腮腺肿瘤112例临床分析

目的：对腮腺肿瘤的临床和病理学特点进行分析，探讨诊断和治疗中的注意事项。方法：对1985～2005年间收治的112例腮腺肿瘤病例的临床和病理学特点进行回顾性分析。结果：112例腮腺肿瘤男性多于女性。年龄14～80岁。良性肿瘤84例，占75％，恶性肿瘤28例，占25％。B超诊断符合率86．4％。细针吸细胞学定性诊断符合率92．9％，组织类型鉴别较困难。24例腮腺良性肿瘤直径〈2cm者行肿瘤加瘤周正常腺体切除术，获得随访18例，1例腺淋巴瘤在其它部位复发。结论：术前定性诊断应根据肿瘤的部位、大小及患者的情况选择合适的检查方法，疑难病例手术中冰冻活体组织检查是确诊的可靠依据。小的腮腺良性肿瘤实施瘤周正常腺体切除术，不增加复发率，并能减少腮腺手术的并发症。     

腮腺恶性肿瘤的治疗（附46例临床分析）

腮腺恶性肿瘤的治疗（附４６例临床分析）李根渊１９７０年至１９９０年底共收治腮腺肿瘤３３５例，良性肿瘤２８９例，占总病例８６．２７％，恶性肿瘤４６例，占总病例１３．９３％。男性２４例占５２．１７％，女性２２例占４７．８３％，男女之比为１．１１：１。年龄...     

儿少期涎腺上皮性肿瘤的诊治特点

作者对６６例发生于１６岁以下的儿童及少年的涎腺上性肿瘤进行了临床分析，此６６例占同期涎腺上皮性肿瘤的３．６％。其中２５例为良性肿瘤，占３７．９％，以多形性腺瘤最多见；４１例为恶性肿瘤，占６２．１％，以粘液表皮样癌居首位。１０岁以上组５０例，占全部病的３／４以上。５岁以上组仅６例，其中恶生肿瘤５例，表明患者年龄越小，患恶性肿瘤的可能性越大，且肿瘤分化程度低，恶性度高。２例腮腺患者曾因同侧腮腺区管瘤而     

腮腺区包块的临床诊断与治疗分析

目的：通过对我院近9年192例腮腺包块的统计分析,探讨腮腺包块分布类型,以及最佳治疗方案。方法：回顾分析192例腮腺包块病例,随访其治疗效果,并进行进行统计分析。结果：192例腮腺肿瘤中,良性肿瘤125例,恶性肿瘤34例,非肿瘤性包块33例。腮腺包块中良性肿瘤占大多数,常见类型为淋巴乳头状囊腺瘤和多形性腺瘤。恶性肿瘤所占比例较少,以黏液表皮样癌和腺样囊性癌居多。非肿瘤性包块多为炎性包块。肿瘤治疗以手术切除为主。炎性包块多采用抗炎治疗。结论：腮腺区包块涵盖的疾病复杂,应根据肿瘤性质、位置及范围选择合适的治疗或手术方案。     

131例老年人腮腺肿瘤构成比分析

目的：了解老年人腮腺肿瘤的发病情况，为早期诊断及治疗提供依据。方法：对15年来13l例老年腮腺患者的临床资料进行分析。结果：60—69岁为老年腮腺肿瘤高发年龄段;性别比为男：女=2．54：1，良恶性肿瘤比为3．68：1；良性肿瘤中以Warthin瘤发病率最高，恶性肿瘤以黏液表皮样癌居首。近年来发病数高于以往。结论：老年腮腺肿瘤患者男性多发，以良性肿瘤为主。总体肿瘤发病呈增长趋势。     

唾液腺上皮性肿瘤1209例临床分析

目的：了解1990-2005年间唾液腺上皮性肿瘤的临床流行病学特点。方法：对南京大学医学院附属口腔医院1990年2月至2005年2月15年间收治的1209例唾液腺上皮性肿瘤患者进行回顾研究，对其病理类型、好发部位、年龄和性别等进行统汁分析。结果：1209例患者中，良性肿瘤与恶性肿瘤之比为1．96：1，男女之比为1：1。良性肿瘤以多形性腺瘤最多见（76．75％）．其次为Warthin瘤（14．75％）；恶性肿瘤以黏液表皮样癌最常见（34．2％），其次为腺样囊性癌（26．2％）。良性肿瘤和恶性肿瘤的好发部位相同，均以腮腺最多，腭部小唾液腺和下颌下腺分列第2位和第3位；发病年龄主要集中于20-70岁之间．结论：唾液腺上皮性肿瘤可发生于任何年龄，良性多于恶性，多形性腺瘤是其最常见的病理类型．     

