无机元素与脆性骨折

骨质疏松症是以骨密度下降和骨微结构破坏的一种系统性骨病,脆性骨折是骨质疏松症的主要并发症,而无机元素在体内的浓度水平与脆性骨折的发生率紧密相关,但分子作用机制尚未清楚。无机元素又分为3类,一类为常量元素,包括钙、磷和镁等元素;第2类为必需微量元素,包括氟、铜、铁、锌等元素;第3类为毒性重金属元素,包括汞、铅、铬等元素。无机元素在体内的浓度水平可能影响骨骼的生长发育和骨组织的代谢活动,如常量元素中的钙和磷元素是组成羟基磷灰石的主要成分,必需微量元素中的锌、铜和锰对骨形成和骨矿化有着不可或缺的作用,毒性重金属元素的铅和镉对骨组织有明显的毒性作用。本文就体内存在的多种无机元素与脆性骨折的关系作一综述,旨为预防和诊治骨质疏松症与脆性骨折提供一定的理论依据。     

Does a fracture liaison service program minimize recurrent fragility fractures in the elderly with osteoporotic vertebral compression fractures

Background

There is a sizable proportion of elderly, both men and women, with fragility fractures, approximately 2 million fractures per year in the United States.

Acetabulum fractures in elderly: A systematic review of fracture pattern and treatment

PurposeAcetabulum fractures are being increasingly seen with low impact injuries in elderly patients. This article aimed to study systematically literature on geriatric acetabulum fractures. Objectives of this systematic review were to study (1) demography of patients, common mechanisms of injury and types of fracture patterns commonly seen in elderly patients, (2) treatment used for these fractures in literature and (3) mortality rates in elderly with these fractures.MethodsSystematic search was carried out in May 2020 using predefined search strategy for all studies published in the English language in last 20 years. Literature search and data abstraction was done by two independent reviewers.ResultsAfter screening of all abstracts, a total of 48 studies were included in the systematic review. In total there were 7876 geriatric patients with acetabulum fractures. Mean age of the patients was 72.47 years. There were 4841 males (61.5%). Fall from low heights was the most common mechanism of injury, present in 47.12% patients followed by motor vehicular accidents in 28.73%. Most common fracture pattern was both column fracture, seen in 19.03% patients, followed by anterior column and posterior hemitransverse fracture in 17.23%, anterior column fractures in 17.13%, and posterior wall fractures in 13.46% patients. Out of total 5160 patients for whom details of treatment were available, 2199 (42.62%) were given non-operative treatment, 2285 (44.28%) were treated with ORIF of acetabulum fracture, 161 (3.12%) were treated with percutaneous fixation and 515 (9.98%) were treated with primary THA. Gull sign, femoral head injury and posterior wall comminution were associated with poorer prognosis after ORIF and may form an indication for a primary THA.ConclusionLiterature on treatment of geriatric acetabulum fractures is not enough to draw any definite conclusions. There is limited evidence from current literature that surgery could be considered a safe treatment option for displaced acetabulum fractures in elderly. Primary THA can provide early mobility and reduce chances of resurgery in fracture patterns where restoration of joint surface may not be possible.     

Acetabulum fractures in elderly: A systematic review of fracture pattern and treatment

PurposeAcetabulum fractures are being increasingly seen with low impact injuries in elderly patients. This article aimed to study systematically literature on geriatric acetabulum fractures. Objectives of this systematic review were to study (1) demography of patients, common mechanisms of injury and types of fracture patterns commonly seen in elderly patients, (2) treatment used for these fractures in literature and (3) mortality rates in elderly with these fractures.MethodsSystematic search was carried out in May 2020 using predefined search strategy for all studies published in the English language in last 20 years. Literature search and data abstraction was done by two independent reviewers.ResultsAfter screening of all abstracts, a total of 48 studies were included in the systematic review. In total there were 7876 geriatric patients with acetabulum fractures. Mean age of the patients was 72.47 years. There were 4841 males (61.5%). Fall from low heights was the most common mechanism of injury, present in 47.12% patients followed by motor vehicular accidents in 28.73%. Most common fracture pattern was both column fracture, seen in 19.03% patients, followed by anterior column and posterior hemitransverse fracture in 17.23%, anterior column fractures in 17.13%, and posterior wall fractures in 13.46% patients. Out of total 5160 patients for whom details of treatment were available, 2199 (42.62%) were given non-operative treatment, 2285 (44.28%) were treated with ORIF of acetabulum fracture, 161 (3.12%) were treated with percutaneous fixation and 515 (9.98%) were treated with primary THA. Gull sign, femoral head injury and posterior wall comminution were associated with poorer prognosis after ORIF and may form an indication for a primary THA.ConclusionLiterature on treatment of geriatric acetabulum fractures is not enough to draw any definite conclusions. There is limited evidence from current literature that surgery could be considered a safe treatment option for displaced acetabulum fractures in elderly. Primary THA can provide early mobility and reduce chances of resurgery in fracture patterns where restoration of joint surface may not be possible.     

