康柏西普联合激光治疗糖尿病性黄斑水肿的疗效

目的：探讨康柏西普眼用注射液(Conbercept ophthalmic injection,COI)玻璃体内注射联合激光治疗对糖尿病性黄斑水肿(diabetic macular edema,DME)患者的有效性及安全性。

方法：纳入2016-08/2018-06我院眼科收治的DME患者,依据患者施行激光治疗是否联合COI分为观察组(激光治疗联合COI)55例55眼和对照组(仅激光治疗)50例50眼,对比两组患者术后1mo的BCVA(LogMAR)、黄斑中心凹视网膜厚度(CMT)、眼压水平及视野、30°视野平均光阈值敏感度、视野平均缺损值水平变化。

结果：两组患者治疗前一般资料比较无差异(P>0.05),两组患者BCVA(0.63±0.13 vs 0.76±0.19; t=4.123,P<0.001)、CMT(305.89±58.76 vs 340.26±60.41μm; t=2.954,P=0.004)比较有差异,而两组患者眼压对比(12.11±1.82 vs 12.24±1.59mmHg; t=0.389,P=0.700)无差异; 观察组患者术后1mo视野灰度值、视野平均缺损值显著低于对照组(P<0.001); 观察组患者术后1mo 30°视野平均光阈值敏感度显著高于对照组(P<0.001)。

结论：玻璃体内注射康柏西普眼用注射液联合激光治疗糖尿病性黄斑水肿患者有效且安全。     

夜间血压下降对开角型青光眼视神经损伤的影响

目的：探讨夜间血压下降与开角型青光眼和正常眼压性青光眼患者视神经损伤进展的关系。

方法：对我院眼科门诊确诊的开角型青光眼和正常眼压性青光眼患者51例51眼分别进行视野、OCT检查,进行平均视神经纤维层厚度、24h动态血压监测、24h眼压监测等检查,分析夜间血压过度下降与视野进展率的关系。

结果：根据夜间血压下降值(dip)进行分组,三组间有显著性差异的数值为平均缺损(MD)差值(P=0.032)、眼压峰值(P=0.003)、视野缺损计分差值(P=0.041)。在视野缺损进展组、视野缺损改善组、视野缺损不变组间,dip有显著性差异(P=0.028)。视野缺损进展组夜间血压下降值明显高于其他两组。夜间血压过度降低组视野缺损进展率明显高于不过度降低组(视野缺损进展率分别为50%,7%)。影响视神经纤维层(RNFL)厚度的相关因素为夜间最低平均动脉压和dip(P=0.011,P=0.032,R²=0.081); 影响MD值的相关因素为眼压波动(P=0.026,R²=0.115); 影响模式标准差(PSD)值的相关因素为眼压波动和dip(P=0.020,P=0.044,R²=0.141)。

结论：与开角型青光眼相比,正常眼压性青光眼患者中夜间血压过度下降的发生率较高。夜间血压过度降低组中视野损伤进展明显。视野缺损进展组夜间血压降低更明显。眼压波动与dip是正常眼压性青光眼和高眼压开角型青光眼的患者视神经损伤与视野缺损高危因素。     

屈光参差儿童单眼配戴角膜塑形镜后调节功能的变化

目的：观察屈光参差儿童单眼配戴角膜塑形镜后双眼调节功能的变化,探讨调节在角膜塑形镜控制近视进展中的机制。

方法：前瞻性自身对照研究,对2016-09/2018-09在我院门诊就诊的屈光参差儿童单眼配戴角膜塑形镜的青少年22例44眼,将配戴角膜塑形镜的眼作为戴镜组,未作处理的另一眼作为未戴镜组。戴镜眼组22眼,等效球镜度-2.75±1.16D; 未戴镜眼组22眼,等效球镜度-0.10±0.32D。观察戴镜前和戴镜12mo后双眼屈光度差值、单眼调节幅度、调节灵敏度和调节反应的变化情况。