31例青少年腮腺肿瘤临床和病理分析

目的 探讨青少年腮腺肿瘤的临床和病理特点,为其治疗提供临床证据. 方法 对31例10~19岁青少年腮腺肿瘤患者的临床和病理资料进行回顾性分析,并将其与同期收治的516例成人腮腺肿瘤患者的临床特点和组织病理类型加以比较. 结果 青少年腮腺肿瘤中恶性肿瘤比例高达38. 7%(12/31),但在成人仅占17. 0%(88/516). 31例青少年腮腺肿瘤中,良性肿瘤19 例,占61. 3%,其中以多形性腺瘤居多,占良性肿瘤的89. 5%(17/19);恶性肿瘤中以黏液表皮样癌居多,占恶性肿瘤的41. 7%(5/12). 31例肿瘤患者均接受手术治疗,其中2例恶性肿瘤术后放疗. 结论 青少年腮腺肿瘤的肿瘤病理类型与成人有明显不同,应当引起重视. 对于青少年腮腺肿瘤,应重视手术治疗的早期性和彻底性.     

舌部肿瘤113例分析

目的：分析舌部肿瘤的病原特征，诊断方法和处理原则。方法：收集我院113例舌部肿瘤的资料并进行临床及病理分析。结果：本组舌部肿瘤113例，其中男性74例，女性39例，男女比例为1：0．53，发病年龄2—72岁，平均年龄41岁，35-55岁占76％。原发部位以舌体边缘处最多，占46％。恶性肿瘤以鳞状细胞癌多见，良性肿瘤中以乳头状瘤、血管瘤、淋巴管瘤多见。恶性肿瘤稍多于良性，良、恶性比约为1：1．21。结论：资料分析提示，舌部肿瘤中恶性稍多于良性，鳞状细胞癌、乳头状瘤占了绝大部分。治疗原则是以手术为主，结合放疗化疗。     

儿童的腮腺肿瘤

儿童涎腺肿瘤较成人少,儿重涎腺良性或恶性肿瘤均和成人一样大多数发生在腮腺。本文报告了一组15岁以下儿童腮腺肿瘤的临床资料。约10000例涎腺疾患病员中,儿童占430例,其中124例为腮腺肿瘤,包括90例良性肿瘤,34例恶性肿瘤。一、良性肿瘤: 混合瘤45例(1例在1岁以内,2例为     

腮腺深叶肿瘤41例临床病例分析

目的：总结腮腺深叶肿瘤的诊断及治疗方法。方法：收集41例腮腺深叶肿瘤的临床资料进行回顾性分析,对诊断、手术方式及临床效果进行比较评价。结果：肿瘤直径大于4cm者37例,最大直径14cm;41例中腮腺混合瘤31例,基底细胞腺瘤2例,肌上皮瘤1例,粘液表皮样癌3例,腺泡细胞癌2例,恶性混合瘤2例。治疗办式：肿瘤小于6cm,术前细胞学检查为良性肿瘤者保留面神经腮腺深叶摘除术;肿瘤大于6cm者,保留面神经伞腮腺摘除术;恶性肿瘤全腮腺及面神经切除＋颈淋巴结清扫术。良性肿瘤随诊1～7年无复发。恶性肿瘤4年后复发3例。结论：腮腺深叶肿瘤在发病情况、临床表现等方面具有自身的特点,应根据肿瘤的大小、位置、肿瘤性质采取不同的手术方式。     

腮腺包块136例临床分析

目的：通过对136例腮腺包块的临床分析,提高腮腺包块的诊断水平和治疗效果。方法：对1985～2004年收治的136例腮腺包块病例进行回顾性分析。其中良性肿瘤112例,恶性肿瘤18例,其它病变6例。所有包块均行手术治疗,对恶性肿瘤术后进行放化疗。结果：128例腮腺包块经手术治愈,3例良性肿瘤及5例恶性肿瘤复发。结论：腮腺包块的正确诊断对治疗方法的选择有重要指导意义。     

