肺肉瘤样癌扁桃体转移1例报道

肺肉瘤样癌(pulmonary sarcomatoid carcinoma,PSC)是一种罕见的非小细胞肺癌(non⁃small cell lung cancer,NSCLC)亚型,占肺原发性恶性肿瘤的0􀆰1%~0􀆰4%,恶性程度高、早期全身转移,预后极差[1⁃2]。PSC扁桃体转移国内罕见报道,现回顾1例PSC转移至扁桃体的病例,以提高临床医师对此种罕见转移的认识。     

肺肉瘤样癌的临床病理特征及分子特点研究进展

正肺肉瘤样癌(pulmonary sarcomatoid carcinomas,PSCs)是一组分化极差、含有肉瘤或肉瘤样分化的非小细胞肺癌(non-small cell lung cancers,NSCLCs),具有高度侵袭性,常见于中老年吸烟人群,发病率占肺癌总数的0.1%~0.4%[1-2]。PSCs临床特征与其他非小细胞肺癌相似,治疗方式主要为手术切除和术后辅助放化疗[3],但有文献报道认     

帕博丽珠单抗致肺肉瘤样癌超进展1例

肺肉瘤样癌(pulmonary sarcomatoid carcinoma,PSC)是一种罕见、低分化、进展迅速、具有高度侵袭性的、治疗手段有限、放化疗不敏感、恶性程度极高、预后极差的肿瘤。高表达PD-L1、高肿瘤突变负荷的患者可以从免疫治疗中获益。本文报道的PSC为高表达PD-L1、帕博丽珠单抗治疗后超进展性疾病(hyperprogressive disease,HPD)。     

肺肉瘤样癌空肠转移1例报道

<正>肺肉瘤样癌( pulmonary sarcomatoid carcinoma,PSC) 是一种含有肉瘤细胞形态或者肉瘤样细胞分化的非小细胞型肺癌,它的发病率低,且相较于其他类型肺恶性肿瘤易发生转移。PSC小肠转移的临床报道罕见,我院偶见1例肺肉瘤样癌空肠转移病例,现报告如下:一、病例报告一般资料:患者男性,71岁,因"痰中带血2月余,间断黑便1月"于2018年3月29日入住我院消化科。患者2018年1月无明显诱因下出现痰中带血,     

帕博利珠单抗治疗晚期肺肉瘤样癌1例

正肺肉瘤样癌(Pulmonary sarcomatoid carcinomas,PSC)是一类恶性度较高、分化差、发病率低的肺恶性肿瘤,占非小细胞肺癌(non-small cell lung cancer,NSCLC)的0.1%～0.4%~([1])。本文回顾了我科收治的一例晚期肺肉瘤样癌病人,应用帕博利珠单抗的治疗过程,并对相关文献进行了复习,以提高对该疾病的治疗认识。临床资料患者男性,60岁,因"确诊肺癌1年余"于2019年5月20日收入我院。既往吸烟20余年,10支/日,戒19年。     

肺肉瘤样癌1例合并文献复习

<正>肺肉瘤样癌(pulmonary sarcomatoid carcinoma,PSC)是一种具有高度侵袭性的罕见肺部恶性肿瘤,其发病率占肺部肿瘤的0. 1%-0. 4%,常见于中老年吸烟人群~([1])。PSC恶性程度高,总体预后差,对放化疗不太敏感,目前首选治疗方法为手术治疗。本院2017年7月收治了1例PSC患者,现报道如下。病例资料患者女,79岁,主因"间断咳嗽伴咯血4月余,     

21例肺肉瘤样癌临床分析和靶向治疗探讨

目的探讨肺肉瘤样癌的临床特点、诊断和治疗方法,提高对该疾病的认识。方法回顾性分析21例肺肉瘤样癌患者的临床资料特点,分别对临床特征、影像表现、病理特征、治疗和预后进行分析。结果肺肉瘤样癌临床表现与其他类型非小细胞肺癌相似,影像和病理特征与其他类型非小细胞肺癌比较存在一定差异,研究中11例复发或晚期PSC患者中有7例单纯化疗,2周期后评价疗效,获得PR 2例,SD2例,PD3例,ORR 28. 6%(2/7),DCR 57. 1%(4/7),中位OS和PFS分别为10. 5个月,3. 5个月;研究中2例EGFR突变的Ⅳ期患者应用吉非替尼分子靶向治疗,其中1例患者获益,另1例患者无效。1例ALK基因融合阳性患者化疗2周期进展后应用克唑替尼症状缓解,肿瘤稳定了4个月。有4例ⅢB～Ⅳ期患者应用恩度联合含铂方案化疗,其中PR 2例,SD 1例,PD 1例; 1例Ⅳ期患者化疗2周期进展后,使用阿帕替尼抗肿瘤血管生成治疗无效。结论肺肉瘤样癌临床罕见,生存期短,预后较差,目前尚无标准治疗方案,肺肉瘤样癌的治疗以手术为主的综合治疗,化疗可延缓肿瘤进展,TKIs、EML4-ALK融合基因抑制剂,对驱动基因阳性晚期PSC患者疗效确切,VEGF抑制剂恩度对晚期PSC疗效确切,阿帕替尼疗效可能欠佳。     

