Family environment and shame: Is there a relationship?

This study was designed to examine the relationship between dysfunctional families in childhood and shame experienced by adults and compare feelings of guilt and shame. The results indicated that the shame young adults feel is correlated with their perceived family environment as a child. Greater feelings of shame on the Test of Self-Conscious Affect (TOSCA) were correlated with lower Family Environment Scale scores on Cohesion, Expressiveness, Intellectual-Cultural Orientation, Moral-Religious Emphasis and Organization and higher Conflict scores. Other variables were also examined. The results support the hypothesis that people coming from dysfunctional families experience more shame as adults and that guilt and shame are differentially related to dysfunctional families. © 1996 John Wiley & Sons, Inc.     

Work–Family Conflicts and Health Behaviors Among British,Finnish, and Japanese Employees

Background  

Work–family conflicts are associated with poor health. However, work–family conflicts and health behaviors have been little studied.     

Genetic and Environmental Influences on Adolescents’ Perceptions of Current Family Environment

Previous studies of the genetic and environmental components of the Family Environment Scale (FES) have typically reported that scales relating to familial acceptance are moderately to strongly genetically influenced while measures of control are more environmentally influenced. These reports relied on retrospective recall, which is not as reliable as recall of current environment. To investigate the genetic contribution to contemporaneous perceptions of one’s rearing environment, the responses on the FES of 471 17-year-old male twins (141 complete MZ twin pairs, 73 complete DZ twin pairs, 43 incomplete twin pairs) participating in the Minnesota Twin-Family Study (MTFS) were analyzed. Individual FES scales were generally modestly to moderately heritable. Unlike previous research, we did not find evidence that measures of control/structure were less heritable than measures of acceptance/support. These findings support a genetic basis of perceptions of one’s family environment and indicate that reports of control/structure may be more genetically influenced than previously believed based on retrospective reports.     

Parental Smoking and Adolescent Smoking Stages: The Role of Parents’ Current and Former Smoking, and Family Structure

This study examined the role of parents’ current and former smoking in predicting adolescent smoking acquisition stages. Participants were 7,426 students from 33 schools in the Netherlands. Participants’ survey data were gathered at baseline and at two-year follow-up. Logistic regression models showed that parental smoking status was not only predictive of transitions from never smoking to trying smoking, monthly smoking, or daily smoking, but also of the progression from trying smoking to daily smoking. Further, although parental former smoking was weaker associated with progressive adolescent smoking transitions than current parental smoking, however absence of parental smoking history was most preventive. Compared to the situation in which both parents had never smoked, cessation of parental smoking after the child was born was associated with an increased risk for children to smoke. Adolescents living in a single-parent family were at greater risk of smoking than adolescents living in an intact family with both mother and father. In sum, the role of parental smoking is not restricted to smoking onset and is present throughout different phases of the acquisition process. Results support the delayed modeling hypothesis that parental smoking affects the likelihood for children to smoke even when parents quit many years before. Children living in single-parent families are only exposed to the behaviour of one parent; in two-parent families the behaviour from one parent may magnify or buffer the behaviour of the other parent.     

Family mealtime interactions and overweight children with asthma: potential for compounded risks?

OBJECTIVE: Exploratory study aimed to examine differences in family interaction patterns during a routine mealtime between overweight, at-risk for overweight, and average weight children with asthma. METHODS: Eighty families of children with asthma, aged 5-12 years, were videotaped during a mealtime in their homes. The videotapes were rated using the McMaster Mealtime Family Interaction Coding System (MICS). Structural aspects of the meal such as presence of sugary drinks and whether the television was on were also coded. RESULTS: Significant differences were found on the MICS with families of children with asthma who were overweight scoring lower on task accomplishment, affect management, interpersonal involvement, and roles. Families of overweight children with asthma also displayed an increased presence of sugary beverages, shorter meal length, and fewer adults at the table. CONCLUSIONS: Preliminary findings suggest that families with children with asthma who are overweight may have a more difficult time managing mealtimes and feel overwhelmed by this family routine.     

Should Patients and Family be Involved in “Do Not Resuscitate” Decisions? Views of Oncology and Palliative Care Doctors and Nurses

Background:

“Do not resuscitate” (DNR) orders are put in place where cardiopulmonary resuscitation is inappropriate. However, it is unclear who should be involved in discussions and decisions around DNR orders.