Major osteoporotic fragility fractures: Risk factor updates and societal impact

Osteoporosis is a silent disease without any evidence of disease until a fracture occurs. Approximately 200 million people in the world are affected by osteoporosis and 8.9 million fractures occur each year worldwide. Fractures of the hip are a major public health burden, by means of both social cost and health condition of the elderly because these fractures are one of the main causes of morbidity, impairment, decreased quality of life and mortality in women and men. The aim of this review is to analyze the most important factors related to the enormous impact of osteoporotic fractures on population. Among the most common risk factors, low body mass index; history of fragility fracture, environmental risk, early menopause, smoking, lack of vitamin D, endocrine disorders(for example insulin-dependent diabetes mellitus), use of glucocorticoids, excessive alcohol intake, immobility and others represented the main clinical risk factors associated with augmented risk of fragility fracture. The increasing trend of osteoporosis is accompanied by an underutilization of the available preventive strategies and only a small number of patients at high fracture risk are recognized and successively referred for therapy. This report provides analytic evidences to assess the best practices in osteoporosis management and indications for the adoption of a correct healthcare strategy to significantly reduce the osteoporosis burden. Early diagnosis is the key to resize the impact of osteoporosis on healthcare system. In this context, attention must be focused on the identification of high fracture risk among osteoporotic patients. It is necessary to increase national awareness campaigns across countries in order to reduce the osteoporotic fractures incidence.     

Changes in cortical microarchitecture are independent of areal bone mineral density in patients with fragility fractures

Dual-energy X-ray absorptiometry (DXA) and high-resolution peripheral quantitative computed tomography (HR-pQCT) are commonly used to assess the areal bone mineral density (aBMD) and peripheral microstructure, respectively. While DXA is the standard to diagnose osteoporosis, HR-pQCT provides information about the cortical and trabecular architecture. Many fragility fractures occur in patients who do not meet the osteoporosis criterion (i.e., T-score ≤ −2.5). We hypothesize that patients with T-score above −2.5 and fragility fracture may have abnormal bone microarchitecture. Therefore, in this retrospective clinical study, HR-pQCT data obtained from patients with fragility fractures and T-scores ≥ −2.5 (n = 71) were compared to corresponding data from patients with fragility fractures and T-scores ≤ −3.5 (n = 56). Types of secondary osteoporosis were excluded from the study. To verify the dependency of alterations in bone microarchitecture and T-score, the association between HR-pQCT values and aBMD as reflected by the T-score at both proximal femora, was assessed. At the distal tibia, cortical thickness was lower (p < 0.001), cortical porosity was similar (p = 0.61), trabecular number was higher (p < 0.001), and bone volume fraction (BV/TV) was higher (p < 0.001) in patients with T-scores ≥ −2.5 than in patients with T-scores ≤ −3.5. Trabecular number and BV/TV correlated with T-score (r = 0.68, p < 0.001; r = 0.61, p < 0.001), whereas the cortical values did not. Our results thus demonstrate the importance of bone structure, as assessed by HR-pQCT, in addition to the standard DXA T-score in the diagnosis of osteoporosis.     

Anaesthetic aspects in the treatment of fragility fracture patients

As longevity increases globally, the number of older, frailer, comorbid patients requiring fragility fracture surgery will increase. Fundamentally, anaesthesia should aim to maintain these patients’ pre-fracture cognitive and physiological trajectories and facilitate early (ie day 1) postoperative recovery. This review describes the 10 general principles of anaesthesia for fragility fracture surgery that best achieve these aims: multidisciplinary care, ‘getting it right first time’, timely surgery, standardisation, sympathetic anaesthesia, avoiding ischaemia, sympathetic analgesia, re-enablement, data collection and training.     

Validation of a new classification system for interprosthetic femoral fractures

Interprosthetic femoral fracture (IFF) incidence is gradually increasing as the population is progressively ageing. However, treatment remains challenging due to several contributing factors, such as poor bone quality, patient comorbidities, small interprosthetic fragment, and prostheses instability. An effective and specific classification system is essential to optimize treatment management, therefore diminishing complication rates. This study aims to validate a previously described classification system for interprosthetic femoral fractures.     