晚期肺肉瘤样癌2例及文献复习

正肺肉瘤样癌((lung sarcomatoid carcinoma,LSC)为非小细胞肺癌(NSCLC)的一种特殊类型,以含有肉瘤样成分、分化差为特点,临床上非常少见,报道原发于肺部的肉瘤样癌仅占肺部恶性肿瘤的0.3%~4.7%,但近年来发病呈上升趋势[1]。肺肉瘤样癌相比普通肺癌,侵袭性更强,恶性程度更高,     

原发性肺胸区上皮样血管肉瘤1例报告

<正>血管肉瘤(Angiosarcoma,AS)是一种血管内皮起源的恶性软组织肿瘤，占所有肉瘤的1%～2%^[1]。上皮样血管肉瘤(epithelioid angiosarcoma,EAS)为其形态学变异，以空泡状核、核仁明显等上皮样瘤细胞排列呈脉管样、乳头状、实性片状为特点，恶性度高，侵袭能力更强，占所有AS的30%左右。胸膜及肺的AS均较为罕见[2-5]，缺乏特异性临床表现，极易被误诊。现报道1例原发性肺胸区上皮样血管肉瘤(Primary pulmonary and thoracic EAS,PPTEAS)，总结分析其临床病理学特点，并复习相关文献，旨在进一步提高对该肿瘤的认知水平。     

胆囊癌的病理、转移及预后

胆囊癌是恶性程度最高、最常见的胆道系统肿瘤 ,发生于胆囊底部 6 0 %、体部 30 %、颈管部 10 %。发病隐匿 ,预后极差 ,因此应高度重视并了解胆囊癌的病理分型、分期、转移及预后情况。1　病理分型、分期其组织学分类腺癌占 80 % (包括硬癌、乳头状癌、粘液癌 ) ,未分化癌占 6 % ,鳞癌占 3% ,混合癌占 1%。其他少见的还有淋巴肉瘤、横纹肌肉瘤、网状组织细胞肉瘤、纤维肉瘤、类癌、癌肉瘤等。病理分型为浸润型、结节型、结节浸润型、乳头型、乳头浸润型。腺癌可为浸润型或乳头型等 ,以前者多见 ;鳞状上皮细胞癌多为浸润型。浸润型肿瘤引起胆…     

State of knowledge of helminth fauna of freshwater fishes of Poland

A total 89 fish and lamprey species has been recorded from Polish freshwater habitats. Twenty-seven of them (30.3%) have not been surveyed for parasitic helminthes. Some of the latter fishes are either rare or not easily accessible. Other live only in specific habitats in scattered localities. An important obstacle for studying parasite faunas of some fishes may be their status on an endangered species. Among the non-surveyed fishes, are those which have been relatively recently introduced to Poland or migrated there on their own. The present paper attempts to review all hitherto not studied helminthologically fish species, their habitats, localities and current protection status.     

高血压降压治疗目标的再认识

根据传统的高血压水平的定义,1993年WHO高血压治疗指南提出血压控制目标为<140/90mm Hg(1mm Hg=0.133kPa),但是并非所有患者都必须将血压降至同一水平,而应根据患者情况进行个体化治疗。Framingham进行的一项长达10～12年的心血管事件研究发现,第5年后,正常上限血压[收缩压(SBP     

Lack of correlation of degree of villous atrophy with severity of clinical presentation of coeliac disease

BACKGROUND AND AIM: Both the clinical presentation and the degree of mucosal damage in coeliac disease vary greatly. In view of conflicting information as to whether the mode of presentation correlates with the degree of villous atrophy, we reviewed a large cohort of patients with coeliac disease. PATIENTS AND METHODS: We correlated mode of presentation (classical, diarrhoea predominant or atypical/silent) with histology of duodenal biopsies and examined their trends over time. RESULTS: The cohort consisted of 499 adults, mean age 44.1 years, 68% females. The majority had silent coeliac disease (56%) and total villous atrophy (65%). There was no correlation of mode of presentation with the degree of villous atrophy (p=0.25). Sixty-eight percent of females and 58% of males had a severe villous atrophy (p=0.052). There was a significant trend over time for a greater proportion of patients presenting as atypical/silent coeliac disease and having partial villous atrophy, though the majority still had total villous atrophy. CONCLUSIONS: Among our patients the degree of villous atrophy in duodenal biopsies did not correlate with the mode of presentation, indicating that factors other than the degree of villous atrophy must account for diarrhoea in coeliac disease.