色甘酸钠气雾剂治疗儿童哮喘52例

为了评价色甘酸钠气雾剂治疗儿童哮喘的价值 ,我科哮喘专业门诊于 1996年 6月～ 1998年 1月进行了临床随机对照研究 ,现将结果报告如下。1　对象及方法1 1　对象 :本组诊断为儿童支气管哮喘轻度～中度发作患儿 15 3例。性别 :男 99例 ,女 5 4例。年龄 6～ 9岁 77例 ,～ 12岁 5 0例 ,～ 14岁 2 6例 ,平均 9 7岁。总病程 3个月～ 10年 ,平均30个月。合并过敏性鼻炎 34例。既往曾患湿疹 2 8例 ,一、二级亲属中患支气管哮喘者 2 6例。1 2　方法 :随机分 3组 ,治疗组Ⅰ 5 2例 ,治疗组Ⅱ 5 1例 ,对照组 5 0例。治疗组Ⅰ吸入色甘酸钠气雾剂 ,6～ 9…     

色甘酸钠异构体(78012)治疗春季结角膜炎效果的观察

春季结角膜炎为一种外源性多因素引起的与Ⅰ型变态反应有关的过敏性疾病。从前用皮质激素治疗取得相当疗效,但久用会产生副作用如出现青光眼、白内障、继发感染等。近年来已研制出一种有效的抗过敏药色甘酸钠(DSCG),它能抑制致敏的肥大细胞脱颗粒释放组织胺等介质,达到治疗目的。今将1983年门诊所见的春季结角膜炎病人,用2％色甘酸钠异构体治疗结果报告如下:接受治疗的共98例,男77例、女21例;194眼,有两例为单眼、轻度的首次发病,病程只一周,余均为双眼发病。首次发病的年龄最小的8个月,最大的45岁,以5～19岁年     

小儿急性氟乙酸钠中毒56例分析

<正>误服鼠药是小儿急性中毒常见原因之一,我院近2年来共收治小儿急性氟乙酸钠中毒56例报道如下。 1.临床资料 一般资料 56例均为住院患儿,男26例,女30例,年龄1～3岁34例,3～6岁20例,10岁、12岁各1例,误服至就诊时间最短1小时,最长20小时。 症状和体征 患儿就诊时均有不同程度呕吐。39例表现为全身强直性阵挛性抽搐,有7例为惊厥持续状态,死亡2例。其它未发现明显阳性体征。 实验室检查 入院后45例作心肌酶谱、肝及肾功能检查。38例心肌酶谱均有不同程度异常,8例肝功能     

沙丁胺醇、色甘酸钠及必可酮吸入治疗支气管哮喘的效果

我科自１９９３年８月起应用沙丁胺醇、色甘酸钠、必可酮吸入治疗支气管哮喘病儿,并进行了临床疗效观察。现将应用药物治疗２年以上资料完整的４６例总结报告如下。１临床资料１．１一般资料支气管哮喘病儿４６例,男３３例,女１３例;年龄２．２５～１２．７５岁,平均...     

应用硝普钠多巴胺治疗急性心肌梗死的临床疗效观察

急性心肌梗死引发充血性心力衰竭及心源性休克是心肌梗死的致死性合并症,致死率很高。本文介绍应用硝普钠、多巴胺治疗急性心肌梗死合并充血性心力衰竭和/或心源性休克的体会。1资料共48例,均符合急性心肌梗死的诊断标准,男34例,女14例。年龄在32～78岁,平均58岁。发病后入院≤4h32例,余均在发病后48h内入院。未经特殊选择,均以硝普钠多巴胺加入葡萄糖液中常规静脉滴注,且应用镇痛剂、吸氧对症处置,临床观察28d。2方法病人住院后吸氧、卧床休息,除对症应用抗心律失常药物及止痛药物外,均应用硝普钠25～50mg,多巴胺20mg,加入5%葡萄糖500mL,…     

小儿氟乙酸钠中毒12例临床分析

近几年来小儿灭鼠药氟乙酸钠中毒在本地时有发生。我科自1995～1998年共收治了12例，为提高对小儿灭鼠药中毒的重视和认识，现将其诊治情况分析报告如下。1临床资料小儿氟乙酸钠中毒12例，男8例，女4例；年龄15个月～5岁11例，系误服，12岁1例，系自杀。轻至中度中毒10例，重度中毒2例。就诊时间：服药后20分钟～10小时。临床表现 全部病例均有呕吐，呕吐物为胃内容，无特殊气味。抽搐5例，谵妄3例，口吐白沫、心音低钝各1例，昏迷、肝肿大各2例，脑膜刺激征及病理反射均阴性，视乳头轻度水肿1例。实验室检查 肝功能异常2例，肾功能均正常…     

