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本文报导病毒性肝炎80例(CAH、AH、LC和CPH各20例)的甲襞微循环和血液流变学变化。血液流变学异常程度,依次为CAH、AH、LC和CPH,并与肝功能损害密切相关,甲襞微循环异常总积分则以CAH和LC最明显,而其管襻形态、血流流态、襻周状态各型之间亦相异。结合文献,讨论病毒性肝炎的血液流变学和微循环检查的临床重要性,两者有相辅相成的价值。 相似文献
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肝病患者血液流变学变化 总被引:2,自引:0,他引:2
<正> 有关肝病患者的血液流变学变化报告不多,其相关因素较复杂,我们对141例各型肝病患者检测其血液流变学、血清脂质及部分患者的红细胞形态,以探讨肝病时血液流变学改变的发生机理及临床意义。材料与方法一、材料:141例均为住院患者。男性120例,女性21例,年龄最小15岁,最大58岁,平均 相似文献
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目的:探讨病毒性肝炎患者血液流变学及部分血脂指标的异常变化。方法:189例病毒性肝炎患者分为急性肝炎组、轻度慢性肝炎组、中度慢性肝炎组、重度慢性肝炎组、肝硬化组、重症肝炎组。采用血液流变技术测定全血粘度(ηb)、血浆粘度(ηp)、红细胞压积(Hct)、血沉(ESR)、血沉方程K值(Kesr)、红细胞聚集指数(RE)、红细胞电泳指数(EE);采用罗氏MODULAR全自动生化分析仪测定甘油三脂(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)及低密度脂蛋白胆固醇(LDL-C),并与55例健康人群对照分析。结果:各肝病组ηb、ηp、RE、EE均高于对照组(P<0.01,肝硬化组和重症肝炎组ηp除外),Hct、Kesr低于对照组(P<0.01),ESR和Kesr在肝硬化组和重症肝炎组有显著性差异(P<0.05)。肝硬化组、重症肝炎组TG、TC、HDL-C、LDL-C水平与对照组比较均显著下降(P<0.01),ηb、ESR、Kesr、RE、TC、LDL-C与急性肝炎组和不同程度慢性肝炎组间比较均有显著性差异(p<0.05);重症肝炎组TC与肝硬化组比较有显著性差异(P<0.01);急性肝炎组与不同程度慢性肝炎组比较,Hct、RE、EE、TG、HDL-C、LDL-C具有显著性差异(P<0.01);重度慢性肝炎组ηb、RE、EE、TC、HDL-C、LDL-C与轻、中度慢性肝炎组间均有显著性差异(P<0.01)。结论:病毒性肝炎患者存在不同程度的血流变指标和血脂异常变化,分析其变化规律对临床诊断及治疗有重要意义。 相似文献
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40例高脂血症患者血液流变学和甲襞微循环观察 总被引:1,自引:0,他引:1
本文用FL系列血液流变学检测仪及F2-FLC甲襞微循环仪对40例高脂血症患者进行检测显示:高血脂症患者血液流变学和甲襞微循环指标与60例体检正常者进行对照,经统计学处理后,其中全血粘度、全血还原粘度、血浆粘度、纤维蛋白原及微循环流态积分、襻周积分有明显差异。说明高血脂症患者的甲襞微循环和血流变有较明显异常。提示心、脑血管疾病患者在治疗原发疾病的同时应注意治疗高脂血症和改善微循环障碍和血液流变性异常 相似文献
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我们对246名企业家的检查发现存在着明显的微循环功能异常和高粘滞血症现象。微循环功能障碍与体内丙二醛(MDA)蓄积相关联。提示:企业家的保健必须注意改善微循环功能,降低血液粘度等。 相似文献
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我们对246名企业家的检查发现存在着明显的微循环功能异常和高粘滞血症现象。微循环功能障碍与体内丙二醛(MDA)蓄积相关联。提示:企业家的保健必须注意改善微循环功能,降低血液粘度等。 相似文献
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慢性乙型肝炎患者血液流变学的研究 总被引:3,自引:0,他引:3
目的 探讨慢性乙型肝炎 (慢性乙肝 )患者血液流变学的改变 ,并分析其与患者HBVDNA、肝功能、氧化损伤各项指标间的关系。方法 检测 5 5例慢性乙肝患者血液流变学指标、氧化损伤指标、肝功能、HBVDNA ,并对此做出相关分析。结果 乙肝组与正常对照组比较 :全血低切粘度、红细胞聚集指数均有明显升高 (P <0.0 5 )。ALT异常组与正常组及正常对照组比较 :红细胞压积、全血低切粘度、红细胞聚集指数均有明显升高 (P <0 .0 5 )。HBVDNA阳性组与阴性组比较差异无统计学意义 (P >0.0 5 )。血液流变学指标和氧化损伤指标间无相关关系 (P >0.0 5 )。结论 慢性乙肝患者体内存在微循环障碍及氧化损伤 ,血液流变学及氧化损伤指标与HBVDNA是慢性乙肝患者检查中相对独立的指标 相似文献
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不同慢性肝病患者血清中乙型肝炎病毒DNA定量检测及其临床意义 总被引:4,自引:0,他引:4
目的探讨乙型肝炎病毒DNA含量的临床意义。了解乙型肝炎病毒(HBV)免疫标志不同状态的慢性肝病患者血清HBVDNA浓度及其临床意义。方法应用建立的竞争性聚合酶链反应(PCR)方法定量检测慢性肝炎(CH)51例、肝硬化(LC)36例、原发性肝癌(PHC)38例的血清HBVDNA浓度。结果HBVDNA阳性的CH患者血清HBVDNA浓度为4.36log10HBVDNA拷贝50μl(下同),LC为4.55,PHC为4.43,三组间无显著性差异(P>0.05);血清HBV五项免疫标志均阴性或抗-HBs阳性的慢性肝病患者中,有37.5%患者存在低水平HBV复制;HBeAg阳性患者的HBVDNA浓度总体上明显高于抗-HBe阳性组,但其中部分患者的HBVDNA浓度也很高。结论提示HBV的复制状态与慢性肝病的病期无明显关系;在抗-HBe阳性的患者中存在个体差异,故不能仅依据抗-HBe阳转来判断HBV复制减少或停止。 相似文献
