Clinical Study on Treatment of Non-small Cell Lung Cancer by Chinese Herbal Medicine Combined with Bronchial Arterial Chemotherapy

Ｓｅｌｅｃｔｉｖｅｂｒｏｎｃｈｉａｌａｒｔｅｒｉａｌｃｈｅｍｏｔｈｅｒａｐｙ（ＢＡＣ）ｉｓｏｎｅｏｆｔｈｅｅｆｆｅｃｔｉｖｅｍｅｔｈｏｄｓｏｆｔｒｅａｔ ｍｅｎｔｆｏｒｍｉｄ ａｄｖａｎｃｅｄｌｕｎｇｃａｎｃｅｒａｔｐｒｅｓｅｎｔ．ＦｒｏｍＪａｎｕａｒｙ 1 994ｏｎ， 45ｃａｓｅｓｏｆｍｉｄ ａｄ ｖａｎｃｅｄｎｏｎ ｓｍａｌｌｃｅｌｌｌｕｎｇｃａｎｃｅｒ（ＮＳＣＬＣ）ｈａｖｅｂｅｅｎｔｒｅａｔｅｄｅｆｆｅｃｔｉｖｅｌｙｂｙｔｈｅａｕｔｈｏｒｓｗｉｔｈＣｈｉｎｅｓｅｈｅｒｂａｌｍｅｄｉｃｉｎｅ（ＣＨＭ）…     

Effect of Feitai Capsule(肺泰胶囊) on Quality of Life and Progression-Free Survival of Patients with Unresectable Non-Small Cell Lung Cancer

<正>Objective:To examine the effect of a Chinese medicinal herbal formula(Feitai Capsule,肺泰胶囊) on the quality of life(QOL) and progression-free survival(PFS) of patients with unresectable non-small cell lung cancer(NSCLC).Methods:Sixty-two patients were randomly divided into the treatment group(31 cases) and the control group(31 cases).For the treatment group,4 capsules(1.2 g/capsule) of Feitai Capsule were administered 3 times a day after meals for 3 weeks;then no drug was administered for 1 week.This schedule was continued for at least 3 more cycles(12 weeks totally).If there were no obvious toxic reactions,the treatment was extended.The patients were evaluated at least once every 8 weeks until progressive disease(PD). For the control group,the regular follow-up and evaluation were performed at least once every 8 weeks until PD.Clinical symptoms,objective response,physical constitution and energy,QOL,and PFS were evaluated regularly.Analysis of variance(ANOVA),a non-parametric test,and analysis of covariance were used to compare clinical features,amelioration of clinical symptoms,physical constitution and energy,and QOL.Kaplan-Meier analysis was used to compare the two-group PFS.Results:Sixty patients finished the final evaluation, with 30 patients in each group.Baseline characters between groups were not significantly different(P0.05). The control group had a 36.7%improvement in clinical symptoms,while the treatment group had a 73.3% improvement.This difference was statistically significant(Z=-2.632,P=0.008).The control group had a 26.7% improvement in the Karnofsky performance status(KPS),while the treatment group had a 53.4%improvement. This was also significantly different(Z=-2.182,P=0.029).A comparative analysis indicated a positive correlation (r=0.917,P0.001).Compared with the control group,QOL in the treatment group was significantly improved, except in the social/family condition and doctor-patient relationship indicators.The PFS of the treatment group and control group were 6.23 months and 4.67 months,respectively(P=0.048).Conclusion:Feitai Capsule,a Chinese medicinal herbal treatment could improve the QOL and extend the PFS of the unresectable NSCLC patients.     

Effect of Chinese herbal medicine combined with acitretin capsule in treating psoriasis of blood-heat syndrome type

Objective:To observe the clinical curative effect of Chinese herbal medicine combined with acitretin capsule in treating psoriasis of blood-heat syndrome(P-BH).Methods:Eighty patients of P-BH were randomly assigned to two groups,39 in Group A and 41 in Group B.Both was treated with Chinese herbal medicines for clearing heat,cooling blood and removing toxic substance,and acitretin capsule was given to Group A additionally,with 8 weeks as one therapeutic course.The clinical curative effect was compared bet...     