结果：戴镜组戴镜前的调节幅度和调节灵敏度低于未戴镜组(P<0.01),调节滞后高于未戴镜组(P<0.05)。戴镜组配戴12mo后的单眼调节幅度15.63±1.66D高于戴镜前11.25±3.15D(t=3.63,P<0.01),与未戴镜组无差异(t=0.75,P=0.46)。戴镜组配戴12mo后的单眼调节灵敏度14.63±1.58cyc/min高于戴镜前9.25±3.38cyc/min(t=2.83,P=0.01),与未戴镜组无差异(t=0.38,P=0.71)。戴镜组配戴12mo后的调节滞后0.62±0.29D较戴镜前1.35±0.26D减少(t=2.57,P=0.02),与未戴镜组无差异(t=0.61,P=0.55)。戴镜12mo后,未戴镜组的平均屈光度为-0.75±0.35D,戴镜组屈光度增长了-0.15±0.22D(t=2.90,P<0.01),未戴镜组屈光度增长了-0.65±0.39D(t=4.24,P<0.01),两组间屈光度的变化差值有差异(t=5.30,P<0.01)。未戴镜组12mo前后调节功能的变化无差异(P>0.05)。

结论：屈光参差儿童单眼配戴角膜塑形镜后戴镜眼的调节功能较戴镜前明显改善,且与对侧眼一致,戴镜眼的屈光状态更稳定,未戴镜眼逐渐呈现轻度近视屈光状态,但调节功能未出现明显变化。     

阻塞性睡眠呼吸暂停综合征对视野及视神经纤维层厚度的影响

目的：探讨阻塞性睡眠呼吸暂停综合征(OSAS)对患者视野及视网膜神经纤维层(RNFL)厚度的影响。

方法：OSAS患者74例74眼及72名健康体检者(72眼)作为对照组被纳入研究。采用Humphrey自动视野计检测视野敏感度(VFS),采用频域光学相干断层扫描仪(OCT)测量视盘周围RNFL厚度。VFS及视盘周围RNFL被划分为上方、下方、颞侧及鼻侧区域。按照多导睡眠图(PSG)监测获得的呼吸暂停低通气指数(AHI)对OSAS病情进行分级。将29例轻度、25例中度及20例重度OSAS患者上方、下方、颞侧和鼻侧区域的VFS及RNFL厚度分别与对照组进行统计学比较。

结果：OSAS组与对照组上方、下方、颞侧和鼻侧区域的VFS均无差异(P>0.05)。OSAS组尤其是重度OSAS患者视盘鼻侧RNFL厚度较对照组降低(P=0.047)。Pearson相关性分析显示鼻侧RNFL厚度与OSAS患者病情呈负相关(r=-0.9998,P=0.0138)。

结论：重度OSAS可导致鼻侧RNFL厚度减少,RNFL厚度可作为评估OSAS病情严重程度的指标之一。     

XEN引流管植入联合丝裂霉素C治疗开角型青光眼

目的：探讨XEN引流管植入联合丝裂霉素C(MMC)治疗开角型青光眼(OAG)的临床疗效和安全性。

方法：回顾性纳入OAG患者37例37眼,按初始接受抗青光眼手术治疗与否分为初次青光眼手术组17例17眼,多次青光眼手术组20例20眼,记录各随访时间点眼压、降眼压药物种类及并发症,术后随访时间大于1 a。

结果：术后1 a,初次与多次青光眼手术组眼压分别从术前27.56±9.94、28.43±14.18 mmHg降至15.16±3.65、17.18±5.83 mmHg,分别下降55.01%和60.43%(t=4.863,P<0.001; t=3.255,P=0.004)。术后不同时间点两组眼压均较术前降低,时间有差异(F_时间=6.876,P_时间<0.001),组间及交互均无差异(F_组间=0.242,P_组间=0.626; F_{时间×组间}=0.959,P_{时间×组间}=0.458)。两组手术完全成功率分别为47%、45%,条件成功率为76%、75%(Z=-0.115,P=0.909),完全成功与条件成功累积生存率分析均无差异(χ²=0.042,P=0.838; χ²=0.004,P=0.949)。术后1 a随访时两组降眼压药物均由术前的3(2,3)种减少为1(0,2)种(Z=-3.289、-3.796,均P<0.001),组间无差异(Z=-0.581,P=0.561)。术后短期并发症以低眼压为主,前房出血次之,远期并发症以滤过泡包裹为主,除外引流管暴露及脱落各1眼,无其他严重并发症发生。