Aim:

The aim was to determine the views of oncology and palliative care doctors and nurses on DNR orders.

Materials and Methods:

A questionnaire survey was conducted on 146 doctors and nurses in oncology and palliative care working within a tertiary specialist cancer center in Singapore.

Results:

Perceived care differences as a result of DNR determinations led to 50.7% of respondents reporting concerns that a DNR order would mean that the patient received a substandard level of care. On the matter of DNR discussions, majority thought that patients (78.8%) and the next of kin (78.1%) should be involved though with whom the ultimate decision lay differed. There was also a wide range of views on the most appropriate time to have a DNR discussion.

Conclusions:

From the viewpoint of oncology and palliative care healthcare professionals, patients should be involved at least in discussing if not in the determination of DNR orders, challenging the norm of familial determination in the Asian context. The varied responses highlight the complexity of decision making on issues relating to the end of life. Thus, it is important to take into account the innumerable bio-psychosocial, practical, and ethical factors that are involved within such deliberations.     

Executive Function and Theory of Mind in 2 Year Olds: A Family Affair?

This study aimed to enhance our understanding of neuropsychological functioning in children with early-treated phenylketonuria (PKU) and assess the relative impact of white matter abnormalities (WMA) and neurotransmitter deficiencies on cognitive functions in this population. The study consisted of 33 children with early-treated PKU and 34 healthy control children aged between 7 to 18 years. All children had a neuropsychological evaluation that included measures of general intelligence, attention, processing speed, memory and learning, executive function, and academic achievement. Children in the PKU group also had a magnetic resonance (MR) brain scan. When compared with the control group, the PKU group exhibited global cognitive impairment including lower IQ, attention problems, slow information processing, reduced learning capacity, mild executive impairments, and educational difficulties. Children in the PKU group with extensive WMA (n = 14) displayed significant impairments across all cognitive domains. Metabolic control correlated weakly to moderately with attention, executive, and memory/learning factors. Within the PKU group, regressions revealed that executive function and attention factors were independently related to severity of WM pathology and age, while the memory and learning factor was independently related to metabolic control and age. It is concluded that children with early-treated PKU exhibit a global pattern of impairment, with a particular deficit in processing speed. WM pathology extending into frontal and subcortical regions correlates with the greatest deficits and a profile of impairment consistent with diffuse WM damage. Our findings also offer some support for dopamine depletion in the prefrontal cortex, however adverse consequences as a result of norepinephrine and serotonin deficiencies should not be discounted.     

Family history of suicidal behavior and early traumatic experiences: additive effect on suicidality and course of bipolar illness?

BACKGROUND: Bipolar disorder (BD) is associated with a high prevalence of suicide attempt and completion. Family history of suicidal behavior and personal history of childhood abuse are reported risk factors for suicide among BD subjects. METHODS: BD individuals with family history of suicidal behavior and personal history of childhood abuse (BD-BOTH), BD individuals with family history of suicidal behavior or personal history of childhood abuse (BD-ONE), and BD individuals with neither of these two risk factors (BD-NONE) were compared with regard to demographic variables and clinical measures. RESULTS: Almost 70% of the sample had a history of a previous suicide attempt. There were significantly higher rates of previous suicide attempts in the BD-BOTH and BD-ONE relative to the BD-NONE group. BD-BOTH were significantly younger at the time of their first suicide attempt and had higher number of suicide attempts compared with BD-NONE. BD-BOTH were significantly younger at the time of their first episode of mood disorder and first psychiatric hospitalization and had significantly higher rates of substance use and borderline personality disorders compared to BD-NONE. LIMITATIONS: Retrospective study. Use of semi-structured interview for the assessment of risk factors. CONCLUSIONS: BD individuals with a familial liability for suicidal behavior and exposed to physical and/or sexual abuse during childhood are at a greater risk to have a more impaired course of bipolar illness and greater suicidality compared to those subjects with either only one or none of these risk factors. Prospective studies are needed to confirm these findings.     

