Digital chest radiography: effect on diagnostic accuracy of hard copy, conventional video, and reversed gray scale video display formats

Observer performance tests were conducted to compare the effects on diagnostic accuracy of hard copy (film) versus video display and to determine the diagnostic merits of conventional negative ("white bone") versus positive ("black bone") video displays. Subjective preferences were elicited from each observer for each display modality, and diagnostic accuracy was determined with receiver operating characteristic analysis. Digitized chest radiographs were used, including normal and abnormal cases with a variety of subtle abnormalities. The hard copy was printed with a 1,024 X 1,024-matrix by a high-quality drum scanner in conventional white bone format only. The video images were displayed on a 1,023-line monitor (30 Hz, interlaced) in both white bone and black bone formats with fixed window and brightness settings. Most observers preferred hard copy to video, but preferences were sharply divided between white bone and black bone video. Diagnostic accuracy was significantly greater with hard copy than with video display, and the conventional white bone format was significantly superior in accuracy to the black bone display.     

Digital processing of film radiographs

Initial clinical experience with a system for the digitization, processing, and display of film radiographs is described. Film is digitized using a high-intensity laser scanner; the recorded image data may then be subjected to a wide variety of processing options, with display of processed images on television monitors. The possibilities of clinical applications to processing and display of chest radiographs and film mammograms are described. A comparison of conventional analog subtraction and digitized film subtraction angiography indicated equivalent diagnostic capability, with the advantage of flexible, interactive image processing with the digital technique. A specially designed, energy-selective cassette permits dual-energy imaging from two films effectively exposed to different x-ray energy spectra. Dual-energy imaging may be capable of the characterization of body materials, including lung nodules, and useful for eliminating obscuring radiographic shadows overlying regions of interest.     

Comparison of 2048-line digital display formats and conventional radiographs: an ROC study

Observer performance tests were conducted to compare the effects on diagnostic accuracy of digital hard copy and video display formats versus conventional radiographic film. Digital images were obtained by digitizing conventional chest radiographs to a 2048 x 2048 matrix with a laser film scanner. Three digital display formats were used: laser-printed digital film, a 2048-line video monitor without user interaction, and a 2048-line video monitor with user interaction. Thirty-one posteroanterior chest radiographs, determined by consensus of four thoracic radiologists to contain septal lines (n = 11), parenchymal nodules (n = 7), nodules and septal lines (n = 7), or neither abnormality (n = 6), were used for the study. Images were interpreted by four radiologists in four separate viewing sessions. Diagnostic accuracy was determined by receiver-operating characteristic analysis for each observer with each viewing technique. No statistical differences in diagnostic accuracy, determined by the area under the receiver-operating-characteristic curve, were found between the analog film, the digital film, and the two video digital display formats. This preliminary study suggests that 2048-line digital displays may be an acceptable alternative to the traditional lightbox viewing method for the perception of these two abnormalities commonly seen on chest radiographs.     

Chest radiography: comparison of high-resolution digital displays with conventional and digital film

This study was performed to compare the performances of observers using three display formats for chest radiography. The display formats were conventional radiographs, digitized radiographs (2,048 X 2,048 X 12 bits) printed on laser film, and digitized radiographs (2,048 X 2,048 X 12 bits) displayed on a high-resolution (2,560 X 2,048 X 12-bit) gray-scale display. The test set for the study consisted of 163 cases. Sixty-four of the cases were normal, whereas the 99 remaining cases demonstrated one or more common radiographic abnormalities. Nine abnormalities were selected for analysis: costophrenic angle blunting, interstitial disease, atelectasis, pneumothorax, parenchymal mass, consolidation, obstructive disease, hilar/mediastinal mass, and apical scarring. Six experienced general radiologists participated in the evaluation. Receiver operating characteristic curves were generated for each abnormality and display format. The results indicate that, while the three display formats are equivalent for the detection of some abnormalities, detectable differences in observer performance may be seen even at 2,048 X 2,048 X 12 bits for the detection of obstructive disease, pneumothorax, interstitial disease, and parenchymal masses.     