结论：XEN引流管植入联合MMC治疗初次与多次青光眼手术OAG患眼均安全有效,但多次青光眼手术组滤过泡包裹发生率高。     

两种手术方法治疗绝对期新生血管性青光眼的疗效对比

目的：对比观察睫状体冷凝联合复合式小梁切除术与单用睫状体冷凝技术治疗绝对期新生血管性青光眼(neovascular glaucoma, NVG)的临床效果。

方法：收集我院2012 -02/2013-06间收治的82例绝对期新生血管性青光眼病例。随机分为观察组和对照组,各41例。对照组给予睫状体冷凝术治疗; 观察组患者给予睫状体冷凝联合复合式小梁切除术治疗。对两组术后视力、眼压和并发症进行观察。

结果：观察组患者术后6mo视力提高率为61.0%,显著性高于对照组(41.5%),差异有统计学意义(χ²=3.843,P=0.018); 观察组患者术后眼压显著性低于对照组,差异有统计学意义(P<0.05); 观察组术后眼球疼痛、前房出血和角膜水肿并发症发生率为9.8%,12.2%,9.8%,显著性低于对照组的51.2%,60.9%,48.8%,差异有统计学意义(χ²=7.594,P=0.007; χ²=9.276,P=0.000; χ²=6.835,P=0.013); 两组球结膜水肿、前房渗出、浅前房和眼球萎缩并发症的发生率比较无统计学意义(P>0.05)。

结论：相比于单用睫状体冷凝术,睫状体冷凝联合复合式小梁切除术治疗NVG具有降眼压效果好、术后并发症少、成功率高的优点,值得推广。     

多媒体训练治疗不同年龄段儿童屈光不正性弱视

目的：探讨多媒体训练系统治疗不同年龄段儿童屈光不正性弱视的临床疗效。

方法：选取2015-03/2016-03我院收治的屈光不正性弱视患儿120例161眼作为研究对象,按其年龄划分为3组,即4～6岁学龄前期组患儿40例54眼,7～9岁学龄期A组患儿40例52眼,10～12岁学龄期B组患儿40例55眼,三组患儿均采用多媒体训练系统治疗,比较三组患儿的临床疗效和治疗依从性。

结果：治疗1个疗程后,学龄前组、学龄期A组、学龄期B组患儿的治疗总有效率分别为96.3%、82.7%、78.2%,差异有统计学意义(χ²=7.875,P<0.05),其中学龄前组患儿治疗总有效率高于学龄期A组和学龄期B组。相关性分析显示,年龄与治疗效果间具有一定的相关性(χ²=7.875,P=0.017),Pearson列联系数r=0.216。学龄前组、学龄期A组、学龄期B组患儿的治疗依从率分别为85.0%、87.5%、90.0%,差异无统计学意义(χ²=1.142,P>0.05)。

结论：多媒体训练系统治疗屈光不正性弱视能够提高患儿的治疗依从性,治疗效果较好,其中4～6岁患儿效果更为显著。     

25G和27G玻璃体切除术联合空气填充治疗RRD的疗效比较

目的：对比25G和27G玻璃体切割术(PPV)联合无菌空气填充治疗孔源性视网膜脱离(RRD)的临床疗效和安全性。

方法：回顾性分析2016-05/2018-06在我院行PPV联合空气填充治疗的RRD患者63例63眼,其中25G组33例33眼,27G组30例30眼。对比分析两组术前和术后BCVA(LogMAR)、眼压、手术时间、视网膜复位率及并发症发生情况。

结果：两组术前的基线资料均无差异(P>0.05)。25G组与27G组末次随访的BCVA均较术前改善(均P<0.01),但两组间视力改善幅度无差异(P>0.05)。25G组和27G组的平均手术时间分别为44.13±5.9、46.07±6.1min(t=0.028,P=0.412)。25G和27G组视网膜复位率分别为91%、93%(χ²=0.015,P=0.902)。25G和27G组术后发生一过性低眼压(<6mmHg)的分别为5眼(15%)和3眼(10%)(χ²=0.376,P=0.540)。两组均未观察到脉络膜脱离、感染性眼内炎等严重并发症。

结论：27G PPV联合空气填充治疗RRD在手术时间、视网膜复位率、视力改善及并发症方面与25G无差异,是治疗RRD安全、经济而有效的手术方式。     

同型半胱氨酸与2型糖尿病合并前部缺血性视神经病变的相关性

目的：探讨血清同型半胱氨酸(Hcy)水平与2型糖尿病合并前部缺血性视神经病变(AION)的关系。

方法：选取2016-01/2019-04于河北省眼科医院就诊的2型糖尿病患者100例，依据是否并发AION分为未合并AION组(A组，53例)和合并AION组(B组，47例)，另选取同期健康体检者38例为对照组(C组)。检测受检者血Hcy、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、肌酐(Cr)、糖化血红蛋白(HbA1c)等生化指标和血压、最佳矫正视力(BCVA)情况，分析2型糖尿病合并AION患者血Hcy水平与上述临床指标的相关性。

