岛状皮瓣修复手指软组织损伤21例

目的 探讨如何选用手部岛状皮瓣修复手指皮肤软组织缺损并报道其疗效.方法 根据手指皮肤软组织缺损的部位、大小及修复要求等有选择的应用手部岛状皮瓣修复手指皮肤软组织缺损21例.结果 21例患者手指皮瓣均一次性修复成功.术后随访4～12个月,皮瓣、弹性、质地良好,伤手功能满意.结论 手部岛状皮瓣是修复手指皮肤软组织缺损的较好方法,应根据手指皮肤软组织缺损部位、大小、修复要求等选用上述皮瓣才能获得理想的修复效果.     

应用扩张器修复头面部软组织缺损的探讨

目的:探讨皮肤软组织扩张技术在头面部软组织缺损手术中的应用.方法:应用扩张器修复35例头面软组织缺损患者.结果:除3例感染外,扩张皮瓣均全部成活,修复后形态色泽自然,术后随访1年,获得满意疗效.结论:皮肤软组织扩张术是修复头面部软组织缺损理想选择.     

足底及足后跟感觉重建方法的选择

目的探讨足底及足后跟皮肤软组织缺损后感觉重建方法,评价各种方法的疗效。方法 27例足底及足后跟皮肤软组织缺损的患者,采用多种方法修复皮肤软组织缺损并重建感觉,观察患者的创面修复效果及感觉恢复效果。结果 27例足底及足后跟皮肤软组织缺损患者中,除1例皮瓣有少部分皮缘坏死外,其余皮瓣修复均一期愈合。皮瓣在术后或术后1年完全或部分恢复皮瓣痛、温、触觉。结论应该根据足底及足后跟皮肤软组织缺损的部位、大小,采用不同方法重建感觉。     

邻指皮瓣修复手指掌侧皮肤软组织缺损治疗体会

目的：用邻近正常的手指指背皮瓣修复伤指掌侧肌腱或骨外露的皮肤缺损—邻指皮瓣,修复手指掌侧皮肤软组织缺损。方法：邻指皮瓣修复手指掌侧皮肤软组织缺损13例。结果：所有皮瓣都成活,随访13例1个月~半年,皮瓣颜色质地和正常接近,手指屈伸功能好,皮肤感觉部分已恢复。结论：手指是上肢重要而灵活的运动器官,皮肤软组织缺损后,需及时修复,使用邻指皮瓣修复效果满意、快捷而方便。     

头颅皮肤软组织缺损治疗的分析

目的总结头颅皮肤软组织缺损的治疗经验。方法分析作者近17年来经治的628例头颅皮肤软组织缺损患者的治疗方法。结果628例病员中除5例合并有其他部位严重烧伤而死亡外均存活。495例出现有头颅或供皮(瓣)区的疤痕。全部病例头颅皮肤软组织缺损创面均得到修复。结论头颅皮肤软组织缺损的治疗是以修复创面为主的综合治疗,早期稳定全身生命体征至关重要。创面的修复方法应根据头颅皮肤软组织缺损局部创面的深浅大小等具体情况而合理选择。     

游离股前外侧皮瓣修复四肢皮肤软组织缺损

目的:探讨应用游离股前外侧皮瓣修复四肢大面积皮肤软组织缺损的临床经验.方法:2008年4月-2010年12月采用游离股前外侧皮瓣修复四肢皮肤软组织缺损13例,单纯皮瓣修复9例,阔筋膜成型修复肌腱缺损3例,桥式交叉修复小腿皮肤缺损1例.结果:术后皮瓣全部成活,平均随访3～24个月,4例臃肿6个月后整形,皮瓣外观及肢体局部...     

浅谈手指指腹缺损植皮术的护理体会

目的:探讨皮瓣修复治疗手指指端指腹皮肤软组织缺损的可行性及疗效。方法:总结分析我院2010-2011年应用皮瓣修复术治疗手指指端指腹皮肤软组织缺损伤67例,观察其治疗效果。结果:67例手指皮肤软组织缺损患者皮瓣全部成活,伤指长度得以保留,皮瓣外观满意,手指功能正常。结论:皮瓣移植是修复手指指端指腹皮肤软组织缺损的一种较好方法,手术操作简单、皮瓣成活率高、外观满意,值得临床推广应用。     

足底内侧皮瓣修复足部皮肤软组织缺损

目的报道足底内侧皮瓣转移进行修复足部皮肤软组织缺损的方法并评价其疗效。方法应用足底内侧皮瓣对9例足跟部及足背皮肤软组织缺损进行修复,其中包括1例皮肤鳞状细胞癌扩大切除创面缺损。结果9例均获随访,时间10个月—3年,转移皮瓣均成活,外形满意,感觉恢复,足及足趾活动良好,鳞状细胞癌患者随访2年未复发。结论足底内侧皮瓣对足部中小面积皮肤软组织缺损的修复疗效较好。     

自体废肢皮瓣修复大面积皮肤缺损疗效分析

目的观察自体废肢皮瓣修复大面积皮肤软组织缺损效果。方法对13例大面积皮肤软组织缺损伴肢体毁损和2例大面积皮肤软组织缺损伴肢体完全离断患者,采用转移或移植修复皮肤软组织缺损。结果本组15例患者术后皮瓣完全成活。术后随访3-12个月,效果满意,毛发生长良好。结论通过自体废肢皮瓣修复大面积皮肤软组织损伤疗效明显,并发症少。     

带旋髂浅血管的髂腹股沟皮瓣修复拇指皮肤软组织缺损

目的：用带旋髂浅血管的髂腹股沟皮瓣修复拇指皮肤软组织缺损。方法：用带旋髂浅血管的髂腹股沟皮瓣修复拇指皮肤软组织缺损20例。结果：皮瓣全部成活,随访19例3个月～2年,皮瓣颜色质地接近正常,拇指功能良好,皮肤感觉部分恢复。结论：拇指是重要且灵活的运动器官,其皮肤软组织缺损后,修复要求高,以质地相似、弹性好的皮瓣修复效果更满意。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.