树枝状尼龙6的合成与研究

用单羧基封端的尼龙6分别与树枝状聚酰胺-胺(PAMAM)的G1代和G2代外围活泼氨基进行缩聚反应，合成出具有规整结构的由核心向外发散增长的树枝状尼龙6，采用红外光谱、扫描电镜、DSC和TGA对缩聚物进行了分析。     

3,5—二卤代—4—羟基苯甲腈的合成

对羟基苯甲酸在溶剂中与尿素反应生成对羟基苯甲腈，产物车溴素和氯酸钠、碘和氯气和反应制得相应的３，５－二卤代－４－羟基苯甲腈。     

镓—溴代二甲氨基苯基荧光酮—氟—TritonX—100四元配合物？…

目的 研究镓－溴代二甲氨基苯基荧光酮－氟ＴｒｉｔｏｎＸ－１００四元配合物的分光光度法。方法 在非离子表面活性剂ＴｒｉｔｏｎＸ－１００存在下，以Ｆ＾－为辅助配位体时，于ｐＨ１０．０的ＮＨ３－ＮＨ４Ｃｌ缓冲溶液中，镓与９－（３′－溴－４′－二甲氨基苯基）－２，３，７－三羟基荧光酮（溴代二甲氨基苯基荧光酮）进行显色反应。结果 四元络合体系基ｐＨ９．０～１１．０范围内，可获得稳定的紫色配合物。其最大吸收波     

镓-溴代二甲氨基苯基荧光酮-氟-Triton X-100 四元配合物分光光度法研究

目的研究镓－溴代二甲氨基苯基荧光酮－氟－ＴｒｉｔｏｎＸ－１００四元配合物的分光光度法。方法在非离子表面活性剂ＴｒｉｔｏｎＸ－１００存在下，以Ｆ－为辅助配位体时，于ｐＨ１０．０的ＮＨ３－ＮＨ４Ｃｌ缓冲溶液中，镓与９－（３′－溴－４′－二甲氨基苯基）－２，３，７－三羟基荧光酮（溴代二甲氨基苯基荧光酮）进行显色反应。结果四元络合体系在ｐＨ９．０～１１．０范围内，可获得稳定的紫色配合物，其最大吸收波长为５７０ｎｍ，表观摩尔吸光系数为３．３１×１０５Ｌｍｏｌ－１ｃｍ－１。镓含量在０～４μｇ／２５ｍｌ范围内符合比尔定律，检出限为０．００２μｇ／ｍｌ。结论大多数常见阳离子不干扰镓（Ⅲ）的测定，而微量铁和铜虽有干扰，可通过加入铜试剂掩蔽，消除干扰，本法可以不经分离直接测定铜合金中镓的含量。     

以聚乙二醇为核聚酰胺—胺树枝状大分子对血液影响的实验研究

目的：观察以聚乙二醇为核聚酰胺－胺树枝状大分子对血液性质的影响。方法：凝血实验、血沉实验、溶血实验。结果：该物质有明显抑制凝血作用，加速红细胞的沉降率，不影响红细胞脆性。结论：各整数代树枝状大分子对血液性质的影响与聚乙二醇具有较好的一致性。     

海洋鳗弧菌铁载体合成的调控

以一株鳗弧菌pJM1质粒缺陷为研究对象，考察了儿茶酚类铁载体Anguibactin的合成代谢调控。研究发现：在由染色体和质粒共同编码介导的铁载体Anguibactin的合成途径中，其分界点位于2，3－二羟基苯甲酸合成，2，3－二羟基苯甲酸合成之前代谢途径受染色体编码调节,后由质粒编码介导；编码2，3－二羟基苯甲酸的染色体相关基因的表达受环境铁离子浓度的诱导调节。     

白藜芦醇的全合成

目的合成天然活性物质白藜芦醇。方法以3，5-二甲氧基苯甲酸为原料，经还原、溴代后，与亚磷酸三乙酯反应成3，5-二甲氧基苄磷酸酯，再与市售茴香醛进行Wittig-Homer反应后，脱去酚羟基保护基而得到目标产物白藜芦醇。结果成功合成得到了白藜芦醇。结论该合成路线具有工艺简单、试剂价格低廉等优点。     

CoSalphen在壳聚糖上的固定化及对DOPA的催化氧化研究

制备了二氧化硅担载的壳聚糖固定化双水杨叉邻苯二胺合钴配合物，用元素分析，红外光谱，紫外－可见光谱和荧光光谱等方法对固定化配合物的组成和结构进行了表征。结果表明：双水杨叉邻苯二胺合钴是通过其钴离子与壳聚糖的氨基氨配位实现其在壳聚糖的固定化。由于高分子固定化配合物对活性中心的基位隔离效应阻碍了双水杨叉邻苯二胺合钴的二聚体及过氧型载氧体的形成而使其对３，４－二羟基苯基丙氨酸（多巴）的催化氧化活性远大于相     