卡瑞利珠单抗+白蛋白紫杉醇+奈达铂/顺铂治疗老年晚期食管癌的临床疗效观察

目的 探讨卡瑞利珠单抗+白蛋白紫杉醇+奈达铂/顺铂治疗老年晚期食管癌的疗效和安全性。方法 回顾性分析2018年10月—2020年8月安徽省立医院62例行一线化疗的晚期食管癌患者的临床资料。依据治疗方案的不同分为A组（30例）和B组（32例）。A组患者接受卡瑞利珠单抗（200 mg d1）+白蛋白紫杉醇（0.1 g d1、d5）+奈达铂（70 mg/m² d2）/顺铂方案（30 mg d1～d4）；B组患者接受白蛋白紫杉醇+奈达铂/顺铂方案。比较两组近期疗效、肿瘤标志物［癌胚抗原（CEA）、鳞状细胞癌抗原（SCC）］水平、毒副反应事件发生率及预后生存情况。结果 A组客观缓解率高于B组（P <0.05）；两组治疗前后CEA、SCC差值比较，差异有统计学意义（P <0.05），A组治疗前后CEA、SCC的差值高于B组；两组治疗期间腹泻、胃肠道反应、骨髓抑制、肝肾功能损伤总发生率比较，差异无统计学意义（P >0.05）；A组存活率高于B组（P <0.05）。结论 老年晚期食管癌患者采用卡瑞利珠单抗+白蛋白紫杉醇+奈达铂/顺铂治疗可提高临床疗效，降低肿瘤标志物水平，提高患者近期生存率，且安全性良好。     

透析间期体重增加与透析患者营养状况和死亡率的关系研究

目的 探讨长期血液透析患者透析间期体重增加(interdialytic weight gain,IDWG)与其营养状况和死亡率之间的关系.方法 观察2004年1月～2005年12月我院80例维持性血液透析患者,按IDWG分为两组,IDWG＜干体重的3%/d为A组,IDWG＞干体重的3%/d为B组.营养状况调查采用生化法(包括清蛋白、前清蛋白、总胆固醇、肌酐、透前血钾和血磷浓度)、标准蛋白分解率(nPCR)、人体测量(包括体重、体重指数、三头肌皮褶厚度).结果 A组前清蛋白、清蛋白、血钾、血磷、血肌酐水平较B组低,A组nPCR、体重、体重指数、三头肌皮褶厚度较B组低,差异均有统计学意义;生存曲线表明,A组患者2年存活率显著低于B组,71.8% vs 92.7%,P＜0.01;血白蛋白水平＜4g/dl的患者较白蛋白水平＞4g/dl患者有较低的生存率,61.9% vs 91.5%,P＜0.03.结论 IDWG与血液透析患者营养参数密切相关,持续低水平的IDWG提示患者可能存在营养不良和较高的死亡率,临床应重视该类患者的营养支持.     

Evaluation on quality of life and analysis on its correlation with TCM syndromes in patients of chronic hepatitis B

Objective:To evaluate the quality of life(QOL) in patients with chronic hepatitis B(CHB) and analyze its correlation with traditional Chinese medicine(TCM) syndrome types.Methods:With cross-sectional investigation adopted,the QOL of 335 CHB patients was studied by the World Health Organization Quality of Life BREF Questionnaire(WHOQOL-BREF) and the chronic liver disease questionnaire(CLDQ).The results was compared with that of 30 healthy persons.Results:The QOL of the patients with chronic hepatitis B wa...     

Effect and prognostic analysis of treatment for acute myeloid leukemia using Chinese drugs combined with chemotherapy

Objective:To observe the clinical efficacy of Chinese drugs combined with chemotherapy in the treatment of acute myeloid leukemia(AML) and to investigate the prognostic relevance of the main parameters in AML treated with integrative medicine.Methods:Forty AML patients hospitalized at the authors' hospital were treated with Chinese drugs and chemotherapy.The routine examination,immunophenotype and karyotype analyses were carried out.The clinical efficacy was observed and the prognostic factors were analy...     

Clinical observation on treatment of Tourette syndrome by integrative medicine

Objective:To explore the clinical efficacy of integrative Chinese and Western medicine in treating Tourette syndrome(TS).Methods:Ninety children with TS were randomized into two groups by randomizing digital table method:the 60 patients in the treated group were treated by Ningdong Granule(宁动颗粒,NDG) plus haloperidol,and the 30 in the control group treated by haloperidol alone.The course for both groups was 6 months.Conditions of the patients were estimated before and after treatment with Yale Global Tic ...     

