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目的 观察白介素-6(IL-6)在成年雌性大鼠、卵巢切除大鼠、卵巢切除后雌二醇替代大鼠心内神经节的表达及变化.方法 免疫组织化学方法.结果 各组大鼠心内神经节均存在IL-6阳性神经元,但卵巢切除组大鼠心内神经节IL-6阳性神经元明显增多,表达明显增强.结论 心房后壁心内神经节存在IL-6,并且受雌激素影响,提示雌二醇可能影响心内神经节IL-6的表达. 相似文献
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目的:观察神经生长因子(NGF)在卵巢切除大鼠心房后壁心内神经节的表达及雌激素的调节作用.方法:实验动物分正常组、卵巢切除组、卵巢切除后雌二醇替代组,各组动物审温下饲养3周后,进行 NGF 免疫组织化学显色.结果:各组大鼠心内神经节均存在 NGF 阳性神经元,该类神经细胞胞体多数呈圆形或椭圆形,大、中、小型细胞均有发现.正常组和卵巢切除后雌二醇替代组 NGF 免疫阳性神经无约占全部神经节细胞总数的比例分别为 61%和64%,但卵巢切除组大鼠心内神经节 NGF 阳性神经元的数量明显减少,表达明显降低,NGF 免疫阳性细胞约占全部神经节细胞总数的比例为28%.结论:心内神经节细胞内含 NGF;雌激素可能影响心内神经节细胞的 NGF 表达. 相似文献
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用免疫细胞化学双重标记技术研究雌激素受体(estrogen receptor,ER)和神经生长因子(NGF)的表达,证实它们在心内神经节共存的可能性。结果显示,在心内神经节可以观察到3种细胞:(1)ER单标细胞,胞核呈棕褐色;(2)NGF单标细胞,胞浆呈红色;(3)ER/NGF双标细胞,胞核棕褐色,胞浆为红色。双标细胞占全部阳性标记细胞的30%~40%。这些结果提示ER和NGF可共存于同一大鼠心内神经节细胞,提示雌激素和NGF在维持心内神经节的结构和功能方面存在复杂的交互作用。 相似文献
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目的:研究雌激素受体(ER)和免疫因子白介素6(IL-6)在心内神经节的表达,并证实它们共存的可能性。方法:免疫细胞化学双重标记技术。结果:切片上观察到3种细胞:①ER单标细胞,胞核呈棕褐色;②IL-6单标细胞,胞浆呈红色;③ER/IL-6双标细胞,胞核棕褐色,胞浆为红色。双标细胞占全部阳性标记细胞的20%~30%。结论:ER和IL-6可共存于同一大鼠心内神经节细胞,从而在细胞水平为神经免疫内分泌网络在心脏的存在提供了直接的形态学证据。 相似文献
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雌性大鼠心内神经节中雌激素受体及其mRNA的表达 总被引:6,自引:0,他引:6
目的 在雌激素受体蛋白及ERmRNA水平提供雌激素对心内神经节中神经元作用的形态学依据。方法 采用免疫组织化学及原位杂交技术。结果 在心内神经节部分神经元中,雌激素受体免疫反应及其mRNA原位杂交反应阳性。雌激素受体免疫反应沉淀物呈棕黄色,定位于胞核,雌激素受体mRNA免疫反应沉淀物呈棕黄色,定位于胞浆。结论 大鼠心内神经节中,部分神经元能合成雌激素受体蛋白,说明ER阳性神经元可以为雌激素提供结合位点,因此,这些神经元可能受到雌激素的影响。 相似文献
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Temporal pattern of nerve growth factor receptor expression in developing cochlear and vestibular ganglia in quail and mouse 总被引:3,自引:0,他引:3
Summary We have previously demonstrated the presence of specific receptors for nerve growth factor (NGF) in cochleovestibular ganglia of 72 h (stage 19–20) quail embryos, with a greater density of NGF receptors in the cochlear portion of the ganglion. The present study was conducted to determine the temporal pattern of NGF receptor expression in cochlear and vestibular ganglia throughout development, and was conducted in two species, quail and mouse. As in the quail, specific binding of125I-NGF was detected in cochleovestibular ganglia of mouse embryos from an embryonic age equivalent to 72 h quail embryos (embryonic day 11, E11), with a similar concentration of125I-NGF binding in the cochlear portion. Quantitative studies revealed that125I-NGF binding continued to increase, in both cochlear and vestibular ganglia, for several days of development, and then began to decrease to minimal levels. Maximal levels were achieved at E7 in the quail, and E14 to E16 in the mouse, while minimal levels were reached by E13 in the quail, and E18 in the mouse. The level of125I-NGF binding in cochlear ganglia was two to three times higher than in vestibular ganglia; a finding corroborated by radioautographic studies. In both quail and mouse, NGF receptors were more heavily concentrated in the ventromedial portion of the cochlear ganglion, adjacent to the cochlear duct; an area containing both support cells and peripheral neuronal processes. In the vestibular ganglion,125I-NGF binding was more homogeneous, although small areas containing high densities of silver grains were observed. The presence of NGF receptors in cochlear and vestibular ganglia suggests that these ganglia may be responsive to and/or dependent upon NGF during their development. 相似文献
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目的:探讨糖尿病(DM)大鼠神经系统中 NGF 的表达与阴茎勃起功能障碍(ED)的相关性。方法:建立糖尿病大鼠模型,分别于造模1~4月注射阿扑吗啡(APO)作阴茎勃起功能试验,然后取大鼠的大脑、胸腰段交感干、阴茎和前列腺,用免疫组织化学法和荧光免疫组化法显示 NGF 阳性神经元或神经纤维,并作图像分析。结果:糖尿病1个月时尚无 ED 出现,但各处的 NGF 阳性神经元及纤维开始下降,与对照组相比有显著性差异,随着病程延长差异更明显;2个月时 DM 大鼠阴茎勃起次数与对照组已有显著差异3个月和4个月时差异非常显著。结论:糖尿病性早期中枢和周围神经系统内 NGF 减少,NGF 的减少与糖尿病性 ED 的发生发展密切相关。 相似文献