Digital radiography: fundamentals and future potentials

Digital radiography consists of four major steps which include X-ray detection, digitization, image processing and display. Important parameters in digitization process is the pixel size and the number of grey levels which affect the quality of digitized images. A number of digital radiographic systems have been or are being developed which include the point-beam, line-beam, slot-beam and multiple slit-beam systems as well as conventional wide-beam systems such as image intensifier-TV system, storage phosphor system and film-based system. Important physical properties of digital radiographic systems are the sensitivity, resolution, noise, system response, scatter rejection, contrast sensitivity and image acquisition time. The resolution property is affected by the pixel size, sampling distance, display pixel size, image processing, detector response and X-ray beam characteristics. From ROC studies on chest images, the pixel size of approximately 0.2 mm and the corresponding image matrix of about 2,000 x 2,000 is considered optimal choice of these parameters. Future potentials of digital radiography are likely to be in the areas of computer-aided diagnosis (CAD) and PACS. Preliminary results obtained from recent studies on quantitative analysis of digital radiographic images are promising. The rms variation and the first moment of the texture of abnormal lungs with various interstitial diseases were clearly different from those of normal lungs. Automated detection scheme of nodules in chest images indicated approximately 70% true positive rates and a few false positives in each lung.(ABSTRACT TRUNCATED AT 250 WORDS)     

Digital separation of primary and scatter components of chest radiographs

This article describes a technique for digital separation of the primary and scatter components of a radiographic image. The method involves mathematical modeling of the process whereby an antiscatter grid reduces scatter patterns in film radiographs. Two superimposable radiographs (one taken with and the other without an intervening antiscatter grid) are applied to the model. Performance characteristics of the grid (primary and scatter transmittance factors) are also determined and used in the model. Radiographs of a humanoid chest phantom are processed. Scatter/primary separation appears to be accurate to within 15%. Film images that are quantitatively faithful to the calculated primary and scatter fields are included.     

双能量数字减影胸片对肺内小结节检出的意义

目的探讨双能量数字减影胸片对肺内小结节检出的意义。方法27例病理证实恶性肿瘤伴肺内转移的患者,分别行增强CT扫描、双能量数字减影胸片与常规DR胸片。使用柯达质量控制检测仪比较双能量数字减影DR与常规DR胸片的图像质量。再以CT扫描结果为金标准,由2位高年资放射科医师采用双盲法对双能量数字减影胸片与常规DR胸片进行分析,比较两者对肺内转移瘤的检出有无显著差异。结果双能量数字减影DR与常规DR图像在噪声上(均匀度)无差异,但清晰度稍差。双能量数字化减影的胸片对肺内小结节的检出率为91.2%;而常规DR胸片对肺转移瘤的检出率为85.0%,两者之间有显著差异(P<0.05)。结论双能量数字减影技术可减少肺野内骨骼及其它钙化影响,对肺内结节的检出能力高于常规DR胸片。     

Digital chest radiography with a selenium-based flat-panel detector versus a storage phosphor system: comparison of soft-copy images

OBJECTIVE. We compared the soft-copy images produced by a digital chest radiography system that uses a flat-panel X-ray detector based on amorphous selenium with images produced by a storage phosphor radiography system for the visualization of anatomic regions of the chest. MATERIALS AND METHODS. Two chest radiologists and two residents analyzed 46 pairs of posteroanterior chest radiographs on high-resolution video monitors (2560 x 2048 x 8 bits). In each pair, one radiograph was obtained with a storage phosphor radiography system, and the other radiograph was obtained with a selenium-based flat-panel detector radiography system. Each pair of radiographs was obtained at the same exposure settings. The interpreter rated the visibility and radiographic quality of 11 different anatomic regions. Each pair of images was ranked on a five-point scale (1 = prefer image A, 3 = no preference, 5 = prefer image B) for preference of technique. Statistical significance of preference was determined using the Wilcoxon's signed rank test. RESULTS. The interpreters had a statistically significant preference for the selenium-based radiography system in six (unobscured lung, hilum, rib, minor fissure, heart border, and overall appearance) of 11 anatomic regions (p<0.001) and for the storage phosphor system in two regions (proximal airway and thoracic spine) (p<0.05). Chest radiologists strongly preferred selenium-based images in eight regions, and they did not prefer storage phosphor images in any region. CONCLUSION. The soft-copy images produced by the selenium-based radiography system were perceived as equal or superior to those produced by the storage phosphor system in most but not all anatomic regions.     