Family companions’ involvement during pre-surgical consent visits for major cancer surgery and its relationship to visit communication and satisfaction

Objective

To examine the association between family companion presence during pre-surgical visits to discuss major cancer surgery and patient-provider communication and satisfaction.

Novel Role and Regulation of the Interleukin-1 Receptor Associated Kinase （IRAK） Family Proteins

The interleukin-1 receptor associated kinases(IRAKs)sit at the bottle neck for the Toll-like-receptor(TLR)mediated signal transduetion process controlling host innate immune response.However,the exact role andregulation of IRAKs are still in the early stage and not fully understood.This review intends to summarize therecent advancement in this important topic and points out areas that need further intensive investigation.Cellular& Molecular Immunology.2005:2(1):36-39.     

Role of Reactive Oxygen Species and Bcl-2 Family Proteins in TNF-α-Induced Apoptosis of Lymphocytes

We studied the in vitro apoptosis-inducing effect of recombinant TNF-α (rTNF-α) on blood lymphocytes from healthy donors. rTNF-α-induced apoptosis was accompanied by an increase in the number of cells with low mitochondrial transmembrane potential, increased intracellular content of reactive oxygen species, reduced content of Bcl-2, Bcl-xL, and Bax proteins, and elevated Bad content. The molecular mechanisms of these changes are discussed.     

The Interleukin (IL)‐2 Family Cytokines: Survival and Proliferation Signaling Pathways in T Lymphocytes

Lymphocyte populations in the immune system are maintained by a well-organized balance between cellular proliferation, cellular survival and programmed cell death (apoptosis(. One of the primary functions of many cytokines is to coordinate these processes. In particular, the interleukin (IL(‐2 family of cytokines, which consists of six cytokines ‐IL‐2, IL‐4, IL‐7, IL‐9, IL‐15 and IL‐21) that all share a common receptor subunit (gc), plays a major role in promoting and maintaining T lymphocyte populations. The details of the molecular signaling pathways mediated by these cytokines have not been fully elucidated. However, the three major pathways clearly involved include the JAK/STAT, MAPK and phosphatidylinositol 3‐kinase ‐PI3K‐ pathways. The details of these pathways as they apply to the IL‐2 family of cytokines is discussed, with a focus on their roles in proliferation and survival signaling.     

A Nonsense Mutation of γD-crystallin Associated with Congenital Nuclear and Posterior Polar Cataract in a Chinese Family

Objective: The goal of this study was to characterize the disease-causing mutations in a Chinese family with congenital nuclear and posterior polar cataracts. Methods: Clinical data of patients in the family were recorded using slit-lamp photography and high definition video. Genomic DNA samples were extracted from the peripheral blood of the pedigree members and 100 healthy controls. Mutation screening was performed in the candidate genes by bi-directional sequencing of the amplified products. Results: The congenital cataract phenotype of the pedigree was identified by slit-lamp examinations and observation during surgery as nuclear and posterior polar cataracts. Through the sequencing of the candidate genes, a heterozygous c. 418C>T change was detected in the coding region of the γD-crystallin gene (CRYGD). As a result of this change, a highly conserved arginine residue was replaced by a stop codon (p. R140X). This change was discovered among all of the affected individuals with cataracts, but not among the unaffected family members or the 100 ethnically matched controls. Conclusions: This study identified a novel congenital nuclear and posterior polar cataract phenotype caused by the recurrent mutation p. R140X in CRYGD.     

Family Interactions and Developmental Risk Associated With Early Cognitive Delay: Influences on Children’s Behavioral Competence

Family interactions can be important contributors to the development of child psychopathology, yet the mechanisms of influence are understudied, particularly for populations at risk. This prospective longitudinal study addresses differences in whole family interactions in 194 families of young children with and without early-identified developmental risk associated with cognitive delay. The influence of family interactions on children’s later externalizing behaviors, internalizing behaviors, and social skills was examined, and developmental risk was tested as a potential moderator of these relations. Results indicated that the presence of cognitive developmental risk was linked to higher levels of family control than in families of typically developing children, but groups did not differ on dimensions of cohesion, warmth, organization, or conflict. Observed cohesion and organization were associated with better social skills for all children, regardless of risk status. Significant interactions emerged, indicating that higher levels of conflict and control were associated with higher levels of behavior problems, but only for families of typically developing children. These findings underscore the importance of family-level assessment in understanding the development of children’s behavior and suggest the need for deeper analysis of the nuances of family process over time.     