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194例慢性乙型肝炎病理及其与血清HBV DNA、HBeAg、ALT关系的研究 总被引:4,自引:0,他引:4
目的探讨慢性乙型肝炎病理及其与血清HBV DNA、HBeAg、ALT关系。方法对194例慢乙肝患者进行肝组织病理、HBV免疫组化检查,并检测肝功能、血清HBVM和HBV DNA。结果血清HBeAg阳性组的肝组织G2、G3~4、S2、S3~4发生率与阴性组比较差异有统计学意义,肝组织S0组与S1~4组比较差异有统计学意义,肝组织G0~1组与G2~4组、HBcAg阳性组与阴性组的HBV DNA含量比较差异亦有统计学意义,肝组织HBsAg表达为" "者与" ~ "者血清HBV DNA含量比较差异无统计学意义,肝组织达S1或(和)G2以上者血清ALT水平分别为:<40U/L组占28.57%,40~80U/L组占53.33%,81~400U/L占80.15%,>400U/L组占77.88%。结论血清HBV DNA与肝组织HBcAg表达有一致性,与肝内HBsAg无关,HBV DNA含量低可能是肝组织炎症活动度和纤维化程度高,ASC和轻度肝损害者应争取肝活检,以及时判断肝组织病理程度和治疗时机。 相似文献
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Haruhiko Sugimura Toshio Fukazawa Megumu Saitoh Ken-ichi Nakamura Hiroyuki Shimada Kohichiroh Ohtsubo 《Virchows Archiv : an international journal of pathology》1991,419(5):409-415
Summary The histopathology of the liver and the detectability of intrahepatic hepatitis B virus (HBV) markers were studied in 34 autopsy cases in elderly patients (mean age 73.9 years, range 60–91 years) who had had a history of positive HBV surface antigenaemia prior to death. Seven of 14 persistent HBV carrier cases (group A) in which long-lasting HBV surface antigen (HBsAg) carriage in the sera had been confirmed by sequential assays, and 5 out of 15 HBV-infected people (group C, single assay) showed significant primary liver damages including chronic hepatitis, toxic hepatitis, liver cirrhosis and hepatocellular carcinoma. In 5 cases (group B), one of which was type B liver cirrhosis, HBsAg became negative and HBsAb appeared during the follow-up period (up to 33 months). Among confirmed HBV carriers, HBsAg and HBV core antigen were most frequently found in the liver of cirrhotic cases with and without hepatocellular carcinoma (5 of 6), whereas these were rarely detected in those with nonspecific changes or slight hepatitic activity (1 of 7). All 5 cases in group B were negative for histological HBV-related antigens and the findings in group C were variously interpreted. Post-mortem cases of the aged HBV carriers who survived their mean life expectancy represent an important population in which to study the natural history of HBV carriers. 相似文献
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TTV在肝炎患者中的检测及临床意义探讨 总被引:73,自引:1,他引:73
目的研究新近报道与丙氨酸转氨酶异常相关的TTV在已知和未知病毒性肝炎中的临床意义。方法设计TTV部分基因的特异性引物,用聚合酶链反应(PCR)方法检测了104例病毒性肝炎的TTVDNA,并对1例TTV阳性标本克隆测序。结果TTVDNA序列与日本TTV部分基因序列相对应位置的核苷酸同源性为98.4%。在104例肝炎患者中TTVDNA阳性检出率为24.0%(25/104),其中在非甲~戊和庚型肝炎患者中为48.0%(12/42),在甲型肝炎中为19.0%(4/21),乙型肝炎为25.0%(8/32),丙型肝炎为11.1%(1/9),9例HGVRNA阳性者中未检出TTVDNA。值得注意的是重型肝炎TTV检出率极高,其中急性重型肝炎6例中阳性为4例(66.7%),慢性重型肝炎6例中阳性为3例(50.0%)。结论TTV在我国肝炎病人中存在。在重型肝炎中有较高的发生率,可能是未知病毒致急性和慢性及重型肝炎的病因之一。 相似文献