色甘酸钠+654-2+地塞米松治疗过敏性鼻炎的临床观察

过敏性鼻炎是鼻腔粘膜的变态反应性疾病 ,是人群中最常见病之一 ,它不但给患者带来难言之隐 ,严重时常常困扰着患者的正常工作。自 2 0 0 0年以来 ,我们使用色甘酸钠 +6 5 4 - 2 +地塞米松治疗过敏性鼻炎 5 4例 ,取得明显效果。现将我们的治疗方法及临床效果介绍如下。1 .临床资料本组病例 5 4例 ,均为过敏性鼻炎就诊的患者 ,其中男 34例 ,女 2 0例 ,年龄 6岁至 72岁。2 .方法与疗效用注射器抽取 6 5 4 - 2针水 1 0mg和地塞米松注射液 1 0mg ,加入 0 .2 %色甘酸纳滴眼液 1 0ml× 2支 ,混合滴鼻 ,每日3次 ,并每晚口服息斯敏片 3～ 1 0mg,时间…     

急性氟乙酸钠中毒患者的抢救护理

本组共16例，女性9例，男性7例，年龄为2～8岁，口服氟乙酸钠量不等，自中毒至就诊时间为20～60min 7人，2～10h 9人。按其临床表现可分为轻，中、重三度，其中轻者5人，中度7人，重度4人。本组16例患者均为误食所致中毒，轻者表现为头晕，头痛，面部肌肉小抽动，窦性心动过速，恶心，呕吐，体温降低：     

脑出血并血钠异常45例临床分析

本文总结我院自2001年9月～2004年9月间收治的脑出血患者310例,其中并发血钠异常者45例,占14.5%。本文就血钠异常与脑出血部位、病死率的关系进行探讨。1临床资料310例脑出血患者均符合中华医学会第四次全国脑血管病学术会议制定的脑出血诊断标准,并经头颅CT证实,均无充血性心力衰竭、内分泌疾病、代谢性疾病和肝肾疾病史。男性182例,女性128例,年龄37～81岁,平均(60.1±4.2)岁。血清钠<135mmol/L为低血钠,血清钠>145mmol/L为高血钠。血钠异常者45例(14.2%),男性25例,女性20例,年龄39～81岁,平均(61.2±4.1)岁。经CT检查,基底节区脑出血1…     

腐植酸钠治疗扁平疣27例

我科从1979年11月至1983年2月试用腐植酸钠(以下简称腐钠)治疗扁平疣27例,据初步临床观察,疗效尚好,现分析报告如下: 一、临床资料: 27例中,男7例,女20例。年龄最小者4(1)/2岁,最大者41岁;其中10岁以下者3例,11～20岁者9例,21～30岁者11例,31～40岁者3例,40岁以上者1例。病程最短者一周,最长者9年;其中1～6个月者4例,7个月～1年者2例,1年以上至3年者19例,3年以上2例。皮损部位:面部8例,手背及前臂者3例,面部及手背者7例,多部位者9例。 27例中有12例既往均接受过一种以上疗法的治疗了。     

A clinical study to describe the corneal topographic pattern and estimation of the prevalence of keratoconus among diagnosed cases of vernal keratoconjunctivitis

BackgroundAssociation of keratoconus with vernal keratoconjunctivitis is well known, but there are few topographic studies describing actual prevalence especially in India where it is a common condition. There is also scarce literature on the topographic patterns and subclinical topographic anomalies in cases of vernal catarrh and their relationship with various subtypes. This study was conducted to estimate the prevalence of subclinical keratoconus among Indian subjects with vernal keratoconjunctivitis and describe the various topographic abnormalities which can help in screening for these cases.MethodsIn the cross-sectional study conducted at a tertiary care center, 76 established cases of vernal keratoconjunctivitis were evaluated with placido disc–based videokeratography for topographic abnormalities and early keratoconus based on modified Rabinowitz–McDonnell criteria.ResultsSeventeen (11.2%) eyes satisfied both the modified Rabinowitz–McDonnell criteria of keratoconus. Corneal topographic pattern analysis showed asymmetric bowtie with inferior steepening in 17.11% of the patients. None of these patients had clinical evidence of keratoconus.ConclusionsThe study showed 11.2% prevalence of keratoconus in patients suffering from vernal keratoconjunctivitis. The findings highlight the importance of using a simple placido disc–based corneal topography system for screening the patients with vernal keratoconjunctivitis for keratoconus. This can help in early detection and preventive intervention.     