中药配合放射治疗鼻咽癌的临床观察

目的 探讨中西医结合治疗鼻咽癌的合理途径。方法 鼻咽癌76例，随机分A，B两组。A组39例为放射治疗加放疗期间以活血化瘀，阴清热为主，放疗后以益气养阴，生津润燥清热为主中药治疗，B组37例为单纯放射。观察比较两组近期疗效，期生存率，临床主要症状变化，颈淋巴转移灶缩小情况及放疗副反应情况。结果 治疗后A，B两组完全缓解率，部分缓解率分别为84．6％，15．4％及73．0％，27．0％，组间比较差异有显著性（P＜0．05）。3年，5年生存率A组分别为82．0％，61．5％，B组分别为70．2％，51．4％，两组比较均P＜0．05。在改善临床症状，颈淋巴转移灶缩小情况及放疗副反应方面，A组比B组更明显。结论 放疗期间配以活血化瘀，养阴清热为主，放疗后配以益气养阴，生津润燥清热中药治疗鼻咽癌优于单纯放射治疗疗法。     

Effect of Chinese drugs combining with chemotherapy on quality of life in 146 children with solid tumor

Objective:To explore the effect of Chinese drugs for supporting essence and strengthening Pi(脾, SESP) combining with chemotherapy on the quality of life(QOL) in the children with solid tumor.Methods:Using a digital table,146 children with solid tumor were randomized into two groups,77 in the control group and 69 in the treated group.They received conventional chemotherapy,but to the patients in the treated group,SESP were administered additionally.The patients' scores of QOL and adverse reaction occurred...     

The treatment of non-small cell lung cancer by interstitial I-125 seeds implantation combined with chemotherapy and Chinese medicine

Objective:To investigate the effects of brachytherapy with computed tomography-guided percutaneous radioactive 1-125 seeds interstitial implantation(ISI) synchronized chemotherapy and Chinese medicine(CM) for the treatment of advanced stage of non-small cell lung cancer(NSCLC).Methods:Ninety patients diagnosed with NSCLC by biopsy were randomly assigned to three groups:the synchronized therapy group(A),the chemotherapy plus CM-treated group(B),and the chemotherapy-treated group(C);a 2-month course of treatment was administered to them all.The effectiveness of treatment was evaluated based on tumor size,tumor markers(carcinoembryonic,squamous cell carcinoma-associated antigen,and cytokeratin 19 fragment),clinical symptoms,and quality of life(QOL) in patients.Results:The total effective rates of Groups A to C were 83.33%,46.67%,and 43.33%,respectively.The tumor markers were reduced obviously in Group A,showing significant difference compared with those in the other two groups.Additionally,QOL was elevated and cancer-related symptoms were alleviated more significant in Group A than those in Group C(all P<0.05). Conclusion:The synchronized therapy of 1-125 implantation with chemotherapy and CM was a safe therapeutic method and can be regarded as a new mode for treatment of advanced-stage NSCLC.     

Meta-analysis of the effectiveness of Chinese and Western integrative medicine on medium and advanced lung cancer

<正>Objective:To summarize the effectiveness of Chinese and Western integrative medicine in treating medium and advanced lung cancer,and to provide guidelines for clinical application.Methods:For this metaanalysis, a comparative search of Chinese medicine data in Chinese National Knowledge Infrastructure(CNKI) and Chinese BioMedical Literature Database(CBM) was undertaken to identify articles related to randomized comparative research of Chinese and Western integrative medicine in treating medium and advanced lung cancer between 1996 to 2006.Quality of life(QOL) was estimated using RevMan 4.2 software for data processing, adopting the odd ratio(OR) and the 95%confidence interval(CI).Results:Through meta-analysis of 10 qualified articles,the results were as follows:the merging effectiveness of QOL[OR=3.80,95%CI(2.65,5.47)];the rate of survival[OR=3.44,95%CI(2.04,5.80)];the tumor response rate[OR=1.88,95%CI(1.37,2.58)];the tumor developing rate[OR=0.33,95%CI(0.23,0.48)].Significant differences existed between the Chinese and Western integrative medicine treatment group and the Western treatment group(P0.01).Conclusions:Chinese and Western integrative medicine treatment of medium and advanced lung cancer has shown to improve patients' QOL and survival rate;it also can control tumor development in the short term.     

Clinical Observation on effect of comprehensive immunotherapy in treating hepatic carcinoma after embolization chemotherapy

Objective: To probe the relationship between survival period and immune function of hepatic carcinoma patients after embolization chemotherapy.Methods: One hundred and eight patients of hepatocarcinoma were randomly divided into three groups. Group A was treated by embolization chemotherapy (ECT) alone, immunotherapy and Chinese herbal medicine were given to Group B and C respectively after ECT.Results: The short-term effective rate of Group A, B and C was 61.1%, 83.3% and 80.6% respectively, the three-year survival rate 28.6%, 39.1% and 47.3%, and the median survival time 11 months, 17 months and 15 months respectively. Observation on immune function after treatment showed that patients who received ECT alone had a lower immunity while those who received immunotherapy or Chinese herbal medicine had a strengthened immunity.Conclusion: Survival period of hepatocarcinoma patients is related with their immune function, strengthening patients’ immunity could extend their survival period relatively.     