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目的 比较原发性肝癌与乙型肝炎肝硬化患者的血清HBV DNA水平、HBV基因型差别。方法 对210例原发性肝癌(HCC)患者及220例乙型肝炎肝硬化(HBV LC)患者的血清HBVDNA水平及HBV基因型进行分析,比较病毒学和基因型差异。结果 210例HCC患者和220例HBV LC患者HBV DNA检测阳性率分别为84.3%(177/210)、94.5%( 208/220);HBV DNA定量为(5.06±1.01) log10拷贝/ml和(5.36±1.13)log10拷贝/ml,HBV LC患者均高于HCC患者(P<0.01);HCC组和HBV LC组均以C基因型为主,两组B,C基因型分布无明显差异。结论 HCC患者血清HBV DNA水平低于HBV LC患者。两组HBV基因型分布无明显差异,均以C基因型为多。 相似文献
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T.C.A. Ferrari M.A.P. Xavier P.V.T. Vidigal N.S. Amaral P.A. Diniz A.P. Resende D.M. Miranda A.C. Faria A.S. Lima L.C. Faria 《Brazilian journal of medical and biological research》2014,47(11):990-994
Estimates of occult hepatitis B virus (HBV) infection prevalence varies among
different studies depending on the prevalence of HBV infection in the study
population and on the sensitivity of the assay used to detect HBV DNA. We
investigated the prevalence of occult HBV infection in cirrhotic patients undergoing
liver transplantation in a Brazilian referral center. Frozen liver samples from 68
adults were analyzed using a nested polymerase chain reaction assay for HBV DNA. The
specificity of the amplified HBV sequences was confirmed by direct sequencing of the
amplicons. The patient population comprised 49 (72.1%) males and 19 (27.9%) females
with a median age of 53 years (range=18-67 years). Occult HBV infection was diagnosed
in three (4.4%) patients. The etiologies of the underlying chronic liver disease in
these cases were alcohol abuse, HBV infection, and cryptogenic cirrhosis. Two of the
patients with cryptic HBV infection also presented hepatocellular carcinoma. Markers
of previous HBV infection were available in two patients with occult HBV infection
and were negative in both. In conclusion, using a sensitive nested polymerase chain
reaction assay to detect HBV DNA in frozen liver tissue, we found a low prevalence of
occult HBV infection in cirrhotic patients undergoing liver transplant, probably due
to the low prevalence of HBV infection in our population. 相似文献
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目的 探究乙型肝炎病毒感染患者肝癌发病的影响因素,为制定有效的预防措施提供参考依据.方法 选择2013年1月至2015年6月在我市一级以上医院接受治疗的乙型肝炎病毒感染并发肝癌患者90例为研究组.选择同期接受治疗的乙型肝炎病毒感染患者90例为对照组.比较两组患者的临床资料,用单因素分析和Logistic回归分析其影响因素.结果 乙型肝炎病毒感染患者并发肝癌与糖尿病、长期饮酒史、不良饮食、HBV DNA(+)、HBSAg(+)、HBeAg(+)、抗-HBS(+)、抗-HBe(+)、抗-HBc(+)、谷草转氨酶(AST)、肝癌家族史、其他肿瘤家族史和未抗病毒有关,差异具有统计学意义(P<0.05).将上述因素纳入Logistic多元回归分析,结果显示糖尿病、长期饮酒史、不良饮食、HBV DNA(+)、HBSAg(+)、抗-HBe(+)、肝癌家族史、未抗病毒是引起乙型肝炎病毒感染患者发生肝癌的独立危险因素(P<0.05).结论 对肝癌发病的危险因素存在较多的乙型肝炎病毒感染患者给予密切关注,早期行抗病毒治疗. 相似文献