Epithelial salivary gland tumors of children and adolescents in west China population: a clinicopathologic study of 79 cases

Objective:  Determine the clinical and histopathologic features of epithelial salivary gland tumors of children and adolescents.
Methods:  A total of 79 cases of epithelial salivary gland tumors of children and adolescents were retrieved from the files. Information about demographic, clinical, histopathologic characteristics, and follow-up status were analyzed.
Results:  Sixty tumors (75.9%) were benign and 19 (24.1%) malignant. The most common tumor overall was pleomorphic adenoma (PA). The parotid was the most frequently involved site (43.0%). PA was the most common type of benign tumor. The most common malignant tumor was mucoepidermoid carcinoma. Five patients with parotid PA and two cases with palate myoepithelioma showed local recurrences. One patient with mucoepidermoid carcinoma showed local recurrences and died from the tumor 3 years after the initial treatment. One patient with adenocarcinoma presented local and neck recurrences, and died 4 years after initial treatment.
Conclusions:  Our data showed that the salivary gland tumors in children and adolescents may be the higher incidence of benign tumors, especially of PA; the slightly higher tendency for female predominance; the higher incidence of parotid glands. Mucoepidermoid carcinoma was the most common malignant tumor, with majority of low grade. Initial treatment should be planned to excise the tumor completely with satisfactory margins. The neck dissections or postoperative radiotherapy were performed in patients with low differentiation malignancies, or patients who present nodal metastasis or with clinically suspicious regional metastasis.     

Diagnosis and treatment of epithelial salivary gland tumours in children and adolescents

In a series of 2,871 epithelial salivary gland neoplasms managed in the Peking University School of Stomatology between 1974 and 1999, 86 arose in children <16 years of age (52 parotid, 12 submandibular gland, 2 sublingual gland, and 20 minor salivary gland). Considerable delay was encountered in diagnosis (benign 24 months and malignant 16 months). In this group of children, 46 tumours (53%) proved to be malignant, with an incidence in the parotid, submandibular, sublingual, and minor salivary glands of 31/52 (60%), 2/12, 0/2, and 13/20 (65%), respectively. Sixty-six of 86 neoplasms (77%) occurred in children between 10 and 16 years of age. Only six neoplasms were encountered in children of 5 years or younger, four of which were high-grade malignant tumours. Benign tumours were successfully treated by local excision with only one recurrence. Of 46 malignant neoplasms, 8 were treated palliatively; of the remainder 8 were lost to follow-up and 2 patients died of their disease.     

Salivary gland tumors in an Iranian population: a retrospective study of 130 cases.

PURPOSE: Tumors of the salivary glands are uncommon, comprising 3% to 10% of head and neck neoplasia. In the absence of epidemiologic studies of these neoplasms in an Iranian population, we conducted a preliminary survey of 130 cases over the last 20 years in Hamedan, Iran. PATIENTS AND METHODS: The medical records and case notes of all patients with histologically confirmed salivary gland tumors were reviewed retrospectively from February 1984 to March 2003. This review found 89 patients with benign tumors and 41 patients with malignant tumors. The collection of data included gender, age, location, and histopathology of the tumor. Other recorded data included diagnostic procedures, operative reports, complications, additional treatment, and follow-up. RESULTS: We studied 78 females and 52 males with a mean age of 44.9 years. Patients with benign and malignant tumors presented with a mean age of 41.3 and 47 years, respectively. The frequency of benign tumors was 68.4% (n = 89) and 31.6% for malignant tumors (n = 41). Tumors were localized in the parotid gland (63%; n = 82), the submandibular gland (23%; n = 30), and in the minor salivary glands (14%; n = 18). The most common benign tumor was pleomorphic adenoma (65.4%; n = 85). Among malignant tumors, mucoepidermoid carcinoma was the most frequent (11.5%; n = 15), followed by adenocarcinoma (10%; n = 13). Greater than 63% of malignant tumors were treated surgically, and the remaining with combined therapy. Seven patients died over the follow-up period (6 with persistent disease), 5 were lost to follow-up, and 23 remained cancer-free. CONCLUSION: Between benign and malignant salivary gland tumors, frequency of pleomorphic adenoma and mucoepidermoid carcinoma was in keeping with studies reported previously. In other salivary gland tumors, however, diversity was obvious and showed significant difference, requiring further studies.     