Strategies for fixation of periprosthetic fragility fractures of the neck of femur below a well-functioning hip resurfacing arthroplasty: A case-series

IntroductionMetal-on-metal Hip Resurfacing (HR) was performed in many young individuals as it conserved bone stock and had low wear rates, before it became less popular due to the detection of Adverse Reactions to Metal Debris. As such, many patients in the community have well-functioning HRs and as they age, the incidence of fragility fractures of the neck of femur around the existing implant is expected to increase. These fractures are amenable to surgical fixation as adequate bone stock remains in the head of the femur and the implants are well fixed.Case-seriesWe present a series of six cases which were treated by fixation using locked plates (3), dynamic hip screws (2) and cephalo-medullary nail (1). Four cases achieved clinical and radiographic union with good function. One case had a delayed union, though union was finally achieved at 23 months. One case had an early failure necessitating revision to a Total Hip Replacement after 6 weeks.DiscussionWe highlight the geometrical principles of placing fixation devices under an HR femoral component. We have also conducted a literature search and present details of all case reports to date.ConclusionFragility per-trochanteric fractures under a well-fixed HR with good baseline function are amenable to fixation using a variety of methods including large screw devices that are commonly used in this location. Locked plates including variable angle locking designs should be kept available if needed.     

绝经后髋部脆性骨折中铁过载指标与骨密度骨转换指标关系的研究

目的 研究绝经后髋部脆性骨折患者血清铁过载指标与骨代谢指标间的相互关系,对两者的临床表现进行探讨.方法 回顾性研究2011年2月至2012年6月76例绝经后髋部脆性骨折患者资料,年龄55 ～ 93岁,平均(73±10)岁;绝经时间5～50年,平均(22±10)年.患者均检测血清铁蛋白、转铁蛋白、碱性磷酸酶(ALP)、Ⅰ型原胶原氨基端延长肽(P1NP)、Ⅰ型胶原C端肽B降解产物(β-CTX)和双能X线股骨颈腰椎骨密度指标.采用t检验、Pearson线性相关分析、多元逐步回归分析、偏相关分析,观察铁代谢指标与骨代谢相关指标的关系.结果 患者血清铁蛋白值升至(230±146) μg/L,转铁蛋白降至(1.89±0.33)g/L.血清P1 NP升至(61±32) ng/L,ALP、β-CTX均在正常范围内.股骨颈和腰椎骨密度T值分别为-2.0±1.1和-2.1±1.2(正常范围-1.0～1.0).将患者按照其血清铁蛋白情况分为铁蛋白正常组(血清铁蛋白≤150 μg/L,25例)和铁蛋白升高组(血清铁蛋白＞ 150μg/L,51例).铁蛋白升高组较铁蛋白正常组的股骨颈和腰椎骨密度降低(t=3.13、2.89,P＜0.01),P1 NP和β-CTX升高(t=-2.38、-3.59,P＜0.05).校正混杂因素后,铁蛋白值与股骨颈和腰椎骨密度T值呈负相关(r=-0.335、-0.295,P＜0.05),与P1NP和β-CTX值呈正相关(r=0.467、0.414,P＜0.05),与ALP无显著相关性(r=0.188,P＞0.05);转铁蛋白值与股骨颈和腰椎骨密度T值呈正相关(r =0.444、0.262,P＜0.05),与ALP、P1NP、β-CTX值呈负相关(r=-0.326、-0.285、-0.278,P＜0.05).结论 绝经后髋部脆性骨折患者存在铁过载现象,铁过载与骨转换活跃导致骨量丢失相关,体内铁过载可能是一个独立影响绝经后骨代谢异常的因素.     

Nursing care of fragility fracture patients

The challenge of caring for patients with fragility fractures is particularly acute for nursing teams who are in short supply and work with patients following fracture on a 24 h basis, coordinating as well as providing complex care. This paper considers the role of nurses within the orthogeriatric team and highlights the value of effective nursing care in patient outcomes. It explores the nature of nursing for patients with fragility fracture with a focus on the provision of safe and effective care and the coordination of care across the interdisciplinary team. It also highlights the need for specific skills in orthopaedic and geriatric nursing as well as specialist education.     