结果：B组受检者血Hcy水平(13.87±5.02μmol/L)显著高于A组(11.83±3.49μmol/L)和C组(11.06±3.62μmol/L)(均P<0.05)，且B组受检者HHcy发生率(36.2%)明显高于A组(11.3%)和C组(10.5%)。校正年龄、TG、LDL-C、Cr、糖尿病病程、收缩压和舒张压后，2型糖尿病合并AION患者血Hcy水平与HbA1c水平呈正相关(r=0.517，P=0.001)，与BCVA呈负相关(r=-0.353，P=0.026)。

结论：血清Hcy可能参与了2型糖尿病患者AION的发病过程，其可作为防治2型糖尿病合并AION的潜在靶点。     

外周血红细胞体积分布宽度与原发性闭角型青光眼的相关性研究

目的：检测原发性闭角型青光眼(PACG)患者外周血红细胞体积分布宽度(RDW)变化水平。

方法：采用回顾性病例对照研究。收集2019-02/2020-10在本院确诊的PACG住院患者306例和体检正常者126名。根据平均视野缺损(MD)大小,将PACG患者分为轻度组(MD≤6dB)、中度组(612dB)。收集纳入研究对象的眼科检查数据和人口学资料。采用全血细胞分析仪和全自动生化分析仪对外周血(RDW)、红细胞计数(RBC)、平均红细胞体积(MCV)、血红蛋白含量(HG)、白细胞计数(WBC)、谷丙转氨酶(ALT)和血清肌酐(Cr)等指标进行检测分析。

结果：PACG组与对照组间年龄、性别、体质量指数、高血压和糖尿病疾病史无差异(P>0.05)。PACG组RDW水平(12.64%±0.96%)高于对照组(12.45%±0.49%)(t=2.132,P=0.034)。轻度PACG组RDW水平显著低于中度PACG组和重度PACG组(P<0.05)。Pearson相关分析显示,PACG组RDW水平与IOP(r=0.148,P=0.002)、MD(r=0.141,P=0.013)呈正相关、与MS(r=-0.154,P=0.007)呈负相关。多因素线性回归分析显示RDW对MD具有正向影响(β=1.405,P=0.018,95% CI：0.240～2.570)。

结论：PACG患者RDW水平高于正常,且RDW水平可以评估PACG疾病进展情况。     

Evaluating the visual experience: visual acuity and the visual analogue scale

PURPOSE: To attempt a comparison of the visual experience [assessed using a visual analogue scale (VAS)] with visual acuity in a group of normally-sighted adult optometric patients. METHODS: A single-item 100 mm paper VAS was administered to a sequence of 142 normally-sighted pre-presbyopic patients. Each individual was invited to indicate their recent subjective distance visual experience between the extremes of 'dreadful' (0 mm) and 'perfect' (100 mm). Each patient's binocular visual acuity was then determined at 6 m using a high-contrast logMAR chart under usual consulting room conditions. RESULTS: A weak association was revealed between the subjective indication of recent visual experience and the actual level of binocular acuity recorded in this normally-sighted group of subjects. On the basis of group responses a statistically significant discontinuity in the scores recorded with the VAS was demonstrated between patients who attained a clinical acuity better or worse than 0.10 logMAR units (6/7.5). Patient gender, age, and whether spectacles were habitually worn for distance viewing, were each revealed to be not statistically significant features. CONCLUSIONS: For normally-sighted optometric patients the subjective criterion of visual satisfaction would appear to be only loosely associated with the contemporaneous record of clinical acuity.     