Effects of image processing on nodule detection rates in digitized chest radiographs: ROC study of observer performance

To evaluate the effects of image processing in digitized chest radiographs when high-resolution images are used, an examination was done in which the detection of pulmonary nodules in unprocessed digitized chest radiographs was compared with that in images that had undergone processing with two methods, adaptive filtration and histogram equalization. The processing techniques have been optimized in previous work to selectively enhance the retrocardiac and subdiaphragmatic areas without significant alteration of detail in the lung. Eight observers were shown 150 test radiographs (50 unprocessed, 50 processed with adaptive filtration, 50 processed with histogram equalization) containing 150 nodules. The results indicate a statistically significant (P less than .03) difference, with highest observer performance in the chest radiographs processed with adaptive filtration (median area under ROC curve = 0.78), compared with unprocessed images (median = 0.68) and chest radiographs processed with histogram equalization (median = 0.62). Performance in the lung was not significantly different. Adaptive filtration applied to selectively enhance underexposed areas of film images may improve nodule detection. Histogram equalization provided no improvement in performance.     

Detectability of catheters on bedside chest radiographs: comparison between liquid crystal display and high-resolution cathode-ray tube monitors

PURPOSE: To compare observer performance with a flat-panel liquid crystal display (LCD) monitor and with a high-resolution gray-scale cathode-ray tube (CRT) monitor in the detection of simulated support catheters on bedside chest radiographs. MATERIALS AND METHODS: The ethics committee did not require approval or patient informed consent when this study began. Because of a change in regulations, before images were acquired the nature of the study and procedures were explained to patients or their relatives, and consent was then obtained. A total of 131 catheter fragments (12-14 per radiograph) were superimposed over 10 anteroposterior bedside chest radiographs obtained with storage phosphor technology. Images were displayed on an LCD monitor (1536 x 2048 matrix) and a CRT monitor (2048 x 2560 matrix). Five radiologists independently located the catheter fragments and rated their confidence in detection with bright and subdued ambient light. A two-way analysis of variance and the Friedman test were used for statistical analysis. RESULTS: There was no significant difference for either display type with respect to correctly detected catheter fragments (mean sensitivity, 56.6% and 56.0% for the CRT and the LCD monitors, respectively, with bright light and 61.2% for both monitors with subdued light). With both display types, detection rate with bright light decreased significantly (P < .05). False-positive rates and confidence ratings were not significantly affected by monitor type or ambient light. CONCLUSION: In a study with simulation of clinical conditions, performance of the LCD monitor and high-resolution CRT monitor for detection of support catheters on bedside chest radiographs was equivalent. With both displays, detection performance was equally reduced with bright ambient light.     

