Neuronavigator-guided percutaneous radiofrequency thermocoagulation in the treatment of intractable trigeminal neuralgia

Background  Percutaneous radiofrequency thermocoagulation of the trigeminal ganglion (PRTTG) is regarded as the first choice for most patients with trigeminal neuralgia (TN) because of its safety and feasibility. However, neuronavigator-guided PRTTG has been seldom reported. The purpose of this study was to assess the safety and efficacy of neuronavigator-guided PRTTG for the treatment of intractable TN.
Methods  Between January 2000 and December 2004, 54 patients with intractable TN were enrolled into this study and were randomly divided into two groups. The patients in navigation group (n=26) underwent PRTTG with frameless neuronavigation, and those in control group (n=28) received PRTTG without neuronavigation. Three months after the operation, the efficacy, side effects, and complications of the surgery were recorded. The patients in the control group were followed up for 10 to 54 months (mean, 34±5), and those in the navigation group were followed up for 13 to 58 months (mean, 36±7). Kaplan-Meier analyses of the pain-free survival curves were used for the censored survival data, and the log-rank test was used to compare survival curves of the two groups.
Results  The immediate complete pain-relief rate of the navigation group was 100%, whereas it was 95% in the control. The proportion of sustained pain-relief rates at 12, 24 and 36 months after the procedure were 85%, 77%, and 62% in the navigation group, and 54%, 40%, and 35% in the control. Recurrences in the control group were more common than that in the navigation group. Annual recurrence rate in the first and second years were 15% and 23% in the navigation group, and 46%, 60% in the control group. No side-effect and complication was noted in the navigation group except minimal facial hypesthesia.
Conclusion  Neuronavigator-guided PRTTG is a safe and promising method for treatment of intractable TN with better short- and long-term outcomes and lower complication rate than PRTTG without neuronavigation.

     

射频热凝术治疗原发性三叉神经痛的临床研究

目的评价射频热凝术治疗原发性三叉神经痛的近、中期临床疗效及安全性。方法将63例原发性三叉神经痛患者随机分成:治疗组(31例)及对照组(32例),治疗组采用数字减影脑血管造影(DSA)机引导下射频热凝术治疗,对照组采用常规药物治疗或封闭方法治疗,分别观察2组的临床疗效,并对治疗组中期疗效进行随访。结果治疗组总有效率96.8%,优良率61.3%,无严重不良反应发生,明显优于对照组总有效率65.6%、优良率28.1%,差异有统计学意义(χ2=9.91、7.01,P0.01),治疗组术后中期的临床疗效随访,总有效率仍为96.8%,2例复发,占6.5%,经第2次射频热凝术治疗完全止痛。结论 DSA机引导射频热凝治疗原发性三叉神经痛穿刺成功率高,近、中期临床疗效确切,安全性高。     

Selective percutaneous radiofrequency thermocoagulation in the treatment of trigeminal neuralgia:report on 1860 cases

Trigeminal neuralgia (TN) is defined by the International Association for the Study of Pain as "a sudden, usually unilateral, severe, brief, stabbing, recurrent pain in the distribution of one or more branches of the fifth cranial nerve".1 The incidence rate is about three to five cases per year per 100000 persons and increases with age.2 In our hospital, percutaneous radiofrequency therapy was performed on 1860 patients with TN from June 1986 to April 2003, and percutaneous trigeminal ganglion radiofrequency therapy on 579 cases. Among this group of patients, X-ray, 3-D CT, and navigational localization of the oval foramen were performed on 42 cases. The indications, techniques, and results are reported here.     

半月神经节射频热凝术治疗7例难治性三叉神经痛

[背景]观察半月神经节射频热凝术对难治性三叉神经痛的治疗效果.[病例报告]采用半月神经节射频热凝术治疗难治性三叉神经痛7例,疗效显著,未发生严重并发症,随访见2例患者在1年内复发.[讨论]射频温控热凝术是治疗三叉神经痛的简单、安全且有效的方法,应熟练掌握操作技术,尽可能减少并发症的发生,降低复发率.     