Association Between Circulating Levels of the Novel TNF Family Members APRIL and BAFF and Lymphoid Organization in Primary Sjögren’s Syndrome

B cell activating factor (BAFF) and a proliferation-inducing ligand (APRIL) are members of the tumour necrosis factor superfamily. We have examined circulating BAFF and APRIL in relation to serological deviations and lymphoid organization in the salivary glands of the chronic, autoimmune disorder Sjögren’s syndrome. Lymphoid organization in the shape of ectopic germinal centers were detected in 33 of 130 consecutive minor salivary gland biopsies and coincided with increased focus score and elevated levels of serum IgG. Follicular dendritic cell networks, proliferation of mononuclear cells and altered B/T cell ratio also separated the two subgroups. Serum levels of sBAFF and sAPRIL were increased in Sjögren’s syndrome compared to healthy blood donors, especially in anti-Ro/La+ patients. Though the differences could not be related to germinal center formation, positive correlations between serum levels of sBAFF and sAPRIL, focus score and IgG denotes their possible role in the disease progression of primary Sjögren’s syndrome.The first two authors contributed equally to this work.     

Enzyme Replacement Therapy in a Gaucher Family

Gaucher disease is a lipid storage disorder due to deficiency of beta glucocerebrosidase. It's an autosomal recessive disease and as a result of this enzyme deficiency, glucocerebroside accumulates in various types of tissues like liver, brain spleen and bone marrow. We aimed to describe the effects of enzyme replacement therapy in three members of a family with Gaucher disease and to emphasize screening of the family members of the patients with Gaucher disease. Furthermore, late diagnosis and treatment in these patients have a minimal effect on improvement of the quality of life, and early diagnosis and treatment are very important in Gaucher disease.     

Combined α-thalassemia and Hemoglobin J-Iran (β77 His → Asp). A Family Study in southern Iran

We report a 23-year-old man and three members of his family with Hb J-Iran confirmed by electrophoresis, chain separation by high performance liquid chromatography and sequencing. Alpha thalassemia was also confirmed in two family members. The substitution at β77 led to a higher negative charge of the βJ-Iran subunit, which enhanced its electrostatic attraction for the normal positively-charged α subunit. Therefore, more Hb J-Iran than Hb A forms in the red blood cells of heterozygotes. In α-thalassemia, the more attractive βJ-Iran subunit outcompetes βA subunits in forming assemblies with deficient α subunits, so even more Hb J-Iran was formed.     

Cardiac dimensions, physical activity, and submaximal working capacity in youth of the Québec Family Study

The relationships between cardiac dimensions and physical activity and submaximal working capacity were examined in 198 boys and 154 girls, aged 9–18 years, who were participants in the first phase of the Québec Family Study. The sample was divided into three age groups, 9–12 years, 13–15 years, and 16–18 years. Indicators of physical activity included estimated daily energy expenditure (EE) and time spent in moderate-to-vigorous physical activity (median metabolic equivalents of energy expenditure above resting metabolic rate ≥4.8). Submaximal physical working capacity (PWC₁₅₀) was determined using a submaximal exercise test on a Monark cycle ergometer. Echocardiographically determined dimensions included posterior wall thickness, septal wall thickness, and left ventricular mass (LVM). The analyses were based on partial correlation and analysis of covariance, controlling for age and body surface area. Relationships between EE/physical activity variables and cardiac dimensions were low and, at best, moderate (r < 0.45). With subjects grouped into tertiles by indicators of physical activity, LVM was significantly different only among 16- to 18-year-old girls (157 g vs 134 g in the highest and lowest quartiles, respectively; P < 0.05). Correlations between cardiac dimensions and PWC₁₅₀ were also low (r < 0.30), with few significant relationships. In general, cardiac dimensions were not related to habitual physical activity and PWC₁₅₀ in young subjects aged 9–18 years. However, significant correlations were positive, as expected. LVM may be related to submaximal power output in boys since it accounts for 3% of the variance, after adjusting for age and BSA. Received: 4 January 1999 / Accepted: 8 June 1999