Temporal subtraction for the detection of hazy pulmonary opacities on chest radiography

OBJECTIVE: The purpose of this study was to evaluate the accuracy of temporal subtraction with a commercially available computer-assisted diagnosis system for the detection of multifocal hazy pulmonary opacities on chest radiographs, which are sometimes difficult to detect directly on chest radiographs. MATERIALS AND METHODS: Thirty healthy patients and 30 patients with new multifocal hazy pulmonary opacities that were confirmed by serial chest CT examinations were evaluated with and without temporal subtraction images. Chest radiographs were taken from either film-screen or digital radiography images and were digitized with a spatial resolution of 0.171 mm per pixel. Temporal subtraction images were produced by an iterative image-warping technique. We designed an observer performance study in which observers (six chest radiologists and four residents) indicated their confidence level for the presence or absence of hazy pulmonary opacities on two sets of images, current and previous radiographs only (set A), and current and previous radiographs with temporal subtraction images (set B). Receiver operating characteristic curves were generated. RESULTS: For chest radiologists, observer performance with set B (with temporal subtraction images; A(z) = 0.947) was superior to that with set A (without temporal subtraction images; A(z) = 0.916) (p < 0.05). For residents, no statistically significant difference was found between sets A and B. CONCLUSION: The temporal subtraction technique clearly improves diagnostic accuracy for the detection of multifocal hazy pulmonary opacities on chest radiographs, especially when the observers are experienced chest radiologists who have sufficient skill to evaluate the patient's condition as revealed on the images.     

Digital radiography of the chest

Digital radiography is an appropriate method for both bedside and in-department chest radiographs. Its major advantage in bedside chest radiography is its control of the displayed optical density of these radiographs. With dynamic range control processing, it improves the visibility of tubes and lines superimposed on the mediastinal tissues. When used for in-department chest radiography, it may offer slight advantages in the evaluation of disease in the mediastinum, but in general is equivalent to film-screen chest radiography. The main reasons for using digital chest radiography for in-department chest radiographs relate mainly to its use as a data entry point method of projection radiography for high-quality teleradiology or for its use in a picture archiving and communication system. Apart from these advantages, there is no reason to change from conventional to digital chest radiographs. Digital radiographs are, with certain systems, printed at smaller than life size. Because of this, there is a necessary period of learning as radiologists adjust to the new image size. The most important change in radiologists' work pattern appears to be the need to sit closer to the film. Findings of disease are smaller, but, with experience, just as easy to see.     

Detection of simulated chest lesions by using soft-copy reading: comparison of an amorphous silicon flat-panel-detector system and a storage-phosphor system

PURPOSE: To compare observer performance by using soft-copy images produced by an amorphous silicon flat-panel-detector system and a storage-phosphor system for the detection of simulated chest lesions. MATERIALS AND METHODS: To test the diagnostic performance of these two systems, four types of simulated lesions (nodules, micronodules, lines, and reticular opacities) were superimposed over an anthropomorphic chest phantom. Digital chest radiographs were acquired with amorphous silicon flat-panel-detector (3-K [K = 1,000] matrix, 12 bits) and storage-phosphor radiography (4-K matrix, 10 bits). Six board-certified radiologists evaluated soft-copy images on a high-resolution video monitor (2,048 x 2,560 x 8 bits). A total of 14,400 observations were analyzed in terms of receiver operating characteristics. RESULTS: Average performance in terms of nodule detection was significantly better (P <.05) with the flat-panel-detector system than with the storage-phosphor system. For micronodules, lines, and reticular opacities, no significant detection differences in averaged performance were found between the two detector systems. CONCLUSION: In the evaluation of soft-copy images, the amorphous silicon detector system appears to be superior to the storage-phosphor system for the detection of pulmonary nodules.     

Image processing in digital chest radiography: effect on diagnostic efficacy.

