贝伐单抗与化疗联合治疗复发性卵巢癌18例临床观察

目的 探讨贝伐单抗（BEV）与化疗联合治疗复发性卵巢癌的疗效、无进展生存时间和毒副反应.方法 对采用BEV联合化疗治疗的18例复发性卵巢癌的有效率、无进展生存时间及毒性反应进行回顾性分析.给予患者BEV7.5 mg/kg,同时与化疗药联合应用,每三周一次,至少治疗2个周期后评价疗效和1个周期后评价毒性.结果 18例复发性卵巢癌（除1例铂敏感型外）均为耐药/难治性患者,BEV治疗的中位周期数为4个.3例（16.7%）患者获得肿瘤完全缓解（CR）,12例（66.7%）部分缓解（PR）,总有效（CR＋PR）率达83.3%.稳定（SD）患者2例（11.1%）,仅1例患者（5.6%）为肿瘤进展（PD）.总临床获益率为94.4%.中位无进展生存时间7个月,有78.0%的患者无进展生存时间超过6个月.白细胞减少是最常见的毒副反应,3～4级仅占22.2%.总的3～4级毒性反应为33.3%..结论 BEV联合化疗治疗复发性卵巢癌有效率高,毒性反应小,有望成为治疗复发性（尤其复发耐药性）卵巢癌的安全、有效候选方案.     

复发性卵巢上皮癌46例治疗分析

目的：回顾分析46例复发性卵巢上皮癌临床情况,指导复发性卵巢上皮癌再治疗。方法：46例复发性卵巢上皮癌,28例给予再次手术治疗,46例患者均给予联合化疗。结果：随访5 a,46例患者中生存11个月-3 a 17例,生存4a 1例,生存5 a 1例,死亡27例。结论：联合治疗可提高患者生存时间,手术治疗谨慎选择。     

子宫颈残端癌二例及文献复习

子宫颈残端癌临床少见,本文报告我院收治的2例子宫颈残端癌,并结合文献进行复习。1病例资料【例1】65岁。因下腹疼痛伴阴道不规则流血18个月入院。18个月前出现腹痛并阴道流血,在当地医院诊断为子宫肌瘤、左侧卵巢囊肿,在持续硬膜外麻醉下行子宫次全切除术,术中见3 cm×2 cm大小肌瘤,剖视子宫见子宫浆膜层呈菜花状,分泌出豆渣样液体约20 m l,奇臭难闻,自诉曾做病理检查为子宫化脓性炎症。术后阴道流血停止,4个月后又出现不规则阴道流血,在当地医院经对症治疗后好转。近1年来阴道流血反复发作,行B超检查见阴道顶端有一6 cm×5 cm大小的混合…     

冷冻治疗面部皮肤病疗效观察

面部皮肤病影响人们的生活和工作，为有效治疗面部皮肤病，我科采用液氮冷冻法治疗，取得较好疗效，分析如下。     

输卵管残端妊娠一例报告

1 病例资料 25岁,孕1产1.因停经52 d,左下腹痛6d,加重4h入院.2年前因左侧输卵管妊娠行左侧输卵管切除术.平素月经规律,停经后无明显早孕反应.6d前无诱因出现左下腹胀痛,呈间歇性,可忍耐.     

平阳霉素局注加冷冻治疗颌面部血管瘤35例临床报告

口腔颌面部的血管瘤占全身血管瘤的６０ % ［１］。其中７０ %在出生后不久就发生。绝大多数在１岁以内出现红色病损 ,随婴儿生长而迅速增大。可明显影响患儿颌面外形。我科利用抗肿瘤药平阳霉素有抑制血管内皮细胞增生 ,促进血管瘤消退的作用 ,且副反应小的优点 ,自１９９１年６月至１９９９年１０月采用平阳霉素局注加冷冻治愈颌面部血管瘤３５例。随访观察最长１例已达８年余 ,无１例复发。临床资料一、一般资料３５例中男性２０例 ,女性１５例。年龄最小３５天 ,最大６０岁 ,其中６个月至１１个月２２例。混合性血管瘤２０例 ,海绵状１…     

冷冻治疗慢 性咽炎500例疗效观察及护理

我院耳鼻喉科于1987年开始用液氮冷冻治疗慢性咽炎500例,疗效显著。现介绍如下. 一、一般资料500例患者中,男性340例、女性160例。年龄最     

巨大卵巢甲状腺肿一例

卵巢甲状腺肿是一类完全或主要由甲状腺组织构成的单胚层成熟性畸胎瘤,占所有卵巢畸胎瘤的1% ~ 3%、所有卵巢肿瘤的0.3% ~ 1.0%。该文报道了1例巨大卵巢甲状腺肿患者的诊治经过,该例患者因下腹部隆起7年、加重伴腹胀不适2年入院,入院完善相关检查后行剖腹探查术。术中见盆腹腔内一大小约20 cm ×18 cm×10 cm囊实混合性肿物,予经腹全子宫+双侧附件切除术,术后病理回报符合卵巢甲状腺肿。术后随访1年,患者阴道断端愈合良好,肿瘤标志物等指标恢复至正常,妇科及甲状腺彩色多普勒超声均未见明显异常。该例的诊治过程提示,卵巢甲状腺肿临床症状缺乏特异性,易误诊,临床医师应提高对此病的认识,增强早期筛查意识,提升诊治水平。     

右输尿管残端复发癌1例

患者男，58岁。于7年前因右输尿管癌行右肾和输尿管中上段切除术，术后恢复顺利，一直无任何不适。一个月前患者无明显诱因出现肉眼血尿，无腰腹疼痛，无尿频、尿急、尿痛、发热等症状。体检：T36．4℃，P78次／分，BP140／85mmHg。一般情况良好，神志清，全身浅表淋巴结无肿大，心肺听诊正常。腹部平坦，无压痛及反跳痛，未触及肿块，肝脾未触及。两侧肾区无膨隆和扣击痛，输尿管走行区无压痛。右侧腹部可见长25cm手术切口瘢痕。     