皮质厚度在骨质疏松性髋部骨折中的应用研究

骨质疏松性髋部骨折作为老年骨质疏松症的严重并发症,是临床医生重点关注的问题。临床中多通过骨密度来评价脆性骨折的发生风险。而通过常规影像学检查获得的皮质厚度,在预测髋部骨折风险方面具有重要的辅助作用,特别是结合骨密度、股骨近端几何结构以及多种生化指标时,可明显提高骨折风险评估的准确率。而对于骨折的治疗,皮质厚度在术式、内固定选择以及术中强化内固定稳定性等方面的作用得到了广泛认识。患者术后恢复情况及治疗的效果评价同样可以通过皮质厚度来评估。本文对皮质厚度的研究和临床应用状况进行综述。     

河北医科大学第三医院2008-2012年成人髋部骨折合并骨折患者临床特征

目的 调查成人髋部骨折合并骨折患者的临床特征.方法 回顾性分析2008年1月至2012年12月河北医科大学第三医院诊治的成人髋部骨折患者的临床资料,统计合并骨折患者的构成比并分析性别、年龄、合并骨折部位等临床特征.结果 髋部骨折共3 310例,存在合并骨折328例,合并骨折患者构成比9.91％;其中男性13.93％,女性6.40％;年龄上呈单峰分布,以30～＜40岁患者最多(26.88％).合并骨折患者以70～＜80岁人数最多(56例),男性30～ ＜40岁、40～＜50岁最多(均41例),女性≥80岁最多(32例).合并骨折536个部位,存在合并骨折的患者人均合并1.63个部位骨折,其中男性1.73个/人、女性1.45个/人.年龄上以16 ～ ＜20岁人均合并骨折数最高(2.22个部位/人).中青年、男性患者最常合并骨折的部位为股骨中段、胫腓骨-踝、足.老年、女性患者最常合并骨折的部位为胸腰椎、尺桡骨远端.结论 中青年、男性患者最易合并其他部位骨折.中青年、男性合并的骨折部位以下肢骨折多见,老年、女性合并的骨折部位以胸腰椎、尺桡骨远端多见.     

Individuals who sustain nonosteoporotic fractures continue to also sustain fragility fractures

Summary This retrospective case control study was done in order to investigate whether patients who sustain a nonosteoporotic fracture early in life also continue to sustain fragility fractures later in life. All patients who had been treated at the Department of Orthopedics in Malmo with a tibial shaft fracture from 1949 to 1963 (n = 767) or an ankle fracture from 1961 to 1965 (n = 786) were included in this study. At the time of follow-up in 1992, 231 of the patients who sustained a tibial shaft fracture and 260 of the patients who sustained an ankle fracture were still living in the city of Malmö. Objective registration was done of all subsequent fractures that these former patients had sustained. Comparison was done with corresponding data from double numbers of age- and sex-matched controls who at that time (1950s and 1960s) had no such fractures. At the time of the fracture as well as today, the controls were living in the area of Malmö. Individuals with earlier tibial or ankle fractures had an increased incidence of fractures generally classified as fragility fractures. There was no difference in this respect between men and women, nor whether the initial fracture had been diaphyseal or metaphyseal. We conclude that sustenance of fractures early in life may serve as a predictor for fragility fractures later in life.     

Quantitative ultrasound and dual-energy X-ray absorptiometry in the prediction of fragility fracture in men