春季角结膜炎中医治疗进展

文章从相关古籍、辨证用药、局部用药等方面阐述了中医治疗春季角结膜炎的近况,并提出了春季角结膜炎未来治疗的展望。     

Ocular effects of long term use of topical steroids among children and adolescents with vernal keratoconjunctivitis: a prospective observational study

Topical steroids were often irrationally used on long term basis for quick relief from ocular discomfort of inflammatory eye conditions like vernal keratoconjunctivitis in spite of their well known deleterious ocular effects. The present study was undertaken to determine the ocular effects of long term use of topical steroids among the patients with vernal keratoconjunctivitis and also to evaluate the ocular responses after withdrawal of steroids. The prospective observational study was carried out in a tertiary eye care centre of West Bengal. A total 150 referred patients of vernal keratoconjunctivitis, those used topical steroids for more than a month were included in the study. A complete set of ophthalmic examinations including measurement of intra-ocular pressure and visual acuity was carried out during registration. After withdrawal of steroids, the patients were followed-up periodically and finally evaluated after 8 weeks for any Improvement of Intra-ocular pressure and best corrected visual acuity. The data was analysed by SPSS 12.0.1 software package. Proportions were used for Interpretation. Paired t-test was used for comparison between two proportions (before and after withdrawal of steroids) and p-value <0.05 was considered as the level of significance. Though ropy mucus discharge with minimal conjunctival involvement was found the most common (74.7%) ocular manifestation, grave consequences like glaucoma was also evident among 8.7% of the study participants. Significant improvements (p<0.05) were observed for both reduction of intra-ocular pressure and visual acuity after 8 weeks of withdrawal of topical steroids. Topical steroids should be used cautiously with periodic ophthalmic examinations including intra-ocular pressure.     

春季角结膜炎巨大乳头微波热凝治疗的临床观察

目的:探讨上睑乳头微波热凝治疗有巨大乳头的春季角结膜炎的临床效果。方法:对18例(36只眼)以上睑结膜巨大乳头增生为特征的、药物治疗无效的春季角结膜炎患者,采用上睑结膜巨大乳头微波热凝变白收缩方法给予治疗。术后随访3～25个月,观察患者症状、体征的改变及并发症等情况。结果:28只眼治愈,眼刺激症状术后4～6周后基本消失,结膜巨大乳头无复发,未出现睑内翻倒睫等并发症,大部分结膜面红润光滑,间有少量不规则瘢痕,血管纹理欠清,术前结膜表浅点片状着色和盾性角膜溃疡全部愈合,随访期间未复发8,只眼结膜巨大乳头不同程度复发,范围较术前缩小,眼刺激症状较术前轻,再次行微波热凝术,术后随访15个月无复发。结论:微波热凝是药物治疗难治的有巨大乳头持续不退的春季角结膜炎的有效方法,操作安全简单,患者易接受。     

Vernal keratoconjunctivitis with shield ulcer--a case report.

This 9-year-old boy had a three-year history of vernal keratoconjunctivitis. A shield ulcer developed in the superior part of the cornea. The shield ulcer is a rare manifestation of the disease. Although the cause of shield ulcer is unknown, the association of shield ulcer with large papillae suggests a mechanical cause. The symptoms of itching and mucous discharge were relieved after medications with topical steroid and cromolyn sodium, but the large shield ulcer was persistent. The vernal ulcer was treated with a 72 hours collagen shield. The ulcer healed rapidly within 5 days, leaving a corneal opacity about the level of Bowman's layer.     

Eye health and adolescence

Complete development of eyes occurs between 8 and 11 years, though longitudinal growth of axial length may occur up to 13 years (approximately). Except a few, most of the eye diseases affecting adolescence age group are similar to adult type. Diseases like myopia, keratoconus, vernal keratoconjunctivitis, juvenile diabetic retinopathy and injuries to eye are exclusively diseases of adolescence that are commonly encountered. Psychologically, impact of eye disease on adolescent mind may be profound, thinking they might lose their eyesight. Early detection of diseases, prevention of injuries, health education and frequent eye check-up are essential.     