The usefulness of digital image processing of chest radiographs was evaluated in a clinical study. In 54 patients, chest radiographs in the posteroanterior projection were obtained by both 14 inch digital image intensifier equipment and the conventional screen-film technique. The digital radiographs (512 x 512 image format) viewed on a 625 line monitor were processed in three different ways: (1) standard display; (2) digital edge enhancement for the standard display; and (3) inverse intensity display. The radiographs were interpreted independently by three radiologists. The diagnoses were confirmed by CT, follow-up radiographs and clinical records. Chest abnormalities of the films analyzed included 21 primary lung tumors, 44 pulmonary nodules, 16 cases with mediastinal disease and 17 cases with pneumonia/atelectasis. Interstitial lung disease, pleural plaques, and pulmonary emphysema were found in 30, 18 and 19 cases, respectively. The sensitivity of conventional radiography when averaged overall findings was better than that of the digital techniques (P less than 0.001). The differences in diagnostic accuracy measured by sensitivity and specificity between the three digital display modes were small. Standard image display showed better sensitivity for pulmonary nodules (0.74 vs 0.66; P less than 0.05) but poorer specificity for pulmonary emphysema (0.85 vs. 0.93; P less than 0.05) compared with inverse intensity display. We conclude that when using 512 x 512 image format, the routine use of digital edge enhancement and tone reversal at digital chest radiographs is not warranted.     

Receiver-operating-characteristic study of chest radiographs in children: digital hard-copy film vs 2K x 2K soft-copy images.

Two methods are commonly used to visualize digital radiologic imaging data: (1) hard-copy viewing, in which the digital data are used to modulate the intensity of a laser beam that exposes an analog film and (2) soft-copy viewing, in which the digital data are converted to an analog video signal and presented on a CRT monitor. The film method allows new digital imaging systems to be easily integrated into conventional radiologic management and viewing methods. The second method, soft-copy viewing, allows digital imaging data to be managed and viewed electronically in a picture archiving and communication system (PACS). These PACS systems are hypothesized to have improved operational efficiency and enhanced image-analysis capabilities. The quality of soft-copy images is still not widely accepted. This article reports on the results of a large-scale receiver-operating-characteristic study comparing observers' performance in detecting various pediatric chest abnormalities on soft-copy 2048 x 2048K byte displays with their performance with digital laser-printed film from computed radiography. The disease categories studied were pneumothorax, linear atelectasis, air bronchogram, and interstitial disease. The selected data set included 239 images; 77 contained no proved abnormality and 162 contained one or more of the abnormalities mentioned. Seven pediatric radiologists participated in the study, two as judges and five as observers. Our results show no significant difference between viewing images on digital hard copy and soft copy for the detection of pneumothoraces and air bronchograms. A slight performance edge for soft copy was seen for interstitial disease and linear atelectasis. This result indicates that computed chest radiographs in children viewed in a soft-copy PACS environment should result in diagnoses similar to or slightly more accurate than those obtained in a laser-printed film-based environment.     

Gray-scale inversion radiographic display for the detection of pulmonary nodules on chest radiographs

The purpose of this study was to investigate gray-scale inversion in nodule detection on chest radiography. Simulated nodules were superimposed randomly onto normal chest radiographs. Six radiologists interpreted 144 chest radiographs during three reading sessions: traditional presentation, inverted gray-scale, and a choice session allowing use of traditional and gray-scale inverted views. Sensitivity and specificity were used to assess accuracy based on presence or absence of a nodule. Gray-scale inversion and choice display sessions resulted in significantly higher nodule detection specificity and decreased sensitivity compared to traditional display. Gray-scale inversion may decrease false-positive nodule findings during chest X-ray interpretation.     

Efficacy of digital radiography for the detection of pneumothorax: comparison with conventional chest radiography.