经周围支射频温控热凝治疗三叉神经第一支痛的研究

目的探讨经周围支射频温控热凝术治疗三叉神经第一支痛的疗效。方法将63例原发性三叉神经第一支痛的患者随机分为3组,第1组（20例患者）应用经三叉神经节射频温控热凝术,第2组（30例患者）应用经眶上孔射频温控热凝术,第3组（13例患者）应用眶上神经撕脱术,然后应用2χ检验评价其即刻疼痛缓解率、并发症及复发率。结果第1组、第2组及第3组的即刻疼痛缓解率为95%、93%及92%,3组间无统计学差异（P=0.948〉0.05）。第1组、第2组及第3组的3年疼痛复发率各为25%、27%及61%,5年疼痛复发率各为35%、40%及69%。结论经眶上孔射频温控热凝术是一种治疗三叉神经第一支痛的有效方法。     

微血管减压术与射频热凝术治疗原发性三叉神经痛效果的比较

目的：比较微血管减压术与射频热凝术治疗原发性三叉神经痛的效果。方法：选取年龄、症状及基础病变基本相同的原发性三叉神经（第Ⅲ支）疼痛患者100例,根据患者意愿将其随机分为两组,各50例,分别采用微血管减压术与射频热凝术进行治疗,观察比较这两种方法的治疗效果。结果：微血管减压术的效果优于射频热凝术。结论：对于原发性三叉神经痛,在患者接受的前提下,应尽量采用微血管减压术治疗。     

射频温控热凝术治疗三叉神经痛的临床应用

目的：阐述射频温控热凝术治疗三叉神经痛的临床疗效及适应证。方法：经皮穿刺达卵圆孔内三叉神经根处,连接射频温控热凝仪及相配套电极作控温热凝至80－85℃,损害三叉神经相关感觉支。结果：总有效率98％,无效为1.40％,复发率为3％。结论：射频温控热凝术治疗三叉神经痛安全,适应证广,效果显著,特别对伴有心血管疾病的三叉神经痛患者,该方法安全可靠。     

CT引导下三叉神经半月节射频热凝治疗原发性三叉神经痛临床观察

目的 评价CT引导下三叉神经半月节射频热凝治疗原发性三又神经痛的临床效果.方法 选取原发性三叉神经痛患者30例,经CT定位引导下向患侧卵园孔穿刺至三叉神经半月节,给予阻抗、神经电生理测试后,先行42℃、60 s的自动脉冲射频治疗,再给予80℃、90s,3个周期的射频热凝,术中监测血压、心率、脉搏血氧饱和度.结果 30例原发性三叉神经痛患者经本法治疗后,27例患者疼痛立即消失,随访2～15个月无复发;1例术后1年疼痛复发,1例术后疼痛减轻,另1例完全无效,均无重大并发症发生.结论 CT引导下三叉神经半月节射频热凝是治疗顽固性三叉神经痛的有效手段     

射频温控热凝术治疗原发性三叉神经痛80例临床分析

目的:观察射频温控热凝术治疗原发性三叉神经痛的治疗效果。方法:80例三叉神经痛患者采用CT定位,在确保穿刺针准确到位的前提下,进行三叉神经节(半月神经节)射频温控凝术治疗。结果:所有患者均穿刺成功,疼痛即刻消失率为100%,味觉减退1例,发生率为1.3%。结论:射频温控热凝术治疗原发性三叉神经痛是一种很好的治疗方法。     

CT定位下射频温控热凝术治疗三叉神经痛疗效分析

目的：探讨CT定位下射频温控热凝治疗原发性三叉神经痛的方法及临床效果。方法：分析用CT引导下经皮穿刺卵圆孔半月神经节,射频温控热凝术（温度设定65～80℃,时间设定为30～60秒治疗三叉神经痛患者32例,对临床资料进行疗效评定。结果：所有操作过程均十分顺利无1例失败。所有患者的疼痛获得缓解,除1例因穿刺起始过程出现血肿外,均无严重的并发症出现。尤其通过C T定位及分层计算,对患者均无第1支的损伤。结论：CT引导下经皮穿刺卵圆孔疗法对三叉神经痛具有定位准确,无痛苦,操作简单、安全,并发症少的优点,具有临床推广应用价值。     