具有内皮祖细胞捕获功能的聚氨酯的合成与研究

以聚碳酸酯二元醇(PCDL)为软段,1,6-六亚甲基二异氰酸酯(HDI)为硬段,二羟甲基丙酸(bis-MPA)为扩链剂合成了一种侧 链含有羧基官能团的聚碳酸酯型聚氨酯材料。将氨基封端的四代树枝状聚酯大分子共价接枝到聚氨酯的侧链上,脱除树枝状分子表 面缩酮保护基后得到了一种新型的侧链树枝化多羟基聚氨酯材料。此聚合物能有效黏附CD133抗体,黏附了抗体的材料可大大提高 CD133内皮祖细胞的黏附。这一结果为通过加速血液接触材料表面内皮化来提高其血液相容性提供了可能。     

含环己烯氮杂环结构的聚醚砜酮三元共聚物合成

用1－甲基－4，5－二（4－氯代苯甲酰基）环己烯与4－（4－羟基苯基）－2，3－二氮杂萘－1－酮、4，4′－二氯二苯砜经亲核共缩聚反应，合成了含环己烯结构的杂环联苯型聚醚砜酮三元共聚物。结果表明，聚合物是一种具有较高的玻璃化转变温度的可溶性无规共聚物。聚合物含有不饱和双键结构，有一种反应性高分子。     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

Acupuncture Combined with Spinal Tui Na for Treatment of Primary Dysmenorrhea in 30 Cases

Objective: To observe the therapeutic effects in acupunture treatment of primary dysmenorrhea combined with spinal Tui Na, and study its mechanism. Methods: Thirty cases of the treatment group were treated by acupuncture combined with spinal Tui Na, and thirty cases in the control group were treated by routine acupuncture. Results: The total effective rate was 93.3% in the treatment group, and 73.3% in the control group, with a significant difference between the two groups (P<0.05). Conclusions: Acupuncture combined with spinal Tui Na has good prospects for treatment of primary dysmenorrhea.     

Luo Lingjie's Experience in Treating Chronic Nephropathy

In treating chronic nephropathy,Luo Lingjie,a chief physician,pays attention to regulating the balance between yin and yang,treating infection if present,and removing pathogenic factors.He prescribes gentle drugs and uses carefully strongly warming-tonifying ones,emphasizes the importance of persuading the patient to persist in treatment with medication and nurse one's health for recuperation,and is good at combined use of TCM and western medicine therapy and brings the merits of various therapies into full play,with obvious theraoeutic effects.     

Dr.Zhang Ren's Experience in the Acupuncture Treatment of Different Diseases with the Same Therapeutic Principle

Dr.Zhang Ren,the chief physician,is the chairman of Shanghai Acupuncture and Moxibustion Association.Having been engaged in medicine for about 40 years,he is experienced in treating various intractable diseases.In his long years of clinical practice,he advocates taking the TCM differentiation as the basis to seek for the acupuncture method for treatment of modern intractable diseases.The author of this essay had the fortune to follow Dr.Zhang in study.The following is a summary of Dr.Zhang's experience in the acupuncture treatment for different intractable diseases with the same therapeutic principle.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

猪肺磷脂注射液联合经鼻持续气道正压通气对呼吸衰竭早产儿的临床疗效及肌酸激酶同工酶活性的影响

目的 探讨猪肺磷脂注射液联合经鼻持续气道正压通气(NCPAP)对呼吸衰竭早产儿的临床疗效及肌酸激酶同工酶活性(CK-MB)的影响.方法 选取呼吸衰竭早产儿80例,分为观察组和对照组各40例.对照组采用NCPAP给氧治疗,观察组给予NCPAP给氧联合猪肺磷脂气管内给药.观察两组患儿治疗前及治疗12h、24 h后PaO2、PaCO2、血氧饱和度(SaO2)、pH的变化情况,检测治疗前及治疗5d后血清CK-MB水平;评估两组患儿的临床治疗效果.结果 两组患儿PaO2、PaCO2、SaO2、pH比较,差异均有统计学意义(P＜0.05),其中观察组治疗后的PaO2、SaO2、pH均高于对照组,PaCO2则低于对照组.两组的PaO2、SaO2、pH均随观察时间延长而升高(P＜0.05),PaCO2均随观察时间的延长而降低(P＜0.05).观察组治疗有效率为87.5％,显著高于对照组的70.0％ (P ＜0.05).治疗5d后两组患儿血清CK-MB水平均较前降低(P＜0.05),且观察组明显低于对照组(P＜0.05).结论 猪肺磷脂注射液气管内给药联合NCPAP可以显著降低呼吸衰竭早产儿CK-MB的含量,提高治疗有效率,起到很好的呼吸循环支持作用.