卵巢动静脉瘘超声表现1例

病例女。38岁,左下腹痛3d来院。患者孕10产3．8年前曾有葡萄胎病史．无不规则阴道流血史．月经正常。超声表现：子宫大小6．5cmx4．4cmχ5．2era,肌层血管小均匀扩张．最宽径0．5-0．7cm（图1）,宫内膜厚度0．6cm,内无异常回声。左附件区见一蜂窝状包块．形态不规则．内呈无声暗区．范围7．5cmχ5．Ocm,CDFI示包块内充满五彩镶嵌的血流信号．内可测及动静脉瘘频谱（图2,3）。该包块向上汇聚成一粗管状回声,延伸流入左肾静脉,最宽径1．9cm,走行迂曲（图4,5）,内可测及静脉频谱。     

卵巢子宫内膜样腺纤维瘤复发并蒂扭转MRI表现一例

患者女,37岁,2016年1月23日因下腹痛入滨州医学院附属医院.下腹及盆腔CT检查发现左腹部及左附件区囊状低密度影,大小约11.8 cm×8.3 cm×11.5 cm,边界清,内密度较均匀,平均CT值约16 HU,偏后部壁较厚,病灶以窄颈与左附件区相连.患者行左卵巢肿物剥除术+左附件复位术.术中所见:左卵巢增大,内有...     

超声诊断先天性阴道斜隔致阴道内残留胎物1例

病例女,２３岁,孕４２天,药流后４天,未见胎囊排出。患者平素月经量中等,经期延长,伴痛经。妇检：右侧阴道壁饱满,可触及一实性包块,不活动。宫体、附件触不清。B超检查：盆腔见双子宫图形（图１）,右侧子宫５．９cm×３．６cm×３．０cm,形态正常,其宫颈下方阴道上段处见３．８cm×１．３cm的异常回声区,呈中、低回声光团。阴道远端可见无回声区（图２左）;左侧子宫５．７cm×３．４cm×３．０cm,宫颈与阴道回声正常（图２右）。探查肾区,右肾区未见肾脏图形,腹腔及盆腔亦未见正常肾脏显示。左肾增大１３cm×６．０cm×５…     

Occult vaginal cancer recurrence after hysterectomy: a case report and literature review

Vaginal cancer is a rare disease of the lower genital tract. We present the case of a 54-year-old woman with occult vaginal cancer after hysterectomy for cervical intraepithelial neoplasia (CIN) III. Despite persistently negative cytology and colposcopy results, a lesion was finally detected by vagino-recto-abdominal examination and she underwent radical parametrectomy and lymph node dissection. We consider the possibility that transabdominal suturing of the vaginal cuff after hysterectomy may reduce the ability to detect subsequent vaginal lesions, and discuss the benefits of a vaginal suture approach. We recommend that suturing the vagina apex transvaginally instead of transabdominally would benefit patients during follow-up.     

贲门失弛缓并食管癌1例

病例女．42岁，声音嘶哑4月余，进食阻挡感2月余，伴黏液返流、咳嗽、胸闷，症状进行性加重。既往史：20年前发现贲门失弛缓，18年前曾行扩张术。实验室检查：大便潜血实验阳性，血红蛋白71g/L。     

Computed tomography diagnosed left ovarian venous thrombophlebitis after vaginal delivery: A case report

BACKGROUNDPostpartum ovarian vein thrombophlebitis (POVT) is a rare but serious postpartum complication that affects mostly postpartum women. A high index of suspicion is required when faced with sudden postpartum abdominal pain.CASE SUMMARYA 25-year-old healthy woman who accepted a vaginal delivery procedure suffered fever (temperature 39.6℃) one day after delivery, accompanied with left lower abdominal pain. Physical examination indicated mild tenderness in the left lower abdomen, accompanied with rebound pain. The patient was confirmed to have left ovarian venous thrombosis with inflammation after receiving a multi-detector row computed tomography scan.CONCLUSIONPOVT is a rare and dangerous postpartum complication. A high index of suspicion is required for the occurrence of ovarian venous thrombosis when faced with postpartum abdominal pain and fever. Early application of Doppler ultrasound, computed tomography, magnetic resonance imaging and other auxiliary examinations is conducive to timely and accurate diagnosis of POVT, thus reducing maternal mortality.     

Extensive cutaneous metastasis of recurrent gastric cancer: A case report

BACKGROUNDCutaneous metastasis is a rare event associated with poor prognosis for gastric cancer and has been rarely reported in the literature.CASE SUMMARYA 69-year-old male patient who had undergone salvage gastrectomy and a few courses of adjuvant chemotherapy 3 mo earlier for recurrent gastric cancer developed widespread cutaneous metastases. Due to the patient’s intolerance to further adjuvant chemotherapy, he was placed in hospice care and expired 1 mo later. In the literature, gastric cancers are rarely reported as the primary malignancies for cutaneous metastasis. We, thus, provide an update on a case review published in 2014 by reviewing 10 more case reports dated from 2014 to 2020. The average age for the new group of patients was 59.4 ± 18.88-years-old. Thirty percent of the patients presented with cutaneous lesions and advanced gastric cancer synchronously while 70% developed cutaneous metastases 1.3 years to 14 years after the initial treatment for primary gastric cancer. Eighty percent of the patients received either local excision or chemo ± radiation therapy to treat their cutaneous metastases. CONCLUSIONThis report highlights cutaneous metastasis as a late and untreatable metastasis of gastric cancer.