调强放疗联合内分泌治疗中晚期前列腺癌的近期疗效观察

目的：观察调强放疗联合内分泌治疗中晚期前列腺癌的近期疗效及毒副反应。方法：将患者分为 A、B、C 三组,即调强放疗+间歇内分泌治疗组（A 组）50例,采用调强放疗,同步给予间歇性内分泌治疗（给药方式同 C 组）;三维适形放疗+内分泌治疗组（B 组）50例,采用三维适形放疗,同步给予间歇性内分泌治疗（给药方式同 C 组）;两组均采用6MV 的 X 射线照射,总剂量 DT=70～76Gy,每次1.8～2Gy,每周5次;单纯内分泌治疗组（C 组）50例,亮丙瑞林,3.75mg/次,皮下注射,每28天一次+比卡鲁胺50mg口服每日一次。随访3年,评价3组的疗效及不良反应。结果：A、B 及 C 三组的有效率分别为84%、68%、46%,A、B 组分别和 C 组比较均有显著差异;A 组的毒副反应显著低于B 组,与 C 组无显著差异;A 组的1、2、3年生存率显著高于 C 组,A 组的1年生存率显著高于 B 组,而 A、B 两组比较2、3年生存率无显著差异。结论：调强放疗联合间歇性内分泌治疗中晚期前列腺癌的近期疗效好,毒副反应轻,患者大多能耐受,是一种行之有效的治疗方法。     

Effect of Gutai Decoction （固胎汤） on the Abortion Rate of in vitro Fertilization and Embryo Transfer

Objective： To study the effect of Chinese herbal medicine Gutai Decoction （固胎汤, GTD） on the abortion rate of in vitro fertilization and embryo transfer （IVF-ET）. Methods： Observed were two hundred and forty-seven women having received IVF-ET and with β-human chorionic gonadotropin （β-HCG） 〉 25 IU/L on the 14th day after transferring. All were treated conventionally with progesterone 20-80 mg per day after transferring and if necessary the treatment was supplemented with Progynova 2 - 4 mg per day, with the medication withdrawn gradually from the 9th week of pregnancy till stopped completely. Among them 131 cases received GTD medication additionally, for 109 cases of whom the medication started from the 2nd day of transferring （taken as Group A） and for the other 22 cases from the 14th day after transferring （taken as Group B）, the other 116 cases with no additional GTD treatment given were taken as the control group, with the medication lasting to the 12th week. The abortion rate in them was observed. Results： The abortion rate in Group A, Group B and the control group was 12.84%, 13.64% and 23.28%, respectively, the difference between the GTD treated groups and the control group was significant （P〈0.05）. Conclusion： Chinese medicine GTD could reduce abortion rate in women receiving IVF-ET.     

Effect of traditional chinese medicine on survival and quality of life in patients with esophageal carcinoma after esophagectomy

Objective： To explore the effect and possible mechanism of traditional Chinese medicine （TCM） on survival and quality of life （QOL） in patients with esophageal carcinoma after esophagectomy. Methods： Adopting prospective controlled method of study, the authors had 128 post-esophagectomy patients, hospitalized from February 2001 to February 2002, randomly divided into 3 groups： the TCM group, treated with TCM drugs alone; the chemotherapy group, with chemotherapy alone applied; and the synthetic group, treated with chemotherapy combined with Chinese medicine. Their survival rate and QOL were compared. Results： In the TOM group, the chemotherapy group and the synthetic group, the respective 3-year relapse and remote metastasis rate were 71.4%, 76.7%, 53.4%, respectively （X2 =6.53, P~0.05） ; the 1-year survival rate 42.9%, 46.5%, 72.1% ; 2-year survival rate 28.6%, 27.9%, 55.8%, and 3-year survival rate 26.2%, 23. 1%, 37. 2%, respectively. And the QOL improving rate was 69. 0%, 37. 2%, 58.1%, respectively, all showing significant difference among them （X^2 =6. 10, all P〈0.05）. Moreover, immune function was increased in the TCM and the synthetic groups. Conclusion： Integrative Chinese and Western medicinal treatment was the beneficial choice for post-operational patients with esophageal carcinoma. However, long time use of simple Chinese medicine was also advisable, especially for those in poverty.     