Epithelial salivary gland tumors of children and adolescents in southern Portugal. A clinicopathologic study of twenty-four cases.

During a 30-year period 24 epithelial salivary gland tumors were diagnosed in children and adolescents less than 18 years of age. The cases were retrieved from a series of 759 consecutive cases of salivary gland tumors (3.2%) from the area corresponding to southern Portugal during the same period of time. The mean age of the patients was 13.4 years, and one case was congenital. There was a slight female predominance (male/female ratio 1:1.7). The parotid gland was affected in most cases (70.8%). Seventeen neoplasms were benign, and the remaining seven were malignant. As in the adult group, pleomorphic adenoma was the most frequent benign tumor (66.6%), with similar histologic findings and clinical course. Mucoepidermoid carcinoma was the prevalent malignant tumor (20.8%), had a high grade of differentiation, and had a favorable outcome. The histologic pattern of the congenital neoplasm was similar to that of adult epithelial-myoepithelial carcinoma.     

127例腮腺肿瘤临床治疗分析

目的:对127例腮腺肿瘤诊断和临床治疗方法进行总结分析,得出提高治愈率的经验.方法:总结本院口腔科1989～2009年收治的127例腮腺肿瘤病例资料并病理分类、手术方式、临床治愈率、术后复发率及并发症情况.结果:本组病例良性肿瘤101例、恶性肿瘤26例.所有病例均行手术治疗,部分恶性肿瘤术后辅助放疗.123例治愈,1例...     

Parotid gland tumors in a Korean population

Salivary gland tumors occur in about 3% of the head and neck tumors, and among the salivary gland tumors, parotid gland tumor occurs in about 80%. Because of its low frequency and small cases, it is hard to establish the epidemiologic characteristics of the tumors. This study was performed retrospectively from February 1987 to August 2010. There were 95 male, and 76 female patients. Most of the patients complained of the painless and progressively enlarged mass in the preauricular area. Peak incidence of benign parotid gland tumor was at the fifth decade of life. In the malignant tumors, peak age in males was the eighth decade, and peak age in females was from the third to the fifth decade of life, which was relatively younger and has a broad range of spectrum. Pleomorphic adenoma was the most common benign tumor of the 93 cases (61.6%) followed by Warthin tumor, occurring in 20 cases (13.2%). Squamous cell carcinoma, reported in 6 cases (30%), is the most frequent. Mucoepidermoid carcinoma was the second leading tumor. In conclusion, parotid gland tumor incidence was found to be higher in males. Pleomorphic adenoma was the most commonly encountered type of parotid gland neoplasms, which is in agreement with findings from all of the published literature from all over world. In contrast to most of the previous studies, squamous cell carcinoma was the most frequent malignant tumor found. Based on the data in this study, it has significant clinical respect and is helpful in the management of parotid gland tumors in Orientals.     

谷胱甘肽过氧化物酶-3在腮腺多形性腺瘤中的表达及意义

目的 :研究谷胱甘肽过氧化物酶-3(glutathione peroxidase-3,GPX-3)基因及蛋白在腮腺良、恶性多形性腺瘤中的表达,以明确GPX-3与腮腺多形性腺瘤发生、发展的相关性,为临床预测腮腺多形性腺瘤的发生及恶变提供理论依据。方法:采用荧光定量PCR和蛋白免疫印迹法检测30例腮腺多形性腺瘤,30例腮腺多形性腺瘤的瘤旁2 cm腺体组织,以及10例恶性腮腺多形性腺瘤中的GPX-3 mRNA及蛋白的表达,对其相对表达量进行统计学分析。结果:GPX-3 mRNA和蛋白在腮腺良、恶性多形性腺瘤中的表达明显低于瘤旁腺体组织,且在腮腺恶性多形性腺瘤中的表达最低,差异有统计学意义(P<0.01)。GPX-3在腮腺多形性腺瘤中的表达与患者的年龄、性别及肿瘤大小无关,差异无统计学意义(P>0.05),且GPX-3在腮腺多形性腺瘤中的表达与肿瘤TNM分期及恶性成分比例有关,其差异有统计学意义(P<0.05)。结论:GPX-3在腮腺良性多形性腺瘤中低表达,且在腮腺恶性多形性腺瘤中的表达最低,提示GPX-3的低表达与腮腺多形性腺瘤的发生及恶变密切相关。