经卵圆孔与经翼腭窝射频温控热凝治疗原发性三叉神经痛临床分析

目的观察经卵圆孔与经翼腭窝射频热凝治疗原发性三叉神经痛（上颌神经）的疗效及不良反应。方法 30例原发性三叉神经痛（上颌神经）患者随机分为A组和B组,每组15例,A组运用经卵圆孔射频热凝治疗原发性三叉神经痛（上颌神经）,B组采用经翼腭窝射频热凝治疗原发性三叉神经痛（上颌神经）,观察治疗前后的视觉模拟评分（VAS）、患者满意度评分（PSS）、不良反应以及6个月内的预后情况。结果两组治疗后组内VSA均明显降低（P〈0.05）,但两组差异无统计学意义（P〉0.05）;两组治疗后组内PSS均明显增高（P〈0.05）,两组差异亦无统计学意义（P〉0.05）;随访6个月,两组疗效相似,但A组的不良反应明显高于B组。结论相比经卵圆孔射频热凝治疗原发性三叉神经痛而言,经翼腭窝射频热凝治疗原发性三叉神经痛是一种更安全及不良反应少的方法。     

DSA透视下射频热凝治疗原发性三叉神经痛

目的 探讨DSA透视下射频热凝治疗原发性三叉神经痛的疗效.方法 28例患者均在DSA透视下,采用前入路穿刺方法对三叉神经痛病变支行射频热凝治疗,观察临床症状缓解情况.结果 28例患者术后有效率达到96.4%(27/28),术后随访6～36个月,1例无效,1例复发,复发率为3.6%.除出现恶心、呕吐、角膜炎、面部麻木及咀...     

CT引导下半月神经节射频热凝治疗三叉神经痛

目的观察CT引导下半月神经节射频热凝术治疗原发性三叉神经痛的临床疗效。方法 40例三叉神经痛患者在CT引导下,经前入路法穿刺三叉神经半月节后行射频热凝毁损治疗,温度控制在65-80℃持续时间3min,共3-4次。结果 40例患者中,32例疗效Ⅰ级,5例疗效Ⅱ,2例疗效Ⅲ级;一次性治疗显效率92.5%,总有效率97.5%。1例为Ⅳ级无效。结论 CT引导行三叉神经半月神经节射频热凝术是一种安全、可靠、有效的微创治疗技术,具有临床推广应用价值。     

不同温度对脉冲射频治疗三叉神经痛疗效的影响

[摘要] 目的 观察不同温度对脉冲射频治疗三叉神经痛疗效的影响。方法 37例接受脉冲射频治疗的三叉神经痛患者随机分为三组（38℃、42℃、45℃）,观察不同时间点的VAS评分及卡马西平服用量,计算有效率。结果 治疗后各组均有较好的镇痛效应,治疗后2周有效率分别是54.5%（38℃组）、66.6% (42℃组)、82.4% (45℃组),45℃组的有效率高于38℃组和42℃组;没有严重并发症。结论 38℃、42℃、45℃脉冲射频均有效,但45℃组的有效率高于38℃组和42℃组。     

功能定位结合CT定位射频热凝术治疗原发性三叉神经痛的中远期疗效

目的评估功能定位结合CT定位射频热凝术治疗原发性三叉神经痛的中远期疗效。方法选择60例原发性三叉神经痛患者,行功能定位结合CT定位射频热凝术,分别于术后1、6、12、18个月随访治疗效果、并发症和复发情况。结果疼痛缓解率术后1个月为96.67%(58/60),18个月为98.33%(59/60)。术后1个月55.00%(33/60)患者存在各种并发症,18个月时15.00%(9/60)患者仍有并发症,并发症主要为面部感觉减退。随访期间共复发4例(6.67%)。结论功能定位结合CT定位射频热凝术可提高卵圆孔和疼痛神经支的定位准确性,从而缩短手术时间,提高患者手术耐受性,改善治疗效果。     

