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目的:建立利巴韦林注射液细菌内毒素的检查方法.方法:用两个生产厂家的鲎试剂至5批样品,把中国药典2000年版二部附录ⅪE方法进行干扰试验考察.结果:利巴韦林注射液最大非干扰浓度为20mg·ml-1,其细菌内毒素限值可定为0.125EU·mg-1.因此可选用灵敏度(λ)为0.5EU·ml-1的鲎试剂,将样品稀释至4mg·ml-1后进行细菌内毒素检查.结论:可以用细菌内毒素检查法(凝胶法)代替家兔热原检查法控制其热原. 相似文献
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硫酸罗通定注射液细菌内毒素检查法的研究 总被引:1,自引:0,他引:1
目的:建立硫酸罗通定注射液细菌内毒素检查方法.方法:按<中国药典>2005年版二部附录Ⅺ E细菌内毒素检查法,对不同生产厂家的样品进行了干扰试验和细菌内毒素检查.结果:本品最大不干扰浓度为0.94 g·L-1.结论:可采用细菌内毒素检查法对硫酸罗通定注射液进行质量控制. 相似文献
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目的建立注射用维库溴铵细菌内毒素的检查方法。方法按《中国药典》2005年版二部附录XIE进行实验和结果判断。结果用三个不同生产厂家,不同标示灵敏度鲎试剂进行研究,注射用维库溴铵最大不干扰浓度为0.1mg/ml,并对两个生产厂家的6批样品进行检查,均无干扰作用,其细菌内毒素量均小于5EU/mg。结论本品可以用细菌内毒素检查法(凝胶法)控制细菌内毒素的含量,其细菌内毒素限值为5EU/mg。 相似文献
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目的建立细菌内毒素检查法替代家兔热原检查法用于苦参素氯化钠注射液质量控制。方法参照中国药典2000年版二部附录ⅪE、ⅪⅩF中细菌内毒素检查法及应用指导原则,使用两个生产厂家的2种灵敏度(λ=0.25或0.125EU/mL)的鲎试剂对苦参素氯化钠注射液进行干扰试验研究。结果苦参素氯化钠注射液对采用鲎试剂进行细菌内毒素检查无干扰作用。结论该制剂可以用细菌内毒素检查法(凝胶法)代替家兔热原检查法控制其产品质量。 相似文献
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目的建立注射用核糖核酸Ⅲ细菌内毒素检查方法。方法按《中国药典》2010年版(二部)附录ⅪE细菌内毒素检查法进行实验和结果判断。结果用两个生产厂家的鲎试剂进行研究,注射用核糖核酸Ⅲ的最大不干扰浓度为1.25 mg·mL-1,并对三批样品进行检查,均无干扰作用,其细菌内毒素均小于15 EU·mg-1。结论本品采用细菌内毒素检查法(凝胶法)控制细菌内毒素的含量合理可靠。 相似文献
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硫酸阿托品注射液中细菌内毒素的鲎试剂检查法 总被引:1,自引:0,他引:1
目的:建立硫酸阿托品注射液细菌内毒素检查法.方法:采用中国药典2005年版附录细菌内毒素检查法.结果:硫酸阿托品注射液稀释至0.25 g·L-1及更低浓度时,用灵敏度分别为0.25 EU·mL-1和0.125 EU·mL-1的鲎试剂检测细菌内毒素,无干扰因素影响.结论:硫酸阿托品注射液细菌内毒素限值确定为50 EU·mg-1,可应用鲎试剂进行细菌内毒素法检查. 相似文献
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The drug problem in The Netherlands 总被引:1,自引:0,他引:1
M Kooyman 《Journal of substance abuse treatment》1984,1(2):125-130
In the Netherlands, the drug problem among adolescents developed as a new phenomenon in the mid 1960s. Without remarkable success, methadone maintenance programs were introduced in 1968. Drug free treatment in therapeutic communities, developed since 1972, was successful after the first experimental years. This success provoked the illusion that drug related problems could be solved by treatment; low threshold programs, putting few demands on participants, were established to dispense methadone. The illusion was that addicts can be motivated into further treatment if they are brought into contact with professionals. As the addict population kept growing and their street crimes increased in number, Dutch drug policies changed in 1978, using methadone as a means to decrease criminal activities rather than to treat addicts. This also turned out to be an illusion. Currently, there is strong political pressure to distribute heroin to addicts to diminish the negative side effects of drug abuse. Dutch drug policies are characterized by the opinion that drug problems cannot be solved and have to be accepted. 相似文献
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Eugenie R Lumbers Ze-Yan Yu Karen J Gibson 《Clinical and experimental pharmacology & physiology》2001,28(11):942-947
1. Brain sparing is a feature of intra-uterine growth retardation (IUGR). This implies that there is a redistribution of metabolic supply so that body growth slows to a greater extent than brain growth. 2. Intra-uterine growth retardation, as evidenced by a low birthweight for gestational age is a predisposing factor for hypertension, cardiovascular disease and diabetes mellitus in adult life. 3. In species like humans, nephrogenesis is complete before birth. In the rat, it is completed shortly after birth. In both species, it can be shown that either undernutrition or IUGR is associated with reduced nephron number. 4. It has been proposed that oligonephropathy results in hyperfiltration, which ultimately leads to glomerulosclerosis and hypertension. The renin-angiotensin system (RAS) is necessary for normal renal development and fetal renal function. In the rat, blockade of the RAS in the first weeks of life by pharmacological agents reduces glomerular number and has been shown to cause hypertension in adult life. Renal denervation reduces the activity of the fetal RAS and also causes abnormal development of the renin-secreting cells. 5. There is tonic renal sympathetic nerve activity in the late gestation fetal sheep. The level of renal sympathetic nerve activity (RSNA) is influenced by the fetal behavioural state. 6. However, interactions between the developing kidney and the developing sympathetic nervous system are poorly understood. On the one hand, renal innervation may be important in the provision of neurotrophic factors that stimulate the development of the RAS and kidney. On the other, high levels of RSNA associated with circulating catecholamines and vasopressin may cause vasoconstriction and limit nephrogenesis. This latter effect could be a predisposing factor to adult hypertension and cardiovascular disease. 相似文献
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目的:寻找临床上采集新生儿足跟血的有利方法。方法:25例新生儿在辐射台保暖下足跟外侧采血与25例新生儿在一般平台上用热毛巾敷足跟采集足跟内侧血两种方法进行分析比较。结果:两种采血方法所需时间、一针采血成功率及血片质量关系差异有显著性。结论:辐射台组简单快捷,血片优质,痛苦少。 相似文献
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The working methods and the results of the system for registration of medicines in the Netherlands are reviewed. The new structure of the Committee for the Evaluation of Medicines is identified. The necessity for more international cooperation is emphasized. The authors propose the establishment of a European registration committee. The current system is discussed from the viewpoints of government and industry. 相似文献
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本文讨论的是人体生命观的问题,从人的本质来看,人体生命与其它生命体有着原则的区别。人体生命是神圣品格、质量品格和价值品格的辩证统一。人体生命三重品格以价值品格为核心,密不可分地联系在一起。片面强调人体生命的质量品格或神圣品格,必然使人们在理论和实践上陷入二难境地。 相似文献
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The history of pharmacology in The Netherlands 总被引:1,自引:0,他引:1
E L Noach 《Trends in pharmacological sciences》1990,11(6):236-239
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本文对PVP作为尼美舒利片粘合剂的浓度与溶出度的关系进行了考察。结果表明;PVP作为尼美舒利片粘合剂,其水溶液浓度在6-7%范围尼美舒利片的溶出度均符合规定。 相似文献