共查询到20条相似文献,搜索用时 31 毫秒
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R A DeRemee 《Mayo Clinic proceedings. Mayo Clinic》1989,64(8):1022-1023
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Several data support the view that impairment of the inflammatory-immune response
is a hallmark of severe sepsis and the level and time of recovery to
immunocompetence has a major impact on the clinical outcome of ICU patients.
Recent studies demonstrate that improvement of anti-tumour immune response by
targeting negative regulatory molecules, such as CD25, chronic T-lymphocyte
activation antigen 4, and programmed death-1 receptor (PD-1)/PD-1 L, offers
a novel opportunity to prevent or even reverse progression of tumour growth in
experimental models and patients. Likewise, severe sepsis is associated with
enhanced expression of those negative regulatory molecules, suggesting a novel
approach to reverse immunoparalysis in sepsis. Consequently, targeting negative
molecules in sepsis can reverse immunoparalysis and improve survival in
experimental sepsis, as shown by Chang and colleagues in a recent issue of
Critical Care. This opens new opportunities to overcome
overwhelming downregulation of the adaptive immune response to prevent and/or
improve recovery from sepsis. 相似文献
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The activation of lymphocytes and development of adaptive immune responses is initiated by the engagement of TCRs by antigenic peptide-MHC complexes and shaped at the clonal level by both positive and negative costimulatory signals. The B7 family members are involved at several stages in this process. In this issue of the JCI, Vogt et al. show that the B7 family-related protein V-set and Ig domain-containing 4 (VSIG4) can act as an inhibitor of T cell activation (see the related article beginning on page 2817). Intriguingly, the same molecule was recently independently identified as a complement receptor of the Ig superfamily (CRIg) and was convincingly demonstrated to be a receptor for complement component 3 fragments. These findings raise interesting questions regarding the physiological roles and mechanisms of action of this molecule. Identification of dual functions of this molecule provides an additional level of complexity in T cell costimulation. 相似文献
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Mulhern RM 《Home healthcare nurse》2012,30(1):63-64
In homecare, skill, education, and experience are vital to success. When the ability to know when to be something instead of do something is learned, the true art is born. 相似文献
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H Funagoshi 《[Kango] Japanese journal of nursing》1971,23(12):158-160
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Heightman AJ 《JEMS : a journal of emergency medical services》2005,30(5):12, 32
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