46例桡骨远端粉碎骨折手术治疗

2001年1月-2004年12月，笔者对桡骨远端粉碎骨折闭合复位不满意者，采用切开复位“T”型纯钛金属板螺钉固定，切开复位外固定架固定及切开复位克氏针内固定加外固定架固定等方法，对46例桡骨远端粉碎骨折进行手术治疗，取得满意疗效，现报告如下。     

T形接骨板结合植骨治疗桡骨远端不稳定骨折

目的 探讨桡骨远端不稳定骨折采用手术切开复位T形接骨板内固定结合植骨治疗的疗效.方法 2006年2月～2010年1月,采用掌侧或掌背联合入路切开复位T形接骨板内固定结合植骨治疗桡骨远端不稳定骨折31例.骨折按AO分型,B2 3例、B3 5例、C1 11例、C2 9例、C3 3例.结果 所有患者均获得10～22个月随诊,按改良McBride评分,优21例、良6例、可3例、差1例,无并发症发生.结论 切开复位T形接骨板内固定是治疗桡骨远端不稳定骨折的有效方法,结合术中植骨能有效防止关节面塌陷和促进骨折愈合.     

桡骨远端骨折319例分析

目的探讨桡骨远端骨折的分型及治疗。方法总结我院1996年-2006年319例桡骨远端骨折病例的临床治疗情况。结果Colles骨折2例手术外,其余均为手法复位外固定。Smith骨折均为手法复位外固定。Barton骨折13例手法复位外固定,7例在透视下复位克氏钉固定,12例切开复位斜T形钢板内固定。Penrada骨折均为切开复位钢板内固定治疗。结论Colles骨折和Smith骨折多采用手法复位外固定,Barton骨折和Penrada骨折多采用切开复位钢板内固定。     

桡骨远端骨折34例手术治疗分析

采用切开复位斜“T”形钛板内固定治疗34例(38侧)桡骨远端复杂关节内骨折,其中桡掌侧入路29侧,桡背侧入路9侧。术中结合螺钉、克氏针固定复位骨折,植骨充填骨缺损以恢复关节面的完整性,有效地恢复桡骨远端的解剖结构。结果术后共31例(32侧)获随访,采用Dienst功能评定标准结果为优26例(27侧),良4例(4侧),可1例(1侧)。结果表明:对于复杂的桡骨远端关节内骨折,切开复位“T”形钛板内固定是有效的治疗方法。     

桡骨远端粉碎性骨折的手术治疗

2000年1月-2009年12月,我们根据桡骨远端的解剖学特点,按Frykma骨折分类及患者骨质疏松等因素,采用切开复位"T"形钛合金金属板螺钉内固定.切开复位外固定架固定及切开复位克氏针内固定加外固定架固定等方法,对96例桡骨远端粉碎性骨折进行手术治疗,取得满意的疗效,现报告如下:     

桡骨远端不稳定性骨折63例治疗分析

目的：探讨桡骨远端不稳定性骨折的治疗方法和疗效。方法：对63例不稳定性桡骨远端骨折采用石膏固定,切开复位螺钉或T形钢板固定及克氏针结合外固定架固定治疗。结果：本组患者平均随访4～10个月,优50例,良9例,可2例,差2例。优良率93．5％。结论：对桡骨远端不稳定性骨折应根据不同类型,采用不同的治疗方法。     

三种固定方式治疗第5掌骨颈骨折的临床效果比较

目的:比较分析三种固定方式(切开复位接骨板螺钉固定、切开复位交叉克氏针固定、闭合复位克氏针横行固定)治疗第5掌骨颈骨折(5-MNF)的临床效果.方法:选取117例5-MNF患者为研究对象,依据随机数字表法,将研究对象分为三组,每组39例,分别采用切开复位接骨板螺钉固定、切开复位交叉克氏针固定及闭合复位克氏针横行固定治疗...     

切开复位内固定治疗桡骨远端关节内骨折36例体会

目的 评价切开复位钢板内固定治疗桡骨远端关节内骨折的临床治疗效果.方法 笔者所在医院36例桡骨远端骨折波及关节面,按AO分类B1型4例,B2型3例,B3型3例,C1型11例,C2型7例,C3型8例.采用Henry氏切口显露,T型接骨板固定,配合克氏针固定.结果 本组36例患者随访时间为10～24个月,平均13 5个月.术后无切口感染及骨不愈发生.骨折愈合时间为4～8周,平均为6周.临床评价:优18例,良13例,可5例.优良率86 1%.结论 Henry入路手术治疗桡骨远端关节内骨折的有效方法.     

桡骨远端骨折63例手术治疗疗效分析

目的：探讨桡骨远端骨折手术治疗的效果。方法：分别采用切开复位“T”形金属板钉内固定或切开复位外固定架固定、切开复位克氏针内固定加外固定架固定的方法治疗63例桡骨远端粉碎性骨折,观察治疗后效果。结果：随访6～12个月以上,骨折愈合时间4～8周,平均4．6周,未发生针道感染、骨不连,伤口均一期愈合。Colles骨折复位后的功能评价：优35例,良22例,可5例,差1例,优良率为90．5％,对手术后腕关节功能满意者54例（85．7％）。结论：切开复位“T”形金属板钉内固定或切开复位外固定架固定治疗桡骨远端粉碎性骨折结构复位和功能恢复比较满意,疗效较好,值得临床推广使用。     

手术治疗不稳定型桡骨远端骨折74例

目的观察不稳定型桡骨远端骨折的手术治疗方法。方法对74例不稳定型桡骨远端骨折采用外固定支架、C形臂X光透视下闭合复位经皮克氏针内固定及切开复位钢板螺钉内固定治疗。结果全部患者均随访1年以上,优良率：外固定支架组为95.3%;闭合性复位经皮克氏针内固定组为79.6%;切开复位钢板螺钉内固定组为84.2%。结论手术治疗不稳定型桡骨远端骨折具有良好的固定作用,能较好地防止骨折畸形愈合和保护腕关节功能。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.