Clinical evaluation of Soothing Gan (肝) and invigorating Pi (脾) acupuncture treatment on diarrhea-predominant irritable bowel syndrome

Objective:To explore the effect of Soothing Gan(肝) and invigorating Pi(脾)(SGIP) acupuncture treatment on the clinical symptoms and quality of life(QOL) in patients with diarrhea-predominant irritable bowel syndrome(IBS-D).Methods:With a single-blinded randomized control study adopted,63 patients who met the inclusion criteria were assigned by a random number table to two groups,31 in the treatment group and 32 in the drug control group.The treatment group received SGIP acupuncture therapy; while the control group was treated orally with pinaverium bromide.The treatment duration of both groups was 28 days.The clinical efficacy was evaluated and compared by scoring patient’s symptom and QOL.Results: A significant difference was found by variance analysis in efficacies between the two groups(P<0.01),shown as the quicker initiation of effect(P<0.05) and the more evident clinical improvement in symptoms along the increase in treatment duration,as well as the more significant elevation of QOL in the acupuncture treatment group(P<0.01).SGIP displayed its superiority especially in improving dysphoria,conflict behavior,dietary restrictions,and social responses.Conclusion:SGIP acupuncture treatment could effectively alleviate the degree and frequency of symptoms’ attack in IBS-D patients,such as abdominal pain,diarrhea,abdominal distension,etc.,markedly relieve the tenesmic sensation,with the efficacy better than that of pinaverium bromide,showing a preponderance in improving patient’s QOL.     

86例晚期卵巢癌盆腔淋巴结清除术的临床分析

目的　探讨对晚期卵巢癌患者施行盆腔淋巴结清除术的临床意义。方法　对 86例晚期卵巢癌患者施行手术治疗 ,根据术后残留病灶的大小及是否行盆腔淋巴结清除术分成 3组 ,A组 :42例 ,行盆腔淋巴结清除术且残留病灶直径 <2cm ;B组 :2 6例 ,行盆腔淋巴结清除术但残留灶直径≥ 2cm ;C组 :18例未行盆腔淋巴结清除术且残留病灶≥ 2cm。 3组术后均行CAP方案化疗 6～ 8疗程 ,3组的临床分期及病理分级基本相同。结果　A组 5年生存率 30 .1% (13/42 ) ,B组 5年生存率 11.5 % (3/2 6 ) ,与A组比较差异显著 (P <0 .0 5 )。C组 5年生存率 11.1% (2 /18) ,与B组比较差异无显著性 (P >0 .0 5 ) ,与A组比较差异显著 (P <0 .0 1)。结论　术中残留病灶直径 <2cm时同时行盆腔淋巴结清除术可明显提高患者生存率。如残留病灶≥ 2cm时勿需行盆腔淋巴结清除术     

166例乳腺癌综合治疗疗效的临床研究

目的：分析166例乳腺癌患者综合治疗的疗效,探讨乳腺癌的治疗方法与预后的关系。方法：回顾性研究166例乳腺癌患者的临床病理学资料,分析以手术、放疗、化疗和内分泌治疗为主的综合治疗的疗效。结果：本组病例3年生存率为87．0％,5年生存率为77．0％,综合治疗改善了患者的生活质量。结论：以手术、放疗、化疗和内分泌治疗为主的综合治疗在降低肿瘤局部复发率、提高生存率的同时,保证了患者的生活质量。     

胃次全切除后残胃-十二指肠-连续性空肠间置术的临床研究

目的探讨胃次全切除后残胃、十二指肠、连续性空肠间置术的临床疗效。方法将远端胃癌患者54例,分为两组,A组(26例)胃次全切除后应用手工缝合或管状消化道吻合器行残胃与空肠、十二指肠与空肠的端侧吻合,再行空肠侧侧吻合,将胃空肠吻合口的近端空肠和十二指肠空肠吻合口的远端空肠分别结扎阻断,以形成连续的间置空肠;B组(28例)胃次全切除后行BillrothⅡ式消化道重建;统计两组患者消化道重建的时间,术后3个月和6个月的体重、预后营养指数(PNI)、Visick分级指数。结果两组患者术后均顺利恢复,未发生吻合口漏或梗阻等术后并发症;A、B组平均消化道重建时间分别为53min±9min和57min±6min(t=-2.145,P=0.037);术后6个月时A组体重和PNI均恢复到手术前水平,而B组虽有所恢复,但与术前相比差异仍有统计学意义。术后6个月Visick分级指数A组明显优于B组(u=2.1,P<0.05)。结论残胃、十二指肠、连续空肠间置术能够使食物通过十二指肠,恢复生理通道,并降低胃次全切除术时消化道重建的难度,避免胆汁反流,改善生活质量。