扫描翻转图像视觉诱发电位视力与对数视力表视力的比较

目的 对扫描图像视觉诱发电位视力(SPVER视力)与对数视力表视力进行比较。方法比较50例受试者的视力表和SPVER视力。在SPVER视力的测定中用了8个不同空间频率的光栅条纹连续扫描,所得数据经离散傅立叶分析后,获得振幅一空间频率曲线,并由外推法估计其视力。结果SPVER视力与视力表视力的总体相关系数r=0．699,在视力表视力大于0．5时,SPVER视力有低估现象,而在视力表视力小于0．5时SPVER视力有高估现象。结论SPVER视力与视力表视力有良好的相关性。由于视力表视力和SPVER视力所用于评估视力的指标不同,使两者结果不完全相同。     

Analysis of real-world visual ergonomics at the visual display unit

Introduction

In this interventional study, the ergonomic workplace set-up and the impact of character size on subjectively estimated working productivity and computer vision syndrome (CVS) were evaluated in the field.

Methods

The number of displays and their size, resolution, surface structure, position in the room and relation to the eye were evaluated for 152 units. CVS was assessed using the CVS-Questionnaire. Habitually used character size for an uppercase E was recorded and compared to the ISO 9241–303:2011, national standards (e.g., ANSI/HFES 100–2007) and national guidelines (e.g., German DGUV Information 215–410). In case of failure to comply with these standards, character size was increased to 22 angular minutes to reach the recommended ranges. Reasons for returning to former or smaller character sizes were recorded, and subjectively perceived changes in productivity were estimated by the participants using a visual analogue scale before and 2 weeks after the intervention using a questionnaire.

Results

The average visual display unit consisted of two non-glare (matt) 24″ widescreen monitors that were located approximately 73 cm (primary) and 76 cm (secondary) from the eyes. The mean (SD) habitually set character size was 14.29 angular minutes (3.53) and therefore both statistically and clinically significantly too small compared with ISO 9241–303:2011 (p < 0.001). Increasing the character size to 22 angular minutes produced a 26% reduction in subjectively rated productivity (p < 0.001). No significant correlation between character size and symptoms of CVS was demonstrated.

Conclusions

In the workplaces investigated, recommendations for character size were not adhered to. This resulted in a reduction in productivity and was not compatible with some of the work requirements, for example, obtaining a broad overview of a spreadsheet.     

灯箱视力表与电脑视力表临床应用对比研究

目的:通过与灯箱视力表的对比研究了解电脑视力表的临床使用价值。方法:选取初三学生63例(126眼)同时用灯箱和电脑视力表进行远用视力检测,对视力检测值进行配对检验。结果:两种视力表检测值的t检验等于1.2671,P>0.20,两种视力表的检测在统计学上无显著性差异。结论:电脑视力表和灯箱视力表在临床上具有相同的应用价值,可以推广和普及。     

Steady-state visual evoked cortical potentials from stimulation of visual field quadrants

The effects of check size and stimulus size were investigated to optimize the steady-state visual evoked cortical potentials from pattern-reversal stimulation of the visual field quadrants. Check sizes of 15, 30, 60, 90, 120 and 180 were investigated at a pattern reversal rate of 11.6 per second for field sizes varying from 2° × 2° to 24° × 24°. The visual evoked cortical potentials were recorded from mid occipital, right occipital and left occipital positions. In the inferonasal quadrant, the largest amplitudes were obtained with 30 and 60 check sizes; however, for these check sizes, the visual evoked cortical potential yielded limited additional information for field sizes greater than 4° × 4° and 6° × 6°, respectively. When a field size of 12° × 12° was investigated, a 90 check size was optimal. The results indicated hat, with the above recording positions and check sizes of 15 to 120, there is an optimal number of pattern elements, 40 to 100, for stimulation of the inferonasal quadrant. This should be taken into account when a check size is selected to investigate a field quadrant of a particular size. Digital signal processing techniques were applied to analyze the visual evoked cortical potential, and the system shows promise for objective examination of the visual field.     

视觉诱发电位评价出生窒息婴儿视觉功能

目的采用闪光视觉诱发电位的检查方法评价出生窒息对患儿视觉功能的影响。方法出生3月龄和6月龄的婴儿共65例,行闪光视觉诱发电位（F—VEP）的检查。分为正常婴儿组和窒息婴儿组,对两组3月龄和6月龄的检查结果统计分析。结果3月龄窒息婴儿和正常婴儿比较,F-VEP的P2波潜伏时差异有统计学,P〈0．005。6月龄时,两组振幅差异有统计学意义,P〈0．005。NBNA评分恢复正常越迟,F-VEP的P2波的潜伏时越长,振幅越低。结论出生窒息婴儿的视觉传导存在明显异常,并且与窒息程度相关。     

