Subcorneal pustular dermatosis

Subcorneal pustular dermatosis (SCPD) (Sneddon-Wilkinson disease) is a rare disorder. We present a case with classical clinical manifestations, and discuss the management of this disorder.     

Subcorneal pustular dermatosis]

Subcorneal dermatosis is a chronic relapsing pustular eruption which has been recognised for 20 years. The diagnosis can be made only by combining the clinical features of a recurrent eruption mainly on the trunk which spares the mucosae and has the histological appearance of a subcorneal bullae filled with polymorphonuclear leucocytes situated on the surface of normal epidermis. No immunofluorescence either direct or indirect similar to that seen in pemphigus, pemphigoid or dermatitis herpetiformis has been reported. No jejunal abnormality has been found in any case but some, though not all, patients respond to treatment with Dapsone (DDS; diaminodiphenylsulfone). The condition can be distinguished from other cases of subcorneal pustular eruptions only by combining the clinical and histological features. The etiology remains unknown.     

Subcorneal pustular dermatosis involving the face

We report an interesting case of subcorneal pustular dermatosis in a young woman with prominent involvement of the face. Facial involvement in this condition has not previously been reported.     

Subcorneal pustular dermatosis with polyarthritis

A 19-year-old man experienced the acute onset of subcorneal pustular dermatosis (SPD), fever, and a symmetrical polyarthritis. The association of SPD with acute polyarthritis is rare.     

Subcorneal pustular dermatosis and IgA myeloma

The authors describe a new case of subcorneal pustular dermatosis associated with IgA myeloma. The significance of this association is unknown, but it seems to be more than a coincidence. The case described is particular, because the interval between skin eruption and first symptoms of myeloma is very long (27 years), and palms and soles are involved.     

Subcorneal pustular dermatosis with seronegative polyarthritis

A 55-year-old woman presented with acute onset of subcorneal pustular dermatosis and a seronegative polyarthritis. There have been a few reports of subcorneal pustular dermatosis associated with arthritis.     

Subcorneal pustular dermatosis and crippling arthritis.

A 25-year-old woman has suffered with subcorneal pustular dermatosis and a rheumatoid-like arthritis for the past 11 years. Both her skin lesions and arthralgia have abated with institution of dapsone administration and have worsened with interruption or reduction of the dose. The coexistence of arthritis and subcorneal pustular dermatosis and the response of both to therapy suggest a probable association.