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Hepatitis B virus DNA in leukocytes of patients with hepatitis B virus-associated liver diseases 总被引:6,自引:0,他引:6
In order to determine the relationship between hepatitis B virus (HBV) infection of human white blood cells and different forms of HBV-associated liver diseases, we tested for HBV DNA in the sera and leukocytes of 11 healthy individuals without any serological markers of HBV infection and 91 patients with HBV infection and other gastrointestinal and urinary diseases by dot and Southern blot hybridization. HBV DNA was found in leukocytes of chronic HBV carriers, in acute and chronic hepatitis, and in patients with liver cirrhosis and hepatocellular carcinoma. Between 27 and 50% of individuals in different categories of patients examined were positive for leukocyte HBV DNA. HBV DNA was also detected in the sera of some of these patients but was absent in others. Serum HBV DNA-positive rates seemed to be highest in hepatitis B e antigen-positive asymptomatic carriers (8/10, 80%), and tended to drop to lower levels as the disease progressed to liver cirrhosis (0/8) while leukocyte HBV DNA-positive rates were highest in patients with cirrhosis (4/8, 50%). The results also show that in individuals who were serologically negative for hepatitis B surface antigen (HBsAg) and positive for antibodies to HBsAg and/or HBcAg, HBV DNA was absent in most of the sera (27/28, 96%) but it was present in leukocytes of some of these patients (7/28, 25%). In control experiments with 11 healthy individual, HBV DNA was not detected in either sera or leukocytes. In all the cases with leukocyte HBV DNA, the HBV DNA molecules were present in free forms with discrete sizes. The exceptions were a case of liver cirrhosis and a case of chronic hepatitis with possible HBV sequence integration into high molecular weight cellular DNA. Since HBV does infect human leukocytes, it may perhaps interfere with the immunological functions of the white blood cells, and thus play an important role in the pathogenesis of HBV-induced liver disease. 相似文献
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慢性乙型肝炎患者血清和肝组织中HBV DNA含量与庚型肝炎病毒感染的关系 总被引:1,自引:1,他引:1
目的:观察慢性乙型肝炎(CH-B)患者血清、肝组织中HBV DNA含量与庚型肝炎病毒(HGV)感染的关系,探讨HGV感染对CH-B患者乙型肝炎病毒(HBV)复制的影响。方法:应用逆转录-聚合酶链反应(RT-PCR)、免疫组织化学法、荧光定量PCR(FQ-PCR)技术方法对56份CH-B患者血清HGV RNA、肝组织HGV Ag、血清及肝组织中HBV DNA含量分别进行了检测,并将血清HGV RNA与肝组织HGV Ag的表达、HGV RNA、HGV Ag阳性与阴性患者HBV DNA含量分别进行了对比研究。结果:血清HGV RNA、肝组织HGV Ag阳性分别为10份(17.9%)、8份(14.3%)。血清HGV RNA阳性与肝组织HGV Ag表达显著相关(P<0.01),但部分肝组织HGV Ag阴性患者亦有血清HGV RNA表达。血清HGV RNA、肝组织HGV Ag阳性与阴性患者血清及肝组织中HBV DNA含量差异无显著性(P>0.05)。结论:HGV感染对CH-B患者HBV复制无影响。HGV可在肝脏中复制,但致病性可能较微弱。 相似文献