Fragility fractures in men represent a major health problem, and this prompts a necessity for reliable tools for the identification of men at risk of fracture. In order to assess the ability of dual-energy X-ray absorptiometry (DXA) and quantitative ultrasound (QUS) in the prediction of fracture risk in men and whether their combination might be useful in a clinical setting, we studied 401 men (age range 45–82 years, mean 60.3±12.5), of whom 133 had osteoporotic fractures and 268 did not. In all subjects we measured bone mineral density at the lumbar spine (BMD-LS) and at the femur, calculating thereafter the standard femoral subregions: neck (BMD-FN), total hip (BMD-T), trochanter (BMD-TR), intertrochanter (BMD-ITR), and Wards triangle (BMD-W), by DXA. We also performed ultrasound parameters at the calcaneus: speed of sound (SOS), broadband ultrasound attenuation (BUA) and Stiffness, by Achilles plus, and at the phalanxes: amplitude dependent speed of sound (AD-SoS) and the parameters of the graphic trace: bone transmission time (BTT), fast wave amplitude (FWA), signal dynamic (SDy) and ultrasound bone profile index (UBPI), by Bone Profiler. All DXA and QUS parameters, apart from FWA, were significantly (P<0.001) lower in patients with a history of fracture. BMD at the proximal femur showed the best ability in discriminating men with or without fractures. QUS at the heel showed discriminatory ability significantly better than QUS at the fingers. By logistic regression analysis, adjusted for age and BMI, BMD-T showed the best association with fragility fracture [odds ratio (OR)=3.43, 95% confidence interval (CI)=2.47–4.77]. Among QUS parameters, the highest value of the OR was shown by stiffness (OR=3.18, CI=2.27–4.48). FWA and SDy were not associated with fragility fractures in men. If DXA and QUS were combined, the prediction of the OR of fragility fracture events in men increases; in fact Stiffness was able to increase the OR when added to BMD-LS (OR=5.44, CI=3.16–10.13) and BMD-T (OR=6.08, CI=2.63–14.27). SOS and BUA showed a similar pattern. AD-SoS improved the prediction of fracture only when combined with BMD-LS (OR=4.36, CI=1.99–9.57). If BMD-LS and BMD-FN or BMD-T were combined, the value of the OR increases (OR=4.59, CI=2.27–9.25 and OR=4.68, CI=2.24–9.76), respectively. Our study supports the effectiveness of QUS in the identification of osteoporotic fractures in men. QUS seems to play an independent and complementary role, with respect to DXA, in order to enhance the power for predicting osteoporotic fractures in men.     

Fixation of ankle fragility fractures by tibiotalocalcaneal nail

Introduction Fragility fractures of the ankle are difficult to treat by conventional fixation due to poor bone quality, compromised soft tissues, and inherent instability. Conservative management of these patients also has its problems. Materials and methods We retrospectively reviewed 13 patients who underwent intramedullary nailing through the tibiotalocalcaneal joints in an attempt to achieve the dual aims of fracture control and early mobilisation. The Olerud and Molander scale was used as outcome measures. Results There were 12 females and 1 male with a mean age of 78.9 (range 64–93). Half of the patients were discharged from hospital within the first 2 weeks after the operation. All achieved a comparable function to their pre-operative state. The mean follow-up period was 11 months (range of 2–62 months). Six are now deceased from unrelated causes. The mean Olerud and Molander score was 50 (range 30–65). All the radiographs showed evidence of fracture union with no changes in the overall alignment of the joint. Conclusion Given the low survivorship of this frail group of patients the main objectives are achieving early mobilisation whilst maintaining good fracture position. In our experience, tibiotalocalcaneal nailing is a very useful and successful way of treating fragility fractures of the ankle because it has a low risk of complications and restores function with impressive patient satisfaction. The potential benefits of this technique, we believe, outweigh the disability ensued from subtalar joint fusion.     

The management of complex fractures of the proximal tibia with minimal intra-articular impaction in fragility patients using intramedullary nailing and compression bolts

Background

Intra-articular fractures of the proximal tibia that extend to the meta-diaphyseal part of the bone represent a severe injury, especially if they occur in osteoporotic patients. Current treatment modalities include either internal fixation with traditional or modern plating techniques or external fixation with circular frames or hybrid systems. However, problems and complications related with these techniques are increasing with age and future reconstructive operations, such as arthroplasty, may be jeopardised.

Method

This is a prospective pilot study about a novel type of osteosynthesis for complex intra-articular proximal tibial fractures without significant articular impaction in patients over 60 years of age. Within a period of 54 months, eight patients underwent fixation of such fractures with condylar compression bolts and intramedullary nailing.

Results

The follow-up period was from 12 to 50 months (mean 24.7 months). There were no neurovascular complications, wound infections, delayed unions or nonunions. All patients had their fractures healed without secondary displacement or malalignment. At the final follow-up, all patients had full extension of the knee joint whilst the flexion ranged from 125 to 140°. The mean new Oxford Knee score was calculated to be 43.75 points.

Conclusions

The management of selected osteoporotic complex intra-articular fractures of the proximal tibia with compression bolts and intramedullary nailing offers specific advantages and, in the present pilot study, provided promising results. These results should be validated and confirmed with larger case series and comparison studies in the future.     

髋部股骨转子间骨折的分型与治疗策略

正2000年全球统计约160万例患者发生髋部骨折,其中20%的骨折患者年龄50岁~([1])。预计到2025年,每年会有约260万患者发生髋部骨折,1年内的死亡率可高达30%~([2])。髋部骨折是全球10大致残疾病之一~([3-4])。由于几乎大部分的髋部骨折患者都需要选择手术治疗,髋部骨折的治疗一