4例（30．8％）,躯干1例（7．7％）。牙源性钙化上皮瘤患者平均年龄38．75岁,均位于颌骨。两种肿瘤无明显性别差异,均有复发、恶变的报道。结论：钙化上皮瘤和牙源性钙化上皮瘤在临床表现和病理诊断上具有明显差别,是两种不同的肿瘤;牙源性钙化上皮瘤具有局部浸润性生长,手术切除必须彻底。     

牙源性钙化上皮瘤1例

牙源性钙化上皮瘤又称Pindborg瘤,是一种发生在颌骨的较罕见的牙源性肿瘤,患者年龄分布较广,20～40岁均可发病,性别无差异[1]。本文报道1例颌骨牙源性钙化上皮瘤。     

牙源性钙化上皮瘤3例报告

牙源性钙化上皮瘤是一种较少见的牙源性肿瘤 ,起源于成釉器中的中间层细胞 ,好发于下颌骨前磨牙区及磨牙区 ,少数可发生于颌骨外的粘膜中、下颌牙龈区及颌下区。以往曾称之为Pinborg瘤、非典型性成釉细胞瘤或囊性牙瘤[1] 。因本病少见 ,临床上较易误诊且治疗不当极易复发 ,故本     

牙源性上皮性联合瘤的临床病理和角蛋白表达研究

目的：研究4例牙源性上皮性联合瘤的临床病理和角蛋白免疫组化表达。方法：4例牙源性上皮性联合瘤均来源于武汉大学口腔医学院病理学教研室，10％福尔马林溶液固定，常规制片HE染色，免疫组化SP法检测肿瘤组织中CKl0、CKl0和13、CKl8和8、CKl9蛋白的表达。结果：全部4例中均显示牙源性腺样瘤的典型组织学特点，牙源性钙化上皮瘤样区大小不等，1例中的CEOT区为主要成分，CKl9呈阳性表达。结论：报告四例牙源性腺样瘤和牙源性钙化上皮瘤构成的牙源性上皮性联合瘤，其中一例为罕见的以牙源性钙化上皮瘤成分为主。     

骨外型牙源性钙化上皮瘤

骨外型牙源性钙化上皮瘤极为罕见,通过复习1966～2011年英文MEDLINE与1994～2011年中文CHKD中收录的文献,仅有37例骨外型牙源性钙化上皮瘤的个案报告。根据上述资料分析,发现该瘤具有以下临床特点,就诊年龄3～71岁,平均35.8岁;男13例,女19例,男女比例为1∶1.46;肿块直径0.5～4 cm,平均1.76 cm;好发部位主要是牙龈,累及下颌与上颌牙龈的比例为1∶1;组织学特征表现与骨内型牙源性钙化上皮瘤基本相同;复发率为5.4%。因该瘤具有浅表骨侵蚀能力,应行完整的肿瘤切除结合骨面刮治术。     

牙源性钙化上皮瘤恶变的临床与组织学分析

牙源性钙化上皮瘤(Calcified epithelial odontogenic tumor,简称CEOT)是一种生长缓慢,较少见的牙源性、肿瘤。过去,该肿瘤一直被认为是一种良性可复发而不发生恶变的牙源性肿瘤。但在我院1973～1989年收治的10例牙源性钙化上皮瘤病例中却有2例发生恶变,现将恶变病例分析报道如下: 1 病例报告 [病例1]王某某,男性,37岁。患者于1979年     

下颌骨中心性牙源性纤维瘤1例

<正>牙源性纤维瘤是一类来源于牙源性间叶组织的良性肿瘤,临床上极为少见,组织病理上牙源性纤维瘤由大量的胶原纤维构成,牙源性上皮细胞构成的上皮岛和上皮条索分布其间,组织内可能含有类似于发育异常的牙本质、发育不良的牙骨质及骨样物质所构成的钙化物。中心性牙源性纤维瘤是一种发生于颌骨中心性的良性肿瘤,我科曾收治1例发生于下颌骨的中心性牙源性纤维瘤,现报告如下。     

Calcifying epithelial odontogenic tumor of the maxilla with ulcerative stomatitis: a case report

Calcifying epithelial odontogenic tumor (CEOT) is a rare benign odontogenic tumor, known as Pindborg tumor. Although ulcer formation was reported in one previously involving the peripheral maxilla, such change of the overlying mucosa has been reported in intraosseous CEOT. We report maxillary CEOT in a patient who complained of spontaneous pain due to extensive ulcer formation of the oral mucosa.     