三种视力表视力测量差异研究

目的:探讨mc-3投影式视力表(A)、普通箱式视力表(B)以及综合验光仪(C)对不同年龄段人的裸眼视力及校正视力的测量结果是否有差异.方法:志愿者206人(395眼),根据患者年龄分为3组:青年组:25～45岁,共116眼;中年组:46～70岁,共102眼;老年组:71～90岁,共177眼.用视力表投影仪、普通箱式视力表以及综合验光仪分别测量各志愿者的裸眼视力及矫正视力.结果:矫正视力:3组中均无差别.裸眼视力:青年组、中年组中无差别.老年组中综合验光仪的视力测量结果要好于视力表投影仪和视力了表箱,差别具有显著性意义(秩和检验P＜0.05).结论:在老年组的裸眼视力测量结果中,综合验光仪好于视力表投影仪和视力表箱,这种视力测量的差异可能足由于不同背景亮度及视标照度下视标的对比度不同所引起.     

Habitual vs optimal distance visual acuity

PURPOSE: The maintenance of a good level of vision is desirable for developmental and social reasons; it is also a requirement that should not be overlooked in the clinical research environment. This study set out to quantify and analyse any difference between 'habitual' (pre-sight test) and 'optimal' (post-refraction) distance visual acuity in an optometric population. It is intended that the outcome of this work will inform not only clinicians but also those undertaking vision research. METHODS: Binocular logMAR visual acuity was determined at 6 m before and after optometric intervention in patients attending optometric practice for a routine sight test. Cases were recorded seriatim but restricted to the 'core' refraction range representative of typical optometric practice; three further exemption criteria included subject illiteracy, the necessity for a non-standard test distance and contact lens wear. Over a 12-month period, two-thirds of patients examined satisfied the study inclusion criteria; it is the clinical data of these 1288 individuals that are described and analysed here. RESULTS: These data provide a quantitative demonstration that an optometric intervention will most likely improve the habitual distance visual acuity of subjects, irrespective of gender, age group, time interval since last test, refractive status and whether or not the subject is a habitual spectacle wearer. The improvement found was typically within one logMAR chart line (<5 letters), being greatest in spectacle-wearing teenagers and in individuals beyond retirement age (increasing to eight letters in elderly habitual non-spectacle wearers); also in non-wearers who left an interval of 2 years or more between sight tests. CONCLUSIONS: Clinical and laboratory-based investigators are advised that a current and optimal refractive correction should be worn by subjects of all ages enrolled in vision-related studies. Refractive defocus may introduce or exaggerate test outcome variability.     

灯箱视力表与Freiburg电子视力表应用对比研究

目的 比较灯箱视力表与Freiburg电子视力表结果的一致性与可重复性,评价Freiburg电子视力表的临床应用价值。设计 诊断性技术评价。研究对象 空军杭州航空医学鉴定训练中心的工作人员86例,平均年龄（26.3±2.1）岁。方法 所有入选者均随机由2位固定检查者分别使用灯箱视力表和Freiburg电子视力表进行检查,两种视力表检查的顺序随机决定。所有检查均在同一房间内完成,房间内亮度小于3 lux。检查距离均为3 m。对不同视力表间与检查者间测量重复性采用配对t检验比较结果的差别并计算相关系数r值。主要指标 使用两种视力表获得的logMAR视力。结果 在检查者一,用灯箱视力表查,被检者logMAR视力为0.19±0.23,Freiburg电子视力表0.20±0.15,两者差值为-0.011±0.141,差异无统计学意义（t=-0.741, P=0.461）,但有显著相关性（r=0.808,P=0.000）。在检查者二,用灯箱视力表查,被检者logMAR视力为0.32±0.25,Freiburg电子视力表为0.20±0.15,两者差值为-0.118±0.151,差异有统计学意义（t=7.191, P=0.000）及显著相关性（r=0.810,P=0.000）。均用灯箱视力表,检查者一、二的差异有统计学意义（F=11.872,P=0.001）,两者显著相关（r=0.938,P=0.000）。而均用Freiburg电子视力表,检查者一、二的差异无统计学意义（F=0.019,P=0.890）,两者显著相关（r=0.986,P=0.000）。结论 Freiburg电子视力表受检查者因素的影响小于灯箱视力表,其在不同测量者间的可重复性优于灯箱视力表。（眼科, 2013, 22: 117-120）