显微神经血管减压术治疗原发性三叉神经痛

目的:探讨神经血管减压术对三叉神经痛的治疗效果.方法:31例患者施行神经血管减压术,采用局麻耳后切口乙状窦后入路行神经血管减压治疗,并进行随访.结果:术后切口一期愈合,疼痛完全消失,近期有效率达100%.经术后6～12个月随访,无1例复发,面部痛觉、温觉正常.结论:神经血管减压术治疗三叉神经痛是一种安全、有效的方法.     

Efficacy of bupivacaine injection after pulsed radiofrequency ablation in the management of trigeminal facial pain: A prospective,randomized, and double-blind study

Objectives:To assess the effect of bupivacaine application following pulsed radiofrequency (PRF) ablation on trigeminal facial pain.Methods:A total of 73 patients with trigeminal facial pain refractory to conservative therapy were randomized into 2 groups. Group I subjects underwent PRF ablation procedure, followed by the injection of 1 ml of bupivacaine. Whereas, Group II underwent the same procedure followed by the injection of 1 ml of normal saline. Pain relief duration, the time of onset of pain relief, and analgesic effect evaluated by numerical pain rating scale were considered as outcomes.Results:Thirty-nine patients in Group I and 34 in Group II. The duration of pain relief in the 2 groups was comparable (5 months in Group I vs. 6 months in Group II, p=0.53). The onset of pain relief in the patients of Group I was shorter than Group II (0 days vs. 4.5 days, p<0.001). The binary logistic regression analysis revealed that the application of bupivacaine alone had a significant effect on the reduction of the intake of medications (p<0.05).Conclusion:In situations involving patients who require rapid pain relief, bupivacaine injection following PRF ablation can be employed to provide immediate relief without subjecting the patients to the risks associated with major complications.     

三叉神经痛颅外射频热凝舒适化治疗的流程与监护管理

目的 通过比较颅外非半月节射频热凝治疗三叉神经痛时局部麻醉与全凭静脉麻醉镇静镇痛效果,以遴选最佳舒适化医疗流程与监护管理措施.方法 将2018年1-10月从本课题组收治并确诊的150例三叉神经痛患者用随机数字表法随机分成甲、乙、丙3组,每组各50例:甲组除穿刺点局部麻醉外不再作任何麻醉干预;乙、丙2组先静脉注射右美托咪...     

影像引导下半月神经节射频毁损术治疗原发性三叉神经痛的疗效观察

目的 观察数字减影血管造影术（DSA）引导下半月神经节射频热凝毁损术治疗原发性三叉神经痛的疗效.方法 原发性三叉神经痛住院患者54例,局麻下DSA引导行半月神经节射频毁损术.随访观察2年,记录VAS评分、有效率、复发率及不良反应.结果 所有患者均1次手术成功,术后3d时治疗有效率100％,术后个6月、1年、2年随访治疗有效率,分别为98.1％ （53/54例）、96.2％（51/53例）、94.1％（48/51例）,除面部神经分布区麻木外,未见严重并发症.结论 DSA引导下半月神经节射频毁损术对治疗原发性三叉神经痛是一种安全、有效的治疗方法.     

三叉神经痛手术治疗——附174例报告

目的：为提高三叉神经痛手术治疗效果，减少术后复发率，方法：对１７４例原发性三叉神经痛采用口腔内手术径路，行三叉神经高位切断术＋神经周围分支切除术，结果：控痛率１００％，术后复发４例（２．３％）无严重并发症，结论：三叉神经高位切断术口内之径路，方法新，创伤小，恢复快，效果好，神经切断，高位比低位好，多支比单支好，切断＋部分切除比单纯切断好。