春季结角膜炎166例临床研究

春季结膜炎在新疆比较常见,现将1983、1984年两年间门诊所见的166例进行临床分析。所有病人均由有经验的固定医生用裂隙灯显微镜检查记录。     

儿童春季卡他性角结膜炎伴干眼状态与病情严重程度的相关性

  目的   全面评估春季卡他性角结膜炎患儿的干眼状况，了解其伴随干眼的临床特点及与病情严重程度的相关性。   方法   取2015年01至06月儿童医院眼科门诊诊断为春季卡他性角结膜炎的患儿65例（65只眼，右眼数据）为观察组。取年龄、性别与之匹配的正常儿童65例（65只眼，右眼数据）为对照组，分别进行症状评估、裂隙灯检查、泪膜破裂时间（break—up time，BUT）检查、角膜荧光素染色试验（fluorescein，FL）及眼睑刷上皮病变（Lid-wiper epitheliopathy，LWE）检查。对数据进行统计分析和评价。   结果   （1）春季卡他性角结膜炎患儿的干眼症状评分较正常儿童明显升高，两者差异有统计学意义（Z = -8.589 P < 0.01），其中畏光（23.59%）、异物感（18.08%）、瞬目异常（14.49%）、迎风不适（20.90%）是患儿最常见的症状；（2）春卡患儿的裂隙灯检查体征评分明显高于正常儿童组（ Z = -9.902 P < 0.01）；（3）干眼相关检查:春卡患儿的泪膜破裂时间（7.06±3.51）较正常儿童（13.34±4.82）明显缩短（ Z = -6.729 P < 0.01）；角膜荧光素染色评分（1.82±1.69）较正常儿童（0.23±0.46）明显升高（ Z = -6.355 P < 0.01）；眼睑刷上皮病变的评分（1.03±1.00）较正常儿童（0.31±0.50）明显升高（ Z = -4.463 P < 0.01）；（4）春卡患儿干眼症状的严重程度与患儿的体征评分相关（ r = 0.259 P < 0.05）；角膜荧光素染色评分与体征评分相关（ r = 0.269 P < 0.05）；泪膜破裂时间与角膜荧光素染色（ r = -0.283 P < 0.05）及眼睑刷上皮病变（ r = -0.252 P < 0.05）的严重程度相关；角膜荧光素染色与眼睑刷上皮病变（ r = 0.307 P < 0.05）的严重程度相关。   结论   春季卡他性角结膜炎的患儿伴随明显的干眼，其干眼的严重程度与患儿结膜炎的严重程度呈正相关。为进一步探讨春卡患儿病情转归过程中的干眼变化情况提供了基础，也为春卡患儿急性期使用人工泪液辅助治疗提供了用药依据。      

Resection and Cryotherapy Combined with Amniotic Membrane Transplantation for the Treatment of Vernal Keratoconjunctivitis with Giant Papillae

To evaluate the efficacy and safety of resection and cryotherapy combined with amniotic membrane transplantation (AMT) for the treatment of vernal keratoconjunctivitis (VKC) with giant papillae (GP). Eight patients (16 eyes involved) with VKC, characterized by GP on the upper tarsal conjunctiva, underwent resection and cryotherapy in combination with AMT. The follow-up lasted for 3-22 months. The results showed that corneal shield ulcers and superficial punctuate keratitis healed during the first week after surgery and did not recur. Fourteen eyes (87.5 %) were symptom-free 1 month after surgery, and no GP, ectropion, trichiasis and other complications were noted, but the blood vessels of upper tarsal conjunctiva could not be clearly seen and a little conjunctival scar was observed. Recurrence of GP was observed in 2 eyes (12.5 %), with the area being less and irritation milder as compared with those before the operation. Among the two eyes, one eye was treated by cyclosporine eyedrops with improvement, but the other eye showed no improvement after the treatment, and underwent a second surgery with a cotton patch soaked in fluorouracil applied onto the su-pratarsal area after resection and cryotherapy. Four months after the treatment the patient presented no symptoms and GP did not recur. It is concluded that the resection and cryotherapy combined with AMT is an effective and safe treatment for VKC with GP.     

松果腺对大鼠脾脏T淋巴细胞增殖率季节性变化的影响

目的:探讨松果腺对脾脏免疫功能季节性变化的影响。方法:采用松果腺摘除动物模型,运用噻唑蓝(MTT)比色分析法,测定冬春两季Wistar大鼠脾脏T淋巴细胞增殖率变化情况。结果:春分时生理组、伪手术组和手术组脾脏T淋巴细胞增殖率均低于冬至时相应组别的数值,差异具有显著性(P<0.01);冬至时生理组与伪手术组脾脏T淋巴细胞增殖率比较,差异具有显著性(P<0.01);春分时,手术组与伪手术组脾脏T淋巴细胞增殖率比较,差异具有显著性(P<0.01);无论冬至或春分,伪手术组和手术组脾脏T淋巴细胞增殖率均低于生理组,其中手术组数值明显低于当季生理组,差异具有显著性(P<0.01)。结论:脾脏T淋巴细胞增殖率存在冬高春低的变化趋势,松果腺摘除对脾脏免疫功能具有下调作用,松果腺对脾脏T淋巴细胞增殖率的影响不具有唯一性。