As part of our continuing evaluation of the clinical applicability of digital radiography, we compared the abilities of radiologists to detect pneumothoraces on conventional chest radiographs with their performances when using three formats of digitally obtained images. Twenty-three frontal-view chest radiographs with pneumothoraces and 22 other chest radiographs, either normal or showing miscellaneous abnormalities, were interpreted by five experienced radiologists in each of four formats: conventional film-screen chest radiographs, small-format (17.8 x 21.6 cm) computed radiographs, large-format (35.6 x 43.1 cm) computed radiographs, and digital images viewed on an interactive electronic workstation. The receiver-operating-characteristic curve areas for each observer for the four types of images were compared by a z test on a critical ratio, and the mean sensitivity and specificity values were compared by the sign rank test. The mean areas under the receiver-operating-characteristic curves ranged from 0.869 for the digital workstation to 0.915 for film-screen images. The differences observed among formats were not statistically significant. Mean specificities also were not significantly different, ranging from 0.90 for large-format computed radiographs to 0.96 for the digital workstation. Mean sensitivity ranged from 0.65 for the digital workstation to 0.82 for film-screen images. Radiologists interpreting digital workstation images were significantly less sensitive in detecting pneumothoraces than with film-screen and small-format computed images (p = .06). In this study, radiologists detected pneumothoraces equally well on conventional film-screen radiographs and digital images printed on film; however, they detected pneumothoraces less well on electronic viewing consoles. This latter finding reflects an important practical difference in the working behavior of radiologists interacting with a digital workstation.     

Evaluation of optical unsharp masking and contrast enhancement of low-scatter chest radiographs

Conventional chest radiography poses a challenging technical problem because of its requirement for simultaneous high-contrast display and wide-latitude recording across the entire image. We developed and evaluated a method of producing chest radiographs by using a tantalum air-interspace grid for highly efficient scatter rejection, wide-latitude X-ray film for recording the low-scatter image, and a LogEtronics printer for optical unsharp masking and contrast enhancement of the recorded image (TWL technique). TWL images can be readily obtained and have excellent contrast and detail across the entire image. In comparison with a conventional technique, the TWL technique provides about a 15% improvement in image contrast in well-penetrated areas and a threefold to tenfold improvement in poorly penetrated areas. A detection study using simulated lung nodules and a chest phantom showed about 10% overall improvement in nodule detection with the TWL technique (51% vs 42%), most of which was due to improvement in detection rates in poorly penetrated areas of the chest (62% vs 26%). In well-penetrated areas, there was a decrease in detection rates (52% vs 44%) using TWL images despite measured improvements in image contrast in these areas. Possibly this was due to the observers' unfamiliarity with the reversed-contrast TWL images. Our results show the TWL technique to be valuable for improving image quality and diagnostic accuracy in chest radiography.     

A filter for breast imaging on a radiotherapy X-ray simulator

Simulator radiographs taken as a record of breast radiotherapy planning often show ill defined breast tissue margins because exposure parameters are set to optimize visualization of the chest wall rather than the bulk of the breast. This creates difficulties when using simulator images as reference images in verification by comparing with either portal film or images from an electronic portal imaging device. Our aim was to improve breast images taken at simulation without changing exposure parameters that have been optimized for visualization of the chest wall. This has been achieved via an external filter to be used when taking radiographs with the treatment simulator. The filter is made of stainless steel coated with tin and is shaped to maintain acceptable imaging of the chest wall by covering only the section of field anterior to the chest wall. Radiographs of breast simulations using the filter have been accepted as satisfactory by both clinicians and radiographers. The filter is now in routine clinical use for breast and chest wall treatment simulation.     

Comparison of scanning equalization and conventional chest radiography

A clinical comparison study of scanning equalization radiography (SER) and conventional chest radiography was performed with the latest prototype SER system. Conventional chest radiography was performed at 120 kVp with Lanex regular screens (Eastman Kodak, Rochester, NY) and Kodak Ortho-G or Ortho-C film (Eastman Kodak). The 253 volunteer patients were examined with both techniques. The chest radiographs were interpreted by four radiologists. The study group was composed of 58 normal and 195 abnormal posteroanterior and lateral chest radiographs. In 31 cases there were two major radiologic diagnoses. The number of correct interpretations increased when the SER images were examined, compared with the conventional Ortho-G (chi 2 = 4.17, P less than .05) and conventional Ortho-C (chi 2 = 16.9, P less than .001) radiographs. The overall accuracy of disease detection improved for all radiologists with the SER system. There was no disease category in which the accuracy of interpretation decreased when the SER system was used. The SER system is a clinically reliable method of improving image quality and increasing diagnostic accuracy.