Calcifying Epithelial Odontogenic Tumour: A Case Report

Calcifying epithelial odontogenic tumour (CEOT) presenting at an unusual site is rare. The characteristic cytologic findings in association with radiologic features can help the cytopathologist and the surgeon in rendering a firm preoperative diagnosis of Calcifying Epithelial Odontogenic Tumour even at atypical sites such as maxilla. The purpose of this article is to report an additional case of CEOT and discuss the radiologic appearance, histologic features, clinical behavior and surgical management.     

Non-calcifying variant of calcifying epithelial odontogenic tumor with Langerhans cells

Calcifying epithelial odontogenic tumor (CEOT) is a rare type of odontogenic tumor. The most characteristic feature of the classical CEOT is the presence of amyloid globules and Liesegang ring calcification in the tumor tissue. Here, we present a non-calcifying variant of intraosseous CEOT with the presence of Langerhans cells within tumor epithelial nests in a 52-year-old Taiwanese woman. The patient was referred from a local dentist to our hospital for treatment of a unilocular radiolucent lesion at the right anterior region of the maxilla. The lesion was excised. Microscopically, the tumor was composed of small nests or strands of odontogenic epithelial cells and amorphous eosinophilic globules of amyloid-like materials in a loose fibrous connective tissue stroma. The tumor epithelial cells were positive for pan-cytokeratins (AE1 and AE3). Langerhans cells demonstrated by anti-CD1a staining were found in nests or strands of tumor epithelial cells. The eosinophilic globules were positive for Congo red and showed green birefringence when subjected to polarized light. Review of the English literature revealed two cases of non-calcifying variant of intraosseous CEOT with Langerhans cells in the anterior and premolar regions of the maxilla. Taken together, we suggest that the non-calcifying, Langerhan cell-rich variant of CEOT may have a distinct predilection for occurrence in the anterior and premolar region of the maxilla in contrast to the classical CEOTs that usually occur in the molar and ascending ramus area of the mandible.     

Immunohistochemical demonstration of enamel proteins in odontogenic tumors

Immunohistochemical localization of two enamel proteins, amelogenin and enamelin, in comparison with that of keratin, was determined in odontogenic tumors and the allied lesions in order to verify functional differentiation of the tumor cells as ameloblasts. Amelogenin and enamelin were demonstrated in small mineralized foci and in the tumor cells surrounding them in adenomatoid odontogenic tumor (AOT), calcifying epithelial odontogenic tumor (CEOT), and calcifying odontogenic cyst (COC). Hyaline droplets in AOT showed positive staining for both enamel proteins. These mineralized and hyaline materials were not positive for keratin, although tumor cells were positive. On the other hand, no immunoreaction for enamel proteins was obtained in ameloblastoima and odontogenic epithelial cell nests within myxoma and epulis. The results suggest that tumor cells of AOT and CEOT and lining epithelial cells of COC show ameloblastic differentiation in part, but that ameloblastoma cells do not attain functional matauration as secretory phase ameloblasts.     

Central calcifying epithelial odontogenic tumour in the posterior maxilla: a case report

The calcifying epithelial odontogenic tumour (CEOT), or Pindborg tumour, is a rare, benign odontogenic tumour. CEOT is usually asymptomatic and an incidental radiological finding, often presenting as a mandibular radiolucency with flecks of calcific material. We report an unusual case of CEOT in the left posterior maxilla of a 46‐year‐old male that was associated with an unerupted tooth. The tumour in this case caused non‐specific sinus symptoms and appeared radiographically similar to an odontoma or ossifying fibroma due to its dense calcific contents. Diagnosis was confirmed histologically following surgical removal of the lesion, which showed classic CEOT histomorphology. We report this case to highlight the unusual clinico‐radiologic presentation and illustrate the diagnostic difficulties that can occur with radiolucent and/or radiopaque lesions in the jaws.     

A variant of calcifying epithelial odontogenic tumor with Langerhans cells

A variant of calcifying epithelial odontogenic tumor (CEOT) with Langerhans cells is reported. Compared to a typical CEOT, the tumor islands of this case were thin and composed of a small number of polyhedral epithelial cells. Almost no calcification of homogeneous eosinophilic materials was observed. In addition, clear cells which structurally corresponded to Langerhans cell were intermingled in the epithelial islands. These cells stain positively for S-100 protein, lysozome, MT 1, LN-3 and OKT 6 antibodies, but not for keratin antibody. Electronmicroscopic examination revealed the rod-shaped and racket-shaped structures called Birbeck's granules in the cytoplasm of these clear cells. Our observations indicate a variant case of CEOT with Langerhans cells in tumor nests.